This a good question - it can happen at both positions, but you can favour the ortho position through hydrogen bonding with the phenol OH, or the para position with additives like cyclodexdrin - the point here is that conditions can change selectivity, but before we can discuss that we need to know the basics.
Very nice explanation Sir.I understood that Mannich reaction product could be further mae to undergo a substitution reaction or an E1cb reaction. Thank you very much Sir.
I'm not too sure about your question as I think your formula is incorrect - are you talking about the Cannizzarro reaction? I don't have a video, but you could Google it.
@@chemistryonefivefour the reaction I have to do is between H2CO and Bu2NH, in this case we could not create an enol, so the N will attack the C and then a prototeopy occurs?
@@stephanegeorgiev6082 I think you are talking about the imminium formation? I didn't show the mechanism as it is covered elsewhere, but the N will attack the C and then eventually eliminate water.
alonge with mannich product water is formed. Sir can you please tell me what other by product can be formed during Manich reaction ?
Thank you. Why the Mannish reaction only happens at otho position instead of both otho and para positions in case of phenol?
This a good question - it can happen at both positions, but you can favour the ortho position through hydrogen bonding with the phenol OH, or the para position with additives like cyclodexdrin - the point here is that conditions can change selectivity, but before we can discuss that we need to know the basics.
Thank you! Very good explanation!
Hello sir.
I need 1,3,4 oxadiazole mannich base mechanism
Thank you, this was very helpful
Very nice explanation Sir.I understood that Mannich reaction product could be further mae to undergo a substitution reaction or an E1cb reaction. Thank you very much Sir.
I'm very much looking forward to know how it's possible H2CO to become HCO ? could you please detail this ?
Thank you
I'm not too sure about your question as I think your formula is incorrect - are you talking about the Cannizzarro reaction? I don't have a video, but you could Google it.
@@chemistryonefivefour the reaction I have to do is between H2CO and Bu2NH, in this case we could not create an enol, so the N will attack the C and then a prototeopy occurs?
@@stephanegeorgiev6082 I think you are talking about the imminium formation? I didn't show the mechanism as it is covered elsewhere, but the N will attack the C and then eventually eliminate water.