Steps of glycolysis | Cellular respiration | Biology | Khan Academy

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  • Опубліковано 24 сер 2015
  • Introduction to glycolysis. Role of glycolysis in producing ATPs and NADHs and converting glucose to pyruvates.
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КОМЕНТАРІ • 416

  • @sccm100
    @sccm100 7 років тому +2985

    Why do I feel like the more science you know, the more you realize the less you know.

    • @onetwoBias
      @onetwoBias 7 років тому +71

      It's a bit like if you inflate a balloon, the volume represents your knowledge, the surface area represents the things your discover that you don't know. I guess it's just that you first have to understand the basic concepts of something to realize how much there is to know about it and until you do, all of that doesn't exist to you.

    • @cosminbarbos4235
      @cosminbarbos4235 7 років тому +56

      Kant has a theory about this. the more you know you are pushing your knowledge limitations further and you realize how little it represents.

    • @fizzakhalid3705
      @fizzakhalid3705 6 років тому +3

      hahaha! same man!

    • @nikitakutakov1184
      @nikitakutakov1184 6 років тому +15

      "As for me, all I know is that I know nothing" Socrates used to say. Humans are always the same:)

    • @TheCassholeJo
      @TheCassholeJo 6 років тому

      That means your learning and your way of thinking has been advised by several of my professors

  • @MrBones-bn7oo
    @MrBones-bn7oo 6 років тому +1200

    ‘mind wanders for 5 seconds’ welp time to go back 3 minutes

  • @leeschloss4840
    @leeschloss4840 4 роки тому +124

    If my body was able to take my biology test for me, I would've totally aced it.

  • @TurulHEMA
    @TurulHEMA 7 років тому +577

    Cool. Now if I watch this 10 more times I might have it memorized. . . Maybe.

    • @onetwoBias
      @onetwoBias 7 років тому +15

      Write it down from memory instead - much more efficient

    • @lisab2631
      @lisab2631 4 роки тому +2

      Wow so fast?! (not even ironic)

    • @adelasefora
      @adelasefora 3 роки тому

      literally same

    • @TrapHut
      @TrapHut 3 роки тому

      @@onetwoBias I agree!

    • @mek2367
      @mek2367 3 роки тому +1

      Maybe checkout a less detailed one? It's rly not tht complicated

  • @languageandmana9255
    @languageandmana9255 Рік тому +53

    Thank you for making FREE videos for PREMED students. Many intelligent students can't afford MCAT prep packages and even basic books! So you are doing a huge favor to them by making detailed videos on MCAT topics. All of the poor students are future doctors and they will be donating regularly to this amazing channel ❤ I wish a free medical school will be established one day just like Khan Academy, professional, kind and generous, in which people can study doctor of medicine for free.✨

  • @earth6738
    @earth6738 6 років тому +154

    Kahn puts my $100 biology textbook to shame. He's straight up out here slaying the science game. Thanks, Kahn.

    • @mohamedmotaz5194
      @mohamedmotaz5194 Рік тому +19

      Atleast spell his name right...

    • @gboy05
      @gboy05 Рік тому +1

      @@mohamedmotaz5194 he clearly khant

  • @asmahaque8558
    @asmahaque8558 6 років тому +1217

    Stop sounding so excited, we hate glycolysis.

    • @ThingsUShouldLike
      @ThingsUShouldLike 6 років тому +8

      Lmao true

    • @fadeskywards1245
      @fadeskywards1245 6 років тому +10

      ahhahahahahaha This one takes the cake

    • @StreetDancer171
      @StreetDancer171 6 років тому +30

      Nah, I enjoy learning about it, it's interesting to know what's going on in our bodies

    • @madhurajoshi3479
      @madhurajoshi3479 5 років тому +16

      WaveDancer171 you do...And that's great! This is just the silly opinion of 90 percent of the people studying glycolysis..😑

    • @hashirrasheedhaider6508
      @hashirrasheedhaider6508 5 років тому +23

      WaveDancer171 you will hate it once you will see this in order to memorize it.

  • @aquariansage1451
    @aquariansage1451 7 років тому +539

    Even if this man was speaking in Navajo, my current level of understanding would still be the same.

  • @eemiaa10
    @eemiaa10 7 років тому +429

    I have to memorize this for Tuesday. Lord help me.

    • @nicholasevans9490
      @nicholasevans9490 7 років тому +19

      May God help you.

    • @shkoata366
      @shkoata366 7 років тому +3

      how did u do?

