Can We Live up to be 200 Years Old? The Science of Longevity With David Sinclair
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- Опубліковано 21 тра 2021
- Aging is a natural process of all living organisms. In humans, it represents the accumulation of physical, psychological, and social changes that are thought of as an inevitable process of health decline. Aging doesn’t have to be that way. Recent publications have argued that the rate at which this decline occurs can be slowed or even reversed.
A growing number of scientists now believe that the first person to reach the age of 200 has already been born.
The idea of anyone living to that age is considered a fantasy by most people. Doing so in good health even more so. By slowing the aging process in human beings, we would also slow the natural decline associated with senescence and thereby extend into old age the health and functional capacity that is normally associated with youth.
David Sinclair is a professor of genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. His work is trying to understand what causes aging and why we age.
Research done by Sinclair and many others have shown that the level of NAD+ declines with age.
They argue that the pace of aging is not inexorable or predetermined, but rather can be slowed and even reversed by a variety of approaches.
According to Sinclair, Sirtuins a family of seven proteins that affect the aging process, and are believed to do a lot of good things in our body are turned on by hormesis.
As part of the aging process, cells produce what is known as oxidants or free radicals which are toxic to cells and which can damage DNA and contribute to the aging process. Researchers in the field think that sirtuins can help prevent this kind of toxicity by speeding up the reaction by which harmful oxidants are neutralized in the body.
#NMN #DavidSinclair #Longevity
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Sources
The Sincliar Lab - BLAVATNIK INSTITUTE GENETICS sinclair.hms.harvard.edu/rese... Retrieved 21.04.2021
Nicotinamide Riboside-The Current State of Research and Therapeutic Uses www.ncbi.nlm.nih.gov/pmc/arti... Retrieved 10.05.2021
Is old age the newest disease? The Dr. Gundry Podcast • is "old age" the newes... - Наука та технологія
As long as we can maintain a youthful appearance. I don't wanna look 100 for another 100 years
too bad
@@zakusa6693 I hope u look like yoda at ur 180’s
@@MartinLopez-nl1hy would be good if i lived to 180. anyways martin look up chuando tan. take his advice
Slayers will continue banging dimes and racking body counts infinitely, while average looking nerds guys will be doom to be inceldom for eternity. Brutal
@@dannyx498 english plz
If we change as much as we do with our current life spans, imagine what sort of personal evolution an individual can go through with an extra century of life!
Interesting thought, but probably a lot of people would still be immature, to grow up and have a better self awareness and spiritual growth in general usually is a decision, not related with time
But yeah more years means more possibilities to change, not necessarily tought, still I think that could be more related to how society see themselves in this new world, as good ideas and moments of realization can have more impact than years and years of ignorance
The best part, work your first 120 years and get a really nice retirement On investments, and spend your last 80 years of life living the damn dream. Yes, we would work more, but we would also get a hell of a lot more time to retire. So I think that’s a fair trade.
For context, it’s likely nobody has ever retired for 80 years. Like you would have to retire at age 20 and live to be 100 to have been retired for 80 years lol
@@aeringothyk5445 we have studied studied longer than ever in history after looking for a job and when you want to enjoy life you are 40.My soul is younger than that so wy we can't live at least 120 yrs and be still active .I want to have 120 and pretend that I'm 80...
Balls will be dragging on the floor 🥲
I don't want to be immortal but I want to live longer to enjoy everything
I wanna be immortal and explore the galaxy
I wanna be both.
When I turn 1,057 years old I can still try out for the NFL
The reasonable wish should be to be able to decide when you want to die and be healthy until then. I suggest a pill that makes you young again. You take it every 20 years. Voluntarily.
Can't enjoy everything without living forever. There will always be new things
I second wanting to be immortal and explore the galaxy
Everybody wants to live long. But living long is not enough, living young is more important.
I wouldnt decline living longer while old. Only because I'll get to see how humanity progresses though. It be fascinating to see the world in like 2200. I'll likely only live to 2100 as I am 17.
Dr. David Sinclair is the best.
How did you come to that conclusion? His looks?
@@sleepsmartsmashstress740
He is actually working on longevity, and he appears in various interviews to increase publicity and awareness.
There is also Dr. George Church and Dr. J. Craig Venter that I know of, but they deal more with genetics research.
