2:58 it seems iron availability is key to mucormycosis, even wiki lists iron overload as a cause. However, deferoxamine, an iron chelator, seems to kill patients. This turns out to be a problem with the particular iron chelator because it actually makes the chelated iron more available to the fungus. Luckily only deferasirox is used for iron chelation therapy nowadays and the latter did not have this problem. Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment, 2008 "In contrast, two other iron chelators, deferiprone and deferasirox, do not supply iron to the fungus and were shown to be cidal against Zygomycetes in vitro. Further, both iron chelators were shown to effectively treat mucormycosis in animal models, and one has been successfully used as salvage therapy for a patient with rhinocerebral mucormycosis."
Thank you so much for putting in the effort. Can you describe any case of mesothelioma or other lung masses and how to do their proper reporting? And also can you make a video on how to differentiate between aspergillosis and mucor - A radiology trainee
Thanks for the great case. How was the diagnosis confirmed in this case? And I also have a general question along the same theme: as radiologists we suggest atypical/fungal infection very frequently- how do the pulmonologists confirm the exact organism? Is it bronchoscopy/sputum cultures? Can you suggest reading material on patterns of atypical/fungal infections radiologically? Many thanks.
in this case, the diagnosis was made based on histology because the patient had a lobectomy. the diagnosis can sometimes be made by bronchoscopy and there is also a serum PCR test. I wrote an article about mucor which you can find here: pubs.rsna.org/doi/10.1148/rg.2020190156
Hey 👋. Couple of questions hopefully you can help me out a bit. I got my “CTA” scan results via a health portal but the doctor hasn’t reached out to me yet. They found a 6x3 mm nodule in the right lower lobe. But they also saw a “10mm low dense lesion medial right lobe of the liver which may represent a small hepatic cyst” I’m mostly confused of the lesion.. is the tech assuming is a cyst by the way it looks or just explaining what it could possibly be? I guess I’m wondering if a bad tumor is easy to differentiate from a lesion? Thanks.
just want to clear up a misconception--the CT was interpreted by a radiologist (i.e. a doctor who has undergone specialized training in medical imaging). A radiology technologist is not a doctor, but another healthcare worker who has undergone training in the use of the equipment that acquires the images (CT, x-ray, MRI machines).
this is something called an incidental finding. Something that we see on imaging but is unrelated to the main reason why the study was done. I would recommend following the recommendation in the report. Commonly these are benign cysts or vascular lesions, but need a follow up to make sure they aren't something else.
@@ThoracicRadiology thank you for replying. He left a recommendation for the nodule 6-12 months for another scan but didn’t mention anything further about the leisure. He did leave under findings: “no significant mediastinal or hilar adenopathy” I’m assuming/hoping that’s good? Just worried about the word “significant”, not sure what he means by that.
That’s amazing, thanks a million
Lungs in water and sputum information thanked sir good health information for lungs nimoniya,
Great content and very informative.
very good approach, excellent learning. Thanks!
Thanks for detailed explanation
2:58 it seems iron availability is key to mucormycosis, even wiki lists iron overload as a cause. However, deferoxamine, an iron chelator, seems to kill patients. This turns out to be a problem with the particular iron chelator because it actually makes the chelated iron more available to the fungus. Luckily only deferasirox is used for iron chelation therapy nowadays and the latter did not have this problem.
Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment, 2008
"In contrast, two other iron chelators, deferiprone and deferasirox, do not supply iron to the fungus and were shown to be cidal against Zygomycetes in vitro. Further, both iron chelators were shown to effectively treat mucormycosis in animal models, and one has been successfully used as salvage therapy for a patient with rhinocerebral mucormycosis."
Thank you
Great case, thanks for sharing
Very interesting. Thank you.
thank you . very helpful
THANKS ! You' re the best
Thanks a ton 🙏,very helpful sir
Very interesting!
Thx you
great video👌
thank you sir
Thank you so much for putting in the effort. Can you describe any case of mesothelioma or other lung masses and how to do their proper reporting? And also can you make a video on how to differentiate between aspergillosis and mucor - A radiology trainee
here's a good article on Mucor: pubs.rsna.org/doi/10.1148/rg.2020190156
@@ThoracicRadiology thank you you are very kind 😇
❤❤❤❤❤
A mild pleural effusion after bullectomy surgery often goes away on its own without treatment?
Yes it will usually go away without any treatment.
Could you explain crazy paving and mosaiq perfusion
Could you please post ct thorax different findings of ILDs
Thanks for the great case. How was the diagnosis confirmed in this case? And I also have a general question along the same theme: as radiologists we suggest atypical/fungal infection very frequently- how do the pulmonologists confirm the exact organism? Is it bronchoscopy/sputum cultures? Can you suggest reading material on patterns of atypical/fungal infections radiologically? Many thanks.
in this case, the diagnosis was made based on histology because the patient had a lobectomy. the diagnosis can sometimes be made by bronchoscopy and there is also a serum PCR test. I wrote an article about mucor which you can find here: pubs.rsna.org/doi/10.1148/rg.2020190156
Hey 👋. Couple of questions hopefully you can help me out a bit. I got my “CTA” scan results via a health portal but the doctor hasn’t reached out to me yet. They found a 6x3 mm nodule in the right lower lobe. But they also saw a “10mm low dense lesion medial right lobe of the liver which may represent a small hepatic cyst” I’m mostly confused of the lesion.. is the tech assuming is a cyst by the way it looks or just explaining what it could possibly be? I guess I’m wondering if a bad tumor is easy to differentiate from a lesion? Thanks.
Forgot to mention.. tech advised follow up for nodule in 6-12 months but didn’t mention anything of the lesion.
just want to clear up a misconception--the CT was interpreted by a radiologist (i.e. a doctor who has undergone specialized training in medical imaging). A radiology technologist is not a doctor, but another healthcare worker who has undergone training in the use of the equipment that acquires the images (CT, x-ray, MRI machines).
this is something called an incidental finding. Something that we see on imaging but is unrelated to the main reason why the study was done. I would recommend following the recommendation in the report. Commonly these are benign cysts or vascular lesions, but need a follow up to make sure they aren't something else.
@@ThoracicRadiology thank you for replying. He left a recommendation for the nodule 6-12 months for another scan but didn’t mention anything further about the leisure. He did leave under findings: “no significant mediastinal or hilar adenopathy” I’m assuming/hoping that’s good? Just worried about the word “significant”, not sure what he means by that.