Bone remodeling in short: -Osteoblast release M-CSF & RANKL → Convert monocytes into osteoclasts → ↓ Bone mass -Osteoblast also release Osteoprotegerin (OPG) → OPG will inhibit RANKL → ↑ Bone mass
Great video. ties everything together nicely. Decided to review bony remodelling today and fascinating what you can pick up again on revision. Initially when learning about bony remodelling I never really thought about the significance of RANKL , but with drugs such as Prolia , a RANKL inhibitor , it becomes obvious as to why the fundamental understanding of the physiological processes is vital to clinical practice with associated pathological states such as Medication related oseteonecrosis of the jaws. Many thanks.
I would have loved to see more infromation about hormones and their influence on bone remodelling, such as the osteolytic effect of cortisol and such. An all-in-one video of what hormones affect bone remodelling.
Wow, this is really informative. Thank you! I lost 2 Parathyroids after a messed-up operation. Still don`t know how to deal with this, but trying and learning. 😰
Yey! We're glad to be of help to your medical journey! If have time, feel free to sign up for a free trial at osmosis.org so you can access more of our video library and other study features. 😊
I think there is a small mistake, yellow bone marrow does not produce blood cells as was indicated in the video. That is actually red bone marrow typically found in the epiphysis
Thank you so much for bringing this to our attention, Grant! I will be sure to pass this along to my colleagues on the Content Team so they can check the details with our Chief Medical Officer. 😊
Hi Francesca! You may access this information when you hop on osmosis.org! Please feel free to sign up for the 7-day free trial (no card needed) anytime 😊
Excellent presentation , but as far as I know osteoclasts doesn't produce COLLAGENASE , it is produced by osteoblasts actually , bone resorption by osteoclasts at it's clear zone (at ruffled borders) mediated by carbonic anhydrase , secondly it pump out hydrogen ions( after CO2 hydartion - H2CO3 formation - breakdown into Hydrogen and carbonate ions -then pump out hydrogen ions) which lowers pH , lysis of collagen in acidic media , which leads to bone resorption , Plz tell me if I m wrong
I just failed my exam because i never prepare for ortho sub the intro was so boring in my university lecture i need to start with this ✊🏻🤞🏻 wish me luck everyone i m gonna start studying this video give me so much hope i find it it very interesting and its very easy to understand this😁
Hi Pitchet! You can rock this exam! If you can, you may sign up for a free trial at osmosis.org so you can access our entire video library and study resources to help you ace your exam. This might help! We won't be asking for your bank details or anything, so no worries. 😊
I have a question please regarding Wolff's Law: if we say that Applied pressure results in bone resorption, while applied tension results in bone formation. is that correct or not?
My stupid bio teacher is making me learn this for a presentation tomorrow. Great vid if you have any clue what the stuff in it is. Does she think I’m majoring in orthopedics or something. No I’m just trying to understand transcription factors and how they affect bones. I’m screwed
This didn't really explain how the bones know what shape they're supposed to be. I am particularly interested to know why spinal stenosis doesn't reverse itself relieving pressure on the spinal cord.
I had 12 years ago a femure fracture very ugly caused by a tumore. I had surgery ofcourse the doctor said he clean everything there very good and he put me a metal plate wich I still have now and than I had the chimioterapy treatment. After 3 years I started to go slowly to gym and workout slowly but still even now after years I still cannot do the exercises for legs I did before the fracture because some pain during workout. You think the femur after this damage has healed properly? I will like your opinion also. Thank you
Hello Sir, i had an small accident and 5th metacarpal was fractured, and it's just in position, doctor said, no need for k-wire , just split is enough for 6weeks. 2weeks back split is removed, now 2months completed, but fracture line still visible, how long it will take to go off fractured line on x-ray, and I'm afraid of do physiotherapy, because when I'm doing physiotherapy some pain on fracture site. Give me some suggestions, please, thanks in advance....