There is synergy and relation between longevity and genetics, however.
I am hetersexual, so I do not care about how a man looks.
I prefer women.
@@zeryphex nicely reply
Either way, life is life. People crave longevity out of fear. Can’t cram what you love in 1-10-100 years? Opps! It is what it is. So stupid... moments not time.
He gives hope to people! I think we age too fast, I wish I could live to 200 looking young!
Live long and prosper.
Vulcans
if I could live 100+ years, cultivating my mind in retreat...elevating my consciousness level...nirvana is a matter of time...and I wish people will dedicate some decades doing this instead of racing in the rat race for decades.
It's all futile. Rich or poor, happy or sad, we die in the end.
knob.
@@robertcain3426 Something isn't futile just because it end.
@@MB-to5gl me being a knob doesn't change the fact.
@@robertcain3426 Truth is I shouldn't have said that to you and I apologize.
Mitochondria is the powerhouse of the cell
mitochondria is the toenail of the cell*
@@zakusa6693 lol
@@luger188 but Bernie I do believe humans can age significantly slower. Just look up Chuando tan. Gotta have a intense full body workout routine. I mean it’s possible to train the head and neck muscles. No one trains these muscles to failure.
Instead of aging slower, humans are aging faster due to horrible education and too many fast food restaurants. We need to replace these fast food restaurant with gyms.
@@zakusa6693 please where can I learn more?
My fantasy is to live 1000 years or even longer.
Please guide me I am only 19 yrs old
@@zakusa6693 i am gonna look up chuando tan
I'm 62 years old. I eat one meal a day, eat keto and exercise most days. I also fast fairly regularly, long enough to induce autophagy. I am hoping this will be enough to give me another 30 years.
As long as your parents didn't curse you with bad genes.....it should be! Good luck to you, sir.
Not sure if keto is healthy, have you looked into Valter Longos research? He says that a high carb plant based diet is what is good for longevity. Just look at the bluezones and what they eat.
@@Dieblauesau I was about to mention this keto diet thing that isn’t being supported in Asian countries because keto diet leads to kidney stones and nutrient deficiency.
Yes when I ate one meal a day I had so much energy! I was never tired! I think that 3 meal a day was a setup! 2 meals is satisfactory!
We could live to see several descendants of ours in this longer life. So there is a convincing that the first person to live to be 200 years old is already alive. I look forward to the future of us living longer. I want to live for 120 years, and I am 31 right now. I wouldn't mind living for 150 years either.
Same
I believe as humans we die fast, we don't have enough years to enjoy life,we need to do something about it
We have too many humans on this planet though, living longer is going to just make it worse
@@jayasmrmore3687 I understand where your coming from but having useful humans is a good thing at the moment probably only 30% of the human population actually contribute to help earth and others around them.
@@jayasmrmore3687 no
@@jayasmrmore3687I know these comments are quite old. but tbf we still have a long way to go till we have too many people on earth, I say we don't have enough, especially once we start expanding outside of earth, becoming an interplanetary civilisation, that's when we will need a lot more people.
@@Azd1r.3358. until we go interplanetary though we have to find a way to decrease population or at least stop it from increasing much more.
Me when turning 115: yeah I remember when I was in high school only 100 years ago.
Lmao
life style is the key factor... work that is engaging and interesting... not physically demanding but requiring mental and physical focus... eating habbits that include regular fasting... living conditions where stress is minimal... enough social activity to stimulate relationships but no unhealthy relationships caused by too much partying.
100 years from now - “let’s take it to 300”.
Everyone can be immortal
Rename yourself as "immortal"
Congrats you are now immortal!
Edit=grammar error "corrected"
@@usefullinventions4houseand59 oh yeah,lol
@@usefullinventions4houseand59 Thanks bro!
A dark lord, maybe, but not really a funny one. Better luck next time, Your Lordship.
@@thegoodlydragon7452 :0
.
If i live to 100 with good mental/body health im a happy man
Me too
Same
2121: going to wal-mart to buy the aging vaccine and a memory deletion headset.
How did you know the vaccine was meant to make you age faster?
Certainly
I want my loved ones to be immortal or at least live longer.