    • @eemiaa10
      @eemiaa10 7 років тому +28

      shko ata well I had Glycolysis down, but the rest of the exam was the beggining of my demise

    • @queenjazmyne
      @queenjazmyne 7 років тому +2

      i need to learn al of this for this tuesday ha. Apparently tuesday is test day

    • @priscillacastro775
      @priscillacastro775 6 років тому +4

      Aimee I have to memorize this for tomorrow...

  • @madisonjoe1911
    @madisonjoe1911 4 роки тому +93

    3:13 is aCtUaLLy litEraLly the epitome of expectation vs reality and I died

  • @Mugen_YG
    @Mugen_YG 4 роки тому +54

    I look away for 20 seconds and next thing you know, I'm as lost as a 3 year old in walmart by how much stuff you just put on the screen
    Sigh, that's biology for you

  • @shay3242
    @shay3242 7 років тому +133

    I can's appreciate the complexity when I need to know all of this for a test lol

  • @linkh1435
    @linkh1435 4 роки тому +77

    I will always love biology the most. Chemistry, well, not so much. I mean it's quite an interesting subject but it makes me struggle so much at school. Same for Physics.

    • @jquizo8530
      @jquizo8530 4 роки тому +1

      Weeeell, we have this topic for biology and I now only understand it more in Khan Academy than my Bio teacher.

    • @DB-gl3jx
      @DB-gl3jx Рік тому

      @@anshikasrivastava3951 Being indian has absolutely nothing to do with that

  • @visneliturta0502
    @visneliturta0502 7 років тому +122

    Great video, however one simple mistake:
    Kinases don't "dephosphorylate" molecules under physiological conditions. Enzymes for dephosphorylation reactions are called "phosphatases".
    The reason why the "pyruvate kinase" is called kinase is that while these metabolic reactions were being discovered, scientists tried out these reactions in vitro to see what the enzymes do and they put too much pyruvate and so turned the reaction balance in favour of phospoenolpyruvate (PEP) as product, so they thought, the enzyme phosphorylated pyruvate.
    But in reality, under physiological concentrations, the enzyme actually "dephosphorylates" PEP.

    • @kingofgames9154
      @kingofgames9154 Рік тому +4

      Thank you for this nice information 👍 It can be crucial detail.

  • @reemaalsweed6748
    @reemaalsweed6748 3 роки тому +48

    90% of the video: we talked about this in another video
    10% of the video: actually explaining glycolysis

    • @shyamsharma530
      @shyamsharma530 2 роки тому +4

      Wish the number of your comment's likes add to your IQ

  • @ezioblazesit9017
    @ezioblazesit9017 4 роки тому +44

    This man knows everything, only rival to Johnny Sins himself.

  • @NikNikNiken
    @NikNikNiken 8 років тому +55

    Gosh this guys you'll be a voice actor; he's got such a soothing and calming voice ^_^

    • @madhurajoshi3479
      @madhurajoshi3479 5 років тому +1

      Sloth no offence but to me he sounded really excited which was kind of annoying since I was breaking my brainpan to try make sense out of glycolysis....

  • @apolloex00
    @apolloex00 6 років тому +251

    Why is life so complicated!?

    • @mjeadeissa2980
      @mjeadeissa2980 5 років тому +6

      Creativity of god

    • @Epopoi27
      @Epopoi27 5 років тому +6

      Yet another equation : law_of_physics x random x huge_amount_of_time x selection = complexity of life

    • @PhantomAyz
      @PhantomAyz 3 роки тому +3

      Cuz complexity makes life awesome

    • @thomasalberto613
      @thomasalberto613 3 роки тому +1

      the double meaning...👍

    • @shubhangnisharma6597
      @shubhangnisharma6597 3 роки тому +1

      Coz we r science students✌

  • @yassminmaher4997
    @yassminmaher4997 5 років тому +6

    i studied glycolysis for nearly 4 years and only that video makes me understand it

  • @JunZDK
    @JunZDK 7 років тому +19

    You really made it so much easier to understand. Thank you!

  • @maturename9817
    @maturename9817 5 років тому +23

    hey, Mr. khan, Id really appreciate it if you could include printable versions of the notes that you write in the videos as a link in the video description.

  • @user-ui7xl9mz3w
    @user-ui7xl9mz3w 3 роки тому +18

    me: finished the video
    Also me: and that's why i hate sugar.

  • @StreetDancer171
    @StreetDancer171 6 років тому +7

    Dope video, I love how you actually enjoy what you're talking about and are enthusiastic about it!

