You probably get positive comments about your teaching all the time, but I need you to know that you're the primary reason I'm probably going to get to my dream job. I have hope in acing my classes and becoming a competitive applicant. Thank you SO much for doing this. Literally changing my life.
This is EXACTLY why we work so hard. It is one of the most rewarding feelings to receive comments like this. Congrats to you, Anita! That is amazing work 😀
Thank you soooooo much!!! My professor had us watch a 6.5 minute video where it sounded like Siri explaining someone's dissertation on how this all works. My sympathetic nervous system kicked in sending a slew of epinephrine and norepinephrine from my adrenal medulla into my autorhythmic cells, flooding them with Calcium positive ions, and giving heart palpitations and a super fast heart rate (tachycardia), an external physical sign of my internal rising fear because I absolutely could not understand the material. After watching Part 1 and Part 2 of your videos, my parasympathetic nervous system encouraged my vagal nerves to release acetylcholine, inhibiting the flood of calcium positive ions, allowing the troponin to reattach to tropomyosin in my contractile cardiac cells, allowing them to relax, and therefore returning my tachycardic heart rate to a normal, confident, Ima-ace-this-bish heart rate. :) These videos are truly genius, and my autorhythmic and contractile cells and I cannot thank you enough!
I can't believe you don't have more views or subscribers!! You are a life saver and super informative, thank you so much for doing this in the best way possible!
Brief Table of Contents: 1:00 - Beta 1 Adrenergic Receptor (Nodal Cells) 1:20 - Sympathetic Nerve 2:10 - Adenylate Cyclase 4:20 - Tachycardia (More than 100 BPM) 5:10 - Parasympathetic Nervous System 7:30 - Bradycardia (less than 60 BPM) 9:40 - Vagus Nerve 10:15 - Chronotropic Action (Positive and Negative) 10:50 - Contractile Cells 12:10 - Phospholamban 16:50 - Heart Rate Graph 18:35 - Refractory Period Graph A twisted way to help you remember is that the Sympathetic nervous system Stimulates and the Parasympathetic nervous system Paralyzes. You may wish to add this to the description or create your own more detailed version. Thanks for these videos.
Mr, i’m from brazil and i study medicine in argentina, i just took my time to comment here and i wanna say that: You are really changing people life, you have such a good way of explaining, thank you for all this knowledge and keep on the good work!!
Dude I'm a second year med student (bachelor's, Dutch system) and after having to re-do the cardiology course and still not getting it, hating it, studying to keep my head above water and just get this part over with, I landed on this channel since uni was just not cutting it guidance-wise. After watching your videos for a couple of hours, I got to really understand the subject (never has the (basic) subject matter been explained so clearly and have relations been made clear). The understanding got me to suddenly enjoy cardiology so much that I watch these darn videos for entertainment instead of ducking Netflix. You're right man, it IS cool. Your inspiration got me rid of some small career choice doubts. Big thumbs up dude.
WOW. ALL of your videos are so amazing! Wish I had found these during my undergrad degree! You have helped me get through first year medicine. THANK YOU
You really deserve a nobel prize for these videos of both part one and part two. This is highly commendable. Its very helpful for every medical and paramedical students. Thanks!
I am a veterinary student and even though your videos are human focussed, they have been the most helpful resource for me and my study group! we are extremely grateful for your clear and concise style while still covering the material at a great depth! Thanks so much Ninja Nerd Team!
Beautifully explained! It's your love for science that owes you all the credit for the tremendous amount of hard work, sincerity, and incomparable enthusiasm! Please keep making such videos! It's so inspires us all to keep working hard towards our goals as well! Thanks a ton!!!!!!
I’m Thai and I’m pharmacy student and I speak and listen English just a little bit but when I see your video, your video is very very very wonderful for me, I can easy to understand it because you , thank you very very very very much my teacher. (From Thailand)
I am in my first year of medical school and we are still doing remote learning, which I appreciate the COVID precautions, but it also makes some topics difficult to understand and/or visualize - especially depending on the professor. I just have to tell you that I am never confused in these lessons. You explain everything so clearly and sensibly... all instructors should study these videos. I can't put into words the amount of gratitude I have for you. I come here anytime I am unsure or need more help with a subject and you come through every time. Thank you so much for what you do. Once I become a paid doctor, I'll be donating to you all because you are the best resource I've ever found. Thank you again and please don't stop what you're doing.