Do you and your loved ones want to be immortal see what the Bible says about this
Romens 2:7
everlasting life to those who are seeking glory and honor and incorruptibleness by endurance in work that is good;
2 Timothy 1:10
but now it has been made clearly evident through the manifestation of our Savior, Christ Jesus, who has abolished death and has shed light on life and incorruption through the good news
Keep up dreaming
We all do, and that’s why the earth is overpopulated because it is too easy to do so.
@@jainsgeorge563 Off course, We are all Christians, me and my loved ones. and also i would not refuse to have longer life here on Earth.
@@jayasmrmore3687 I would say, that Earth is not overpopulated. Third world countries are overpopulated. Developed countries has population decrease crisis.
Sentencing a person to life in prison brings up a whole new meaning. 200 years in a cell could be pretty hard!!!!!!
I wonder if the possibility is there where even if we dont know how to physically de-age or stop aging for people biologically, if we could somehow move their brain or consciousness into a synthetic body.
I don't think so (that it would happen in that order) because aging is probably a much simpler problem to solve than consciousness transfer outside of the body. That said, I think solving both are inevitable.
What unfortunately does not appear here: NAD in old bodies promotes the development of cancer cells from senescent cells. It is a protective function of the body to reduce NAD with age. So I guess we have to dig a little deeper.
Love videos like this
Thank y'all so much dearest 🌹
Y'all such an inspiration 🥰
Appreciate y'all from the bottom of my heart 💖
Be Blissful Eternally 🙏👼🌈
I just browsed across an article about a study that is about living long lives, and the theories behind the studies of life length.
The article spoke about datasets that involved gathering the data about those individuals that live to be over the age of 100.
This is the type of information that modern record keeping and data analysis is great for. We can use this data over time to figure out what possibly affected those that lived that long.
Of course we know that nutrition and activity along with mental well being are the greatest determining factors of ones length of life.
Though there are other factors that affect the length of life, for instance, we know that among African American males, there is a more prevalent chance of heard disease or heart attack.
I suspect the reason for that in hindsight with everything that has been happening is that many of them do not like "greens", lettuce, or leafy vegetables. I think that somehow they have been affected in a way that would discourage this type of healthy eating.
Anyway, this subject interests me because I would like to live as long as possible, and I can see the benefit of data collection and storage for this specific purpose, though we have a pretty good idea so far.
I am a smoker, so that affects my health, I also drink alot of coffee, and probably intake too much sugar because of my coffee intake.
The best thing for me to do is to minimize and eventually quit smoking, and also drink less coffee, and drink alot of water to preserve my liver.
Those who die naturally, usually start their death with a failure of the liver, this failure causes a chain reaction of the failure of the rest of our internal organs. After that, we're done.
Longevity is genetics + environment along with diet and exorcise...
@@kingali-el4416la longevidad son tus hábitos
Yes we can live forever 🌟💪
this remembers me of the music : " Do you want to live forever ? " Actualy Methusalem lived to be a Thousand Years of age !, and he enjoyed it every minute !
I want to be immortal, even if it's less cool that everyone else is doing it.
not in biological body,
but digitally, until we can figure out a way to transfer data from the digital world to biological beings with cloud transfer, that way, we can be immortal,
Biologically is not easy, it´s a process, but digital is close in our lifetime, we just need more people working on it.
Imagine being a decapitated head in the bottom of the ocean from the rest of the existence of the earth. Not sounding very fun.
Immortal = not invincible.
@@HugoTron Don't agree. We don't eve know what consciousness is so how can we make it digital? Where as there is actually roadmaps and scientific progress being made to reverse damage done to our bodies and DNA overtime.
But how would you know you're immortal until you reach the end of time? :)
(See also the very entertaining SF novel The Demon Breed (in the UK, its title is The Tuvela.) )
@@Globovoyeur I won't know if I'm immortal or not until I reach the end of time or end my life myself.
