Video 15 Ig Antibodies and Immunoglobulin Function

15) The core of adaptive immunity: immunoglobulin antibodies
The immune system depends on special binding molecules known as immunoglobulins, also referred to as "antibodies" or "Ig" for short. Immunoglobulins are "Y" shaped molecules that connect on one end to invading microbes (antigens) and on the other end they bind with various white cells that effectivley block and destroy the antigen. These specialized antibody molecules come in different shapes and sizes in order to provide flexibility in matching and destroying targeted antigens. Antibody molecules are found floating in the plasma as well as on the surface of specialized B-cells.
Immunoglobulins are constructed from two types of amino acid chains, heavy chains and light chains. Ig molecules contain two identical strands of heavy chains and two identical strands of light chains. The end with the two heavy chains forms a stable non-variable receptor point called an effector, which is the part of the Ig molecule that binds with our own immune system cells.
On the opposite end of the antibody are two antigen binding sites, each with a light chain and heavy chain combination. This combination of light and heavy chains forms highly variable tips that can adapt to match a specific antigen.
Immunoglobulins come in five basic types: IgA, IgD, IgE, IgG and IgM. Each type targets a specific type of antigen, which determines the make-up of the Y chain structure of each.
IgD, IgE and IgGs all use a single Y chain whether as stand alone antibodies or as receptors connected to white cells.
IgAs use a double Y chain, called a Dimer.
IgMs are unique in that they form a single Y chain when expressed on the surface of a B-cell, but the stand alone version of the IgM molecule forms a combination of five Y chains, known as a pentamer. Consequently, stand alone IgMs form a very large antibody molecule.

[@larsmolema3270]

I SEARCHED 2 HOURS ON INTERNET AND HERE IT IS, A NORMAL EXPLANATION, I CANNOT THANK YOU ENOUGH

[@taratateah14]

LITERALLLLLYYYY

[@syedwaqasshah5744]

Watch antibodies Lecture given by Dr Najeeb
ua-cam.com/video/UBPgySKEAG8/v-deo.html

[@astha_yadav]

When 8 year old vids explain WAYYY better and more concise than most shi- out there

[@callmema14]

I can understand these concepts much better in a video like this. You helped me a lot.

[@ByTurkoglu]

hello sir, my ige value is 1.00 mm/mL in every blood test I give and i have recurring infections, is it because my ige level is low thank you

[@mimiendlovu8390]

Great explanation!!

[@debrakleid5752]

Thank you for the explanation. I have CVID and I’m on IVIG via infusion through a central line every 28 days (occasionally is 5 weeks if it falls on a holiday. My IGG is low as well as must of the subclasses. My hematologist said I have a more severe form of CVID apparently which is why I still get bad pneumonia’s and sepsis even while on IVIG but it has reduced the number of pneumonia’s I’ve had. If I can get to below once per year I would be happy. Have had it twice this year and both were pretty bad requiring IV antibiotics to treat and one took a total of 4 (1 oral and 3 others were IV form and a week hospitalized, again).

[@aimeewalnofer8391]

Thanks for this very helpful and concise video.

[@bint-ehwa9681]

aslamm o alikum . sir . your all videos are just stunning ...plzzz continue your work.. why you leave this ..your all videos are very helpfull .... plz comple the main concept of biology by your spectacular way ... we are waiting for your next video !!!!❤️❤️❤️❤️

[@carolinegreen4771]

Thanks for sharing this informative video.
The immunoglobulin superfamily (IgSF) is a large group of transmembrane glycoproteins with multiple extracellular disulfide bonded loops. These regions are homologous to ones in immunoglobulin molecules. IgSF molecules are 70-110 amino acids and associate with their ligands in a Ca2+-independent manor. There are two major types of IgSF: the C1-type is responsible for antigen recognition and the C2-type is responsible for non-antigen specific functions such as cell adhesion. Members of the latter type have a variable number of extracellular Ig-like domains with conserved cysteine residues which form intra-chain disulfide bonds to stabilize the β-sheets of the tertiary structure. Five members of the C2-type of IgSF mediate leukocyte adhesion and these are expressed on endothelium: ICAM-1 (CD54), ICAM-2(CD 102), VCAM-1 (CD106), PECAM (CD31), and MadCAM-1.
-Creative BioMart

[@larsmolema3270]

it makes so much sense

[@treyquintanilla3746]

Thanks for the brief overview! 🙌🏼
Could you consider adding the youtube links
of each separate antibody video
into the description section?
If you're not able to edit,
then add a comment with them and pin it!
I just think it would be easier for other users to have quick access to your videos(:

[@medicallaboratory3722]

like how did they discover it ??
I always ask how did they discover this stuffs but no answer

[@omnipenne9101]

Poster summarising the discoveries, you could try googling for the papers (papers are listed under references. Some require paid subscriptions to access but you could try requesting the papers on ResearchGate. It may take a while before you get a response): www.biolegend.com/media_assets/literature/images/MilestonesPoster_small.pdf

[@FatimaMD7]

Thank you

[@simrankahlon50]

Hey why you stopped posting videos?

