Cystatin C and Race free GFR Estimation Evaluating both clinical guidelines and laboratory perspecti

Presented By:
Amy B. Karger, MD, PhD
O. Alison Potok, MD
Speaker Biography:
Dr. Amy Karger is an Associate Professor in the Department of Laboratory Medicine and Pathology at the University of Minnesota. She received her MD and PhD degrees from the Mayo Clinic, and completed her residency and fellowship training in clinical pathology and clinical chemistry at the University of Minnesota. Dr. Karger has served as the director of the Central Laboratory for the CKD-EPI research group since 2015, and therefore has expertise on the measurement of filtration markers, including creatinine, cystatin C, beta-2 microglobulin, and beta-trace protein. Dr. Karger is a recognized leader in the field of laboratory medicine, currently serving in leadership roles with both the College of American Pathologists and the American Association of Clinical Chemistry, and is a Vice President and Chair of the Credentials Committee for the American Board of Clinical Chemistry. Dr. Karger has extensive experience directing or co-directing central laboratory testing for large clinical trials and multi-institutional research studies, including the Preventing Early Renal Loss in Diabetes (PERL) study and the Epidemiology of Diabetes Interventions and Complications (EDIC) study.
Dr. O. Alison Potok pursued her medical education in Paris, France (where she grew up) at the Université Paris V. She completed a residency in internal medicine at the University of Pennsylvania Health System, in Philadelphia, PA, and pursued a nephrology fellowship at the University of California, San Diego (UCSD). She was awarded the prestigious American Kidney Fund Clinical Scientist in Nephrology fellowship grant and is currently funded by an NIH career development award. She was appointed Assistant Professor of Clinical Medicine at UCSD in August, 2021. Dr. Potok’s research focuses on the difference in estimated glomerular filtration rate (eGFR) by cystatin C vs. by creatinine, and the important clinical information embedded in this difference. She co-authored a review on cystatin C and has been interested in determining whether cystatin C or creatinine provides the most accurate eGFR in the elderly.
Webinar:
Cystatin C and Race-free GFR Estimation: Evaluating both clinical guidelines and laboratory perspectives on more widespread implementation
Webinar Abstract:
The use of algorithms that alter patient medical care based on race has fallen under increasing criticism, as race-based medicine has been shown to contribute to healthcare disparities. In response, the National Kidney Foundation (NKF) and American Society of Nephrology (ASN) formed the “Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases”. One of the primary recommendations of the final report (September 2021) was to “facilitate increased, routine, and timely use of cystatin C", as eGFR based on cystatin C alone has never relied on a race parameter to estimate GFR.
Given recommendations by ASN-NKF Task Force to increase use of cystatin C, two key perspectives are discussed:
(1) the current state of cystatin C assay performance and standardization, as well as the barriers and potential strategies to aid in more widespread implementation of cystatin C testing in clinical laboratories.
(2) the clinical evaluation of cystatin C results under the new recommendations, and differences in eGFR values compared to the former guidelines using serum creatinine values.
This webinar is designed for clinicians and laboratorians interested in learning more about this area of Cystatin C and Race-free GFR Estimation, particularly those new to this field or in need of a refresher.
Earn PACE Credits:
1. Make sure you're a registered member of LabRoots (www.labroots.c...)
2. Watch the webinar on the LabRoots Website (www.labroots.c...)
3. Click Here to get your PACE credits (Expiration date - FEB 21, 2025): (www.labroots.c...)
LabRoots on Social:
Facebook: / labrootsinc
Twitter: / labroots
LinkedIn: / labroots
Instagram: / labrootsinc
Pinterest: / labroots
SnapChat: labroots_inc

[@awheat641]

Great presentation by Dr. Potok and Dr. Karger. I believe my lab values are a good example of what Dr. Potok is talking about. I’m a 36yr old Caucasian male, 205lbs and have been resistance training for 18yrs. My creatinine level has always been above one, but my most result blood work had a creatinine level of 1.45mg/dl (with NO creatine supplements) resulting in an Egfr of 55ml/min. This required me to do further investigation into my kidney function. My serum cystatin was 0.85mg/l putting my Egfrcyc at 106 ml/min and my urinalysis was negative for albuminuria. These more specific lab values definitely reduced my anxiety that I was progressing into CKD at such a young age.