My sinusitis will be a huge problem in the far future. It annoys me since birth. It will be deadly when I become old
Shut up go.read more
I'm really just curious i do plan to live as long as possible i was just wondering how long i could feasibly if apply alot of health measures how long i could push like for instance is it feasible to be 100 but look 30 for example like if u do all these repairs to your body how old could u get to i would be interested in seeing what the next 200 years would look like but if I start now can I make it ive been watching alot of David videos and I was wondering if I biohack my body by fasting injection of stem cells supplements oxidation therapy constant blood work to see where can feasibly hault my aging to point where I can make a difference or can I at least survive long enough for more advanced treatments I mean I understand that it might not be completely possible for me to fully be bio immortality but I do believe that I can eventually start cybogization the process of slowly replacing organic parts and nano machines constantly cleaning my body as well as genetic enhancements ill probably be able to live indefinitely and if uploading my mind eventually becomes so seamless I can't tell if I transferred from one body to my digital existence then I can finally say im immortal and make no mistake thats my long term goal overall but first let's see how long I can push my limits
lol 4:30 smooth, Mr. Resveratrol
Where do I sign up for human trials?
I hope to still be alive in the year 2110
I was hungry & planning to have dinner after this video, now I don't know what to do 😐
I want to live as long as possible
Why
@@blacklyfe5543 because living allows me to do whatever I want, keep learning new things, being curious about the future and looking forward to what it may offer. Never worry to have too little time to start doing something new.
@@blacklyfe5543because life is to short to do anything
i wouldn't mind living for a long time, but i'd have to be happy during that time and I'm not really happy with my life atm.
NAD+ is an important factor in aging and the development of age-related diseases in the role of a cofactor in redox reactions and a coenzyme in metabolic processes. It also has a decisive role in non-redox reactions, such as cellular signal transduction, when acting as a substrate for sirtuins and PARPs
Maximum stretching of lifespan works bit like elastic bands. There is a 10-15 year limit. For those wishing to attempt that the first step is to buy a century calander. Using clock works best for testing how long one slept just like a stop watch for a 100m sprint. You wont prolong your life more than 12 hours using these clocks or may be 24 hrs max if you use the Army clocks.
Your opinion
Like this video!
I’d love forever for sure I’m built for it
i want to live as long as i am happy in my life!
By exercising you help your body stay younger for long as possible also your less likely to have stroke at middle of age or after 60 year of age .
Immortal can be achieve but it is a dark shadowy process of taking healthy cell, organ etc from younger individuals and replace it with your defective parts.
Not necessarily, I think we will harvest adult stems cells, fix their genetic errors using crisper, and then return them back to the patients body, to make the changes need to prevent damage from aging occurring.
Within the next several decades, I would expect being able to halt aging by macro interventions, triggering genes; later on, we should eventually be able to reconstruct the body cell by cell, molecule by molecule, as if it were a machine (using biological robots, of course); it would be enough to extend human consciousness indefinitely, without even understanding it - simply because the body and brain would keep function flawlessly forever; even later, we should be able to drastically improve our biology.
Instead, we have funding for better potato chips or whatever nonsense.
you can easily do reverse ageing by gain some knowledge and there is already technology exist that reverse ageing or live longer
Where can i find the knowledge?.and where is the technology...i rly want to contribute improving it. Don't be so generic with your statements.
Hi, check out for B3 in niacin with flush at low dose (10mg for instance) or/and vitamin B13 in NAD+ Pathway.
I don't want to achieve longevity escape velocity without my parents 😭
@Appu So you aro not a noob because...?
I’m going to live to be 800 at least.
Yeah man let's study bioengineering
Man I want to live forever but how long my memory will have enough space to save memories and information
You can probably store about 300 years some scientist sustain, the problem is aging but if you didn't 300 years worth of episodic memory. Obviously you would want a back up later on and an upgrade.
I could see us using tech Neroi-interface technology in the future. Or generically engineering ourselves with crisper to increase our memory banks.
Does NAD+ result in accelerated cancer cell growth? Maybe there is positive to I’ve and negative impacts of this chemical. Maybe there’s a reason why as you age the concentration of NAD decreases naturally.
M daughter of 7yrs cry every night hugging me not to get old n die as she has no one except me n she is not in good terms with her father...n really, I want to live till 200yrs just for her
Such an advance would be devastating to the world.
If at any point in the near or not so near future human lifespan suddenly doubled then assuming that "suddenly everyone got this increase of lifespan" and that "births/deaths are at equilibrium (population size doesn't change)", then there would effectively not be any deaths from aging for the next 70 or so years, and after that the death rate would still be reduced as those who are born "now" are only in their 70s from their 150 year life span.
