Diabetes & Alzheimer’s -- save your brain by going to the gym | Ewan McNay | TEDxAlbany
Вставка
- Опубліковано 8 лип 2024
- This talk was given at a local TEDx event, produced independently of the TED Conferences. Recent discoveries (many in my lab) on the links between type 2 diabetes and Alzheimer’s disease; translation of that lab work into real-life advice and consequences.
My work examines the role of metabolic processes in regulating brain function, and specifically in regulating memory processing. We use a variety of animal models to examine the behavioral and neurochemical impact of modulations including diet-induced insulin resistance, beta-amyloid, insulin, and recurrent hypoglycemia.
Key discoveries have included:
Drainage of glucose from the brain extracellular fluid at times of high cognitive demand, showing that glucose demand can exceed supply and be limiting for cognitive performance.
Altered brain glucose transport and diffusion in the aged brain.
A key role for insulin in hippocampal cognitive and metabolic processes; conversely, the impact of insulin resistance on hippocampal function.
The cognitive, metabolic and neural impact of recurrent hypoglycemia (RH), a key side-effect of insulin therapy that limits achievement of target blood glucose levels in patients with diabetes. Recently, the mechanistic links between RH and subsequent weight gain.
Mechanistic links between beta-amyloid and both (i) hippocampal metabolism and (ii) central insulin signalling.
A central role for GluT4 in hippocampal cognitive processes.
To date I have roughly 50 peer-reviewed journal papers with ~2500 citations, at an h-index of 26; my work has been funded by the NIH, ADA, JDRF, Alzheimer’s Association and several state and private grants. In addition, my lab has won awards for excellence in student research every year during my time at U.Albany, and I have several teaching and mentoring awards.
From a patient or layperson’s point of view, my work shows that lifestyle elements - such as lack of exercise, caffeine intake, drinking red wine, or overeating - have direct and measureable impact on brain function, diseases such as Alzheimer’s disease, and risk of death. We can make specific recommendations for change, and show at the molecular level how choices made every day about diet - and even about things like doing a crossword instead of watching TV - affect your brain’s function.
About TEDx, x = independently organized event In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)
My mom was lean, active, avoided saturated fats, avoided sugars, had no level of diabetes, drank wine-minimally, was an artist, singer, and very engaged socially. Symptoms presented age 66, she was severely affected by 70, passed away at 73 from Alzheimer’s related issues.
My mom has
been afflicted with Dementia all these ten years after her retirement at 66.
She started by being aggressive towards my sister and niece even to the point of killing them.
Always refused to see the doctor. Now at 76 years old, her behavior has been progressively worse.
She has mood swings, a few minutes she is in a good mood other times she can be mean and do unusual behavior.
SHE has always been an independent and strong woman before her retirement. In her aggressive state she will tel all of us to mind our business.🥺
Did u see if she could have had the genetic for alzheimers
Saturated fats protect against Alzheimer’s
My uncle was really healthy his whole life and got Alzheimer's. He exercised daily, was thin, ate healthy, didn't eat sugar snacks. He was very social. He tried brain exercises and journaling in the beginning but he still got and died from it. His mother died from it also. I feel like genetically he was doomed.
اللي جاي من عند دكتور كريم علي
الله يسعدو ويسعد الجميع يارب
I’m type two since my thirties. At 43, I started to notice the word recall issues which has progressed. I’m 57 now and this is the first I’m hearing about this. I definitely have this. Both parents were diabetic but no dementia of any kind…
My dad exercised all his life, and he has an extremely bad case of dementia. He was riding 40 kms at 65. Everyone is different. Being healthy is a good thing. But I feel the true cause of his dementia was sleep. As he was a doctor who woke up many times in the night to deliver babies... the cause of dementia could actually caused by interrupted sleep patterns. And possibly over-exercising too. He is not a case of mild confusion ... he can’t speak, read, or watch a movie. He was once a brilliant doctor. Total lose of function. He never got a good night sleep in 35 years. I believe it caused his extreme case.
