Top NBME Concepts - Hematology (USMLE Step 1)
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- Опубліковано 15 лип 2024
- Timestamps 🚀
Start (0:00)
Introduction (4:08)
Lecture Preview (10:50)
Heme Synthesis (13:54)
CYP Inducers (19:35)
Lead Poisoning (23:21)
Approach to the Blood Smear (26:23)
Intro to Anemia (34:55)
Microcytic Anemia (38:02)
Acute Phase Reactants (Integration!) (43:03)
Summary of Microcytic (44:44)
Macrocytic Anemia (46:37)
B12 Physiology (52:05)
Normocytic Anemia (53:35)
HUS/TTP (1:00:33)
Polycythemia (1:03:34)
Platelet Pathology (1:06:32)
Warfarin vs. Heparin (1:12:06)
Multiple Myeloma (1:14:41)
Summary & Courses (1:17:24)
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Haematology is a very interesting subject for Doctors.
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Hello, Rod from South Carolina
waiting for the leukemia video eagerly!!
Sure
Suggested errata:Fe and ferritin would be normal in thalassemia;hereditary spherocytosis has negative direct Coombs.
USA Florida
Thank you very much for your effort to support us…dr I would like to say some of the notes contents are hidden by your video ..would you mind making it on opposite side or free areas?🙏🏼
❤
Hello! Rashmi from Massachusetts.
Thank you for all your amazing videos! Quick question at 58:16, although we know the patient is infected with mycoplasma pneumoniae and we see the positive indirect coomb's test causing AIHA, why does the patient have low haptoglobin? Didn't the slides prior say that AIHA is an extravascular hemolysis --> splenomegaly while intravascular hemolysis pathologies lead to low haptoglobin which is described in the vignette?
Hey Brian!! Thanks so much:
Cold-sensitive antibodies (cold agglutinins): mostly IgM antibodies cause extravascular hemolysis and acute intravascular hemolysis.
Warm-sensitive antibodies (warm agglutinins): polyclonal IgG antibodies that then bind to multiple RBC antigens. Binding of the antibodies leads to ↑ extravascular hemolysis.
Hope this helps! Sorry for any confusion!
Hello, st louis MO
Doc if 58:34 is an AIHA how come you calling it an intravascular anemia ? Isnt AIHA an extravascular anemia ?
I have a question about pernicious anemia. Within the question, it didn't mention nervous system symptoms. I understand that the patient had a preexisting AI condition, but would we automatically go to PA over folate deficiency without the nervous system symptoms?
Great question - the neurologic symptoms while common are sometimes seen in severe B12 deficiency. You are correct about the autoimmune stigmata in the question. Folate deficiency may have more of a tea-toast/lack of adequate nutrition within the vignette. Just given the most likely cause in an autoimmune patient (she had hypoT4 & Addisons) the best answer here would be pernicious anemia. However your through process is correct! Hope this helps!!
i have a question about 56:42 . Extravascular hemolysis is showing autoimmune hemolytic anemia in the flow chart but on 58:42 the question is showing low haptoglobin and as you mentioned intravascular hemolysis. the answer is coombs positivity and autoimmune hemolytic anemia? so is autoimmune hemolytic anemia also in intravascular hemolysis as well ?
Same question
did you get the answer? I am still confusing this point
I have the same question
From mumbai
i want you to mentor me one on one for a year for step one. Please let me know where to start
Start at 2;05
Hello there i just had a question, at 29:57 why is the answer not B, this is my logical thought, splenectomy suggests asplenia which suggests increased basophillic nuclear remnants like Howell-Jolly bodys - clusters,
My bad, ijust realised the histology photo is not consistent with the answer being clusters of remnant DNA, the target cell is more likely
HI doctor Rahul, I don't understand, you and the First Aid both say low haptoglobin is a characteristic of intravascular hemolysis but in the question about AIHA and Mycoplasma it says the patient has low haptoglobin and AIHA is a extravascular hemolysis and you said haptoglobin is normal in extravascular hemolysis. Can you please explain that part?
Thanks Emmanuel, Low haptoglobin levels are typically associated with intravascular hemolysis, which occurs when red blood cells break down in the bloodstream. However, in the case of autoimmune hemolytic anemia (AIHA), which is an extravascular hemolysis, low haptoglobin levels can also occur. This is because in AIHA, the immune system targets and destroys red blood cells in the spleen and liver, leading to the release of hemoglobin into the bloodstream.
This free hemoglobin can bind to haptoglobin and be removed from the bloodstream, leading to low levels of haptoglobin.
So while low haptoglobin is more commonly associated with intravascular hemolysis, it can also occur in certain cases of extravascular hemolysis like AIHA. The context will be important and USMLE will be very explicit! Sorry for any confusion!
@@hyguruprep thank you so much for taking the time to answer my question, your videos are great and are helping me a lot 🤗
Hello
AIHA is extracellular hemotysis ,,,,,, then how come u included in intravascular ( low haptoglobinuria) …?…??
Botswana
Hi
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Hi! Please feel free to enroll at hyguru.com [I also have an email list and update my website for my Zoom/UA-cam live sessions!] Thanks!
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Pakistan
@elite medical tutor why are u even here? we get that you're a tutor and im sure you make mistakes aswell but its not cool for you to keep nip picking at everything thats being said
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