This would effectively add another 3 or so generations of people on the world nearly doubling the population.
We can't afford such a sudden increase on top of what is already happening.
Even in developed countries a rule would have to be set in place for a limited number of children.
Not to mention the economic toll. Assuming that increasing the lifespan doesn't grant the ability to be healthy and work again to the full potential, then there would be like 5 times as many elderly that need to be supported.
Such demand for resources but not enough supply would result in a catastrophe.
If anything, then the only people who should achieve such a milestone, should be those sent to Mars. If it's possible to populate Mars with humans, then a longer lifespan would be generally advantageous as there would be a less of a need to send "more" humans to Mars.
8:50 we just move to Mars and explore space not everyone tryna stay on earth 😂💯
What are you supposed to take and how many milligrams?
I am board now at the age of 72 because I been there and done it so many times and if I get to 100, I will be even more board.
Try video games
Don’t know why but always deep within I felt I can reach times where I can be physically or live at least 264 years
How?
I have been told by a physicist and a doctor they believe part of the cause of human and animal aging has to do with radiation exposure. The Earth's geomagnetic field and ozone layer cannot stop 100% of the cosmic and solar radiation hitting the Earth. Over time this radiation causes mutation and degeneration of cells in our body. Most of my family members lived till in their late 90s and a few past 100. After they got in to their late 90s things started to get very difficult for them. Lots of health issues.
My background is in physics and electrical engineering. My knowledge of biology is limited. I found this video extremely interesting.
My favourite kind of videos :D
I believe everyone should have "free" longevity medicine but one of the biggest benefits will be scientists, doctors, and astronauts. you could travel to Pluto and return to earth no older than when you left and still have a full career, life, family here on earth.
Yes I believe that is true. I actually think life extension is going to be a necessity as we begin to explore space. Right now if we wanted to send a crew of people to Pluto and back, it would have to be a generational ship. Which would be cruel in some way to the people born on the ship as they would not return to earth till they where 40 or 50 years old.
I want 250 years life to explore world ❤
I would just hope I’d have enough money to support myself for that long.
You'd have more opportunity to make money. You could even work min. wage and then self educate the rest of the time for years if you wanted, and then once you have the knowledge, go into lucrative business.
Yea the way this place is going I don't think I want to be around that long.
I want to live longer naturally not to allow anyone mess around with my body, last thing avoid hospitalizations. Watch my diet, sleep at least 6 hours each night, work as tolerated around my home, enjoy as much as I can to be with family and friends, cut down on extra curricular activities for ex: minimize exercise daily.
I would like to work for them, unfortunately I chose stupid computer science cuz of family and situations around me
anyone got a good source on buying the blood of younglings?
The other questions science and society need to ask themselves is, how will the laws keep up with the new realities? Would a 20-year-old me who happens to live to age 220, and still look like a 20-year-old, be frowned upon by society, or castigated for marrying a 20-year-old woman, who is 200 years my junior? Would society need to come out with new laws to answer those questions? How about is I decide to marry an 18-year-old woman? Would it still be ok? Let's make it fun, how about a 500-year-old me marrying an 18-year-old?
I know this is 2 years old, but I think it would be weird, because they would be like babies mentally in comparison. The goal is to be 200 years old, and get with someone who is also 200 years old, but you both look young and are healthy. So you can go on adventures, have fun, and yes, get kinky if you like XD
I think the better question is could we still get it up if we live to 200 years old
@Dont Care he already answered that. did you watch the video einstein?
Interesting this guy is 🤯
Dr. Nun amen ra though! Fasting has been shown to increase lifespan in mice by 30% and when you combine that with diet and exercise 200 years old might be easy lol
@@prestonjong nice! How's it going for you? I struggle with fasting the entire 24 hours but I work full time.
not in biological body,
but digitally, until we can figure out a way to transfer data from the digital world to biological beings with cloud transfer, that way, we can be immortal,
Biologically is not easy, it´s a process, but digital is close in our lifetime, we just need more people working on it.
Oh brother this iis cool wowowowowowo
The technology to live far longer is already here, the question is, will governments, politics, skeptics, organized religion, powerful nutjobs and people obsessed with death and killing allow it and respect people who want to live and enjoy life longer? What we need is a jurisdiction where advanced experiments will be allowed for the benefit of ALL humanity.
