Notes: adenosine binds to receptor coupled to inhibitory G-Protein in SA node cells --> activated inhibitory G-protein --> subsequent inactivation of adenylate cyclase --> subsequent inhibition of CAMP and PKA synthesis. Final result = decreased Ca influx into cell and K efflux out of cell --> SA node hyper-polarizes = delayed SA node action potential
I'm assuming this is for med students? I'm very much not a med student, found this video after seeing a random UA-cam short about adenosine restarting the heart and wanted to know how it works. This only made me more clueless 😂
Very intricate exclamation all the way down to the cellular level. Now all we need is a little addendum warning the patient how he will feel if God forbid he ever needs this drug.
Notes: adenosine binds to receptor coupled to inhibitory G-Protein in SA node cells --> activated inhibitory G-protein --> subsequent inactivation of adenylate cyclase --> subsequent inhibition of CAMP and PKA synthesis. Final result = decreased Ca influx into cell and K efflux out of cell --> SA node hyper-polarizes = delayed SA node action potential
Thanks 🙏
God
Great note-taking skills! This is a skill I could do with learning...
Basically, it offsets the action Potential.
absolutely amazing breakdown, no oversimplifications yet explained in a way that is easy to pick up on and understand. thank you.
Concise and to the point. Thanks!
I'm assuming this is for med students? I'm very much not a med student, found this video after seeing a random UA-cam short about adenosine restarting the heart and wanted to know how it works.
This only made me more clueless 😂
Very intricate exclamation all the way down to the cellular level. Now all we need is a little addendum warning the patient how he will feel if God forbid he ever needs this drug.
Is it not the AV node? Considering that adenosine is used primarily for SVT, would it not make sense to regulate cardiac rhythm at the AV node?
You are correct. It ALSO exerts its effect on the SA node.
thank you! very clear and helpful.
Thank you! Could u please make a video on how Ranolazine works :)
Very concise, did not understand a single word
i have to do this in school some time soon :(
HOW DO I GET RID OF (NOT BLOCK) ADENOSINE ! I AM CONSTANTLY TIRED, AND I THINK I AM SWIMMING IN IT.
Aarre Peltomaa of Mississauga, Ontario
Is this occurring on the pre or post synaptic neuron?
How exactly does reduced PKA synthesis cause a K efflux? Is potassium channel activity decreased by phosphorylation?
you just saved my exams in 49 seconds
Very nice
Please explain adenosine decrease the k eflux or increases the k eflux?
isnt a2 receptor ? instead of a1
What he said..
Normally it resets the HEART
now you node