GABAPENTIN FOR CANINE ARTHRITIS - MORE HARM THAN GOOD?
Вставка
- Опубліковано 8 чер 2024
- In this evidence-based review, board-certified specialist Dr Mike Farrell explains how gabapentin works, its risks, and its benefits as a treatment for arthritis pain in dogs.
Watch time: 22 minutes
Complexity: Moderate (US Grade 10)
00:00 Gabapentin versus Donald Trump
01:50 Licensed indications
02:43 Gabapentin versus OxyContin
05:33 Researchers concealed harms
06:48 Off label use research
09:09 Prescribing trends
09:55 Veterinary prescribing
11:01 Sedation causes a placebo effect
11:23 Gabapentin for arthritis pain
11:53 Is gabapentin powerful when used off label?
13:40 Why is gabapentin becoming less popular?
14:16 Lack of effectiveness of tramadol
14:48 Arthritis treatment priorities
15:21 The cardinal rule of painkillers
16:02 Psychological side-effects
17:36 Weight gain
18:07 Veterinary data isn’t encouraging
19:15 Gabapentin and hypothyroidism
19:45 Mike Farrell BVetMed CertVA CertSAS DipECVS
20:26 More to learn
20:58 Conclusion - Домашні улюбленці та дикі тварини
Lack of effectiveness of tramadol for canine arthritis - pubmed.ncbi.nlm.nih.gov/29393744/
15-min JAMA interview with two pain specialists about gabapentin overprescribing - edhub.ama-assn.org/jn-learning/audio-player/17435168?PDF&PDFlink&PDF&.2019.0086
Reporting biases of Neurontin - 2008 report by Dr K Dickersin (Cochrane Centre) - www.communitycatalyst.org/wp-content/uploads/2022/11/neurontin_exh_O.pdf
Hypothyroidism induced by phenytoin and gabapentin - pubmed.ncbi.nlm.nih.gov/30412107/
Prescribing practices for gabapentin as a painkiller among veterinary professionals - pubmed.ncbi.nlm.nih.gov/34275755/
Harms were detected but not reported in six clinical trials of gabapentin - pubmed.ncbi.nlm.nih.gov/37871835/
97% of US gabapentin prescriptions were off label between 2003 and 2016 - pubmed.ncbi.nlm.nih.gov/31905718/
“We were all looking for the magic pill”: A qualitative study of patient experiences using gabapentinoids for chronic pain - pubmed.ncbi.nlm.nih.gov/37453375/
Gabapentin’s effectiveness as a surgical pain reliever evaporates when compared to a sedative - pubmed.ncbi.nlm.nih.gov/29238824/
A 2017 Cochrane Review concludes that over half of those treated with gabapentin will not have worthwhile pain relief but may experience adverse events - pubmed.ncbi.nlm.nih.gov/28597471/
Overview of off-label gabapentinoid use - pubmed.ncbi.nlm.nih.gov/30907944/
The Neurontin legacy - Marketing through misinformation and manipulation - pubmed.ncbi.nlm.nih.gov/19129523/
A high-quality meta-analysis including 859 patients concludes that gabapentinoids are ineffective for treatment of low back pain and radicular pain - pubmed.ncbi.nlm.nih.gov/29970367/
A high-quality meta-analysis does not support the routine use of pregabalin or gabapentin for the management of postoperative pain - pubmed.ncbi.nlm.nih.gov/32667154/
National Institute for Health and Care Excellence (NICE) guidelines for osteoarthritis - www.nice.org.uk/guidance/ng226/chapter/Recommendations#non-pharmacological-management
Gabapentin produces an average 2.2kg weight gain within 6 weeks - pubmed.ncbi.nlm.nih.gov/25590213/
Gabapentin and gabapentin-meloxicam were not better than placebo in 29 dogs with neuropathic pain - pubmed.ncbi.nlm.nih.gov/33253197/
Gabapentinoids have a significant risk of adverse effects without any demonstrated benefit for people with chronic lower back pain - pubmed.ncbi.nlm.nih.gov/28809936/
Gabapentin prescribing trends in the UK - www.thelancet.com/pdfs/journals/lanepe/PIIS2666-7762(22)00275-7.pdf
Gabapentinoid pharmacology in the context of emerging misuse liability - pubmed.ncbi.nlm.nih.gov/34396549/
Gabapentin doesn't improve pain control after TPLO - www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-1751069
Gabapentin doesn't improve pain control after amputation - pubmed.ncbi.nlm.nih.gov/20367041/
Retrospective study of 240 dogs receiving gabapentin for chronic pain relief - www.jscimedcentral.com/public/assets/articles/veterinarymedicine-7-1194.pdf