With what quality of life?
Imagine, the people being born when you are 100 turn 100 when you die.
How we increase NAD levels
Crazy dude 🔥
Yes people can live infinitely through their works. Physical bodies of all have to follow time limits law of nature.
If such treatment is approved by the government, it would be priced to only be affordable to top 20-30%.
Rejuvenation biotechnologies will be available to non-wealthy elderly people since aging is expensive, so to avoid bankruptcy and make money in the biggest industry ever, governments will provide their elderly citizens with said damage repair medicine.
Only if they can control the aging process, your brain can function correctly and enjoy life, and your vital organs can last that long. I dont see how that is possible at this time, things wear out. If you live to be around 100 is doing good.
If they achieve it, it would be like the movie "IN TIME" were they stop the aging gene and you would stay young as 25 years old until your of time and your dead...
I think we are designed to live forever, getting old is a disease and has to be treated as such, grats to the people who are researching this. Hope they get it done before i die lol First people in the bible are described as living over 1000 years and with every next generation the age limit was dropping....its time to raise it again, good luck!
You have to modify the bodies ability to recall the stem genetics through genetic programming.
This would require a complete deciphering of the genetic and rna coding and a re-engineering of the transcriptase processing to be mistake free.
It's likely artificial cells will be created that can divide and remain mistake free.
energy measure device or scan
Well, Noah was 950 years old, soooooooo
During the Qing Dynasty in China, a Dao herbalist lived to 250 years old.
... supposedly...
I've already decided to live to 130. At least. No matter what.
Anybody else?
If rats can live 4 years we can live 200 years. Because everything starts with rat
I would like to particpate
Live to the age of 200? Stock-up on birthday cake candles!
Wish you too live 200 years 💜💜💜💞☘️💞☘️💚💚🙂🥰🥰🥰🥰
I use to buy into this but the reality of it is that these guys need funding and what better way than to get people obsessed about staying young and living forever. I sincerely do not believe this anymore. We are really far away from understanding the mechanism of cancer let alone how to manipulate it. I bring that up because cancer is immortal and it is key in solving the aging problem. Either way we may never be able to manipulate this process successfully.
inEXorable
Absolutely YES,we will live upto 200-250 years after take a pill per day THE FORMULA of this pill is little bit complicated but manageable and this formula implies in 2024,size of the formula is take space equal to A2 size paper both side,no special chemical required but no. of reactions are atleast 50-100 required,minimum age to take this pill is 30 yrs,highest time we take this pill is 150-200 yrs,over all organs functionality of body will improves upto 3 times and this pill improves immunity 3 times
EXAMPLE:- if any normal patient who doesn't take this pill and person affected with CANCER and another person who take this pill requires 3 times more viruses to dead.
I think 95% of aging problem solved by this comment, only one step is required to implement on HUMANS is practicle exersice,
SHREE HARI JI.
200 years - so I can only retire at 155 ???
What steps is everyone currently taking to increase lifespan?
1000 years would be fair
just think if you could get a 500 year loan on your house!!! :-)
@@senju2024 haha, what a nightmare!
Google has been working on it for a while now.
It is possible that your facebook page will be accessible 200 years from now. So your digital footprint will live forever!!!!!
Unless you are the only immortal in the universe, the idea of immortality sounds like time has stopped.
Not necessary think how much an individual would change and improve given an immortal life span. Think how different a person is given a decade. Plus their will always be new people born.
@@themercurytranshumanist4052 And these "changed individuals" - living for 100s of years - would they be different from anyone that preceded them. I am not sure if you are implying change of character or physiology or other aspects of the self.
If you are different from your parents - would you agree that they and you combined, may be an example of a 150 year old human that was seen to change over that time span.
I am inclined to believe that human emotions have undergone almost no change for as long as we know, why they may be the same as that of other animals on planet earth.
I take nad with resveratrol
Being hungry and doing lots of exercise
I conclude that the children in the democratic Republic of the Congo will be the first to achieve immortality
Hahaha
Jokes aside : Up to a certain point.
Being hungry won't kill you being hungry to the point where you are too close to starvation will.
5:59 truth