i have been on all the SSRIs, TCAs, atypicals, lithium etc nothing works anywhere near as good as the MAOI Nardil (Phenlzine). it has worked consistently many many years, i have never have had one problem with the diet or interactions. it almost cures me if both depression and social phobia. BUT it takes a long time to kick in (up to 8 or so weeks) and most people need a dose of 60mg minimum. can't recommend this med enough.
Thank you for watching and interesting question! MAOIs were indeed the first antidepressants to be shown to be effective in social phobia. However, they are not first line, as they carry much higher risk of side effects than your SSRIs. I have not used MAOIs in the treatment of social anxiety for patients, but it is something one could consider. I tend to be more likely to augment SSRIs/ SNRIs with low dose SGAs if symptoms are severe (and really recommend cognitive behavioral therapy [CBT] - particularly exposure therapy). - Dr. Pagnani
Foods nowadays don’t contain substantial amounts of Tyramine. One should still be mindful about it, but the tyramine restriction is very, very exaggerated. And most doctors are only familiar with research from decades ago, which for the most part isn’t accurate. Check out Ken Gillman, he has up to date knowledge on Maoi’s. People shouldn’t have to miss out on robust treatments due to doctors not being adequately educated.
Completely agree with this statement! It’s sad that this drug isn’t prescribed faster way before electric shock therapy is even considered! Drs are so afraid of this drug it’s ridiculous
Thank you for your question, and I'm sorry for the delay with the reply. If someone is taking an MAOI, I would not recommend having foods with tyramine, regardless of the timing of medication doses. MAOIs can irreversibly block the effects of monoamine oxidase enzymes, and 12 or 18 hours would not be enough time, because it's irreversible. This is why there's actually a 2 to 6 week (depending on the medication) washout period for someone to stop an MAOI, before starting a new antidepressant. I hope that this is helpful, and be sure to discuss with your provider. Best, - Dr. Pagnani
@RittenhousePsych the tyramine diet and interactions are WAY overblown a grear article is Gillman, "much ado about nothing, monoamine oxidase inhibitors, drug interactions, and dietary tyramine" all the very best. @RittenhousePsych
i have been on all the SSRIs, TCAs, atypicals, lithium etc nothing works anywhere near as good as the MAOI Nardil (Phenlzine). it has worked consistently many many years, i have never have had one problem with the diet or interactions. it almost cures me if both depression and social phobia. BUT it takes a long time to kick in (up to 8 or so weeks) and most people need a dose of 60mg minimum. can't recommend this med enough.
Dr. Pagnani, is it true that MAOIs are superior to SSRIs in improving social anxiety symptoms?
Thank you for watching and interesting question! MAOIs were indeed the first antidepressants to be shown to be effective in social phobia. However, they are not first line, as they carry much higher risk of side effects than your SSRIs. I have not used MAOIs in the treatment of social anxiety for patients, but it is something one could consider. I tend to be more likely to augment SSRIs/ SNRIs with low dose SGAs if symptoms are severe (and really recommend cognitive behavioral therapy [CBT] - particularly exposure therapy). - Dr. Pagnani
@@RittenhousePsych OK, thank you! Have a good day.
Side effects? What about the suicide effects or ssri?? Like the fucking things literally tell people to kill themselves
@@RittenhousePsychinteresting information
ssri are **it for me
emotional anesthesia and apathy with abulia
Does Tesofensine carry these same risks?
Foods nowadays don’t contain substantial amounts of Tyramine.
One should still be mindful about it, but the tyramine restriction is very, very exaggerated.
And most doctors are only familiar with research from decades ago, which for the most part isn’t accurate.
Check out Ken Gillman, he has up to date knowledge on Maoi’s. People shouldn’t have to miss out on robust treatments due to doctors not being adequately educated.
Completely agree with this statement! It’s sad that this drug isn’t prescribed faster way before electric shock therapy is even considered! Drs are so afraid of this drug it’s ridiculous
100%😊 correct! I've been over 2 decades on Nardil. never had the slightest problem. MAOIs are the best!
Dr., are the diet risks with tyramine reduced if medication is taken in the morning and the foods are consumed much later in the day?
Thank you for your question, and I'm sorry for the delay with the reply. If someone is taking an MAOI, I would not recommend having foods with tyramine, regardless of the timing of medication doses. MAOIs can irreversibly block the effects of monoamine oxidase enzymes, and 12 or 18 hours would not be enough time, because it's irreversible. This is why there's actually a 2 to 6 week (depending on the medication) washout period for someone to stop an MAOI, before starting a new antidepressant. I hope that this is helpful, and be sure to discuss with your provider. Best, - Dr. Pagnani
@RittenhousePsych the tyramine diet and interactions are WAY overblown a grear article is Gillman, "much ado about nothing, monoamine oxidase inhibitors, drug interactions, and dietary tyramine" all the very best. @RittenhousePsych
I have the exact symptoms of low monoamine oxidase. I get horrible tyramine induced migraines. I dont take any ssris or other meds. What can I do?
Try carnivore!