Same bhai mujhe foot m 5th metatarsal fracture hua h bs pair mudne ki wajah se maine bs Casting krayi hui h..... Ab Aapki fracture line invisible ho gyi h X Ray se
so why do women experiance terrible bone pain after menopause / hysterectomy/ ovaries removed,,this process stops estrogen production correct,where does the lack of estrogen fit into this equation,was it stimulating the parathyroid or what,????thanx for the great info,
Hello sir my 5th metacarpal was fractured (oblique fracture ), and it's just in position, doctor said just split is enough for 6weeks. 15days back split is removed, now 2months and 10days completed, but fracture lines still visible, how long it will take to go off fracture lines on x-ray, metacarpal fractured lines still visible after 2months??? how long it will take to disappear fractured lines on X-ray.. can I do physiotherapy because, fractured lines are still visible now. please tell me, thanks in advance....
Thanks for sharing your condition, Vijaya. Unfortunately, we don’t provide medical advice through this channel. We’d recommend reaching out to a local health professional for any consultation and diagnosis of your medical condition. 🙏🏻
Bone remodeling in short:
-Osteoblast release M-CSF & RANKL → Convert monocytes into osteoclasts → ↓ Bone mass
-Osteoblast also release Osteoprotegerin (OPG) → OPG will inhibit RANKL → ↑ Bone mass
why this gave me more understanding than my college..i love it
Focused on lecture rather than Girls 😂😂😁
Willl my bone density will grow after quitting drugs? I am 23+.
Because you are fool 🤣
Finally understood the mechanism after 5 retake. love this type of resource, really insightful and articulate.
We're glad it helped, Dhruv! 🙏🏼
I've searched more than 1 hour for a video like this, thank you so much 😍 this sums up everything i want about bone tissue 👏
Hi Eva, Glad it was helpful!
Read your bible! (KJV, preferably) ♥
Great video. ties everything together nicely. Decided to review bony remodelling today and fascinating what you can pick up again on revision. Initially when learning about bony remodelling I never really thought about the significance of RANKL , but with drugs such as Prolia , a RANKL inhibitor , it becomes obvious as to why the fundamental understanding of the physiological processes is vital to clinical practice with associated pathological states such as Medication related oseteonecrosis of the jaws. Many thanks.
I would have loved to see more infromation about hormones and their influence on bone remodelling, such as the osteolytic effect of cortisol and such. An all-in-one video of what hormones affect bone remodelling.
This was really helpful plus the illustrations are adorable!! Thank you so much.
The illustrations are fabulous
Simple yet deep and well explained. Thanks a lot. Please make more animationlike this. I really appreciate it. Gbu all team!
Thank you Mikhail for that wonderful feedback!
Wow, this is really informative. Thank you! I lost 2 Parathyroids after a messed-up operation. Still don`t know how to deal with this, but trying and learning. 😰
Sorry to hear that. Katharina. We hope you're doing better now. 🙏🏼
Osmosis makes med school easy♥️love this channel. So accessible
Yey! We're glad to be of help to your medical journey! If have time, feel free to sign up for a free trial at osmosis.org so you can access more of our video library and other study features. 😊
Thank you for sharing. Please we would love to see more videos like this
This is the perfect video for this subject. Thank you so much!
Glad you think so!
Parathyroid gland stimulates osteoclasts (not osteoblasts) for bone resorption to occur. Small mistake at 5:05.
can you please make a video on the 2 types of bone ossification and the stages for each!!! I canot find any animations on youtube
Thanks for your recommendation! Our team will be taking this into consideration. Have a wonderful weekend! 💖
What a vivid way to present such hard topic. Thanks a lot !
Thanks for your wonderful comment! 🥰
That was exactly what was needed
Great visuals and wonderfully concise and explanatory! Thanks so much!
You're very welcome! Thanks for letting us know!
One of the best video on bone remodeling
Wow, thanks for that feedback!
Watching this on my way to my test. Thank you
We hope it went well! 🙏🏼
Amazing. Now i remmeber the core of a complicated process in our body. TKs a lot
Glad to hear that, Minh! ❤️
Wow thats so helpful...Thanks alot. In the midst of confusion and infodemic, its like a hopeful rays.
