MS Virtual 2020: Remyelination Clinical Trial Results - Bexarotene - Dr Will Brown
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- Опубліковано 21 лип 2024
- One of the major talking points from the MS Virtual 2020 conference was the results from a recent clinical trial testing a potential remyelination therapy, called bexarotene. We had the pleasure of talking to Dr Will Brown, from the University of Cambridge, about this study and the future of myelin repair in multiple sclerosis. We thank Will for generously volunteering his time for this discussion.
If you have questions on any aspects of this interview, please comment below or email them directly to Brett at brett@mstranslate.com.au.
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thank you for this. i was diagnosed with MS in 2020 and went blind. and still have deficits. i’m 25 and really scared. i feel at least a little bit of hope knowing people like you are working towards reversing disability and helping people like me
Thank you so much for devoting your career to this field! I have stable primary progressive MS (20years) And I am anticipating the day you are able to Use progressive patients and your studies
Dr. Brown, so good to know that people like you are doing this important work. I've been learning about MS as I have noticed unusual symptoms over the last five years that I have no other explanation for. It is a scary thing and I wish all the best for people suffering this awful disease. The way you explain your studies is very reassuring and I hope you hit upon the right therapy. Thanks for this video.
I'll take any risk to get my life back again.
Thanks for the comment demoskunk and I'm sure that view is expressed by many in the MS community. We will continue to provide updates on clinical trials that are recruiting people living with MS, so stay tuned to all of our channels. Participating in research is such an amazing thing to do, not just for the potential benefits that the individual may derive, but also for the help that it provides scientists and the rest of the MS community. Thank you for expressing such a willingness to be involved - Brett
@@MStranslate1 Thanks for the support, Brett!
Seems Drs. and researchers don't understand that. I'd rather have 10 better years ahead, than 30 with progressing disability.
same.
Dr Will Brown, what a lovely guy!
Indeed Richard! We can't thank Will enough for giving up his time to chat with us and share these important findings. We're sure that we will feature Will again at some point in the future. Thanks, Brett
@@MStranslate1 credit goes to yourself also for making these videos. Thank you.
It's not here yet but we are a step closer 😀
Definitely Mathew. It's always important that results are viewed in the right context. This trial was neither a massive success, nor a massive failure...yet often we think it has to be one or the other. As you say, the important thing is that we are a step closer. As always, thanks for your engagement on our content, it is much appreciated - Brett
Is there any UA-cam chance I could join for updates and notifications ?
What are the active research groups about MS ? Is there any trial program of Ayurvedic Medicine in progress ?
What kind of dosage are we looking at
when will the animal that repair myelin do it please reply
When will remyelination drug be available please
Hi, great lecture. Does eliminating EBV from ms patient’s system help him in remyelination.
what´s EBV?
when will remyeation be found please reply
Last December 2020 I had been diagnosed MS based on MRI
Now I remember I had early stage symptoms (gait deformity and imbalance) since a decade but then it was presumed sciatica probably and I only had pain killers then
Now I got irregular difficult speech but my Dr says my MS is progressing but very slowly
I can ride negotiate roads by bicycle or walk but I can't run because movement speed of limbs are very different
Dr has been asking any vision problems but I don't have any
How to forecast the progression of my MS ?
Same symptoms here. I began the Wahl's Protocol back in Feb, 2023 when admitted for a week. Was given IV anti-inflammatory IV for at least the loss of vision, then released. When I came home, I immediately began Wahl's Protocol. Within weeks, vision slowly returned to normal. Balance improved, and I began to feel noticeably better, until I went back to my old processed foods regular diet, and the signs and symptoms are slowly coming back now.. So, it's back to Wahl's to manage the auto-immune problem, but I am convinced, that Wahl's Protocol helps substantially to slowly restore function. Best, MDM. \\//
What is the name of the other drug given along with clemastine?
It's Metformin.
Another failed remyelination study. Not surprising, we can add this to the dustbin that includes Biogen's very expensive and failed drug candidate, anti-LINGO. The problem is that demyelination is not driving the disability exclusively, but axonal loss. This occurs early on in MS and is the reason disability accrues and becomes irreversible. The focus on demyelination does a disservice to the 50% of progressive patients in whom this strategy will fail. Axons that have died will not likely remyelinate from the many studies I have reviewed. We need to focus on the potential of stem cells to not just remyelinate, like MSCs, but to also grow back axons, which only embryonic or iPSC lines will do.
Thanks for the comment Quantum. I think at the moment we are in a position where we want to be exploring as many different avenues as possible, especially when it comes to myelin repair. As we have seen with the existing therapies for MS, they don't all work for every individual. Therefore, I think it's reasonable to suggest that we may see something similar in this space as well. By developing different strategies, using different targets, techniques and approaches, I'd hope that we would then have multiple options that, between them, would help all people living with MS (both relapsing and progressive). It's an emerging space and we will continue to provide updates on all of those different approaches. Thanks again - Brett
Hi
Is it possible Mayline sheet recovery plz reply thanks
Hi Iqra, thanks for your question. Yes, we do have a lot of evidence now that suggests it is possible for the myelin sheath to be repaired. In fact, demyelination (damage to the myelin) isn't that uncommon, it's just usually it is repaired quite quickly. This is not the case in multiple sclerosis and so researchers are trying to find a way to promote that repair process. This trial, although it failed, did show that the myelin repair was possible and now will be continuing to try and find the right compound that generates the benefits without the bad side-effects. Thanks, Brett
@@MStranslate1 what's your feelings on this newest discovery?
multiplesclerosisnewstoday.com/news-posts/2020/10/29/discovery-of-new-cell-may-be-key-to-treating-incurable-neurological-diseases/
@@Durace11Bunny I feel numbness unblance walk problem
@@iqraiqq7314 are you diagnosed with MS? These are all unpleasant symptoms, but work with you health care team to lessen the impact of these.
@@Durace11Bunny yeah diagnosed MS
I use the ocrevus
Metformin did nothing 😕
Hello I am Dr Ashok Dave MIE C.Eng. (MechanicalEng)
Flooded basement.
I think about that a lot.
I’m progressive. It’s been 32 years.
Help.
Thanks for the comment Vivianne and I think the flooded basement analogy works well. While I know it can be frustrating, please know that there are many, many dedicated researchers (such as Will) that are working incredibly hard to find answers to help improve the quality of life for people living with MS. We will continue to try and help accelerate this process as much as we can and help however we can. Best wishes, Brett