Part 1 - Immunology Of Leprosy

Hi. With this video [Part 1], we will discuss the action and reaction of the immune system to Mycobacterium leprae infection, and understand the specific immune system mediating cytokines related to the tuberculoid pole and the lepromatous pole of leprosy. This video is directed towards dermatologists and is not at all advisory for non-medical personnel.
Skin reactions in leprosy - 06:10
Immune response to M. Leprae - 09:22
Innate Immunity: Introduction - 17:30
Innate Immunity: Entry - 20:24
Innate Immunity: Macrophage - 31:57
Innate Immunity: Dendritic Cells - 41:16
Innate Immunity: Keratinocytes - 48:28
Innate Immunity: Schwann Cells - 51:00
Innate Immunity: Neutrophils - 55:27
Acquired Immunity - 57:47
End - 59:36

[@priyankasingh-dr6cj]

Excellent video.thank you sir🙏🏻

[@priyankasingh-dr6cj]

Sir Please make a video on ultrastructure of M.lepra.

[@Maddy-op3gy]

Sir please make one on lepra reactions. Great video 🙏🏻

[@sabhderma]

Thank you for commenting ☺️. Will surely make one on lepra reactions

[@dermgeeks]

Wonderful video. Thank you Sir.

[@sabhderma]

You are very welcome 😁. Keep watching and share with others! 😊😊😊

[@Priya41297]

Thank you so much Sir 🙏

[@sabhderma]

Most welcome. Thank you for watching. 😊

[@kalyandharavath4698]

Thank you sir 🙏🏻

[@dhanshrikurekar6752]

Sir systemic involvment and mainly occular.. Plez do make video of this topic asap

[@sabhderma]

That's a good idea. Will surely make one, leprosy is interesting 😊

[@m4motivation181]

Sir if possible cover large plaque small plaque parasoriasis plc and pleva

[@sabhderma]

I will in due time 😊😊

[@azharahamed202]

Thank you sir, sir If IDO increasing granuloma formation, then why it is found more in lepromatous pole

[@sabhderma]

That's a good question. IDO is required to inhibit granuloma formation by interfering with the tryptophan metabolism. The main function is to regulate granuloma formation. In the lepromatous pole, the expression of IDO increases on the immune cells. Hence they are inhibited to form good granulomas. This leads to the lepromatous pole with loose infiltrate rather than granulomatous infiltrate.

[@jshk5664]

is IL1b anti-inflammatory as you said?

[@sabhderma]

Thank you for your doubt. Truly speaking, IL1b is a lymphocyte mitogen and recruiter, and is mainly responsible of B cell activation and fever production. Increased levels of IL1b has been found in multibacillary Hansen cases, where they recruit Bcells and inflammatory cells for lepra reactions. However, this pushes the immunity to a more humoral based immune reaction rather than a cell based immunity, thereby decreasing the cell mediated damage to the bacilli. So acute inflammatory response is on the same lines as TNFa, that is recruitment of inflammatory cells which are readily available for infection. I hope this makes a bit of sense sir. Thank you for asking😊

[@cutekannu8685]

This video is from IAL or Kabir sardana

[@sabhderma]

The video on immunology of leprosy is from IAL and individual articles, older joplings, not the new one.

[@cutekannu8685]

Kindly share the link of pdf

[@sabhderma]

Hi, there is no pdf as of now. Currently making videos only. Maybe in the future I may consider PDFs😊