Uronic Acid Pathway / Essential Pentosuria : Medical Biochemistry by Dr G Bhanu Prakash
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- Опубліковано 19 чер 2024
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Uronic Acid Pathway / Essential Pentosuria : Medical Biochemistry
Overview
• Part of carbohydrate metabolism
• Involved in the conversion of sugars and uronic acids
• Primarily functions in the liver
Major Reactions
• Formation of Glucuronic Acid: Uronic acids are converted into glucuronic acid, used in detoxification
• Formation of Ascorbic Acid in Plants: Not applicable in humans
• Formation of L-Gulonic Acid and L-Xylulose: Metabolism of glucose
Importance
• Detoxification: Conjugation with glucuronic acid increases water solubility of compounds
• Excretion of Bilirubin: Glucuronic acid combines with bilirubin for excretion
• Metabolism of Carbohydrates: Converts hexoses into pentoses, useful in various metabolic pathways
Clinical Relevance
• Essential Pentosuria: Linked to a deficiency in the pathway (explained below)
• Drug Metabolism: Many drugs are conjugated with glucuronic acid for excretion
Essential Pentosuria
Overview
• A rare, benign metabolic condition
• Included in Garrod's tetrad (Pentosuria, Albinism, Cystinuria, Alkaptonuria)
Cause
• Deficiency of Xylitol Dehydrogenase: Enzyme involved in the conversion of L-xylulose
Symptoms
• Excretion of L-Xylulose in Urine: Leading to pentose sugars in urine
Diagnosis
• Benedict's Test Positive: Indicates reducing sugar in the urine
• Bial's Test Positive: Specific for pentoses
Alimentary Pentosuria
• Occurs after consumption of large amounts of fruits rich in pentoses, like pears
• Temporary and not linked to enzyme deficiency
Treatment
• Dietary Management: Limiting pentose intake
• Monitoring: Regular check-ups to monitor urinary sugars
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Always great listening to your voice in a new video 🙏
Thank u
Medical Legend Dr Bhanu Prakash sir
Thats a big statement, Thank you so much
Sir when will app launch?
What will happen with NADH produced will they go through ETC?
3Atps are form 1 molecule of NADH
What two tests are positive?
Benedict's test and bial's test
Hi sir I'm a forgein medical student (Indian citizen)
Studying at Anna medical collage Mauritius (1st year)
My country of study is not recognised by WFME yet .
Should I proceed with ECFMGE CERTIFICATE which will cost me 160$? Or should I wait untill my country gets recognised?
wait till thy get permission
@@doctorbhanuprakash what if they never get permission? because 2024 is deadline