Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
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- Опубліковано 24 січ 2023
- Psychedelic drugs have received attention recently for their potential use as treatments for psychiatric disorders. Single, high doses of LSD have shown promise for treating depressive disorders. But there’s another way in which people have been using LSD, and it’s what’s known as micro-dosing, taking LSD at below noticeable levels, where it doesn’t seem to have a psychedelic impact-but users say it does in fact have an impact on their overall sense of well-being.
This is just what Harriet de Wit, University of Chicago professor in the department of psychiatry and behavioral neuroscience, wanted to study. Dr. de Wit partnered with James Glazer, a postdoc in psychiatry at Northwestern University.
Read their full study here: www.nature.com/articles/s4138...
The effective low low dose was 13mcg for anyone that was wondering
What's strange about this study is the participants reported feeling no drug effects at 13mcg. I'm not a lightweight and I definitely feel the effects at even 8mcg.
For perspective: a 1960s "death and rebirth" 8-hour trip is about 250mcg (Orange sunshine had 300.)
A 1970s dose of "disco acid" was about 75 to 100 Mcg. That was supposed to make a night at the disco more fun, but not make you deeply introspective or to see the walls melt.
I used to take a quarter hit of disco acid, and it was enough to give me a nice mild buzz.
So 13 mcd would be about half of that. It would have an effect, but a very mild one.
@@rd5854 I think that they felt it but did not know it because they did not know what they should be looking for. They did not know that their mild changes in perceptions were caused by the LSD. Like how sometimes a person who smokes weed for the first time will report not being high.
It is because you know you have taken it. The brain is a powerful thing.@@rd5854
@@rd5854 But maybe not to the mind of someone who's never had a full trip before. They literally have no idea what to expect. In a similar way not everyone gets stoned for the first time (i.e. they don't have enough to notice).
If we only lived in a world were we could ask millions of LSD users all around the globe which often took the drug for decades about their experiences... **sigh**
But wait a moment... 😮
The day after my very first acid trip, many years ago, I immediately noticed that my craving for any kind of alcohol had almost completely vanished. And I actually had been a quite regular drinker of beer, wine, rum, whiskey and other stuff. This craving never came back!
Yes, I am not a 'scientist'. But I am very sure, that millions of people who died from alcohol addiction since those days of shame, when one President Nixon declared total 'war on drugs', could have lived a much longer and healthier life, if 'science' had not shyed away from confronting the truth: that politics, racism and business alone have demonised and surpressed one of the most valuable therapeutic agents mankind has ever discovered.
The ability of "classic psychedelics" to help cure addictions has tons of anecdotal testimony. Plus I know of studies of ayahuasca specifically in the treatment of addiction. And there's a center called Takiwasi in Peru that has been using ayahuasca to treat cocaine addiction for over 20 years. I've also heard of studies of psilocybin used to help people stop smoking. And ibogaine is known to cure opiate addiction sometimes in a single session.
If that's what you call science then Bigfoot is real, scientifically.
@@treewalker1070 Plenty of anecdotes about people quitting drugs with no outside help whatsoever. So does doing literally nothing cure addiction? Cool, so we cured addiction then!?
@@treewalker1070strangly, is not only about addiction. I was not addicted to alcohol but... after starting using psychedelics I just feel that alcohol is harmful and just avoid it as much as I can.
I stopped cigarettes after being introduced to LSD. My life in general has changed for the better after LSD.
First time listening to NPP all info was explain well, looking forward to listening to more
the problem with LSD has always been that it is so potent and powerful and the street doses were far too large.
Not if you want to trip. In the psychedelic scene here in the U.K. we have it as liquid so we can adjust the dose accurately. I get mine as concentrate at 500 mics per drop, and can adjust it to any strength using drops of high strength vodka - if I want a shamanic experience I’ll take 1500mics, if I want to microdose I’ll take 5-10mics
@@villhelm thanks for making my point clear. you obviously were not around in the 60's and 70's.
Personally i would say the street dosages during last 60’s -70’s was great.
@@jesternotclown i say that because they(high doses) gave the press and government all the reason they needed to vilify and outlaw the drug to the world. back in those days, one 'experience' would ruin one forever, so went the mythos. this microdose regime is very recent. we had to suffer Art Linkletter and Charlie Manson.
@@stephenmorton8017
But you also should mention that since LSD and magic mushrooms have no lethal dose, and are not addictive and don't harm the body, the american government and media created a campain of scaremongering with totally exaggerated and more often than not simply bogus news about those drugs - which the conservative middle aged majority of the public eagerly swallowed, while they were still in shock about their very own rebellious, long-haired, free loving, pacifist, anti-establisment children.
None of those 'myths' that were created then have any grounding in facts or significant numbers of accidents etc. as everybody can easily find out if he is doing even minimal research work online today. But there have always been truths and facts that the public would rather not know because they damage their comfortable worldview and trigger primal fears.
On the other hand: people then did not have the Internet and didn't have access to facts and data like we have nowadays - so it is even more annoying that still the majority of the people today believe the very same bs that was drummed into their parents.
In my opinion and experience, there is no other subject in the world where the firm opinion of the vast majority of people, who mostly have no personal experience with it, is so far removed from the actual facts as with the subject of 'psychedelic drugs'. And that this even includes the majority of scientists and researchers that work in the field is totally laughable.
