Gotta love how with quarantined schooling teachers have given up on teaching and recognized that people like you have been the ones actually teaching us.
Even with a biology degree and in medical school, this is the most straight forward and easy to understand video on DNA replication. You sir are the GOAT.
I love that I can learn by watching videos. I am interested in many subjects and my idea of a good session is learning something new. I will definitely be checking out Professor Dave!
I just realized something very important in terms of how to interpret your animation. The directionality of the synthesis of the new strand is correct. However, I initially thought that the numbers you put on the leading strand was identifying the ends of the new strand, not the original strand. In other words, the new strand would read/synthesize as such: 3' under the 5' of the leading strand and 5' under the 3' of the leading strand with the arrow going in the same direction.
Thank you Prof. Dave! I spent like two hours trying to understand my professors lecture, and you helped quite a lot! I am really grateful that I found this video online. Thank you for what you do! :)
sir you are a really talented teacher and a speaker ...... a process which would take me hrs to understand was made easy by you and i got it in juat 6 mins ! thanks man
Spending hours in boring college lectures with professors that lack the ability to teach and not learning ANYTHİNG vs watching a 6 minute video from a great teacher and understanding everything. I think I have spoken enough
I enjoy that I can learn the basics from your mini-lectures. Great job, Professor Dave. You put me in mind of my late father, a physician, teaching me about reproduction, mitosis, meiosis, etc. He started with onions and went on from there, ending with human reproduction when he felt it was age-appropriate (about 13-14 in my case). This puts me in mind of his teaching methods. I just subscribed a couple of hours ago and will be adding your videos to my Geology/Volcanology and Evolution and Extinctions playlists. So glad I found your channel!
All the videos I have viewed on DNA replication struggle to explain the 5'-3' process. Unfortunately, this wasn't any better, but the rest of the video was helpful.
DNA chain can only be synthesized in 5'-to-3' direction, not 3 to 5. As the subunits is being added at the 3' end, that means it runs in 5'-to-3' direction....
Actually he's correct, the DNA polymerase III moves in a direction of 3'- 5' of the preexisting strand. However, the new strand that's being synthesized is 5'-'3. The video is crystal clear .
The video is correct, but NOT clear. This "Dave" person knows the stuff but doesn't know how to explain it to a naive mind. Someone listening to this for the first time can get confused for all his life ! REPLICATION HAPPENS FROM 5 to 3 END !
Video was crystal clear . I understood the whole topic In ONLY 6 minutes where I didn’t get one thing through my head in a 80 minute class . Thank you so much Professor Dave !!
Loving the vids, I'm revising what I learned in the balkan equivalent of advanced biology & chemistry highschool. Just one thing: the audio volume is a bit low everywhere except the intro. These are old af but if you plan to make more videos maybe amplify the volume a bit in post.
Not sure if nitpicky or not but it could help to clarify that DNA polymerase III/I are those used in prokaryotes. I remember in high school still using the terms generically but I believe DNA pol-alpha/delta are the current standards for eukaryotes?
Do you have a video about endogenous retroviruses (ERVs)? Would like to get a better grasp about the subject. Thanks for these videos btw. Really helpful.
Its so frustrating, I understand the protein syntecis, the DNAs structure, mitoses and meiose, transcription, translation etc. when I get it explained to me, but there is no way I can repeat it😂😭
As was stated previously, the direction is NOT 3' -5'. According to Mc Graw-Hill 11th ed. Biology, "As with all known DNA polymerases, all three of these enzymes synthesize polynucleotide strands only in the 5'-3' direction and require a primer"
i meant that it moves along the template strand 3'-5', though you are correct the new strand is synthesized 5'-3', perhaps i should have been clearer in the animation.
