Krebs Cycle | Citric Acid Cycle | Cellular Respiration
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- Опубліковано 24 вер 2018
- #Krebscycle #TCAcycle #Tricarboxylicacidcycle #Citricacidcycle #oxidation #Citrate
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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
The citric acid cycle (CAC) - also known as the TCA cycle (tricarboxylic acid cycle) or the Krebs cycle - is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. In addition, the cycle provides precursors of certain amino acids, as well as the reducing agent NADH, that are used in numerous other reactions. Its central importance to many biochemical pathways suggests that it was one of the earliest components of metabolism and may have originated abiogenically. Even though it is branded as a 'cycle', it is not necessary for metabolites to follow only one specific route; at least three segments of the citric acid cycle have been recognized.
The name of this metabolic pathway is derived from the citric acid (a tricarboxylic acid, often called citrate, as the ionized form predominates at biological pH) that is consumed and then regenerated by this sequence of reactions to complete the cycle. The cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, releasing carbon dioxide. The NADH generated by the citric acid cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP.
In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria, which lack mitochondria, the citric acid cycle reaction sequence is performed in the cytosol with the proton gradient for ATP production being across the cell's surface (plasma membrane) rather than the inner membrane of the mitochondrion. The overall yield of energy-containing compounds from the TCA cycle is three NADH, one FADH2, and one GTP.
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But it is not necessary that one NADH will always give 3 ATP molecules it may give 2.5 in malate aspartate shuttle pathway or one NADH may give 1.5 ATP molecules as in glycerol phosphate pathway...😇😇 Still ur great ...
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In the krabs cycle actyl coenzyme have 2 time decarboxilation process and release energy in form of 2NADH but where is the 3rd NADPH come.... Plz tell me I am confused..
You asked about the 3rd NADPH2 he come from glycolysis
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