SWIM has had life altering experiences with the help of said substance. They kicked a long opiate and benzo addiction almost immediately within the first week lowering the dose slowly with no problem, much easier without said substance/tool. It can be used in many beneficial ways to change your views, but with that said it also needs to be done in a certain setting. Personally speaking, i would not have the same type of experience in a doctors office with wires hooked up, as i would outdoors in the public or in my room where im comfortable with people im familiar with. This is where science and medicine needs to really pay attention to each specific individual. It's not right for some and for others it can be the key to success as it broadens your way of thinking and perspective. It also needs to be monitored closely how often you dose because you can get "ate up" from it. I lost two jobs because i took too many in a short period of time as a young teen... Just my two cents as someone who could benefit greatly from it but doesn't dare get anything off the streets.
great info, thanks!
Finally! Torquemada retreats, reason advances. ☮
I can't find a source anywhere for any good psychedelics in my area, I suffer some pretty bad depression and i got a chance to try K and man it was a miracle substance, I felt free,the only high or euphoria was from the relief of my vices being released, that's exactly what it did
The psychedelic experience is temporary but many people have permanent results
Mushroom completely turned my life around and my anxiety and panic attack disappeared and my personality changed into a much more generous loving person
🍄
Look up how to grow your own shrums, or extract from acacia bark.
@@derickmartenshow much and which mushrooms u take ? Should I take every day mushrooms or better every day Microdosing?
Ssri's suck. Look up how many mass shooters are on them. That's the real problem, not inanimate objects
You sure it's not correlation rather than causation? Many school shooters are depressed and many school shooters are on SSRIs because they're depressed. Sure, the SSRIs may not be effective enough to prevent them from comitting atrocious acts of violence, but they would be just as depressed without them.
@@spopydude69You've obviously never been on, or known someone on SSRI's or SNRI's. Because if you did, you'd know that's complete BS. I have _never_ met one person on those drugs who's not completely fucked. Depression leads to suicide. SSRI's and SNRI's turn suicide into homicide. Cut and dry. They have not helped one person outside of the first 4 to 8 weeks. After that you're fucked.
ssris create government obeying zombies end of discussion
Legal? 😅
Are you kidding me microdosing do you know how much a hit of acid is? It's microdosing
How do you micro dose a micro dose ?
@ryankottke8120 I don't I haven't done LSD since I was 23 after doing DMT I never looked back at LSD ever again. I was implementing you can't microdose LSD it's impossible
lmao this is funny and ignorant, i love it
@@Ryan-xq3kl I think I was micrdosing DMT but then I saw a tiny crystal on the ash and said to myself this shouldn't be too bad. But once I hit that shit I went from reality to OMFG WTF IS GOING ON HERE WHY AN I TRAVELING THROUGH SPACE, I don't see anyone micrdosing DMT either cause that will change your whole life to see the real truth of our existence and when we see when everyone dies. Something that supposed to last 5 minute felt life I live a while another life from birth to death in 5 minute. Then what takes the cake is your hanging out in a tunnel on the edge of another universe taking to GOD himself and no she he's not a physical being god is pure energy every question you asked it was immediately answered. I saw the my next journey when I pass this world and saw few planters with 2 suns ones much further away than the other one. But it feels right. Then once he tells you how simple the secrets to the universe is it pulls you from this dream reality check instantly and your faced around the ones you knew before you left now you have no idea who or what they. I couldn't talk and had to relearn everything for the next 20 minutes. Every tolerance in your body has be ZEROED OUT. I never touched LSD again or shrooms I couldn't smoke weed for 9 months coffee felt like the first time drinking it and got me so high of caffeine beer only took a half a can and drunk AF. EVERYTHING on this planet looked and felt differently. Religion became a fraud setting through every lie around you that was taught by generations to s scare you in thinking everything in the book of BS were true events then realized that Jesus was an alien sent from his father in space on his ship after creating him for months ago. All this from one hit of DMT. LEARN Knowledge WHILE sleeping in your dreams from that day forward, seeing the future before it happened we call deja vue is real. So I'm actually there is no heaven or hell that's a myth. Earth had many gods come teach us the future and every religion had that god sent to that location on earth. Every parts of the world has a different god but from then same origin like classmates. DMT made me see all of these things throughout my life and understand the real truth that lies around us but cults will always doubt you for blasphemy. We all die but we all live and eternal life is just not on the same planet. JWST has shown us some facts that the Bible can't explain cause the Bible is only made for the planet cause alien gods didn't think we would ever know the real truth about what God really are. Everyone on earth needs to do DMT once and you'll see.
@@Ryan-xq3kleveryone is ignorant here because microdosing has been proven to be a placebo
Oh sorry me and my childrn are not the neighbors where i live
@Mark Smith hate to tell you I don't do that drug I'm not the Miller child abusing animal abusing drunk driving thieves neither me nor my children are them liars cause I turned them in my self that right where I lived they sell all kind drugs threaten to kill me and my kids and there liars police already know there liars and oh yea me and my children don't steal other ppl mail neither or forge there names neither
Alcoholic grammar?
@@libertariantranslator1929 I don't drink so shut the hell up with your lies
Another useful meditation lost due to the ignorance of the Government FDA / DEA which scheduled it as schedule 1 or no medical use, testing .
Correction, do to the greed and corruption of the FDA, which in the end is from ignorance because they don’t know that there is a God and that this God has a devil (enemy) on this earth that hates all that is good due to their choice to be evil.
@TrumpThreetimeswhy do bots always do weird punctuation like upside down question marks?