It's a bit like if you inflate a balloon, the volume represents your knowledge, the surface area represents the things your discover that you don't know. I guess it's just that you first have to understand the basic concepts of something to realize how much there is to know about it and until you do, all of that doesn't exist to you.
Thank you for making FREE videos for PREMED students. Many intelligent students can't afford MCAT prep packages and even basic books! So you are doing a huge favor to them by making detailed videos on MCAT topics. All of the poor students are future doctors and they will be donating regularly to this amazing channel ❤ I wish a free medical school will be established one day just like Khan Academy, professional, kind and generous, in which people can study doctor of medicine for free.✨
Great video, however one simple mistake: Kinases don't "dephosphorylate" molecules under physiological conditions. Enzymes for dephosphorylation reactions are called "phosphatases". The reason why the "pyruvate kinase" is called kinase is that while these metabolic reactions were being discovered, scientists tried out these reactions in vitro to see what the enzymes do and they put too much pyruvate and so turned the reaction balance in favour of phospoenolpyruvate (PEP) as product, so they thought, the enzyme phosphorylated pyruvate. But in reality, under physiological concentrations, the enzyme actually "dephosphorylates" PEP.
I will always love biology the most. Chemistry, well, not so much. I mean it's quite an interesting subject but it makes me struggle so much at school. Same for Physics.
Sloth no offence but to me he sounded really excited which was kind of annoying since I was breaking my brainpan to try make sense out of glycolysis....
Thanks SO much, for all the videos you provide... It's helped me a lot throughout my medical career in the Dominican Republic. I finished it, and will graduate soon. Right now, I'm studying for the USMLE and reviewing quite a bunch of knowledge gaps! I don't agree with the comments on how his speech is too excited or whatever. Precisely, that's what makes me NOT fall asleep or get bored, since the way he talks makes everything much more interesting.
@@emeka3033 best of luck my friend...make sure you work hard and make every moment of studying count. Perhaps even more important, make sure you give yourself time every week to rest and reward yourself for your hard work. Best of luck to you
I look away for 20 seconds and next thing you know, I'm as lost as a 3 year old in walmart by how much stuff you just put on the screen Sigh, that's biology for you
hey, Mr. khan, Id really appreciate it if you could include printable versions of the notes that you write in the videos as a link in the video description.
I had to walk out of my biology lecture and just look this process up on Kahn Academy because there was no way I was going to absorb any information with the way she was teaching it.
Thank you so much. A wonderful review for SAT subject test for which I am preparing even though College Board requires me to know much less about Glycolysis than what this video taught me.
just for the record, the two kinase enzymes in steps 1 and 2 transfer a phosphoryl group, NOT a phosphate. It seems like splitting hairs, but it's important to account for the oxygen atom.
Triosephosphate isomerase (TPI) is a perfect enzyme that catalyzes dihydrooxyacetone phosphate into 3-phosphoglyceric acid. There is an enol middle metabolite between these two steps. But this enol middle metabolite is easy to release phosphate group and become to malonaldehyde in a neutral cellular environment. The significance of TPI enzyme lies in that it has approximately 10 aa residues forming a loop that is designed to cover the enol middle metabolite preventing its release. In the end, as long as 3-phosphoglyceric acid is produced, this loop or cover will leave and let 3-phosphoglyceric acid go and do next reaction into 1,3- diphosphoglyceric acid.
I think it’s cruel that the A.P. Bio, 12u bio curriculum requires us to memorize the steps of glycolysis. Although, I do appreciate the complex process that allows us to break down sugar from food and convert into the universal energy currency, ATP.
Hi there, In the graph you drew, you only have 5 hydrogens for glyceraldehyde 3 phosphate. However, the formulate for this molecule is C3H7O6P. Just a little confused with why there are 2 missing hydrogen. Thank you so much
the phosphate is with or withour hydrogen atoms, since it reacts with water in an equilibrium reaction. He chose to draw it without the hydrogen; yet, we can still put the phosphate with the ti hydroxyles
You guys should run a few ads but only before and after the video. It is very profitable, and it would ensure your survival as a channel. Ads before and after the video also wouldn't interfere with the learning process in the same way that ads in the middle of the video would.
In my chemistry book and other sources there is one hydrogen less on the final pyruvate molecule. You have a full COOH group there, which one is correct ? Pyruvate with COO- or COOH ?
Nice video! Actually the enzyme hexokinase is accompanied by the enzyme glukokinase which works at higher glucose concentrations. Otherwise, pretty cool!
