Thanks for the post. I fast daily 16/8, once a week 24 hrs, once a month 72 hrs. Omnivore, zero processed foods, no grains or sugar. Workout 6 days a week raising heartbeat to point of being chased by a hungry lion. 59 yrs old, checking all the boxes that I can. I think I'm on a good trajectory, definitely noticeable results.
I have never been able to claim omnivore status, closer to Atkins due to eating healthy greens like spinach and one or two other low glycemic carbs. I have worked out with weights most of my life after 14, and jogged or ran most of my life along with playing most school and adult league sports. I felt fantastic until my late 60s when I starting having lower back pain. Now at 78, my right shoulder has been replaced, knees are mostly gone, my hips have pain, and when the back pain gets bad enough to motivate me, I will have a rod put in my back. I still go to the fitness center to use the treadmill and do curls and stretches, but when I see someone in mid-years lifting heavy, I advise them to back off to toning only or they will likely destroy their joints.
@@vonheise i am 63 had back pain for years, tried every supplement, massage device known, 2 things helped a inversion table and most importantly massive dosages of vit d3+k2, research massive dosages of vit d3 and don't believe the bullshit that anything over 1000ius will kill you. i take 20k ius per day as matinence after taking 50k for a couple weeks.
@vonheise I don't lift heavy, all body weight exercises. Lot can be done with body weight. I can bang out 100 pushups, and do good on a pullup bar. I've been going hardcore on joint maintenance and supplementation. Amino acids like Proline, Hyaluronic acid, and taking collagen peptides. I blew out a meniscus bad, and I've totally healed it. I also use an inversion table 15 minutes per day and have totally fixed my compressed vertebrae that was pinching a nerve. I do a lot of stretching daily. If you haven't tried collagen peptides, it may help with your joints. I take Vital Protiens 20 grams per day. Read the reviews, it may convince you. My 82 yr old mother takes it too, she hikes in the forest every day for 2 hrs with her dog. Best of luck on your health.
Liked the animated diagrams. Very helpful. They clarified the static diagrams a lot of us have seen over and over but have never sunk in properly. Cheers!
Lance provides the best and most succinct source of information on antiaging technology of anyone on UA-cam. I wish him well and hope that he continues to grow his audience. 👍
Great video, thanks. I do take NMN at a dose of around 400-500 mg/day, and have noticed it helps with energy levels. After watching this video, it turns out that I am also doing most of the other things, with the exception of fasting, so maybe that's why I'm seeing results with NMN..
Thanks for this video, you've really synthesized the background well, and I appreciate your new insights and recommendations. I understand you're highlighting the importance of first activating NAMPT and inhibiting CD38 and NNMT before moving on to precursor supplementation, but regarding supplementation, have you ever investigated use of simple nicotinic acid alone as an NAD+ precursor in lieu of NR or NMN?
So many have different ideas which are mostly the same: Nicotinic acid (also generally known as niacin) and niacinamide (also known as nicotinamide) are similarly effective as a vitamin because they can be converted into each other within the organism. The blanket term vitamin B(3) is used for both.
To control cd38 you also need to lower your TMAO levels. Tmao will skyrocket your cd38. Garlic and berberine will inhibit the production of tmao by gut bacteria.
@@monnoo8221 in all due rrespect. There is is a point where it is incumbant on individuals to research and backup their own research. I am often called out by people who demand ciitations and research. Like " show me the proof". I would say quut being lazy and seek the truth yourself. Thats not my job. Prove me wrong. You wont. The proof is self evident in the often hidden research that nobody knows about. Search pubmed for anything you care about and you will find a pletrhora of research that is ignored by the medical community. Drs are often 20 years behind medical science. Sometimes 100 years behind medical science. As proof of our mismanagement of tyoe 2 diabetes. For 60 years it was trreated as an incurable disease ...but it turns out its curable by diet . I cured my own type 2 diabetes in one month...from diet alone . If you doubt what I say then research it yourself . Obly then you will you be truly infiormed . You will be the wiser individual for it.
I certainly appreciate your work, and contributions, yet here you miss several points. You also have good points here, like the report about the effect of exercise, but these are now the issues: 1. fasting for >30..36h is strictly prohibited for anyone over 55..60y of age, if body fat is
Thank you so much for this information. Desatinib requires a prescription and will cost you your eye teeth or more to buy so I can't include that in my regimen. But all the rest is very doable. Thanks again.