You have just given me a light at the end of the tunnel.. Physiology final is this Friday and thanks to you, I think I'll make it!! I will forever recommend you to anyone needing to understand all this wonderful stuff that our bodies do!! YOU ROCK!!!! THANK YOU!
I never understood things better than I'm able to do from your video. They are really much better than any of the professor in our college or any other book. You explain things so very easily that I have no problem in grasping the concepts. I really appreciate the way you integrate things so well along with pictorial representation that helps me to retain things for much longer time. I really don't know how to thank you but definitely you are really doing a great job & loads of love from India.💓😘
just here to say thank you! I recently went from MA to EKG tech and your videos have helped me so much through the process. You’ve answered questions and simplified things more than the 5 cardiologists I work with.We must protect you at all costs!!!!
Your videos are truly incredible. You make my classes seem way less overwhelming and I feel like I actually understand the information you are teaching. Can't thank you enough!
Thank you so much!! To be able to look at the entire whiteboard at the end of part 1 and part 2 and fully understand EVERYTHING that is going on, and beat you to the answers of the outcomes of events is SO relieving. Wonderful job.
Never really understood this topic in my physiology class, even after having studied textbooks for days.. I had so much stess and self doubt, and now after this video I finally got it. And it's not even that difficult (when properly explained) 😮 I'm deeply thankful for your work, Ninja Nerd team
Like everyone else here in the comments I want to thank you for your videos. The videos are so long and do actually provide the connections to all the events. Most videos only show the small process of a event but you connect them all together. This is so helpful. Thank you!!
thank you so much! i don't know what to do without your amazing videos! me and a lot of Syrian students watch and learn from you! thank you for giving us this opportunity !
Thank you so much for the video. Towards the end it would have been great to mention that sympathetic stimulation increases the slope of phase 4 on the action potential graph of the pacemaker cell driving it closer to the threshold. Parasympathetic decreases the slope of phase 4 on the graph driving it further away from the threshold. You drew it, but it is worthwhile to have mentioned it. Many students do not understand the word slope.
That is due to another effect of the proteinkinase A, it phosphorylates the voltage gated potassium channels responsable for the repolarisation to open earlier and cause a faster repolarisation to decrease the systole accordingly.
You are an awesome teacher Zach and really funny too. I always laugh at the jokes you make whilst absorbing everything you’re teaching us. Thank you from the bottom of my heart.
I am so glad I found this channel, I was so worried about my classes this coming semester but going through some of your videos for pre-studying is going to get me some good grades
You are literally the greatest teacher ever. I cant stress this enough, this is like looking at art, you make pure art !!!! My heart goes out to the beauty of these classes!!!!! Hugs and congrats from mexico !!
I am a Adult critical care nurse in Bristol UK. I am currently revising for an exam which goes towards my masters. Your videos have been super super helpful making all the nuggets of knowledge I have link up. You make this not only easy but also an enjoyable topic to revise!!!
I am in my first semester of NP school and you have been a life saver so far. I have learned so much from you already and I will be using your videos throughout this process. Thank you so much for doing these. You are awesome!!! I can’t thank you enough!!!!
Hey.. You are saving lifes of Italian med students too! ... I owe you a big thank. I have just passed my physiology exam thanks to your amazing explanations. Everything made really sense after seeing your videos! Thanks a lot again!
I ABSOLUTLY LOVE all of your videos! I am currently a PA student and your teaching method has REALLY helped me better understand the accelerated material!!! THANK YOU Ninja Nerd Science
Thank u so much Zach!!!!! I have no words to express uuu and ur team!!!! U guys are savior!!! Where I'm a dental student no one..medical dept cared us when dealing with gen physio, path med etc I always wanted to know and learn these things... In depth and u like a angel came !! Oh man u are amazing🤩... Tons of happiness when realizing that oh! I'm getting to know and correlate these stuffs.. Understanding is crucial and u made us do that!! And that's all we want.. THANK U 🙏TO LOADS
I'm an electrical engineering student but I love to watch your videos in my free time! Your videos are so great that I bet they can make everyone interested in physiology, including engineers-to-be like me :)
Came here just to say you're extremely helpful! I haven't learned much from my anatomy teacher, a few minutes on your channel & I've learned so much! Thank you thank you!
Thank you so much ninja nerd. No words can describe my appreciation to all the videos. You guys are one of the reason I passed my frcem primary June 2019. Thank you so much.