[@simrankahlon50]

Praying that you are fine and will be back soon❤️

[@AnneScrubsFan]

Great video, thanks!

[@drasadkhan129]

good lecture.thank you

[@rajifusama]

Ig is instagram you must be kidding me

[@MonkeyDLuffy-xr4fl]

Troll

[@anudhiman5122]

rajifusama

[@caribaez5711]

rajifusama dumb 😂

[@negativeiq3792]

And yes,you are one of those idiot

[@Ahmed-tu3ms]

Lol

[@grandtheo]

can't believe it took me these two minutes to know what this is about... thank u so much

[@athenajohnston]

This video was very helpful for my A & P exam - thank you!

[@stompinknowledge3968]

What's A & P?

[@riefilms]

@@stompinknowledge3968 anatomy and physiology

[@stompinknowledge3968]

@@riefilms danke

[@DoctorJx-x5x]

This is awesome 😅

[@eboromiracle]

I'm susbcribing ASAP!!! My God!!😮 The most detailed and short video on antibodies
Thank you so much sir!!

[@r.f9962]

splended thanks

[@Anas-uh6lo]

very thanks

[@diaherawati1335]

thank youuu.

[@gurusoma3169]

Good information thank u

[@محمد-ظ9د7ذ]

thanks you

[@tingbatuuka7278]

Very good explanation

[@mujeebgaming7912]

Superb short and to the point.. please clear one thing what are B cells.. thanks

[@Viratgupta___11]

2 minutes and long topic irs realy praisable

[@brendagomez8593]

Very helpful. Thank you so much!

[@malikfayaz2542]

yea bb

[@kiranpatil3262]

Yesterday i had a Antibody test for Covid19 and the report of my test was igG positive and igM negative.

[@wahi3250]

Best understanding concept...good luck🥀🥀

[@margaretpok9679]

Hi

[@souravsarkar6982]

I suffering ige 358 from 3years . please give me solution

[@MarshaJones-q6o]

Thank you

[@112hidde112]

seriously, who came up with this shit? WHY ARE HUMANS SO SMART!?

[@Fati.chaine]

I asked my self same question

[@guytelfer1353]

There's more to it by now?

[@dishadidi3000]

Nice

[@pianoLee-sx9dx]

My doctor has asked me to do a full blood test but only mentioned ig E and ig A only

[@nadasalah4343]

أشهد أن لا إله إلا الله و أشهد أن محمداً عبده و رسوله صلى الله عليه و سلم

[@soamazing7027]

Great Video! (Jesimiel Millar Fernåndez) 1M948

[@Roberto-nk3ed]

IgE other 2000 che significa ? Sono due anni che il mio esame del sangue risulta così alto , purtroppo non solo questo o anche problemi alle gambe e braccia con duroni e prurito.

[@rittenbrake1613]

Thanks ! It's informative !

[@Bimpstar]

Very useful overview, thanks so much!!

[@WholeFuture]

Excellent, thank you

[@nicoleteufel6118]

you're amazing- thank you!

[@asithsahul6903]

I suffering ige level 1025 from 5 years please give me yours solution doctor.

[@jaydem3624]

I got ige connecting to my red blood cells help please please

[@BB-hm9mq]

This video is CLUTCH😎😎

[@poke3r]

حح^دد. 5tu K:230,X:554,Y:5896

[@mahdimahdikassim1592]

thank you doctor

[@qudratullahibrahimi6947]

Thank you help me in this matter very good thanks i like you

[@afiyabegum8192]

my mother in law is suffering from ige her level is 590

[@jazzminemonroee]

MAY GOD BLESS YOU

[@priscillalk5324]

Thank you 🙏🏾

[@diksha3267]

Thanks sir 😊

[@jugabratdeka2191]

Does ivig work for polymyositis?

[@shaunamcelvogue6755]

Good video ❤️

[@mads5965]

splendid

[@Epicgamer-fw4cn]

immunoglobulin

[@nermeenpal6034]

Thank you doctor

[@karamelbadry7222]

usefull many thanks

[@kiranmaychauliya9979]

very good concept

[@brad4908]

So clear!

[@anudhiman5122]

It's good

[@atheerzak4599]

Thanks ✨

[@raphaelkenyuri8420]

Great

[@muhammedozdemir1571]

This video was very helpful for my Exam 4. Komite thank you! 😊

[@syedwaqasshah5744]

Watch antibodies Lecture given by Dr Najeeb
ua-cam.com/video/UBPgySKEAG8/v-deo.html

[@dr.jijivijayan5365]

Thanku💛

[@samnsami6004]

GAMED, igG,igA,igM,igE,igD

[@Yotay597]

thanks a lot for this helpful video , i really benefited , god bless you 🤍🤍🤍🤍