VDJ recombination | antibody class switching
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- Опубліковано 3 жов 2024
- VDJ recombination lecture - This lecture explains about the mechanism of antibody class switching and somatic mutation that leads to the development of antibodies by the plasma cells. Plasma cells undergo genetic VDJ recombination that allows them to shuffle DNA segment between variable region of antibody which helps in the generation of different types of antibody modifications. This process is known as antibody class switching when the antibody class is switched from one type to the other.
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Thank you for watching the VDJ recombination and antibody class switching video lecture in immunology.
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I opened kuby book I was confused with how this switching taking place but within a mints I got the concept
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The best explanation of Antibody diversity
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wow it's so clear now ,thank you
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Big thanks your sir❣️If i haven't seen this video I will never understand vdj recombination thanks legend of microbiology.
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this is the best detaied mechanism explanation I could found. thank youu
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Unbelievable explanation!!
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Genius ...thnks alot from kashmir
you’re so good at explaining things, thank you for clarifying this, just wondering if you have a video on T cell receptor diversity?
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I don't like immunology ..... but I try to understand it .Your explanation is nice and simple to helpe me alot ,,, Thank you
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Thank you sm!! Very clear
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Brilliant ❤️
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It was very well explained !! Thank u so much
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Thanks a lot Brother ❤
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I'm watching the vedio in 2020 it's so easy to understand. Thank you
Clearly explained Sir. Thank you very much.
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my immunology teacher suggested me to watch thiz video:)...nd its amzaing sir...
Very well explained sir😊
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my teacher -from korea-
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First comment
I m BS Biotechnology student of 4th semester
Explanation is oxm
I HV no words 💓
Love from Pakistan
This was a great help thankyou
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thanks a lot shomu....ur lectures have been helpfull to me olwz
Super helpful!!
Simply excellent........
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thankyou proff ❤
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thank you sir, that was really healpful, i have difficulty to understand that TDT part , and how it cleave the unnecessary part of the gene
Beautifully explained. Thank you!
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Why did it get so much more difficult in the last two minutes :(
exactly .. i also could not understand the VDJ part ...
@@sahelidas244 Same here brother .
Keep watching this part again and try to draw the same step by step. It's not that difficult.
@@viveksinghchauhan7496 *Sister*
Because he plagiarized it.
clear explanation sir
Sir,really amazing ...well defined !!...
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Ur explanations are superb but I lost at 17:17 😅...but I got the main chunk of my topic ..thank u so much ..
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superb explanation sir...
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Very informative lecture, Thank you very much
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Plz get understand somatic hyoermutation and somatic recombination( vdj )..bcz I think both process are different but mostly it is mixed in all online videos..
It was really a nice video,it’s been beneficial to me,thank you so much please
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Hi, first I really like your videos but I have 2Q: 1.Why does a class switch occure later in the course of an immune response? 2.When does clonal expansion not occur?
Great sir..
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superb... thank u sir......
i would have failed without this, thank you :'|
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This was very useful! Thank you :)
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May I ask something, Sir? How B cell creates IgD when Mu and delta segment always cleaved together? Thank you
My answer is probably a bit late and I can only guess but as far as I know when IgD is produced, IgM is also produced, seems like IgD definitely cannot be produced if IgM isn't since they sit in the same region. Also since the frequency of IgD is below 1% i think there must be a specific pathway that somehow overgoes the immunoglobulin becoming an IgM. I know this is not really an answer to your question, just my thoughts.
You didn’t listen carefully then.. there is a small chance of recombination between the blue dots. Then if it’s between M&D, there will be IgD. And if both are cleaved together only IgM will be produced which has the highest concentration by the way
ur new surcriber from Pakistan,u did great job☺
thnxx fr making it..
+Benish Shah thank you. Glad you liked my lectures
☺
Sir I have some doubts. Is VDJ recombination and class switch same?
VDJ recombination gives the different paratopes or different classes of antibodies?
Class switch involves VDJ recombination but it generates different isotypes of antibodies. So how the VDJ recombination and class switch is different from one another. VDJ recombination changes the variable region of antibody while class switch changes the whole antibody type. What is difference between them?? I'm so confused please make a video for difference between VDJ recombination and class switch. And the mechanism of both also.
According to the blue dots you made on the board, IgD will never be made as it'll never be joint directly after variable region. Then How is IgD made?
IgD is expressed alongside IgM in immature B cells. So it is already there as a B cell receptor
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very helpful
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thank you sir
As the title says it produces antibodies of different class but can you please clarify would they be of different subclasses as well?
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+sanwithz thank you.