Glad it was helpful! 💫 🥰 💖
Dear Osmosa,,, please make a video about closed fracture.. thanks a lot.
Where's repair???
It starts at 4:20
I think there is a mistake at 2:41. Myeloid progenitor cells come from hematopoietic stem cells, not lymphoid stem cells.
Thanks for pointing this out! Our team will be reviewing this information and update the video as needed. 🙏🏻
Great video! Helped me a lot!
Another great video by the Osmosis Team! Thank you!
Thank you too! 🙏🏼
That's wonderfully explained..Made understanding very clear just in 5 min..
Thank you so much
Glad it was helpful, Foram! ❤️
What is the duration of this process
My daughter had PAO surgery. The coverage is good no doubt. She still has pain and is very thin, could bone remodeling be an issue?
I think there is a small mistake, yellow bone marrow does not produce blood cells as was indicated in the video. That is actually red bone marrow typically found in the epiphysis
Thank you so much for bringing this to our attention, Grant! I will be sure to pass this along to my colleagues on the Content Team so they can check the details with our Chief Medical Officer. 😊
Are these cytokines that these cells use to signl or use as a communication to start og stop a process?
hi, could you add the bibliography used to make this video? it was so useful to me and i'd like to read sources too
Hi Francesca! You may access this information when you hop on osmosis.org! Please feel free to sign up for the 7-day free trial (no card needed) anytime 😊
Thank you!!! It makes so much sense now!
Glad to help! 😊
I'm gonna send this video to my professor 💀✌️
Very clear and straight forward
Thanks, Mary! 👍🏼
excellent job
Many thanks! ❤️
Very brief vidio......Thanks alot
why there is resorption in one side and the deposition in the other side not in the same side ?
great vid
Thanks, Hanan! 😊
This is so good but i dont know english well so it was hard to understand😭😭 but tysm anyways that helped a lot🥹🫶
When the bone is getting remodeled due to stress fracture , does it add 2-3 inches in height growth . When fully recovered
Excellent presentation , but as far as I know osteoclasts doesn't produce COLLAGENASE , it is produced by osteoblasts actually , bone resorption by osteoclasts at it's clear zone (at ruffled borders) mediated by carbonic anhydrase , secondly it pump out hydrogen ions( after CO2 hydartion - H2CO3 formation - breakdown into Hydrogen and carbonate ions -then pump out hydrogen ions) which lowers pH , lysis of collagen in acidic media , which leads to bone resorption , Plz tell me if I m wrong
Well explained 👏👏👏, thank you so much 🙏
Glad you think so, Ramokunupi! 🥰❤️🙏🏼
what if person diabetic? how will heal
Medical college life is easier with osmosis! 💗💗
Glad to be of help! 😊
I just failed my exam because i never prepare for ortho sub the intro was so boring in my university lecture i need to start with this ✊🏻🤞🏻 wish me luck everyone i m gonna start studying this video give me so much hope i find it it very interesting and its very easy to understand this😁
Hi Pitchet! You can rock this exam! If you can, you may sign up for a free trial at osmosis.org so you can access our entire video library and study resources to help you ace your exam. This might help! We won't be asking for your bank details or anything, so no worries. 😊
@5:03 I think you’re mistaken. Shouldn’t the osteoclast be reabsorbing bone to release calcium in the bone?
Hi Kevin! Thanks for pointing this out. We've notified our team about this so they can have the information reviewed. 😊
I have a question please regarding Wolff's Law: if we say that
Applied pressure results in bone resorption, while applied tension results in bone formation.
is that correct or not?
excuse me but do you have a video explaining mechanism of healing of bone's fracture?
Thank you!
I wish my actual lecture was that easy with less deatails :(
Thank you. ❤
You're welcome 😊
Thanks Bro! this really helped me.
how long is it ? how long the process go ?
U ppl.arw.doing such a great teaching
..thanks a lottt
Hi Navyashree, thank you, we're glad you find our videos useful! :)
How about left humerus? How many months it takes before healing?