Dave, polymerase III reads from 3' to 5' but polymerases new strand from 5' to 3'? But you said polymerase copies 3' to 5'. Did you mean polymerase reads 3' to 5'?
hi prof, had a few doubts: 1. after binding the primer to the DNA strand, the primase leaves the spot, and DNA polymerase iii takes the same spot to start adding the free DNA nucleotides? 2. on which strand do the following take place first or do the following processes take place simultaneously (as there is one molecule of enzyme allocated for each strand?) on both the strands? a) exonuclease removing the RNA nucleotides/primers b) DNA polymerase I adding DNA nucleotides in place of the primers c) Primase adding primers d) polymerase III adding free DNA nucleotides
Thank you very much for this lecture! But isn't it, that the direction is from 5' to 3' and not the other way around? At least that is what Amboss states.
Polymerase starts traveling at the 3’ end of the existing strand(so 3’to5’). The new strand it adds would be in the opposite direction. And that is what is confusing you.
Gotta love how with quarantined schooling teachers have given up on teaching and recognized that people like you have been the ones actually teaching us.
that why im currently watching this
@@Emily-gy8pe same!
🙌🏽
Professors and teachers are getting lazy and it is so much easier for them to just send us to a website and let someone else explain it! Thank you!
Even with a biology degree and in medical school, this is the most straight forward and easy to understand video on DNA replication. You sir are the GOAT.
You literally just summarized about half of what I learned in an entire semester-long molecular biology class in a 6 minute video. Nice.
Dang what!?!?!?!
really this is day one for us..... it is fricking hard XD
I love that I can learn by watching videos. I am interested in many subjects and my idea of a good session is learning something new. I will definitely be checking out Professor Dave!
Every time I struggle to understand a course material and find out you have a video for it, I cry tears of joy
I just realized something very important in terms of how to interpret your animation.
The directionality of the synthesis of the new strand is correct. However, I initially thought that the numbers you put on the leading strand was identifying the ends of the new strand, not the original strand.
In other words, the new strand would read/synthesize as such: 3' under the 5' of the leading strand and 5' under the 3' of the leading strand with the arrow going in the same direction.
You single handedly made me not only pass but EXCEL in my biology 101 class. Thank you professor dave
Bro, why does the microscopic world low key feels like a mini-society
Thank you Prof. Dave! I spent like two hours trying to understand my professors lecture, and you helped quite a lot! I am really grateful that I found this video online. Thank you for what you do! :)
sir you are a really talented teacher and a speaker ...... a process which would take me hrs to understand was made easy by you and i got it in juat 6 mins ! thanks man
That Addicted Guy you forgot the 15 seconds
Spending hours in boring college lectures with professors that lack the ability to teach and not learning ANYTHİNG vs watching a 6 minute video from a great teacher and understanding everything. I think I have spoken enough
I like the fact that what I learned here was better than what I learned in school, more detailed and compact
Keep it up 😊
I enjoy that I can learn the basics from your mini-lectures. Great job, Professor Dave. You put me in mind of my late father, a physician, teaching me about reproduction, mitosis, meiosis, etc. He started with onions and went on from there, ending with human reproduction when he felt it was age-appropriate (about 13-14 in my case). This puts me in mind of his teaching methods.
I just subscribed a couple of hours ago and will be adding your videos to my Geology/Volcanology and Evolution and Extinctions playlists. So glad I found your channel!
5' and 3' DNA template strand should be more specific indicated in the slide. Its a little bit confusing.
yeah a lot of people have mentioned this, i wish i had made it a bit more clear. nothing i can do now!
Yes, he needs to label the new and old strand as it is very confusing (he's labeling the old strand)......this is where students get mixed up often.
@@ProfessorDaveExplains
You should make another video...
Please sir this is a humble request...
All the videos I have viewed on DNA replication struggle to explain the 5'-3' process. Unfortunately, this wasn't any better, but the rest of the video was helpful.
@@ProfessorDaveExplains annotations?
my test is in an hour and your videos are the only thing that has made me understand replication/transcription/translation omg 😭😭😭
A great, fast, easy and organized video! Thanks!
I love the way you explain each step of DNA replication and other biological processes in your videos, I'm just glad to find your channel :')
You remind me of an off-brand Dave Grohl and it makes studying way easier, thank you
If only I had you as my lecturer ! Absolute legend mate!
DNA chain can only be synthesized in 5'-to-3' direction, not 3 to 5. As the subunits is being added at the 3' end, that means it runs in 5'-to-3' direction....