The magnesium coupled atp is to make sure as you break atp to adp you dont go throwing energy grenades all around the cell. So the magnesium is used to stabilize the phosphate offloading.
Hexokinase is also deliberately used to trap the glucose in the cell. To create a negative charge on glucose and allow for repulsion to the cell membrane.
Bro that moment when he scrolled up at 3:19 , man I started freaking out. He said "more detailed" like it was no big deal. I'm scared. What's it going to be like later on then? DO I DRAW THESE IN THE FUTURE?
Why do I feel like the more science you know, the more you realize the less you know.
It's a bit like if you inflate a balloon, the volume represents your knowledge, the surface area represents the things your discover that you don't know. I guess it's just that you first have to understand the basic concepts of something to realize how much there is to know about it and until you do, all of that doesn't exist to you.
Kant has a theory about this. the more you know you are pushing your knowledge limitations further and you realize how little it represents.
hahaha! same man!
"As for me, all I know is that I know nothing" Socrates used to say. Humans are always the same:)
That means your learning and your way of thinking has been advised by several of my professors
Cool. Now if I watch this 10 more times I might have it memorized. . . Maybe.
Write it down from memory instead - much more efficient
Wow so fast?! (not even ironic)
literally same
@@onetwoBias I agree!
Maybe checkout a less detailed one? It's rly not tht complicated
‘mind wanders for 5 seconds’ welp time to go back 3 minutes
facts
That’s so true
so true!
story of my life
Seriously smh
Kahn puts my $100 biology textbook to shame. He's straight up out here slaying the science game. Thanks, Kahn.
Atleast spell his name right...
@@mohamedmotaz5194 he clearly khant
Thank you for making FREE videos for PREMED students. Many intelligent students can't afford MCAT prep packages and even basic books! So you are doing a huge favor to them by making detailed videos on MCAT topics. All of the poor students are future doctors and they will be donating regularly to this amazing channel ❤ I wish a free medical school will be established one day just like Khan Academy, professional, kind and generous, in which people can study doctor of medicine for free.✨
I have to memorize this for Tuesday. Lord help me.
May God help you.
how did u do?
shko ata well I had Glycolysis down, but the rest of the exam was the beggining of my demise
i need to learn al of this for this tuesday ha. Apparently tuesday is test day
Aimee I have to memorize this for tomorrow...
Great video, however one simple mistake:
Kinases don't "dephosphorylate" molecules under physiological conditions. Enzymes for dephosphorylation reactions are called "phosphatases".
The reason why the "pyruvate kinase" is called kinase is that while these metabolic reactions were being discovered, scientists tried out these reactions in vitro to see what the enzymes do and they put too much pyruvate and so turned the reaction balance in favour of phospoenolpyruvate (PEP) as product, so they thought, the enzyme phosphorylated pyruvate.
But in reality, under physiological concentrations, the enzyme actually "dephosphorylates" PEP.
Thank you for this nice information 👍 It can be crucial detail.
If my body was able to take my biology test for me, I would've totally aced it.
I will always love biology the most. Chemistry, well, not so much. I mean it's quite an interesting subject but it makes me struggle so much at school. Same for Physics.
Weeeell, we have this topic for biology and I now only understand it more in Khan Academy than my Bio teacher.
@@anshikasrivastava3951 Being indian has absolutely nothing to do with that
Even if this man was speaking in Navajo, my current level of understanding would still be the same.
Aquarian Sage retweet
that is literally me 2 years later. funniest thing i read all day..
🤣🤣
you know it that well?
Gosh this guys you'll be a voice actor; he's got such a soothing and calming voice ^_^
Sloth no offence but to me he sounded really excited which was kind of annoying since I was breaking my brainpan to try make sense out of glycolysis....
You just made me understand the cycle in 12 mins that my teacher couldn’t in a 2 hours lecture. Thank you so much for putting this out for FREE
3:13 is aCtUaLLy litEraLly the epitome of expectation vs reality and I died
best comment
i cant stop laughing !!!
😭so tough for a class 10 student like me
i studied glycolysis for nearly 4 years and only that video makes me understand it
Thanks SO much, for all the videos you provide... It's helped me a lot throughout my medical career in the Dominican Republic. I finished it, and will graduate soon. Right now, I'm studying for the USMLE and reviewing quite a bunch of knowledge gaps!
I don't agree with the comments on how his speech is too excited or whatever. Precisely, that's what makes me NOT fall asleep or get bored, since the way he talks makes everything much more interesting.