You are a legend.....we need more dedicated people like you ...... We appreciate the hardwork you pour into making your videos and your utmost dedication......you help us .....this videos are helping me so much ....
I am so glad to have discovered your videos. You Tube needs to put you at the top of the search list. Your ability to tell how the human body works is amazing. Some thing else I appreciate is your pronunciation. I found out I was miss pronouncing some key words. OPPS!! Here's something else you have that other sites don't ,your videos are in groups. I didn't have to go through 100 videos looking for my subject or for a video you referenced. Hats off to Ninja Nerd!!
I think it should be noted that phospholambans are proteins attached to SERCA that inhibits its action. SERCA is the one responsible for transporting Ca++ from cytoplasm to SR. But when phosphorylated, phospholambans allow SERCA's action of Ca++ reuptake from the cytoplasm to the SR. Other than this, you are doing a fantastic job! Thank you!
You are honestly such a blessing in my life!!!!! I don't where I'd be right now in Med school without you. Thank you so much! Never stop making these videos :)
Up 22k subs in 2 weeks! Woohoo 🙌 That's awesome to see. Very exciting for your entire team, but also for all of us fans. I recommend your channel so much! Very helpful. Thank-you 💪🥳💖
Hey first I want to be thankful for your hard work I appreciate it But I have to notice when checked your notes on the Ninja Need website I understand you wrote PSNS has No effect on Contractility BUT you know PSNS has a little bit of supply of cardiomyocytes which are located in the atrium (ref: Guyton) so The effect of the parasympathetic nervous system on the heart rate is based on ACh binding to muscarinic receptors. Muscarinic receptors (M2) is a Gi bound protein which means that alpha-GDP subunit of Gi protein inhibits the activity of adenylyl cyclase. Due to a decrease/halt in this activity, the intracellular concentration of the cAMP is decreased as well as the activity of protein kinase A. Therefore, the influx of sodium and calcium ions into the cell is reduced which prolongs the duration of slow depolarization so depolarization before reaching the threshold. The beta and gamma subunits of the G protein travel along the cell membrane binding to GIRK potassium channels. GIRK potassium channels open allowing for the outflux of potassium ions from the cell to occur. Because of GIRK potassium channel activity, the membrane potential is more negative and therefore it is more difficult to induce an action potential after ACh binds to muscarinic receptors.
You should get a nobel prize for this work!!!!
+Nguyen Nguyen LOL!!! Well thank you so much for your super kind words. I truly do wish you the best of luck in your future endeavors.
I agree
Indeed
how about 2 Nobel prizes or more..
For sure... Fantastic!!!
You probably get positive comments about your teaching all the time, but I need you to know that you're the primary reason I'm probably going to get to my dream job. I have hope in acing my classes and becoming a competitive applicant. Thank you SO much for doing this. Literally changing my life.
This is EXACTLY why we work so hard. It is one of the most rewarding feelings to receive comments like this. Congrats to you, Anita! That is amazing work 😀
You are an amazing excellent teacher worth million medical books
Love your lectures thank you so much 😊
Thank you soooooo much!!! My professor had us watch a 6.5 minute video where it sounded like Siri explaining someone's dissertation on how this all works. My sympathetic nervous system kicked in sending a slew of epinephrine and norepinephrine from my adrenal medulla into my autorhythmic cells, flooding them with Calcium positive ions, and giving heart palpitations and a super fast heart rate (tachycardia), an external physical sign of my internal rising fear because I absolutely could not understand the material. After watching Part 1 and Part 2 of your videos, my parasympathetic nervous system encouraged my vagal nerves to release acetylcholine, inhibiting the flood of calcium positive ions, allowing the troponin to reattach to tropomyosin in my contractile cardiac cells, allowing them to relax, and therefore returning my tachycardic heart rate to a normal, confident, Ima-ace-this-bish heart rate. :) These videos are truly genius, and my autorhythmic and contractile cells and I cannot thank you enough!
lmao best comment I found today. Literally so creative and made my day.
Brooooooo
this is how scientific comment look like 😅😅
I always skip the ads but I let youtube play them on ninja nerd’s videos. That’s how much I love them.
Trueeeeeeeeee 💯
I can't believe you don't have more views or subscribers!! You are a life saver and super informative, thank you so much for doing this in the best way possible!
We are so happy you found us! Thank you so much for those kind words!