  • @dina6177
    @dina6177 5 років тому +17

    “this over here was replaced with that over there”

  • @rosy5565
    @rosy5565 7 місяців тому +2

    You just made me understand the cycle in 12 mins that my teacher couldn’t in a 2 hours lecture. Thank you so much for putting this out for FREE

  • @gtarules1
    @gtarules1 7 років тому +66

    It only took him 6 years to post the video. lol

  • @lisagonzalez2902
    @lisagonzalez2902 4 роки тому +6

    Thanks SO much, for all the videos you provide... It's helped me a lot throughout my medical career in the Dominican Republic. I finished it, and will graduate soon. Right now, I'm studying for the USMLE and reviewing quite a bunch of knowledge gaps!
    I don't agree with the comments on how his speech is too excited or whatever. Precisely, that's what makes me NOT fall asleep or get bored, since the way he talks makes everything much more interesting.

  • @BereketMinisha
    @BereketMinisha Рік тому

    wow! BRILLIANT!,I am from Ethiopia East Africa and I love learning from your video!

  • @monaipsm
    @monaipsm 3 роки тому +3

    THIS IS THE BEST VIDEO ON GLYCOLYSIS EVER! Please do one like this on kreb cycle please!!!

  • @charlottedelaet5430
    @charlottedelaet5430 3 роки тому +2

    I always watch your videos if I need to study something or I need to teach it’s so well explained!

  • @sirian3092
    @sirian3092 8 років тому +3

    This video helps me a lot to understand the glycolysis process. Thanks!

  • @Myleanne14
    @Myleanne14 4 роки тому +4

    Great video, thanks for mentioning all the enzymes involved

  • @davidadams255
    @davidadams255 4 роки тому +5

    MCAT is in one month. This is a life saver. Thank you!

    • @emeka3033
      @emeka3033 3 роки тому

      howd u do

    • @davidadams255
      @davidadams255 3 роки тому +2

      @@emeka3033 92 percentile! Thank you again!

    • @emeka3033
      @emeka3033 3 роки тому

      @@davidadams255 you legend, I’m studying for my first test in mid august

    • @davidadams255
      @davidadams255 3 роки тому +1

      @@emeka3033 best of luck my friend...make sure you work hard and make every moment of studying count. Perhaps even more important, make sure you give yourself time every week to rest and reward yourself for your hard work. Best of luck to you

  • @xdaebakxab6344
    @xdaebakxab6344 7 років тому +4

    thank you so much for this vid! helped me so much! my biochem professor is clearly failing at explaining

  • @shivampatel9233
    @shivampatel9233 4 роки тому +3

    thanks to this academy, my grades aren't dropping like hell. love this channel

  • @tinashechidzambga5422
    @tinashechidzambga5422 8 років тому +6

    Thanks a bunch mate. That is exactly what I needed.

  • @chezlise.holisticbeautyhea2012
    @chezlise.holisticbeautyhea2012 6 років тому +2

    This is GREAT!!! Thank you!

  • @michellegeorge1853
    @michellegeorge1853 6 років тому +3

    Amazing video. Very very helpful! Thank you Khan Academy!

  • @pouyaejtemaeimehr9352
    @pouyaejtemaeimehr9352 6 років тому +3

    Thank you so much. A wonderful review for SAT subject test for which I am preparing even though College Board requires me to know much less about Glycolysis than what this video taught me.

  • @Leah-ep3wh
    @Leah-ep3wh 7 років тому +1

    Had to memorize all the anabolic and catabolic processes for my upcoming test next week. Please bless my soul.

  • @briemarie8609
    @briemarie8609 6 років тому +1

    This helped me so much, thank you.

  • @crystalkan4862
    @crystalkan4862 4 роки тому +1

    my teacher explained this in a way that is hard to understand, and i am soooo happy this channel exist

  • @elissar2004
    @elissar2004 Рік тому +1

    The best! Thank you so much!!

  • @ghulammustafamemon3382
    @ghulammustafamemon3382 3 роки тому +1

    This is really appreciated. This one is the best one 😍

  • @halaabdullah4168
    @halaabdullah4168 7 років тому +1

    Thank you very much you make my life easier !

  • @lamimkader8823
    @lamimkader8823 7 років тому +3

    itd be nice to have the whole page in one shot, so i could follow the reaction process

  • @gayathrymuthumani9946
    @gayathrymuthumani9946 4 роки тому +1

    Really helpful.. Thanks alot and much appreciated

  • @tquathlouis2521
    @tquathlouis2521 4 роки тому +1

    This is what I need for the exam next week 😌😌 Thanks God you are here Khan

  • @stephenstralka6391
    @stephenstralka6391 5 років тому

    I real appreciate this video. Helps too much

  • @gustavobasulto6759
    @gustavobasulto6759 7 років тому +3

    In what Universe would anyone consider disliking this video. Thanks you 🙏🏻

  • @mrsquidward9454
    @mrsquidward9454 8 років тому

    Omg thank you so much this really helped me for my freshman bio class

  • @dannyawesome63
    @dannyawesome63 7 років тому +27

    You just explained what my biochem professor has been trying to explain for the past 2 weeks. (and drastically failing at it) Thanks!!

