SENOLYTICS: ELIMINATING SENESCENT CELLS / The Latest Updates [2022]
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- Опубліковано 30 чер 2024
- A lot has been going on in the field of cellular senescence and senolytics in the last year. In today's video, we catch up on the latest breaking news in this field.
We'll be taking a look at second-generation senolytics, molecules that can eliminate senescent cells while leaving healthy cells intact. We'll talk about grape-seed extract, a naturally occurring substance that's getting a closer look from researchers.
We'll also be examining a new senolytics that acts like a "smart bomb" to seek-and-destroy senescent cells and a new senolytic "vaccine" that uses the immune system to eliminate senescent cells.
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CHAPTERS & TIMESTAMPS:
Intro: 00:00
What Are Senescent Cells?: 00:55
How To Get Rid Of Senescent Cells: 02:35
Grape-Seed Extract: 04:15
"Smart Bombs": 07:15
Senolytic Vaccination: 09:10
Can Any Of These Strategies Be Used Now?: 12:50
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it is so funny when non doctors always kick the bucket of responsibility down to the doctor when we all know doctors are not taught about supplements....everytime i have asked a doctor about supplements i get a blank look and a scholarly reply of i dont know its not approved by the fda...its so funny how every supplement commercial says please consult a physician before use???? just look up the contraindications yourself...that is what i do...perhaps we may need to add our senolytics vaccine to the hundreds of vaccines we will need in our vaccine passports 20 years into the future....i take senolyitics when i fast...maybe the combination of that and increased autophagy works synergistically...just a hypothesis though
that's actually true, lol - I guess it's done to avoid legal liability
@Anomalies Tontoorkon Good point. It's not just about ignorance.
Doctors draw a blank on anything that is outside the prescription list. It is like going through their script and only prescribe those medication that are listed. I have noticed the supplements and also some books on healing state to consult your doctor prior to taking them. Why write a book, when they just list supplements but not when and how much to take them?
they don’t want to get sued by the AMA who is an authoritarian almost oppressive institution
I Use a functional doctor who researches the best clinical data, ingredients and manufacturing on over the counter supplements. He has a supplement store inside his building, with many of the supplements having his private label. He, along with other Drs in the group, recommend various supplements to their patients. Anyone can purchase from his store, even online.
Nice reporting on this important topic. Thanks for the update. Adding grape seed extract on an intermittent basis to my supplements is an easy solution for senescent cells until more work is done.
The searcher said: No. You cannot get PCC1 from eating Grape Seed Extract. Because there are many different kinds/types of Grape which contains different rate of PCC1, even don't contain any PCC1 in some kinds of grape.
Your presentations are excellent. This isn’t easy info to follow but the info is delivered crisply and the graphics communicate well. This is vital info so thank you
Congrats on your UA-cam success, Lance.
This made my day!
Thank you, Lance.
You're welcome.
I'm sticking to my 1.5g Fisetin with 500mg Quercetin Phytosome taken for two consecutive days, every fortnight. Been doing this for over 2yrs. But fascinating to see gen 2 senolutics are making progress.
Are you taking the liposomal version of either? Any significant side effects?
Which brand do you take?
Any noticeable effect? I have a friend that sells this. Fileting and Quercetin.
Thank you. Very enlightening information to know vs just taking grape seed. Could you let us know the brand on the above-mentioned product?t
Very interesting video. I have been working on senescence research (in vivo detection using PET) for around 10 years and somehow missed these developments. I’m subscribed now, so will hopefully catch any new developments :)
What is your job role
Clear, precise and well done.
So clear and concise. Thank you
Great , I had gotten away from this for a while since getting dasitinab is not easy. Glad to see you following the trials etc...
I'm sure we can find the equivalent of the life promoting factors of grapes in pomegranates and berries (ellagic acid), mangoes (spermidine) Kiwi (pqq) Citrus (putrescine) etc the list is as long as as many fruits there are.
Another great topic.
Great video, thank you!
Glad you liked it!
Great job!
Lance is just number one on utube
Greeting from France 🇫🇷🍷
Thanks.
Great video thank you for this information! What might an optimal intermittence be for cycling the grape seed extract?
No idea. Sorry.
Been using Terry's Naturals French GSE for years, it has low molecular weight tannins,, so it is better absorbed and has less irritating tannins. I knew there was something to GSE that they hadn't quite known about.