Brief Table of Contents:
1:00 - Beta 1 Adrenergic Receptor (Nodal Cells)
1:20 - Sympathetic Nerve
2:10 - Adenylate Cyclase
4:20 - Tachycardia (More than 100 BPM)
5:10 - Parasympathetic Nervous System
7:30 - Bradycardia (less than 60 BPM)
9:40 - Vagus Nerve
10:15 - Chronotropic Action (Positive and Negative)
10:50 - Contractile Cells
12:10 - Phospholamban
16:50 - Heart Rate Graph
18:35 - Refractory Period Graph
A twisted way to help you remember is that the Sympathetic nervous system Stimulates and the Parasympathetic nervous system Paralyzes. You may wish to add this to the description or create your own more detailed version. Thanks for these videos.
Thank you bro
That’s genius! Thank you
Not all heroes wear capes. Great content!
Some of them wear mask and throw kunai knives 😅
Mr, i’m from brazil and i study medicine in argentina, i just took my time to comment here and i wanna say that:
You are really changing people life, you have such a good way of explaining, thank you for all this knowledge and keep on the good work!!
Retweet x100000
This guy enjoys teaching..watch him smiling and subtly laughing while explaining simplified complex theories!! WOW.. amazing.!!
Zack you are such a hero man... i love you so so much ... you’re making me a genius... Thank you so so much
Dude
I'm a second year med student (bachelor's, Dutch system) and after having to re-do the cardiology course and still not getting it, hating it, studying to keep my head above water and just get this part over with, I landed on this channel since uni was just not cutting it guidance-wise. After watching your videos for a couple of hours, I got to really understand the subject (never has the (basic) subject matter been explained so clearly and have relations been made clear). The understanding got me to suddenly enjoy cardiology so much that I watch these darn videos for entertainment instead of ducking Netflix.
You're right man, it IS cool. Your inspiration got me rid of some small career choice doubts. Big thumbs up dude.
this guy is an absolute boss!! I never comment but I feel like I should... thank you brother!! you are truly making an impact out here
You deserve more subscribers! Thank you so much, your videos have been so helpful!
During these quarentine days..it really help me a lot to understand much of this topic..u r really a genius 😎
I mean this is just pure BLISS! especially being a medical student with all classes going online . I want to THANK YOU
I watched both part 1 and 2 the detail is incredible, I’m glad I came across your videos. Thank you.
Every time I’m studying I always supplement all my study time with these videos. It makes me feel more confident! Thanks!
WOW. ALL of your videos are so amazing! Wish I had found these during my undergrad degree!
You have helped me get through first year medicine.
THANK YOU
I remember back in medschool trying to study and understand this for days, where were you 10 years ago you could've saved me much time and effort.
You really deserve a nobel prize for these videos of both part one and part two. This is highly commendable. Its very helpful for every medical and paramedical students. Thanks!
I am a veterinary student and even though your videos are human focussed, they have been the most helpful resource for me and my study group! we are extremely grateful for your clear and concise style while still covering the material at a great depth! Thanks so much Ninja Nerd Team!
Beautifully explained! It's your love for science that owes you all the credit for the tremendous amount of hard work, sincerity, and incomparable enthusiasm! Please keep making such videos! It's so inspires us all to keep working hard towards our goals as well! Thanks a ton!!!!!!
this guy is getting me through my medical degree..... thank you !
I’m Thai and I’m pharmacy student and I speak and listen English just a little bit but when I see your video, your video is very very very wonderful for me, I can easy to understand it because you , thank you very very very very much my teacher. (From Thailand)
Outstanding way of delivering infos , amazing energy👏👏 thank you so much :)
As always, the best work ever. You make a topic look so simple and enjoyable. This is one of the reasons why I love medicine (you).
you are quite literally the BEST TEACHER out there!! thank you for doing what you do
I hit like before i see the videos :D
you are my best channel eveeeeer
AWESOME LECTURE SERIES! GOD BLESS YOU. I CANT WAIT TO TEACH MY KIDS THIS THROUGH YOU ONE DAY!!! Keep the content coming.
The best and most generous tutor of our generation.
This was like art, thank u so much for your hard work u helped a lot
The immense detail yet simplicity is what makes everyone understand step by step. Thank you!!!!!!
Sharing the knowledge by teaching others, and taking so much effort for the same is a noble deed. You will reach great heights 👏
I am in my first year of medical school and we are still doing remote learning, which I appreciate the COVID precautions, but it also makes some topics difficult to understand and/or visualize - especially depending on the professor. I just have to tell you that I am never confused in these lessons. You explain everything so clearly and sensibly... all instructors should study these videos. I can't put into words the amount of gratitude I have for you. I come here anytime I am unsure or need more help with a subject and you come through every time. Thank you so much for what you do. Once I become a paid doctor, I'll be donating to you all because you are the best resource I've ever found. Thank you again and please don't stop what you're doing.