You can take nmn +tmg and quercetin. On the same day, maybe couple of hours after take berberin after a meal. Berberin sevres as ampk activator. One thing to note: quercetin serves as a mild blood thinner. Berberin serves as a much stronger blood thinner. So taking them separately at different times makes more sense. If you take any medications then you have to consider these things to avoid any issues.
Is that 5-7 day fast you do dry or water? Also can you do a detailed updated video on phlebotomy as a longevity protocol? I saw that in a podcast you said that was the biggest needle mover for you and I've seen similar comments from Dave Pascoe so I was curious. Thanks again for always being a beckon of the longevity community!
It is true that high dose niacin can raise NAD levels. However, you should know that high dose niacin has many side effects including increase of pace of aging. High dose niacin may increase NAD to toxic levels and increase vascular inflammation and cardiovascular risk. At least get your NAD level tested.
@@Jin-XiongShe how much is a "high dose" of NA to raise NAD? Re: testing, what is a good range to be in? ..And how much does one's level fluctuate throughout the day?
@@7solove 500mg or more are usually considered high doses. I would not encourage people taking niacin to raise NAD levels. Niacin is also not a good way to reduce cardiovascular risk even though it can effectively reduce cholesterol levels.
Hi, I have just watched your masterclass - do you address women in your programs ? We have different issues when we age as we go through a menopause. Can age be reversed for women as well ?
I disagree with monnoo8221. First off, you may or may not need hormone replacement therapy. Regardless, this is not just for men, anyone can slow aging and reduce their biological age using the strategies I talk about on this channel. Sign up for my online clas or coaching.
NMN & NR is usually sold only by companies the specialize in "longevity" supplements. Not sure what you mean by "affordable," but DoNotAge has fairly inexpensive NMN, and it's checked for quality and purity by a third party lab. You can also use my discount code of LANCE to get it a little cheaper. A new player is partiQlar.com. They're little cheaper than DoNotAge and also third party tested. Don't have a discount code for partiQlar.
To the best of my knowledges, there's no data implying that spemidine is a senolytic, and in fact, some that says it's not. Autophagy and the clearing of senescent cells are not similar processes. Autophagy improves cell health and makes them more resistant to apoptosis, programmed cell death. Senescent cells are cleared by the immune system, an entirely different process, after they undergo apoptosis. Which is less likely to occur after autophagy.
I just take 300-500mg NAM and I've got instant energy. If I take more thah this I feel unwell unlike my mother who can take up to 1000mg. Last pretty much the entire day. NMN does the same but is quadruple the cost. NR dose was half as effective for me. If I take NAM and NMN together I'm in overdrive. I can do minute long sprints at full speed. I think Na added to both NAM and NMN would be potentially hyper charging. Not brave enough to try yet.
@@LanceHitchings i did 250mg NMN with 500mg NAM. It's the only time I can sprint like I'm 20 again. And along with 200 mg of B1 hcl. Best I've ever felt.
Hi there, Lance! I've been trying to contact you through email in regards to a business proposal. Could you share your email again, in case the email address provided is not correct.
![[UA] Eternal Fire проти NAVI | EPL Season 20 Malta](http://i.ytimg.com/vi/chvlsDygrZM/mqdefault.jpg)
![GlyNAC Supplement: Reversing Aging. [Study 117 - 119 Analysis]](/img/n.gif)
Thanks for the post. I fast daily 16/8, once a week 24 hrs, once a month 72 hrs. Omnivore, zero processed foods, no grains or sugar. Workout 6 days a week raising heartbeat to point of being chased by a hungry lion.
59 yrs old, checking all the boxes that I can. I think I'm on a good trajectory, definitely noticeable results.
I have never been able to claim omnivore status, closer to Atkins due to eating healthy greens like spinach and one or two other low glycemic carbs. I have worked out with weights most of my life after 14, and jogged or ran most of my life along with playing most school and adult league sports. I felt fantastic until my late 60s when I starting having lower back pain. Now at 78, my right shoulder has been replaced, knees are mostly gone, my hips have pain, and when the back pain gets bad enough to motivate me, I will have a rod put in my back. I still go to the fitness center to use the treadmill and do curls and stretches, but when I see someone in mid-years lifting heavy, I advise them to back off to toning only or they will likely destroy their joints.
@@vonheise i am 63 had back pain for years, tried every supplement, massage device known, 2 things helped a inversion table and most importantly massive dosages of vit d3+k2, research massive dosages of vit d3 and don't believe the bullshit that anything over 1000ius will kill you. i take 20k ius per day as matinence after taking 50k for a couple weeks.