Interesting you say that because I’m taking Terry Naturals extra strength GSX tannin free. I will continue to take this brand.
Supposedly add to the list pine bark extract (according to the Sheekey Science Show), also available as a supplement. I'm doing Fisetin, grape seed extract, pine bark extract, curcumin (with piperine) and quercetin. Not all at once but for a few days in a row and then move to the next. Maybe just focusing on one or two types a month and then another type the next month would be better.
Should watch Dr Brads video yesterday on useless Fisetin
Yeah. I watched. Bummer.
@@RJay121 no offense but Dr Brad is the one that's useless. He puts out those videos on a regular basis, how he stopped taking a popular supplement because it gets tons of attention on his channel. Then later he goes back to taking it again. That guy grosses me out.
Brad also didn’t take it right. You need to take it with fats like Resveratrol, and there’s a difference between high dose and low dose Fisetin. Low dose doesn’t get rid of them.
Hi Mr. Hitchings, thanks for all your information, it helps a lot.
I take Senolytic Activator from Life Extension, 3 capsules once a week. Is that not enough effective?
Amazing!!
Thanks for the information Lance sir with ur synoptic research it will work on brain disease please make a video
Thanks for the informative video! This is one of best channels I found on cellular health , it's quick to the points . My daily supplement contained grape seed extract for over a decade , should I change that?
I don't see why, but I'm not a doctor.
The research on mice was every two weeks of PCC1 (GSE senolitics component). So, I stopped taking GSE everyday - maybe every 2 weeks at a dosage that I am still trying to determine. Is there any research on the dosage as PCC1 is only a part of GSE?
Good information!!!
Thanks, glad you liked it.
Great video.
Thanks!
Can you do a video about what to look for when buying products?
How do i know i am not being scammed?
Product suggestions might be helpful too, thank you!
Hi Lance.Fab content.Can you share with us your antiaging supplement protocol?
I'm posting a video tonite where I reveal all...my personal longevity plan. What I eat, how I eat, what supplements I take, what interventions I do. Everything! Even strategies I don't do but that I'm very interested in and am considering implementing in the future.
Thank you✨🤩🥳✨🙋🏼♀️🙏☀️
The research on mice was every two weeks of PCC1 (GSE senolitics component). So, I stopped taking GSE everyday - maybe every 2 weeks at a dosage that I am still trying to determine. Is there any research on the dosage as PCC1 is only a part of GSE?
I also would like your opinion about telomeres therapy, Cycloastragenol and Epitalon, nobody is speaking about this suposed miracle molecule
very nice presentation
thanks
You are most welcome
Great video, just found your channel and I love your content. Question- is there information out there on how to rotate different senolytics to target senescence cells from different parts of the body? I’m just starting out with Fisetin and quercetin, but I wasn’t sure if there was info out there that stated which ones targeted which organs/ tissues?
Also, since you mention PCC1 as a gen 2, would that imply that taking grape seed oil would target all senescence cells and not just certain areas?
I appreciate any feedback 😊
The science of senolytics is so new that there are no definitive answers. I'm currently taking dasatinib + quercetin and I'm also taking fisetin. I'm taking the D+Q every 6 months. Fisetin can be taken for 2 or 3 days once a month, although I'm currently taking it with the D+Q. There's a lot of advice, but in my opinion, no one really know the exact proper dosage and timing.
@@LanceHitchings thank you for the response!
Time to find a good grape seed extract supplement.
Thank you Lance
You're welcome.
This is good stuff.
If one eat grapes and bites the seeds, he also gets the antioxidant the skin.
And you get the sugar from the grape too! Hey that might not be so good huh?
Any trials for grape seed extract on best schedule, dosing and amount - like take 100 mg for only two days each month? And should maybe combine with fisetin and or parsley at other amounts and dosing?
So..
PCC1 that we can't use.
Smart bombs that are not available for us.
GPNMB proteine restrictions that are not available for us.
Grape seed extract is hard.. there is many types of grapes and this doesn't help me much :(
Hi Lance.. I’m 57 and totally new on senolitics: quercetin, grape seeds etc etc.. There are so many variants and it is not so easy to chose.. I am very healthy and training every days taking daily non and with plant base diet.. may I ask which is the most efficient senolitic for you or the one you prefer given that any way it is the right choice for you and I would have to check anything I usually take with my physician? Thanks in advance and take care
Paul
I am trying one from a company called Neurohacker. The product is called Qualia Senolytic. They have very high quality products
It's a proven fact that those folks who only eat plant based meals their skull is reduced in size. Men were hunters of meat( buffalo, cattle preferably.)and ROOTS. Women were gatherers of vegetables. It doesn't mean that you don't have to eat greens I do specially BRUSSEL SPROUTS AND BROCCOLI SPROUTS. CABAGGE. LOVE ORGANIC SPROUTED WHOLE WHEAT BERRY BREAD. AND FRESH CHICKEN EGGS FRIM MY OWN COOP.
