Expert Cancer Panel: Metastatic adenosquamous lung cancer

Recorded on 7/24/2021
Metastatic Adenosquamous Lung Cancer
Scenario A Summary:
Patients with metastatic lung adenosquamous cancer with MET Exon Skipping mutation who progress on capmatinib, adding carboplatin/pemetrexed to capmatinib is preferred.
Alternatively, switching to chemoimmunotherapy or other MET-directed agents like cabozantinib are secondary options.
Ablative radiotherapy to oligoprogressive sites should be considered.
Consider a liquid biopsy at time of progression to reassess mutational status.
Scenario B Summary:
Patients with oligometastatic lung adenosquamous cancer, either upfront ablative radiation to metastatic sites or a consolidative radiation approach after systemic therapy is appropriate.
Panelists recommend platinum-doublet chemotherapy with pembrolizumab for first-line therapy.
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