Really any concept difficult to understand simply search for egpat yt channel great content related to pharmacy still underrated salute to ur consistency sir... Would be greatfull if get a chance to learn under ur guidance.
What if I don't have concentrations. I need to know the pH solvent needs to be, in order for it to ionize a drug, when I am only given the pka of the drug (weakly acidic pka=4.69) and for % ionized 5%, 20% etc..
Definitely, strength of a base can be measured by kb values or its pkb value. Lower the pkb higher the basicity. But for convenience we indicate its strength in terms of pka as we have relation of pkw = pka + pkb . So at STP conditions, pka = 14-pkb . So we can convert pkb value into pka. Again you can see that if a base has lower pkb value, it is a strong base and it will have higher pka value so it is relatively very weak acid. So when a compound acts as strong base it also acts as very weak acid. Hope its clear now. Thanks for posting.
In the working example 1, please read the pKa value as 6.6 instead of 8.6
The first example** would be 10 to the power of -4. because Pka value changed down 4 pKa units. so the answer would be .009% ionized.
I think thats what he meant because thats what my calculator gives me as well
yeah, exactly. 4.6-8.6 will be -4.
i thought i was crazy for a sec. Thanks for posting this
Really any concept difficult to understand simply search for egpat yt channel
great content related to pharmacy still underrated salute to ur consistency sir... Would be greatfull if get a chance to learn under ur guidance.
Happy to help by these videos. Thank you and keep watching
Very good and funny videos bring a great sense of entertainment!
Great video, how would u calculate it from strong bases and acids
This is very useful. Thanks so much for sharing this 😇🙏🏻
Glad it was helpful!
What if I don't have concentrations. I need to know the pH solvent needs to be, in order for it to ionize a drug, when I am only given the pka of the drug (weakly acidic pka=4.69) and for % ionized 5%, 20% etc..
ua-cam.com/video/sJoJ7WgALI4/v-deo.html this might be helpful 🙂
The video sound is pretty good, beyond my imagination
Sir
In 1st example, you calculated 4.6-8.6 = -2, where you find 10 to the power of 4.6-8.6 equals to 0.01 . How it is possible
i did not get 0.01 too, my % ionisation is 0.01%
@@kolupia i got the same too.
Yeah true
「もっと多くの人が必要なので、このビデオをもっと
In 1 question 1% is ionized and 99% in unionized this means the drug is highly lipophilic right
Exactly, it will be highly lipophilic.
if I was given the pKa of a conjugate acid which equation would I use?
U would use the weak acid one
Can a basic drug have a pka value or its always pkb for weak bases?
In many cases I have seen pka value given for a weak base .how is it possible
Definitely, strength of a base can be measured by kb values or its pkb value. Lower the pkb higher the basicity. But for convenience we indicate its strength in terms of pka as we have relation of pkw = pka + pkb . So at STP conditions, pka = 14-pkb . So we can convert pkb value into pka. Again you can see that if a base has lower pkb value, it is a strong base and it will have higher pka value so it is relatively very weak acid. So when a compound acts as strong base it also acts as very weak acid. Hope its clear now. Thanks for posting.
@@egpat thank you for your response.
Thank you so much! Very helpful!
I think you are on the wrong side bcz 10^(4.6-8.6) is equal to not -2
Actually, pKa value is 6.6 instead of 8.6 by mistake. Thanks for informing.
4.6- 8.6= -4
That's wrong in 1st example
Re do the first example it's wrong
Right bro
To make strong ELECTROLYTES
Can you speak slowely pls?
geil alter