Man I'm blessed, why? Because I don't take any doctor's prescription medicine. " Your food is your medicine and your medicine is your food." I do have Quercetin and Fisetin and take periodically a break. AKG too.
I really hate when people say check with your Dr before starting a vitamin protocol or any other thing that isn't mainstream, if I asked my Dr he would just look at me with bewilderment cuz he just doesn't know anything about it, if your healthy and know how to read your body according to what you are supplementing them I would not even bother saying anything to my Dr. On the other hand if you have a bunch of issues and are taking medication or multiple meds then yeah talk with the doctor
Can you tell me what is the Dosage and should it be taken daily or intermittently.
Amazing 🔥
Thanks 🔥
@@LanceHitchings Certainly
This is one of the video . All your videos are sooo educational ...
Good vid. Next one on rapamycin?
Probably not. I did a video on rapamycin last summer. ua-cam.com/video/-BtP3z_wqHo/v-deo.html
@@LanceHitchings Is too expensive
I wonder why invariant Natural Killer T (iNKT) cells sometimes fail to eliminate senescent cells.
FOXO4 blockers like new generation FOXO4-DRI are extremely promising.
Ginger ginger ginger
What you think about fox04 dri ?
Could there be a written option to read and digest bette
Lance, do you still support the aggressive bi-annual Fisetin protocol suggested by AliveByScience? (i.e.) twenty pumps per day for two days then the same a month later and repeated every 5-6 months?
Yes, I"m still on that protocol. Except that, per instructions I received directly from the good folks at Alive By Science, I do it for 3 consecutive days, not 2.
@@LanceHitchings My mistake. Yes, it’s three days. I’m due my next course, so better get ordering 😉
Can you research and do a video on ProLon fasting mimicking diet created by Dr. Valter Longo? His name was also brought up by Dr. David Sinclair as well.
You have lovely skin. What supplements do you take Abbie?
"The mice's adipose tissues..." 11:21 Venturing into a situation in English where few dare to tread. It reminds me of the cartoon cat, "I hate meeces to pieces." I suppose I would say, "The adipose tissue of the meeces." Or "The adipose tissues of the mouse cohort." Or "The murine adipose tissues."
If I'm taking Fisetin already, and I wanted to add grape seed extract, can I take both at the same time with no alteration to dosage?
Ditto on that, but alternating them daily.
As far as I know, that should be fine...but I'm not the expert. I believe that they eliminate different types of senescent cells. I do a course of senolytics once a month, for 3 consecutive days.
Lately there is a doctor who follows David Sinclair that found out that Fisetin not Quercetin work.
even
And the winner IS: The good old ONION" (rich in q.) 🙌 👏 🙏 🤝 👍
A vaccine seems interesting. My concerns are that overtime, an immune-like response might surface, pushing more cells into senescence. I shy away from vaccines in general, because once in the hands of a pharmaceutical company, the primary focus becomes profitability rather than safety.
Thank you for the video Lance. Have you seen the video by Brad Stanfield talking about how the ITB found no lifespan or Senolytic activity from Fisetin? Brad found it concerning and so do I. I am not throwing in the towel yet, but my fear is that the experiments done to confirm the activity of Senolytics Could have Made some sort of critical error in methodology. I would be very curious to hear your views on the matter. Thanks again.
Also to test the efficacy of any drug etc can cost uo to £10,000,0000, so companies will skewered their results.
Is 100-300 mg of grape-seed extract per day or in hit and run mode?
I would take the higher dose for 14 days every month. He said that the effect lasts for 19 days, if I recall well, and that high dose for a short period is better to prevent side effects. For Quercitine I do not do that. I am taking 1 gram of a not very pure version every day to improve zinc absorption. I am doing that because NAC tends to remove zinc and this counteracts that effect. You should also take copper because zinc and cooper compete in the same metabolic route. As you can see, things tend to complicate naturally.
