Mitochondria being the "bacteria" which are converting the nutrients into energy, and which can be harmed by iodine deficiency or a toxin like an antibiotica.
If I could go back in time and relive my life over again without forgetting everything I know now I'd do it and major in biochemistry instead of mathematics and computer science. This is very cool. So much more to learn in the complexities of how life works.
Biochemistry is wildly interesting - it's sort of a proxy field to mine, so I use it a lot, but a true biochemist can explain things even better. You could become proficient in it with a few years of work, Donald - of that, I have no doubt.
We know saturated fats generate reverse electron transport, which generates reactive oxygen species, base on the F/N ratio. This turns down the insulin receptor, and keeps the cell from bringing in more energy/substrate. The cell has plenty of fuel, and this seems to be how it signals it. With unsaturated fats, this is negligible, or flat out doesn't happen. If the cells has plenty of energy, it would make sense for the cell to not signal to make more mitochondria. I'm very curious as to the mechanism of action for creation of pgc1alpha.. I've just started to dip my toe in here... And looks like I need to start studying..
The decomposition of unsaturated fat needs an extra step compared to the metabolising of saturated fat. Could it be that the measured increase is only compensating for the Enoyl-CoA-(∆) isomerase, needed to get the same job done with a more complicated type of fat.
It's so confusing sometimes because you have paul saladino showing studies that sterate c18 fat helps the mitochondria etc then your showing a study that could be the opposite
What a great subject, thankyou so much. If you have any advice for supplements or herbs etc to help nourish mitochondrial cells/help delay the shortening of telomeres, it would be very appreciated. Now I’m going to watch 😊
Do you think polyunsaturated fats are safe to consume? Is it safer to consume compared to saturated fat? Im asking because I heard that some studies show that polyunsaturated is a potential cause of cancer.
Omega 3 are PUFA and they are the healthiest but lineolic is the most problematic and it is PUFA too. Worrying about saturated or not is questionable and goes back to the long debunked ancel keys diet heart hypothesis.
Very nice as always! very interesting, but like you said , it's soon to jump in to conclusions, we can't tell(for sure) that this would happen in real life, thanks for your job.
![Saturated vs Unsaturated Fats on Mitochondrial Behavior [Study 24]](http://i.ytimg.com/vi/6_S3oXlOWRM/mqdefault.jpg)
![Saturated vs Unsaturated Fats on Mitochondrial Behavior [Study 24]](/img/tr.png)
![Unsaturated Fat to the Rescue? Muscle Mitochondrial Health. [Study 28]](http://i.ytimg.com/vi/aqZqEge5UsA/mqdefault.jpg)
I just love your vibe, genius yet humble, passionate and sincere. Please stay that way! Your channel will grow for sure
Thanks, Jack - high praise. I definitely have to keep reminding myself to stay cognizant of all you listed (staying true to the path). I'm trying!
Mitochondria being the "bacteria" which are converting the nutrients into energy, and which can be harmed by iodine deficiency or a toxin like an antibiotica.
If I could go back in time and relive my life over again without forgetting everything I know now I'd do it and major in biochemistry instead of mathematics and computer science. This is very cool. So much more to learn in the complexities of how life works.
Biochemistry is wildly interesting - it's sort of a proxy field to mine, so I use it a lot, but a true biochemist can explain things even better. You could become proficient in it with a few years of work, Donald - of that, I have no doubt.
If you'd still do it in this life, your previous studies in mathematics and computer science would probably give you an edge
I wonder if the results would be different for keto adapted cells versus those use to bring fuelled on glucose.
We know saturated fats generate reverse electron transport, which generates reactive oxygen species, base on the F/N ratio. This turns down the insulin receptor, and keeps the cell from bringing in more energy/substrate.
The cell has plenty of fuel, and this seems to be how it signals it.
With unsaturated fats, this is negligible, or flat out doesn't happen.
If the cells has plenty of energy, it would make sense for the cell to not signal to make more mitochondria.
I'm very curious as to the mechanism of action for creation of pgc1alpha..
I've just started to dip my toe in here... And looks like I need to start studying..
The decomposition of unsaturated fat needs an extra step compared to the metabolising of saturated fat. Could it be that the measured increase is only compensating for the Enoyl-CoA-(∆) isomerase, needed to get the same job done with a more complicated type of fat.
It's so confusing sometimes because you have paul saladino showing studies that sterate c18 fat helps the mitochondria etc then your showing a study that could be the opposite
I would believe other studies that measure protein content and mitochondrial content directly before I would believe this one, d w.
I can't loose my visceral fat during prolonged fasting. Is it possible the gluconeogenesis uses the muscle proteins first and then the fat as a fuel?
That's highly unlikely. Do you get DEXA scans to verify you aren't losing visceral fat?
Also, I only know human physiology, so...
I'd be curious what effect capric acid and caprylic acid would have on mitochondria.
stearic acid promotes mitochondrial fusion. Which is a GOOD thing.
What a great subject, thankyou so much. If you have any advice for supplements or herbs etc to help nourish mitochondrial cells/help delay the shortening of telomeres, it would be very appreciated. Now I’m going to watch 😊
My pleasure, Mel. I'm going to be looking into a few things, but they may not necessarily be mitochondria related.
@@Physionic I’m sure your future chosen topics will be great, too :)
Hope alpha PGC supplement is similar to PGC 1alpha and seratate fats are. similar to evening primrose linoleic fats
Not sure what you mean, but I'd be skeptical of supplements for PGC1a, if that's what you're referring.
Thanks, very interesting analysis
Thank you, Brian.
Do you think polyunsaturated fats are safe to consume? Is it safer to consume compared to saturated fat? Im asking because I heard that some studies show that polyunsaturated is a potential cause of cancer.
Georgi Dinkov and Ray Peat constantly rant about that.
If you get them from eggs or nuts or fish, sure. The problem is most people get them in oxidized seed oils which are essentially pure poison.
Plant leafs have PUFAs/antioxdants and are able to withstand days and days of direct sunlight.
So to conclude... saturated are less helpful than unsaturated? And if you have saturated are plant saturated or animal best?
Omega 3 are PUFA and they are the healthiest but lineolic is the most problematic and it is PUFA too. Worrying about saturated or not is questionable and goes back to the long debunked ancel keys diet heart hypothesis.
@@LTPottenger where is linoleic found?
@@littlevoice_11In nearly all fake processed foods.
Have a trial without varns that is carnivore and comparison with carbs and fat and all vegan
So, pgc1a and nfr are only stimulated by fats? or other stuff too?
Good question - its' stimulated by other things as well.
Very nice as always! very interesting, but like you said , it's soon to jump in to conclusions, we can't tell(for sure) that this would happen in real life, thanks for your job.
Thanks, KK! Have a good weekend!
Damn, can you just say what fat is good and what is bad for you?
No.