Bawan Colnadar I noticed that error in the vid as well
He's going to get people confused. Need an upgrade.
Actually he's correct, the DNA polymerase III moves in a direction of 3'- 5' of the preexisting strand. However, the new strand that's being synthesized is 5'-'3. The video is crystal clear .
The video is correct, but NOT clear. This "Dave" person knows the stuff but doesn't know how to explain it to a naive mind. Someone listening to this for the first time can get confused for all his life !
REPLICATION HAPPENS FROM 5 to 3 END !
Sounds like you're not interested in using your logic only in memorizing facts.
i have a bio final tomorrow i love u professor dave ure the goat
This man has Taught me for 3 separate courses, its amazing
Video was crystal clear . I understood the whole topic In ONLY 6 minutes where I didn’t get one thing through my head in a 80 minute class . Thank you so much Professor Dave !!
Thank you sir
I spend 2 days on this topic but this 6 minutes video clear my concepts too much
I have a final task in Genetics, thanks for this vid. It means a lot to me!
Makes so much more sense hearing it from you vs. in class
This helped me so so much! Your video really cleared this up! Thank you!
hi professor. i thought polymerase creates the leading strand in a 5'-3' direction towards the fork?
Its perfect!!!!😍
Each time i want to search for something scientific i find a video for you, your explanation is perfecttttt, keep on Dr.♥️
This is one of the best videos I have seen on DNA Replication!! thanks a whole whole lot!!
Your videos are so helpful!
I'm in 12 standard from INDIA 🇮🇳 & I found this video which really boosted my knowledge ☺
This is the only video I've seen that accurately explains the difference in role of Topoisomerase and Helicase...Thank you
Explained in very easy and simple manner... Thank u sir
Sir, can you state the difference between DNA polymerase alpha beta, gamma, delta,epsilon and DNA polymerase 1,2,3??
Loving the vids, I'm revising what I learned in the balkan equivalent of advanced biology & chemistry highschool.
Just one thing: the audio volume is a bit low everywhere except the intro. These are old af but if you plan to make more videos maybe amplify the volume a bit in post.
This is such a great video! short and sweet :)
I can leisurely watch Professor Dave in my free time and enjoy every second learning as many videos as I can.
Super helpful! Would have taken hours for me to understand just by reading this.
Thank you Sir!
Not sure if nitpicky or not but it could help to clarify that DNA polymerase III/I are those used in prokaryotes. I remember in high school still using the terms generically but I believe DNA pol-alpha/delta are the current standards for eukaryotes?
You are awesome.. I was jumping from video to another and I can’t understand that. But with you just in 6 min I take it very well !!
Your explanation is very clear and the footnotes are very helpful, i now can understand the replication process thankyou prof
Thank you so much Prof Dave
I wish you could explain the rolling cycle mechanism too
Thank you couldn’t understand from the biology book with the diagrams you just made me understand in 6 minutes
Whenever I am in need of help in biology, I go to this dude! Nice job! 👍🏻
Thanks for hearting!
Do you have a video about endogenous retroviruses (ERVs)? Would like to get a better grasp about the subject.
Thanks for these videos btw. Really helpful.
Best explanation I've ever heard and seen my whole life. Ily.
it was beautiful sir. it helped me memorize it smoothly.
Great explanation, thanks!
Thanks for this explanation. Some things are simplified. But this is a very good overview. It was really helpful.
From Professor to Professor 👉🏼 you are great !!!
Great video... But did you forget SSBPs??
Watched so many videos on this and this one finally made sense. Thank you!
Thank you for this.. I had no idea what was going on until I saw your videos! Thank you so so much!
Its so frustrating, I understand the protein syntecis, the DNAs structure, mitoses and meiose, transcription, translation etc. when I get it explained to me, but there is no way I can repeat it😂😭
Thank proff Devi .....am really enjoy your session
Easy & concept clear explanation.... thank you sir.