Does induced autophagy helps to rid senescence cells too?
yeah
I don't understand the connection between the hayflick limit and aging. Take skin cells. The hayflick limit stipulates that a cell can only divide 50-75x, and skin cells are replaced every 2-3 months. 75 divisions x 3 months per division = about 18 years. So why do we still have skin after the age of 18?
Think have a reserve of skin cells - these skin “stem cells” that only become full new skin cells and start dividing when activated as replacement for the skin cells that stop dividing or died off.
@@michael-qp9xd So we only have original skin cells until we're in our teens, and then stem cells take over for the next 60 years?
@@scottk1525 hi - saying stem cells always produced for replacement of dying regular differentiated cells but of course in late life stem cell replication and usage degrades.
@@michael-qp9xd Ok so let's take a single skin cell. It divides 50-75x and then dies. Then is replaced by a stem cell? And then that skin cell divides 50-75x before dying? At which point it's replaced by another stem cell, and so on and so forth? Is that how it works?
I thought this video was about newly discovered senescent removing nutrients *senolytics) but it
It is actually "promises of the future". These promises could take years to produce and will be classified as a drug, only available to a few people that have a particular disease.
Dear Sir,
Which supplements are you taking currently and quantity?
Please reply...
He never replied. Oh my
is there a concern that if a vaccine method was used to target senescent cells and the recipient has a larger than normal amount of senescent cells the immune system could create a cytokine storm ? not even sure if that’s the correct storm but a reaction from the immune system that would cause mortality for wiping out too many senescent cells at once?
Problem with vaccine is that there are senescent cells that are useful, for example with wound healing.
You bring up a very interesting point.
Senescent cells play a contradictory role in wound healing, depending on a variety of factors including population density in the area of interest.
There's a recent paper exploring this very issue:
Clinical Implications of Cellular Senescence on Wound Healing
Resnik et al
07 Nov 2020
Current Dermatology Reports (9) 286-297
My observation is that wounds heal faster at a younger age than an older age, so inversely proportional to the stock of senescent cells.
Perhaps we should reduce senescent cell population down to a specific count?
No doubt, some senescent cell are required. But I think too many accumulate as we age.
@@LanceHitchingsnot only accumulate but their response can cause a cytokine storm.
What am I telling you? What do I offer them? What, now, do I offer you? The great adventure. The goal. The only one: don't die,don't get old.
Bring this essential problem all around...politic,science,medecine,technology...fight aging.
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That's the message. For the first time in history, it's no longer science fiction.
grape seed is the same of Resveratrol???
What Freja said.
Apparently Resveratrol doesn't have senolytic properties.
On resveratrol - new video by dr. Brad stanfeild that summarizes findins over past several yrs that resveratrol is of no benefit and somewhat toxic to humans.
I was already munching on blue berries at the gym :-)
Doesn't fasting and autophagy help clear these cells?
Nope. You're confusing autophagy with apoptosis. Apoptosis, or programmed cell death, is a process that happens TO cells, to the entire cell. Apoptosis eventually kills senescent cells and then they are cleared out be the immune system.
Autophagy is a process that goes on INSIDE of cells, where they recycle damaged proteins and other cellular waste, making the cells healthier. And much less likely to undergo apoptosis.
However, autophagy can SUPPRESS cellular senescence. It's makes the cells more healthy and much less like to become senescent.
Isn't resveratrol supposed to do the same thing?
It actives sirtuins genes rather resveratrol
I've been following resveratrol, and there's quite a bit of controversy around whether it does anything or not. Still waiting for this to be resolved.
3 day fast...
I think your presentations are better when you are standing.
Agreed. I got rid of the stool and now stand.
Fisetin is safe to leave healthy cells intact ?
No. Fisetin can destroy some healthy cells. But I'm willing to sacrifice some healthy cells to get rid of senescent cells. The healthy cells can be replaced (by stem cells) but senescent cells can cause chronic inflammation that can be hard to overcome...among other things.
Interesting vid, thanks (but some slightly annoying pauses)
Lance has to breathe occasionally
the better is fast. intermitent
Not for clearing out senescent cells. It may help to prevent senescence, but it also promotes SASPs, indicating that it may also be pro-senescent.
I thought prolong fasting with autophagy kills scenecent cell?
❤️☕️
Spermidine works great
Spermadine can help to prevent cellular senescence, but I'm not sure that it works as a senolytic.
Your here from TikTok also? Saved y'all a seat. 🪑💺