My stupid bio teacher is making me learn this for a presentation tomorrow. Great vid if you have any clue what the stuff in it is. Does she think I’m majoring in orthopedics or something. No I’m just trying to understand transcription factors and how they affect bones. I’m screwed
This didn't really explain how the bones know what shape they're supposed to be. I am particularly interested to know why spinal stenosis doesn't reverse itself relieving pressure on the spinal cord.
Awesome explanation. Loved it.
Thanks, Chris! 😊
What do you think about bonesmashing?
Thank you so much this is amazing
You're so welcome! 💖
❤️❤️.. plz make a video on osteoporosis
Great explanation ma sha Allah!
Thanks a lot !!!
We hope our video helped! 🥰
Thank you.....very usefull video
Welcome! 😊
Excellent ... well done ...
Thank you, Mahu! 🙏🏼
Great video, thank you
You're welcome, Euge! 🥰
Thank u! ♡
Thank you very much
I had 12 years ago a femure fracture very ugly caused by a tumore. I had surgery ofcourse the doctor said he clean everything there very good and he put me a metal plate wich I still have now and than I had the chimioterapy treatment. After 3 years I started to go slowly to gym and workout slowly but still even now after years I still cannot do the exercises for legs I did before the fracture because some pain during workout. You think the femur after this damage has healed properly? I will like your opinion also. Thank you
Really nice
Thank you! 🥰❤️🙏🏼
Understand thanks. A lot
Happy to help 🙏🏼
very appreciable
Thanks!
God bless you people
the best explanation 😍
Thanks, Dunya! 💕
So...is bone death reversible?
thx! it help me a lot
This is amazing
Pretty helpful! Thanks!
nicely explained :)
You are a life saver ❤️
Always glad to help, Muhammad! 🥰
Amazing ♥️♥️♥️♥️ thank you very much
Awesome
You are the best ❤️
Aww.. thank you Kiaan! ❤️
Great ❤❤❤❤❤🥳🥳
Does this process take place in the skull bones like the jaw or cheekbones?
Good question
Great
This is nice
Monocytes looks like a friendly thing 😊
Monocytes are the most badass myeloid cells
Amazing !!!!
I was struggling with this topic in Harrison Internal Medicine...you made it a cakewalk.
PS- 9 days to go for my DNB Medicine finals😢
Best of luck, Mahmudul! You got this! 🤓🩺 🙌🏼
woow I love this one, thank for amazing video :)))
Glad you like it, Siti! 🙌🏼
Perfect👌Tnks✨🌸
Nice
Thanks! 😊
Amaaaaazing !!!!
🙌🏼 💕 ✨
Hello Sir, i had an small accident and 5th metacarpal was fractured, and it's just in position, doctor said, no need for k-wire , just split is enough for 6weeks. 2weeks back split is removed, now 2months completed, but fracture line still visible, how long it will take to go off fractured line on x-ray, and I'm afraid of do physiotherapy, because when I'm doing physiotherapy some pain on fracture site. Give me some suggestions, please, thanks in advance....
Same bhai mujhe foot m 5th metatarsal fracture hua h bs pair mudne ki wajah se maine bs Casting krayi hui h.....
Ab Aapki fracture line invisible ho gyi h X Ray se
so why do women experiance terrible bone pain after menopause / hysterectomy/ ovaries removed,,this process stops estrogen production correct,where does the lack of estrogen fit into this equation,was it stimulating the parathyroid or what,????thanx for the great info,
Hello sir my 5th metacarpal was fractured (oblique fracture ), and it's just in position, doctor said just split is enough for 6weeks. 15days back split is removed, now 2months and 10days completed, but fracture lines still visible, how long it will take to go off fracture lines on x-ray, metacarpal fractured lines still visible after 2months??? how long it will take to disappear fractured lines on X-ray.. can I do physiotherapy because, fractured lines are still visible now. please tell me, thanks in advance....
Thanks for sharing your condition, Vijaya. Unfortunately, we don’t provide medical advice through this channel. We’d recommend reaching out to a local health professional for any consultation and diagnosis of your medical condition. 🙏🏻
holy shit that's so good
amazing❤❤❤❤❤❤❤❤❤