Gluconeogenesis Biochemistry - Dr G Bhanu Prakash
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- Опубліковано 14 сер 2023
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Gluconeogenesis from Pyruvate : Medical Biochemistry - Dr G Bhanu Prakash
Gluconeogenesis is the process of synthesizing glucose from noncarbohydrate precursors.
The major substrates are the glucogenic amino acids, lactate, glycerol, and propionate.
The liver and kidneys are the major gluconeogenic tissues.
Glucocorticoids and glucagon-stimulated cAMP induce synthesis of key enzymes of gluconeogenesis.
Hexokinase, phosphofructokinase, and pyruvate kinase are the steps in glycolysis differing from gluconeogenesis. These steps are replaced by glucose-6-phosphatase; fructose-1,6-bisphosphatase; and a combination of pyruvate carboxylase and PEP carboxykinase, respectively.
No cell in the human body can have both glycolysis and gluconeogenesis working alongside each other because of the opposing hormonal and allosteric regulators of these cycles.
PFK-1 is allosterically activated by a high concentration of AMP and ADP, but the most potent activator is fructose-2,6-bisphosphate.
PFK-1 is inhibited by glucagon through repression of synthesis and by citrate and ATP.
Glucagon-stimulated cAMP-dependent protein kinase inactivates phosphofructokinase-2 and activates fructose-2,6-bisphosphatase by phosphorylation.
Insulin-mediated increase in fructose-2,6-bisphosphate activates phosphofructokinase-1 and inhibits fructose 1,6-bisphosphatase.
Glucokinase-regulatory protein (GKRP) maintains an inactive reserve of glucokinase. This glucokinase reserve is used in response to increasing levels of portal vein glucose, favoring glycolysis.
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Namaskar, Doc
You’re the best sir
Very good detailed explanations
Tysm
If I register in ECFMG and get an ID now in 2022, can I pass the USMLE Step 1 and 2 and have my licence after 2024 knowing that my med school isn't going to be accredited after 2024?
is there is part 2 of this vdeos????
❤❤
Dear Professor !! I have a Question ;
I have completed my graduation in Zoology ۔
( BS Zoology )
Now can i move in cardiology branch for M۔phil degree ???
not possible
@@doctorbhanuprakash
O۔K !! Dear Professor can you also tell me that
It is possible for me
if i can move to Biotechnology branch ???
( Cancer Biotechnology ; gene therapy for cancer )