Multiple Endocrine Neoplasia Type 1 (MEN1 Syndrome) - Causes, Symptoms, Treatment, Pathology

Multiple Endocrine Neoplasia Type 1 (MEN1 Syndrome) - Causes, Symptoms, Diagnosis, Treatment, Pathology | wermer syndrome
Multiple Endocrine Neoplasia Type 1 (MEN1) is a hereditary disorder characterized by the development of tumors in multiple endocrine glands, primarily affecting the parathyroid glands, pancreatic islets, and anterior pituitary gland. It results from mutations in the MEN1 gene, which encodes the tumor suppressor protein menin. The syndrome's hallmark features include hyperparathyroidism (leading to hypercalcemia and associated complications), various pancreatic neuroendocrine tumors (such as gastrinomas, insulinomas, and others causing specific hormonal imbalances), and pituitary adenomas (most commonly prolactinomas causing galactorrhea and infertility). MEN1 is inherited in an autosomal dominant pattern, and diagnosis involves clinical evaluation, biochemical tests, imaging studies, and genetic testing for MEN1 mutations. Treatment typically involves surgical removal of tumors and medical management tailored to the specific type of tumor and associated symptoms. Regular monitoring and early diagnosis are vital for effective management and improved quality of life. Genetic counseling is recommended to help affected individuals and their families understand the hereditary nature and implications of MEN1.
#MEN1 #MEN1syndrome #MEN1vsMEN2 #MultipleEndocrineNeoplasiaType1 #wermersyndrome
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