You have just given me a light at the end of the tunnel.. Physiology final is this Friday and thanks to you, I think I'll make it!! I will forever recommend you to anyone needing to understand all this wonderful stuff that our bodies do!! YOU ROCK!!!! THANK YOU!
no one explains like you. You really know what you talk about and go into details. Thank you!
Beautifully explained sir !! I dont have words !! I just have deep deep gratitude!!
Dude your teaching techniques is from a different planet! I really appreciate all your effort to make things more understandable for most of us!
best channel ever!!!!!
whenever I graduate from medschool I will mention you. YOU ARE INCREDIBLE
Hats off to this guy! Very obvious you have passion and enjoy teaching! Thank you so much!
I never understood things better than I'm able to do from your video. They are really much better than any of the professor in our college or any other book. You explain things so very easily that I have no problem in grasping the concepts. I really appreciate the way you integrate things so well along with pictorial representation that helps me to retain things for much longer time.
I really don't know how to thank you but definitely you are really doing a great job & loads of love from India.💓😘
just here to say thank you! I recently went from MA to EKG tech and your videos have helped me so much through the process. You’ve answered questions and simplified things more than the 5 cardiologists I work with.We must protect you at all costs!!!!
you have remarkable ability to correlate so many concepts.
i've watched both videos and i cant wait to finish the whole cardiovascular video series . Thanks for such inspiring and motivating videos
Your videos are truly incredible. You make my classes seem way less overwhelming and I feel like I actually understand the information you are teaching. Can't thank you enough!
No one could explain electrophysiology of heart better than this.........really liked your vedio
Thank you so much!! To be able to look at the entire whiteboard at the end of part 1 and part 2 and fully understand EVERYTHING that is going on, and beat you to the answers of the outcomes of events is SO relieving. Wonderful job.
you're an absolute gem and i genuinely don't know how how folks do med school without you. Thank you💙
Hey ninja nerd YOU DECREASES SUPER BIG CHAPTER WHICH R HARD TO UNDERSTAND IN JUST 2 PAGES......
THANK U.... Keep the videos coming always.....
I can't thank you enough Zach, your channel is so underrated you def deserve more!
Never really understood this topic in my physiology class, even after having studied textbooks for days.. I had so much stess and self doubt, and now after this video I finally got it. And it's not even that difficult (when properly explained) 😮 I'm deeply thankful for your work, Ninja Nerd team
Best tutoring videos I've watched by far.You're a great instructor!! Recommended you to all my classmates.
I can't seriously thank YOU enough ! I watch your videos all the time, they help me tremendously
Like everyone else here in the comments I want to thank you for your videos. The videos are so long and do actually provide the connections to all the events. Most videos only show the small process of a event but you connect them all together. This is so helpful. Thank you!!
I absolutely love your content! your videos are better than any book on physiology I have come across so far xD
Always feel relieved when i see ninja nerd has covered a topic i’m learning at school
you are truly the only reason i pass my tests. i cant thank you enough! i hope your life is amazing and full of love
2 years later still helping me pass gas. Thank you Ninja Master and Ninja Nerd Science team!
You are an angel with dry erase markers!! You have made a very complicated and complex subject approachable and understandable.
I love the way you give these lectures. It's like a story and it's so easy to remember
thank you so much! i don't know what to do without your amazing videos! me and a lot of Syrian students watch and learn from you! thank you for giving us this opportunity !
Thank you so much for the video. Towards the end it would have been great to mention that sympathetic stimulation increases the slope of phase 4 on the action potential graph of the pacemaker cell driving it closer to the threshold. Parasympathetic decreases the slope of phase 4 on the graph driving it further away from the threshold. You drew it, but it is worthwhile to have mentioned it. Many students do not understand the word slope.
That is due to another effect of the proteinkinase A, it phosphorylates the voltage gated potassium channels responsable for the repolarisation to open earlier and cause a faster repolarisation to decrease the systole accordingly.
Really love the way u teach complex topics so simply......❤️👍
You are an awesome teacher Zach and really funny too. I always laugh at the jokes you make whilst absorbing everything you’re teaching us. Thank you from the bottom of my heart.
