Renin is a protein (made of amino acids) and an enzyme (it helps to catalyze reactions such as the cleavage of another protein) and a hormone (it is released from one cell and acts at a distant location). These are all different descriptions that apply to Renin equally well.
Hypervolemia with Hyponatremia sounds like an SIADH type syndrome. In SIADH, GFR is high so there will be a naturesis (ANP plays a role in this). High sodium levels in the filtrate means that the macula densa will not be triggering renin release.
The Macula Densa senses LOW sodium levels in the filtrate/urine. Low sodium means low GFR (sodium is being reabsorbed easily with low GFR), and the Macula Densa causes a release in renin to increase blood pressure. I want to do a video to stress this point.
In my book it says that it senses high level of sodium which would be accurate because it would indicate that there is a small reabsorption of sodium in the nephrone which causes the release of renin -> angiotensin -> aldosterone which reabsorb sodium back into the blood ;)
Wow! Your voice a is so cool and you teach incredibly well! ✨ I'm so happy that this amazing channel is free and I can't thank you enough for being here and helping students like me who can't afford even low membership fees. Please don't forget people like me and continue to make FREE contents as you are amazing at explaining things and making the most informative short videos! ✨❤🙏
Thank you, I'm studying Naturopathic Medicine and the basics of the Kidney were not sinking in even after lectures and reading Guyton... and you've done it in two videos :) Keep up the awesome work, thank you so much!
Awesome video as usual. Just one thing I'd like to add - apparently renin is pronounced ree-nin, because the reh-nin pronunciation is already "taken" by rennin (aka chymosin),an enzyme some animals have, that induces milk curdling in their stomachs. I like saying reh-nin though, and I will rarely if ever talk about chymosin, so I'm gonna keep calling renin reh-nin. Just thought that was cool trivia. Thanks again!
A question about the macula densa: Does the macula densa sense high concentration of Na+ levels in the urine, causing it to believe that enough Na+ is not being reabsorbed to the blood? Which is probably why the blood pressure is low?
is this process completely unrelated to the feedback loop of macula densa cells that reduce filtration rate in response to increased glomerular filtration rate? because if there was an increase in GFR there would be more Na+ for the macula densa cells so can macula densa cells also go the other way using different paracines/hormones?
Thanks, I feel like I learned something. I have a question about the last info about Renin as a hormone, I read that Renin is an enzyme secreted by the kidney (and also, possibly, by the placenta) that breaks down protein and produces a rise in blood pressure. so is Renin a Hormone or an enzyme ? Thanks
a guy repetition. Watching these videos, writing it down, drawing it, and explaining it to people when you’re comfortable. That’s why KA’s videos work so well. People connect with illustration and explanation in simple, functional terms. During your day, watch these videos and try to “beat the presenter” by explaining what he’s talking about.
low na=lower glomerular filtration rate, so it wants increase this rate which requires vasodilation of the arteriole --> more blood flow into the glomerulus --> increase in blood pressure in the glomerulus --> higher filtration rate --> higher Na concentration in the distal
Glomerulus Filtration Rate is determined by Blood Pressure. For example, if there is high blood pressure the rate in which the filtrates are travelling through the renal tubules are also high due to the large force exerted into the glomerulus. Here's a link for better understanding ua-cam.com/video/SDQ5wrdplSk/v-deo.html
You're very welcome. Happy new year!
khanacademymedicine don't be proud brat
8years later I still find the video helpful, thank you very much. Sending love from South Africa
Renin is a protein (made of amino acids) and an enzyme (it helps to catalyze reactions such as the cleavage of another protein) and a hormone (it is released from one cell and acts at a distant location). These are all different descriptions that apply to Renin equally well.
To reduce the complexity of any problem to the simplest understanding is an art ,thank you so much for the effort you put in these videos
Hypervolemia with Hyponatremia sounds like an SIADH type syndrome. In SIADH, GFR is high so there will be a naturesis (ANP plays a role in this). High sodium levels in the filtrate means that the macula densa will not be triggering renin release.
Finally, I understood it! Thank you very much, sir! I wish you were my teacher
I'm glad you found it helpful!
The Macula Densa senses LOW sodium levels in the filtrate/urine. Low sodium means low GFR (sodium is being reabsorbed easily with low GFR), and the Macula Densa causes a release in renin to increase blood pressure. I want to do a video to stress this point.
In my book it says that it senses high level of sodium which would be accurate because it would indicate that there is a small reabsorption of sodium in the nephrone which causes the release of renin -> angiotensin -> aldosterone which reabsorb sodium back into the blood ;)
Wow! Your voice a is so cool and you teach incredibly well! ✨
I'm so happy that this amazing channel is free and I can't thank you enough for being here and helping students like me who can't afford even low membership fees.
Please don't forget people like me and continue to make FREE contents as you are amazing at explaining things and making the most informative short videos! ✨❤🙏
What an understandable video this is!! I study physiology of kidney now. Thank you!