Stop sounding so excited, we hate glycolysis.
Lmao true
ahhahahahahaha This one takes the cake
Nah, I enjoy learning about it, it's interesting to know what's going on in our bodies
WaveDancer171 you do...And that's great! This is just the silly opinion of 90 percent of the people studying glycolysis..😑
WaveDancer171 you will hate it once you will see this in order to memorize it.
90% of the video: we talked about this in another video
10% of the video: actually explaining glycolysis
Wish the number of your comment's likes add to your IQ
realll🤣
This man knows everything, only rival to Johnny Sins himself.
I can's appreciate the complexity when I need to know all of this for a test lol
You really made it so much easier to understand. Thank you!
THIS IS THE BEST VIDEO ON GLYCOLYSIS EVER! Please do one like this on kreb cycle please!!!
MCAT is in one month. This is a life saver. Thank you!
howd u do
@@emeka3033 92 percentile! Thank you again!
@@davidadams255 you legend, I’m studying for my first test in mid august
@@emeka3033 best of luck my friend...make sure you work hard and make every moment of studying count. Perhaps even more important, make sure you give yourself time every week to rest and reward yourself for your hard work. Best of luck to you
Why is life so complicated!?
Creativity of god
Yet another equation : law_of_physics x random x huge_amount_of_time x selection = complexity of life
Cuz complexity makes life awesome
the double meaning...👍
Coz we r science students✌
I look away for 20 seconds and next thing you know, I'm as lost as a 3 year old in walmart by how much stuff you just put on the screen
Sigh, that's biology for you
Dope video, I love how you actually enjoy what you're talking about and are enthusiastic about it!
hey, Mr. khan, Id really appreciate it if you could include printable versions of the notes that you write in the videos as a link in the video description.
thanks to this academy, my grades aren't dropping like hell. love this channel
my teacher explained this in a way that is hard to understand, and i am soooo happy this channel exist
You just explained what my biochem professor has been trying to explain for the past 2 weeks. (and drastically failing at it) Thanks!!
DannyAwesome63 A professor had to explain this in bio chem?! Wow I am learning this in general biology. Makes me less afraid of biochemistry now!
I had to walk out of my biology lecture and just look this process up on Kahn Academy because there was no way I was going to absorb any information with the way she was teaching it.
@@Autumnpaige19 Biochem, you learn the mechanisms and reproduce them.
wow! BRILLIANT!,I am from Ethiopia East Africa and I love learning from your video!
This is what I need for the exam next week 😌😌 Thanks God you are here Khan
Had to memorize all the anabolic and catabolic processes for my upcoming test next week. Please bless my soul.
This video helps me a lot to understand the glycolysis process. Thanks!
thank you so much for this vid! helped me so much! my biochem professor is clearly failing at explaining
Great video, thanks for mentioning all the enzymes involved
I always watch your videos if I need to study something or I need to teach it’s so well explained!
itd be nice to have the whole page in one shot, so i could follow the reaction process
Last 2 seconds of the video:
"Actually makes sense"
(JAW DROPS)👍
Thank you so much. A wonderful review for SAT subject test for which I am preparing even though College Board requires me to know much less about Glycolysis than what this video taught me.
Superb explanation 👌👌👌🙏🙏🙏
In what Universe would anyone consider disliking this video. Thanks you 🙏🏻
Wow... I just began bio 20 and I’m already hooked on this, but I really should’ve taken Chem first!
The best! Thank you so much!!
just for the record, the two kinase enzymes in steps 1 and 2 transfer a phosphoryl group, NOT a phosphate. It seems like splitting hairs, but it's important to account for the oxygen atom.
Thank you very much you make my life easier !
Thanks a bunch mate. That is exactly what I needed.
Amazing video. Very very helpful! Thank you Khan Academy!
I love you man come and teach in my University,:")
Thank you that was very helpful for me 🙏❤
Triosephosphate isomerase (TPI) is a perfect enzyme that catalyzes dihydrooxyacetone phosphate into 3-phosphoglyceric acid. There is an enol middle metabolite between these two steps. But this enol middle metabolite is easy to release phosphate group and become to malonaldehyde in a neutral cellular environment. The significance of TPI enzyme lies in that it has approximately 10 aa residues forming a loop that is designed to cover the enol middle metabolite preventing its release. In the end, as long as 3-phosphoglyceric acid is produced, this loop or cover will leave and let 3-phosphoglyceric acid go and do next reaction into 1,3- diphosphoglyceric acid.
me: finished the video
Also me: and that's why i hate sugar.
great video, glad to know i can always come here for science help! :D
Ur talking style and ur voice make me listen u again and again.. 😅😍
This is really appreciated. This one is the best one 😍
Khan academy is a life saver
This is GREAT!!! Thank you!