@vonheise I don't lift heavy, all body weight exercises. Lot can be done with body weight. I can bang out 100 pushups, and do good on a pullup bar. I've been going hardcore on joint maintenance and supplementation. Amino acids like Proline, Hyaluronic acid, and taking collagen peptides. I blew out a meniscus bad, and I've totally healed it.
I also use an inversion table 15 minutes per day and have totally fixed my compressed vertebrae that was pinching a nerve. I do a lot of stretching daily.
If you haven't tried collagen peptides, it may help with your joints. I take Vital Protiens 20 grams per day. Read the reviews, it may convince you. My 82 yr old mother takes it too, she hikes in the forest every day for 2 hrs with her dog.
Best of luck on your health.
@@vonheise absolutely
Hi friends. I do same thing but vegetarian whole life.
I have been taking NMN for 3 months now and it has been a game changer for my health.
Glad to hear it.
Liked the animated diagrams. Very helpful. They clarified the static diagrams a lot of us have seen over and over but have never sunk in properly. Cheers!
Glad to hear that. That's what I thought too.
Just found you yesterday. I love your chunky, beefy, detail-filled videos.
Lance Legend.
Cheers.
Thanks and welcome
Lance provides the best and most succinct source of information on antiaging technology of anyone on UA-cam. I wish him well and hope that he continues to grow his audience. 👍
Thank you.
Great video, thanks. I do take NMN at a dose of around 400-500 mg/day, and have noticed it helps with energy levels. After watching this video, it turns out that I am also doing most of the other things, with the exception of fasting, so maybe that's why I'm seeing results with NMN..
Thanks for such a thorough exposition.
Glad it was helpful!
Thanks for this video, you've really synthesized the background well, and I appreciate your new insights and recommendations. I understand you're highlighting the importance of first activating NAMPT and inhibiting CD38 and NNMT before moving on to precursor supplementation, but regarding supplementation, have you ever investigated use of simple nicotinic acid alone as an NAD+ precursor in lieu of NR or NMN?
So many have different ideas which are mostly the same: Nicotinic acid (also generally known as niacin) and niacinamide (also known as nicotinamide) are similarly effective as a vitamin because they can be converted into each other within the organism. The blanket term vitamin B(3) is used for both.
To control cd38 you also need to lower your TMAO levels. Tmao will skyrocket your cd38. Garlic and berberine will inhibit the production of tmao by gut bacteria.
that's interesting. Do you have a reference for that? thank you
@@monnoo8221 in all due rrespect. There is is a point where it is incumbant on individuals to research and backup their own research. I am often called out by people who demand ciitations and research. Like " show me the proof". I would say quut being lazy and seek the truth yourself. Thats not my job. Prove me wrong. You wont. The proof is self evident in the often hidden research that nobody knows about. Search pubmed for anything you care about and you will find a pletrhora of research that is ignored by the medical community. Drs are often 20 years behind medical science. Sometimes 100 years behind medical science. As proof of our mismanagement of tyoe 2 diabetes. For 60 years it was trreated as an incurable disease ...but it turns out its curable by diet . I cured my own type 2 diabetes in one month...from diet alone . If you doubt what I say then research it yourself . Obly then you will you be truly infiormed . You will be the wiser individual for it.
Apigenin inhibits CD38. Quercetin helps. Both raise NAD levels.
@@Terrybear27Yes...Apigenin is the boss ! ❤❤❤
I certainly appreciate your work, and contributions, yet here you miss several points. You also have good points here, like the report about the effect of exercise, but these are now the issues:
1. fasting for >30..36h is strictly prohibited for anyone over 55..60y of age, if body fat is
Wow, a lot of great information. I hadn't heard about fasting being prohibited for people over 60. Where could I find that data?
Love your class on NAD+..
Pls make enlightment on protein intake.... I am 62 yo from Indonesia...
You know, I've been working on that for a couple years. There's just so much controversy. Once I get it worked out, I'll do a video. Thanks.
Thank you so much for this information. Desatinib requires a prescription and will cost you your eye teeth or more to buy so I can't include that in my regimen. But all the rest is very doable. Thanks again.
I recommend to start with 1000mg of quercetin and 1000-2000mg of vitamin C, daily. Jinfiniti has a senescence test to monitor it.
You can take nmn +tmg and quercetin. On the same day, maybe couple of hours after take berberin after a meal. Berberin sevres as ampk activator. One thing to note: quercetin serves as a mild blood thinner. Berberin serves as a much stronger blood thinner. So taking them separately at different times makes more sense. If you take any medications then you have to consider these things to avoid any issues.