As was stated previously, the direction is NOT 3' -5'. According to Mc Graw-Hill 11th ed. Biology, "As with all known DNA polymerases, all three of these enzymes synthesize polynucleotide strands only in the 5'-3' direction and require a primer"
i meant that it moves along the template strand 3'-5', though you are correct the new strand is synthesized 5'-3', perhaps i should have been clearer in the animation.
Thank you for your timely reply! Perhaps it could have been clearer, but you are right as well. Thanks for the video, anyhow :D
It is very impressive to listen your explanation specifically biology 🎉🎉🧬🧬🧬
I like how you dont use gimics at all, you tell what needs to be told and have easy to understand diagrams
Dave, polymerase III reads from 3' to 5' but polymerases new strand from 5' to 3'? But you said polymerase copies 3' to 5'. Did you mean polymerase reads 3' to 5'?
I said moves along the template strand, so yes "reads" would be a good way to interpret that.
holy shit i've been looking for videos like this all year
search no longer!
Easy understanding explanation
thank you so much for your explaining
Thank you so much! You helped clarify a lot of areas that my textbook failed to properly explain.
Excellent video, Thanks!
Amazing explanation
Thank you for saving my exam! Very clear and well structured explanation.
You’re a life saver Professor Dave..
1:23-1:47!, 2:06, 4:17!, 4:43
hi prof, had a few doubts:
1. after binding the primer to the DNA strand, the primase leaves the spot, and DNA polymerase iii takes the same spot to start adding the free DNA nucleotides?
2. on which strand do the following take place first or do the following processes take place simultaneously (as there is one molecule of enzyme allocated for each strand?) on both the strands?
a) exonuclease removing the RNA nucleotides/primers
b) DNA polymerase I adding DNA nucleotides in place of the primers
c) Primase adding primers
d) polymerase III adding free DNA nucleotides
Professor why the one strand is continuous and the other one is discontinue??
I love u Prof. Dave , u made it simpler
Thank you very much for this lecture! But isn't it, that the direction is from 5' to 3' and not the other way around? At least that is what Amboss states.
Watch that section again and listen carefully.
Thank you, Dave!
I'm confused ! isn't it always 5' to 3' direction ? In some videos I heard that DNA polymerase can only move in the (5' → 3') .
direction of motion along template and direction of synthesis are complementary
thank you so much, i am so grateful for this video. Explanations are perfect.
very much well explained
You just made this shenegan simple.
best DNA replication video!
I got more than I asked for! A lot of these stuff aren’t part of my textbook but I don’t care. I’ve always wanted to learn this anyway.
Why RNA primer is used in DNA replication sir??plz reply
you are truly God sent Prof. Dave
Doesn't polymerase travel 5' to 3' not 3' to 5'?
Polymerase starts traveling at the 3’ end of the existing strand(so 3’to5’). The new strand it adds would be in the opposite direction. And that is what is confusing you.
great refresher vid, great name
This video is perfect thanks a lot sir.
Can you explain the difference between DNA pol 1 and pol 3 a little more? I'm not getting it
Hey Mrs.Hartley, am I still counted absent if I watch this full video?
Nice explanation..
U r the best.... Respect SIR. ❤❤❤
nice explanation!!
Thanks for the help. Now I get DNA replication better than ever!
Nucleotides added 5' to 3' direction. labelling of slides incorrect.
If the strand is built 5' to 3', then the enzyme moves along the template 3' to 5', as the video states. The video is correct.
What happens to that mutation cells which polymerase and enzymes dont fix. Does that cells turn in cancer cells if immune system dont kill them?
Depends on the mutation. If it's in a proto-oncogene, then maybe.
Thank you so much sir.... It really helped✌️👌
Awesome description!!!!
You have the replication going from 3' --> 5'. This is incorrect. Replication always goes from 5' -->3'.
the daughter strand is 5' to 3'. polymerase moves along the template strand 3' to 5'.
Yes Please See again...
Great work sir
Wow! I love the lecture. Thank you Prof
Just telling, I think polymerase lll work towards 5' to 3' direction and in the video it is opposite, little bit confusing.
Remember to distinguish between direction of synthesis and direction of motion along the template strand.
thank you for your great explanation