“this over here was replaced with that over there”
Really helpful.. Thanks alot and much appreciated
you need to start putting adds on the videos my man.. they are so good.
majestirial,world class,sensational,brilliant,astonishing,intimate,definitive,point-wise.......
literally helped me SOOOOO******* MUCH thank you Khan!!!!!!!!!!!!!!!
Omg thank you so much this really helped me for my freshman bio class
I real appreciate this video. Helps too much
This helped me so much, thank you.
I think it’s cruel that the A.P. Bio, 12u bio curriculum requires us to memorize the steps of glycolysis. Although, I do appreciate the complex process that allows us to break down sugar from food and convert into the universal energy currency, ATP.
"3 cahhh bunn molecule" at 0:26
couldn't stop laughing at that part lol
To make it a bit more complex you could have drawn it in spiral instead of in circle.
No, but seriously, thanks for the explanation! Very helpful.
Hi there,
In the graph you drew, you only have 5 hydrogens for glyceraldehyde 3 phosphate. However, the formulate for this molecule is C3H7O6P. Just a little confused with why there are 2 missing hydrogen.
Thank you so much
the phosphate is with or withour hydrogen atoms, since it reacts with water in an equilibrium reaction. He chose to draw it without the hydrogen; yet, we can still put the phosphate with the ti hydroxyles
Thanks 🤩🤩🤩🤩
You should do all the videos man,
It only took him 6 years to post the video. lol
You guys should run a few ads but only before and after the video. It is very profitable, and it would ensure your survival as a channel. Ads before and after the video also wouldn't interfere with the learning process in the same way that ads in the middle of the video would.
Now glycolysis sat in my mind😍
How can we appreciate its complexity
Thnxs this is very helpful of my study
thank you for the vidya, you got a fire voice
thanks a lot... u helped a lot
Have to freakin memorize this for report tomorrow. Wish me luck guys😭
How was it? Gosh Amma report this next week help me
Its our exam day and im watching , cramming is life
that was great! thank you sm
2 atp for anaerobic and 38atp for aerobic respiration energetics.
Great video👍
Awesome👍
No matter how many times I watch this I still don't get it lol Lord be with me I have a test Wednesday
Hey girl! I found you here lol. No worries we are on the same boat.
Jenet Kolaparan lmao
I learned this at the start of my school year. Forgot it by the end
u are a genius sir
In my chemistry book and other sources there is one hydrogen less on the final pyruvate molecule. You have a full COOH group there, which one is correct ? Pyruvate with COO- or COOH ?
Nice video! Actually the enzyme hexokinase is accompanied by the enzyme glukokinase which works at higher glucose concentrations. Otherwise, pretty cool!
Can some one please explain where the second phosphate group that was attached on the glyceraldehyde came from
just know that whenever there is formation of ch2oh in glycolysis, the h gets replaced by a phosphate group
@@FavouredElm2 thank you so much I really appreciate it
@@goshakrasovskiy7072 no problem
Borrowing your brain to take the exams sounds better than this lol
i thought i was the only one who thought like that
Shani Williams I know right!!!
Lol bet they graduated by now
The magnesium coupled atp is to make sure as you break atp to adp you dont go throwing energy grenades all around the cell. So the magnesium is used to stabilize the phosphate offloading.
Hexokinase is also deliberately used to trap the glucose in the cell. To create a negative charge on glucose and allow for repulsion to the cell membrane.
Haha, gotta love the excitement :D Thank you
I love you thank you for everything you do.
teacher moved test to tmrw. panicking. no time. bye
How’d it go
The people demand answers
so much effort..😄 god bless u
thxx sooo muchhh!!
Lord I just need to pass this class , and I will never heard of this again in my life
Same dude I got a test in 2 hours
@@Ja-vx2nr howd you do?
@@asha_4095 Good enough
finally I've understsnd
Bro that moment when he scrolled up at 3:19 , man I started freaking out. He said "more detailed" like it was no big deal. I'm scared. What's it going to be like later on then? DO I DRAW THESE IN THE FUTURE?
It's better to admire the complexity than to fear it
thankyou so much