What would be a suggested quantity of dried parsley for apigenin to lower CD38?
Is that 5-7 day fast you do dry or water?
Also can you do a detailed updated video on phlebotomy as a longevity protocol? I saw that in a podcast you said that was the biggest needle mover for you and I've seen similar comments from Dave Pascoe so I was curious. Thanks again for always being a beckon of the longevity community!
A much cheaper way is to take a little niacin, which has shown to raise NAD+ levels just as well as the other molecules
It is true that high dose niacin can raise NAD levels. However, you should know that high dose niacin has many side effects including increase of pace of aging. High dose niacin may increase NAD to toxic levels and increase vascular inflammation and cardiovascular risk. At least get your NAD level tested.
I completely agree.
@@Jin-XiongShe how much is a "high dose" of NA to raise NAD? Re: testing, what is a good range to be in? ..And how much does one's level fluctuate throughout the day?
@@7solove 500mg or more are usually considered high doses. I would not encourage people taking niacin to raise NAD levels. Niacin is also not a good way to reduce cardiovascular risk even though it can effectively reduce cholesterol levels.
How little in mg?
Very good. 👍🏾
Very good, insightful,.. compared to other 'biohackers'
Nmn... for increasing estrogen? For 65 yo.. thoughts?
Hi, I have just watched your masterclass - do you address women in your programs ? We have different issues when we age as we go through a menopause. Can age be reversed for women as well ?
there is only 1 single answer: hormone replacement therapy. This allows normal or even slowed down aging.
he rest then is just as for men
I disagree with monnoo8221. First off, you may or may not need hormone replacement therapy. Regardless, this is not just for men, anyone can slow aging and reduce their biological age using the strategies I talk about on this channel. Sign up for my online clas or coaching.
where can i buy affordable NMN? iherb hasn't got any of that. why is that? is it so ''experimental'' as a molecule?
NMN & NR is usually sold only by companies the specialize in "longevity" supplements. Not sure what you mean by "affordable," but DoNotAge has fairly inexpensive NMN, and it's checked for quality and purity by a third party lab. You can also use my discount code of LANCE to get it a little cheaper. A new player is partiQlar.com. They're little cheaper than DoNotAge and also third party tested. Don't have a discount code for partiQlar.
So if all indications show nampt to be good (high vo2max) then just supplement nmn at low levels until a test shows low nad?
Really super thanks lot.We are waiting more latest ınv.results.of health
What about spermidine as senolytic ? Do you think it works ?
is not a senolytic, it promotes autophagy == cleanup in cells, mostly as long as they are not senescent
I am aware about that. But nonetheless it serves the similar purpose so I still would be curious to read response.
To the best of my knowledges, there's no data implying that spemidine is a senolytic, and in fact, some that says it's not. Autophagy and the clearing of senescent cells are not similar processes. Autophagy improves cell health and makes them more resistant to apoptosis, programmed cell death. Senescent cells are cleared by the immune system, an entirely different process, after they undergo apoptosis. Which is less likely to occur after autophagy.
Nuchido
Get tested to see whether your NAD is optimized if you are taking the product. I love to know how it works for you.
No studies yet have demonstrated any benefits. Studies so far and good but not convincing
Your voice is so much clearer and younger!!!
Sometimes. It still gets gravelly when I'm tired.
I just take 300-500mg NAM and I've got instant energy. If I take more thah this I feel unwell unlike my mother who can take up to 1000mg. Last pretty much the entire day. NMN does the same but is quadruple the cost. NR dose was half as effective for me. If I take NAM and NMN together I'm in overdrive. I can do minute long sprints at full speed. I think Na added to both NAM and NMN would be potentially hyper charging. Not brave enough to try yet.
Interesting combo, I'll have to try it.
@@LanceHitchings i did 250mg NMN with 500mg NAM. It's the only time I can sprint like I'm 20 again. And along with 200 mg of B1 hcl. Best I've ever felt.
Nice video. Just curious why we should inhibit CD38 as this protein is good fighting against senescent cells?
Because it consumes so much NAD+.
nuchido time plus works on the salvage pathways....most viable and logical approach i think
yes, agree. Have a great experience with that
Hi there, Lance! I've been trying to contact you through email in regards to a business proposal. Could you share your email again, in case the email address provided is not correct.
Try this one: lance.hitchings@icloud.com