I have a question: in the dissociation equation; shouldn't the base part (B) carry a negative charge like a typical acid base reaction? how come has a neutral charge and crosses the cell membrane ?
Local anesthetics are weak bases and therefore the equilibrium equation is B + H+ BH + Only the non-charged molecule can pass the membrane (membranes are very liphophil). Once inside the cell, the pH is slightly more acidic. Thus, there will be more of BH+ available. Only this form (BH+) can block the Na-channel. Hope this answers your question.
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THE BEST EXPLAINTION
I have a question: in the dissociation equation; shouldn't the base part (B) carry a negative charge like a typical acid base reaction? how come has a neutral charge and crosses the cell membrane ?
Local anesthetics are weak bases and therefore the equilibrium equation is B + H+ BH +
Only the non-charged molecule can pass the membrane (membranes are very liphophil). Once inside the cell, the pH is slightly more acidic. Thus, there will be more of BH+ available. Only this form (BH+) can block the Na-channel. Hope this answers your question.
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Why local anesthetics not require reversal