Part 2 - Manipulation of Immune System In Leprosy

Hi. With this video [Part 2], we will discuss the action and reaction of the Mycobacterium leprae bacilli to our immune system, and understand the unresponsiveness of the immune system to the bacilli leading to persisting infection and subsequent development of lepromatous leprosy. This video is directed towards dermatologists and is not at all advisory for non-medical personnel.
Immune unresponsiveness - 02:27
Immune unresponsiveness: Antigen presentation - 07:20
FOXP3 - 10:56
TH17 Cells - 14:25
CD4 Cells - 16:34
T Cell maturation - 18:53
Manipulation of Immune System - 21:32
TOLL-like receptors - 21:59
NOD-like receptors - 26:45
Autophagy - 30:13
Apoptosis of Immune Cells - 32:49
Complement Cascade - 35:22
Treg Cells - 38:40
TH9 Cells - 41:36
PD1/PDL1 System - 44:21
B-regulatory Cells - 45:49
Summary of the Immune Response - 47:49
Further Reading - 54:35
Dr. Stephen E. Wolverton tribute - 56:56
End - 58:20
Further Reading:
1. Nath I, Saini C, Valluri VL. Immunology of leprosy and diagnostic challenges. Clin Dermatol. 2015 Jan-Feb;33(1):90-8. doi: 10.1016/j.clindermatol.2014.07.005. PMID: 25432814.
2. Froes LAR Junior, Sotto MN, Trindade MAB. Leprosy: clinical and immunopathological characteristics. An Bras Dermatol. 2022 May-Jun;97(3):338-347. doi: 10.1016/j.abd.2021.08.006. Epub 2022 Apr 2. PMID: 35379512; PMCID: PMC9133310.
3. Sugawara-Mikami M, Tanigawa K, Kawashima A, Kiriya M, Nakamura Y, Fujiwara Y, Suzuki K. Pathogenicity and virulence of Mycobacterium leprae. Virulence. 2022 Dec;13(1):1985-2011. doi: 10.1080/21505594.2022.2141987. PMID: 36326715; PMCID: PMC9635560.
4. Froes LAR Jr, Trindade MAB, Sotto MN. Immunology of leprosy. Int Rev Immunol. 2022;41(2):72-83. doi: 10.1080/08830185.2020.1851370. Epub 2020 Nov 26. PMID: 33241709.
5. Mi Z, Liu H, Zhang F. Advances in the Immunology and Genetics of Leprosy. Front Immunol. 2020 Apr 16;11:567. doi: 10.3389/fimmu.2020.00567. PMID: 32373110; PMCID: PMC7176874.
6. Berto da Silva Prata R, Garcia de Mattos Barbosa M, Jorge de Andrade Silva B, Araujo da Paixão de Oliveira J, Lameira Bittencourt T, Olmo Pinheiro R. Macrophages in the Pathogenesis of Leprosy [Internet]. Macrophage Activation - Biology and Disease. IntechOpen; 2020. Available from: dx.doi.org/10.5...

[@princysharone919]

Thank you sooo muchhh sir for this wonderful pg lecture which is precious ,you made the concepts crystal clear without just reading the slide explained each and every concept and made this so intresting.i request you to post more lecture for leprosy for pg exam going students

[@sabhderma]

You are most welcome. Thank you for your kind words. I want to explain difficult topics in an easy to understand manner. I hope these videos are helpful to the listeners. 😊😊 Keep watching and sharing videos. There are many more to come!!!

[@indusree8]

Awesome explanation and thank you sir...

[@sabhderma]

Thank you for your reply. Leprosy is very interesting 😊 I am glad you found the video useful. Let me know the further topics in leprosy that we can discuss with others. Till then, keep watching other videos on the channel 😁😁

[@itsmemrunali9078]

Thank you sir for these videos

[@sabhderma]

Thank you for your kind words 😊😊🙏

[@m4motivation181]

Sir please don't stop making videos aa awesome ho

[@sabhderma]

Sure, keep watching 😀

[@vikaspurushottam8542]

Please made other vedios of leprosy to cover the whole topic of leprosy

[@sabhderma]

Thank you for your suggestion 🙂 Leprosy is neither simple nor short. So I wish to have detailed PG level lectures on it. I will be uploading those lectures from time to time on the channel. Till then keep watching 😊😊