    • @Autumnpaige19
      @Autumnpaige19 6 років тому

      DannyAwesome63 A professor had to explain this in bio chem?! Wow I am learning this in general biology. Makes me less afraid of biochemistry now!

    • @earth6738
      @earth6738 6 років тому +1

      I had to walk out of my biology lecture and just look this process up on Kahn Academy because there was no way I was going to absorb any information with the way she was teaching it.

    • @nicoletaylor1497
      @nicoletaylor1497 5 років тому

      @@Autumnpaige19 Biochem, you learn the mechanisms and reproduce them.

  • @lili-cl1zx
    @lili-cl1zx 2 роки тому +1

    great video, glad to know i can always come here for science help! :D

  • @arman8543
    @arman8543 3 роки тому +2

    Thank you that was very helpful for me 🙏❤

  • @khushidogra4677
    @khushidogra4677 6 років тому

    Thnxs this is very helpful of my study

  • @omarelhousseiny6155
    @omarelhousseiny6155 2 роки тому

    Last 2 seconds of the video:
    "Actually makes sense"
    (JAW DROPS)👍

  • @lilyablitt7047
    @lilyablitt7047 3 роки тому

    that was great! thank you sm

  • @theblimo4747
    @theblimo4747 5 років тому +1

    Wow... I just began bio 20 and I’m already hooked on this, but I really should’ve taken Chem first!

  • @alshorty85
    @alshorty85 6 років тому +60

    Borrowing your brain to take the exams sounds better than this lol

    • @shaniw.4728
      @shaniw.4728 6 років тому

      i thought i was the only one who thought like that

    • @madhurajoshi3479
      @madhurajoshi3479 5 років тому

      Shani Williams I know right!!!

    • @normiel7135
      @normiel7135 3 роки тому

      Lol bet they graduated by now

  • @blinbin8415
    @blinbin8415 3 роки тому +9

    crying in the club rn my teacher didnt even teach us she gave us a ppt and some hw ffs

  • @ouiemfrs4373
    @ouiemfrs4373 4 роки тому +4

    I love you man come and teach in my University,:")

  • @shyamraiyani6954
    @shyamraiyani6954 3 роки тому +3

    Superb explanation 👌👌👌🙏🙏🙏

  • @boristodorovic5735
    @boristodorovic5735 7 років тому

    thanks a lot... u helped a lot

  • @thepunlady3036
    @thepunlady3036 7 років тому +98

    teacher moved test to tmrw. panicking. no time. bye

    • @Vic661
      @Vic661 5 років тому

      How’d it go

    • @Birthold
      @Birthold 4 роки тому +12

      The people demand answers

  • @ferrariluther5910
    @ferrariluther5910 8 років тому

    majestirial,world class,sensational,brilliant,astonishing,intimate,definitive,point-wise.......

  • @SupagalSimmi
    @SupagalSimmi 7 років тому

    so much effort..😄 god bless u

  • @gabrielqin9687
    @gabrielqin9687 2 роки тому +1

    Triosephosphate isomerase (TPI) is a perfect enzyme that catalyzes dihydrooxyacetone phosphate into 3-phosphoglyceric acid. There is an enol middle metabolite between these two steps. But this enol middle metabolite is easy to release phosphate group and become to malonaldehyde in a neutral cellular environment. The significance of TPI enzyme lies in that it has approximately 10 aa residues forming a loop that is designed to cover the enol middle metabolite preventing its release. In the end, as long as 3-phosphoglyceric acid is produced, this loop or cover will leave and let 3-phosphoglyceric acid go and do next reaction into 1,3- diphosphoglyceric acid.

  • @bencarusomed
    @bencarusomed 4 роки тому

    I love you thank you for everything you do.

  • @billcheney856
    @billcheney856 7 років тому +4

    just for the record, the two kinase enzymes in steps 1 and 2 transfer a phosphoryl group, NOT a phosphate. It seems like splitting hairs, but it's important to account for the oxygen atom.

  • @robinbernales8914
    @robinbernales8914 8 років тому

    THANK YOU!!!!

  • @hillaryherrera2125
    @hillaryherrera2125 7 років тому +2

    "3 cahhh bunn molecule" at 0:26
    couldn't stop laughing at that part lol

  • @juliam2070
    @juliam2070 Рік тому

    literally helped me SOOOOO******* MUCH thank you Khan!!!!!!!!!!!!!!!