Thank you, I'm studying Naturopathic Medicine and the basics of the Kidney were not sinking in even after lectures and reading Guyton... and you've done it in two videos :) Keep up the awesome work, thank you so much!
Ashley Romanchuk you must be dumb
This is such an excellent video.
Amazing video, I wasn't too sure when people other than Sal make khan academy videos, but you nailed it
Awesome video as usual. Just one thing I'd like to add - apparently renin is pronounced ree-nin, because the reh-nin pronunciation is already "taken" by rennin (aka chymosin),an enzyme some animals have, that induces milk curdling in their stomachs.
I like saying reh-nin though, and I will rarely if ever talk about chymosin, so I'm gonna keep calling renin reh-nin. Just thought that was cool trivia.
Thanks again!
Thank youuuuu sooo muchhhhhhh
i have always hated the kidneys, the renal is always the last one i want to learn, i always put it at the end of my study. but not anymore, thank you.
The explanation is excellent!
I wish words could describe how much you have helped me throughout my anatomy class and now physic!! Thank you sooooo much!!
Thanks u are life saver
In case anyone is wondering the sympathetic receptors are B1 receptors. Rest of the detail in this vid is perfect.
Zakeria A direct cardiac effects/response is what you’re saying?
A question about the macula densa: Does the macula densa sense high concentration of Na+ levels in the urine, causing it to believe that enough Na+ is not being reabsorbed to the blood? Which is probably why the blood pressure is low?
That makes sense.
I'm glad you liked it... =)
thank you
thanks!
Thanks a lot for this clearful explanation but I hope you make 3 separated videos each one is for one trigger of renin release ...thanks again
Thank you, very helpful. Love watching your videos
you are just amazing!!!!!!!
thank you for all what you do
i have no clue why but you teach so well that a 10 year old like me can even understand
itz awesome.... thanx :)
Wonderful detailing. Thank you very much.
Excellent
EXCELLENT!
this is brilliant!
Thank you so much!
Please, do not stop doing this, you are awesome! This was so helpfull!
This is awesome bro
wow awesome man
will these videos be taken down when the NCLEX course is retired?
That was really helpful! Thank you so much :D
Shermaine Cruz call me
will low Na in proximal tubule stimulate renin secretion?
Can you please explain what is renorenal refles
With diabetic nephropathy, do the macula densa cells also detect high glucose?
is this process completely unrelated to the feedback loop of macula densa cells that reduce filtration rate in response to increased glomerular filtration rate? because if there was an increase in GFR there would be more Na+ for the macula densa cells so can macula densa cells also go the other way using different paracines/hormones?
love ur videos, thank you ^^
Thanks, I feel like I learned something. I have a question about the last info about Renin as a hormone, I read that Renin is an enzyme secreted by the kidney (and also, possibly, by the placenta) that breaks down protein and produces a rise in blood pressure. so is Renin a Hormone or an enzyme ?
Thanks
Can someone tell me how this video was recorded-black background and added
notes with markers?? Connie What program???
Finally a way I can remember this! THANK YOU!
Amazing!!!
Does anyone know any tips to make memorizing this stuff easier?
a guy repetition. Watching these videos, writing it down, drawing it, and explaining it to people when you’re comfortable. That’s why KA’s videos work so well. People connect with illustration and explanation in simple, functional terms.
During your day, watch these videos and try to “beat the presenter” by explaining what he’s talking about.
This is an excellent video, so clear, thank you so much!
I'm really so grateful to you for this wonderful video dear
Hey bud what if the BP is high then what does the kidneys use to lower the BP ??
Uhm isn't the "messenger" supposed to be Adenosin?
even if renin is an enzyme :D this is awesome :D
Doesn't prostaglandin cause vasodilation of the afferent arterioles? Then how is it produced by macula densa cells in response to low Na/low BP?
low na=lower glomerular filtration rate, so it wants increase this rate which requires vasodilation of the arteriole --> more blood flow into the glomerulus --> increase in blood pressure in the glomerulus --> higher filtration rate --> higher Na concentration in the distal
how is gfr and bp related?
Glomerulus Filtration Rate is determined by Blood Pressure. For example, if there is high blood pressure the rate in which the filtrates are travelling through the renal tubules are also high due to the large force exerted into the glomerulus. Here's a link for better understanding ua-cam.com/video/SDQ5wrdplSk/v-deo.html
very impressive.
the book was very confusing with all these words, thanks for the explanation.
Reflex*
you missed lacis cells. other than that this video is amazing
the extra glomerular mesengial cells he drew are the lacis cells
he forgot to mention that their another name for it.
Are you still answering here after 11 years?
Are you left handed?
mmm imagine him being my personal tutor..;)
We want arabic translation please?????????????????????
Allen Mark Anderson Matthew Brown Susan
I LOVE THIS!
Want arabic translation pleas???????????????
look it up to see if they translate khan academy to arabic version
Arbic
Arabic
Thank you!
Arabic
Arabic
Arabic