Jack Rolley
Really sorry to hear your story. Yes, sleep is under-estimated. There is some study that sleep rectifies/reverses the plaque buildup. Can you provide more info if you dont mind? When was your dad diagnozed and how did it progress. What treatments he (and you) researched? I am sure you would have looked into food sources for benefit. There is some promise with coconut oil/MCT oils/Ketones and I am looking into supplements as well. Thanks and hope your father had a peaceful end.
Sorry for your good dad will be so nice to find a cure and help for him 🙏💞
Superb... 👍
Only glucose? What about ketones?
I think you need to learn a little more about the energy systems. The body uses directly the three energy sources (free fatty acids, ketones, glucose) It does not turn the first two into glucose for energy. ADP and ATP are the true energy systems. The first 3 mentioned are used to drive the ADP/ATP energy system. The brain does not make glucose form fat or keytones.
***** Also the body is very efficient at converting glucose into fat for storage and later use. Glucose is toxic in very low levels and that is why our bodies quickly release insulin to drive the glucose out of our blood and into our cells where it is converted to fatty chains. Our kidneys and red blood cells and brain can't use fatty acids for energy but the rest of our body can. So for those energy needs we produce keytones from the fat. For many years it has been said that we can not make glucose from the fats however new studies show we can make very small amounts of glucose from our fat stores. Not enough to run our entire body but enough for the minimum need, not skeletal muscle operation. That is all part of the argument that glucose is not our primary energy source by analysis of the operational design of our bodies. We are fat based energy system.
***** Sounds good. They are a great source of real info not the typical contrived info. The body can run directly on fats and ketones and very efficiently. No converting to glucose required!
@@Stan_in_Shelton_WA you are a keto person for the last 5 years ? Are you still alive ?
How can someone
be a researcher in this area and not knowing that the brain can utilize other substrates than glucose?
Could be an answer to Alzheimers. Too much sugar again.
I thought it was a very very good and clear talk.
Thank you Ewan!
Steven Brown
يادكتور
Weights? Cardio? Or both ?
I doubt sugar in the diet causes AD. For example, people in Israel have a diet very low in sugar yet Israel is placed inside the top twenty globally for AD deaths. The death rate from diabetes in Middle Eastern countries is among the world's highest yet death rate from AD is among the world's lowest. Countries with low obesity levels like Switzerland have high death rates from AD. Moreover, many people who have done "all the right things" still get AD.
Robert Nield Corrollary examples of populations and anecdotes of individuals do not substitute for research that centers around the causal mechanism for the disease. There is a growing body of research which demonstrates that insulin resistance, as it appears in the brain, plays a huge part in the development of Alzheimer's and dementia.
Robert Nield well people differ in how they develop diseases, my grandmother and her sisters got it after experiencing diabetes but only one sister didn't because she isn't diabetic so
Robert, don't forget that age is by far the greatest risk factor for AD. The countries you mentioned (Switzerland, Israel) have some of the highest life expectancies in the world. Paradoxically, the main reason behind the current AD epidemics is improvements in healthcare and increased life expectancy.
What about Japan? They should have a very high rate of AD given their longevity. And they are the thinnest and healthiest people on the planet. If they don't have a high rate of AD we should just do what they do.
Oh, and one reason the Japanese are so thin - FAT SHAMING. You are a loser if you are fat (other than the sumo wrestlers). I believe their obesity rate is something like 3%.
@@rubygreta1 3 years late but asian lifestyles also play a key role.
💚
.hii... a complete health package by nature is curcumin capsules is really very effective for healing the problemes allergies, diabties alzhimer also
فين الترجمه 😂😂😂
Surely you are forgetting ketone bodies!?! They cross the blood-brain barrier and the brain does very well on them.
I'm sure that the speaker is right in general. But funny thing...I have Type-2 Diabetes & Hypertension while my wife doesn't. And yet, she has Alzheimer's and I don't. That's life. 😀
انا مافهمت حتى حاجة يريت بالفرنسية او العربية
This video stressed me out and gave me diabeetus.