  • @infiredpumpkins1970
    @infiredpumpkins1970 3 роки тому

    Khan academy is a life saver

  • @memcore1312
    @memcore1312 Рік тому +2

    And I thought intro to microbiology was going to be easy 😂

  • @alyssaalcantara6739
    @alyssaalcantara6739 6 років тому +4

    I think it’s cruel that the A.P. Bio, 12u bio curriculum requires us to memorize the steps of glycolysis. Although, I do appreciate the complex process that allows us to break down sugar from food and convert into the universal energy currency, ATP.

  • @plusgaming3878
    @plusgaming3878 5 років тому

    Great video👍

  • @naythamhussein9662
    @naythamhussein9662 7 років тому

    finally I've understsnd

  • @rayaheenahmed9996
    @rayaheenahmed9996 6 років тому

    thankyou so much

  • @Pipita79
    @Pipita79 7 років тому

    You should do all the videos man,

  • @veronicahovengen
    @veronicahovengen 6 років тому

    thank you for a really nice presentation! Like your drawings and your voice ;)

  • @Nidacolada
    @Nidacolada Рік тому

    Haha, gotta love the excitement :D Thank you

  • @maybenikhil
    @maybenikhil 7 років тому

    I learned this at the start of my school year. Forgot it by the end

  • @MehranaMoments
    @MehranaMoments 4 роки тому

    Awesome👍

  • @Itsme-rn1zb
    @Itsme-rn1zb 2 роки тому

    Ur talking style and ur voice make me listen u again and again.. 😅😍

  • @fahdchmanti7632
    @fahdchmanti7632 2 роки тому

    thank you

  • @goshakrasovskiy7072
    @goshakrasovskiy7072 4 роки тому +2

    Can some one please explain where the second phosphate group that was attached on the glyceraldehyde came from

    • @shivampatel9233
      @shivampatel9233 4 роки тому

      just know that whenever there is formation of ch2oh in glycolysis, the h gets replaced by a phosphate group

    • @goshakrasovskiy7072
      @goshakrasovskiy7072 3 роки тому

      @@shivampatel9233 thank you so much I really appreciate it

    • @shivampatel9233
      @shivampatel9233 3 роки тому

      @@goshakrasovskiy7072 no problem

  • @eden5695
    @eden5695 Рік тому

    thank you for the vidya, you got a fire voice

  • @linzhuo3099
    @linzhuo3099 8 років тому +3

    Hi there,
    In the graph you drew, you only have 5 hydrogens for glyceraldehyde 3 phosphate. However, the formulate for this molecule is C3H7O6P. Just a little confused with why there are 2 missing hydrogen.
    Thank you so much

    • @farouk98kh
      @farouk98kh 8 років тому +1

      the phosphate is with or withour hydrogen atoms, since it reacts with water in an equilibrium reaction. He chose to draw it without the hydrogen; yet, we can still put the phosphate with the ti hydroxyles

  • @foxy9403
    @foxy9403 2 роки тому

    you need to start putting adds on the videos my man.. they are so good.

  • @maheentahseen9039
    @maheentahseen9039 4 роки тому

    Lmao your voice literally made me excited when reaching the end😂 anyways, I always understand anything through your videos. Love em❤️

  • @kayleeknaggs7662
    @kayleeknaggs7662 6 років тому

    Is there a video of cellular respiration using fructose or sucrose? I need to know it and can't find a video anywhere! Please help

  • @a-hope9810
    @a-hope9810 5 років тому

    interesting.

  • @iluvspongebob88
    @iluvspongebob88 7 років тому +3

    after the phosphoglycerate mutase step where does the hydrogen on the bottom of the next step come from?

  • @ashleyplease7479
    @ashleyplease7479 6 років тому +1

    Hi there, during the cleavage phase, what molecule or enzyme splits the p-c3-p into the G-3-p?

  • @shummu1458
    @shummu1458 3 роки тому

    Now glycolysis sat in my mind😍

  • @noziphoprudymaphori3836
    @noziphoprudymaphori3836 6 років тому

    u are a genius sir

  • @martinmitter5697
    @martinmitter5697 3 роки тому +1

    In my chemistry book and other sources there is one hydrogen less on the final pyruvate molecule. You have a full COOH group there, which one is correct ? Pyruvate with COO- or COOH ?

  • @marielabandero846
    @marielabandero846 4 роки тому

    Its our exam day and im watching , cramming is life

  • @hala1151
    @hala1151 4 роки тому

    thxx sooo muchhh!!

  • @rubi22teresa
    @rubi22teresa Рік тому

    Thanks 🤩🤩🤩🤩