I am so glad I found this channel, I was so worried about my classes this coming semester but going through some of your videos for pre-studying is going to get me some good grades
You are literally the greatest teacher ever.
I cant stress this enough, this is like looking at art, you make pure art !!!!
My heart goes out to the beauty of these classes!!!!!
Hugs and congrats from mexico !!
I am a Adult critical care nurse in Bristol UK. I am currently revising for an exam which goes towards my masters. Your videos have been super super helpful making all the nuggets of knowledge I have link up. You make this not only easy but also an enjoyable topic to revise!!!
This video is life saving!! Your videos are so clear and informative! Thank you for your amazing work!
I am in my first semester of NP school and you have been a life saver so far. I have learned so much from you already and I will be using your videos throughout this process. Thank you so much for doing these. You are awesome!!! I can’t thank you enough!!!!
Hey.. You are saving lifes of Italian med students too! ... I owe you a big thank. I have just passed my physiology exam thanks to your amazing explanations. Everything made really sense after seeing your videos! Thanks a lot again!
You are the best teacher I have ever seen ... Thank you for this great work !!!!
I ABSOLUTLY LOVE all of your videos! I am currently a PA student and your teaching method has REALLY helped me better understand the accelerated material!!! THANK YOU Ninja Nerd Science
Thank u so much Zach!!!!! I have no words to express uuu and ur team!!!!
U guys are savior!!!
Where I'm a dental student no one..medical dept cared us when dealing with gen physio, path med etc
I always wanted to know and learn these things... In depth and u like a angel came !! Oh man u are amazing🤩... Tons of happiness when realizing that oh! I'm getting to know and correlate these stuffs..
Understanding is crucial and u made us do that!! And that's all we want.. THANK U 🙏TO LOADS
I'm an electrical engineering student but I love to watch your videos in my free time! Your videos are so great that I bet they can make everyone interested in physiology, including engineers-to-be like me :)
Information and knowledge knows no bounds! Welcome to the Ninja Nerd community! - TG
Came here just to say you're extremely helpful! I haven't learned much from my anatomy teacher, a few minutes on your channel & I've learned so much! Thank you thank you!
Thank you so much ninja nerd. No words can describe my appreciation to all the videos. You guys are one of the reason I passed my frcem primary June 2019. Thank you so much.
Medical students saver!!!! you're the best ever! thank you so much for the hard work and the great videos.
You are a fantastic teacher! A subject that took me 3 hours to understand 4 years ago you made it very clear in 20 minutes. Thank you!
You are a legend.....we need more dedicated people like you ...... We appreciate the hardwork you pour into making your videos and your utmost dedication......you help us .....this videos are helping me so much ....
I am so glad to have discovered your videos. You Tube needs to put you at the top of the search list. Your ability to tell how the human body works is amazing. Some thing else I appreciate is your pronunciation. I found out I was miss pronouncing some key words. OPPS!! Here's something else you have that other sites don't ,your videos are in groups. I didn't have to go through 100 videos looking for my subject or for a video you referenced. Hats off to Ninja Nerd!!
Best teacher award goes to ninja nerd teachers ..superb explanation ,,,better than any medical proffesor in my medical college...
You deserve so much more ❤
I think it should be noted that phospholambans are proteins attached to SERCA that inhibits its action. SERCA is the one responsible for transporting Ca++ from cytoplasm to SR. But when phosphorylated, phospholambans allow SERCA's action of Ca++ reuptake from the cytoplasm to the SR.
Other than this, you are doing a fantastic job! Thank you!
You are honestly such a blessing in my life!!!!! I don't where I'd be right now in Med school without you. Thank you so much! Never stop making these videos :)
Isn’t that beautiful?
Sure is. Thanks a ton for this. Blessed we can learn this from such a gifted instructor for completely free.
I'm a medical student from Brazil and you saved my day appreciate it!!!
You are a born teacher.. your teaching skill is an art..GOD bless you with long life!!
IMPRESSIVE!!! Thank you Ninja Nerd. You are the only reason why I am surviving my exams!
med student from South Africa here. You are amazing. i dont know why I didn't start watching these sooner!
Life saver for med school A&P.. Thanks so much
Best youtube channel for medicine content. you rock, my friend
Up 22k subs in 2 weeks! Woohoo 🙌
That's awesome to see. Very exciting for your entire team, but also for all of us fans.
I recommend your channel so much! Very helpful. Thank-you 💪🥳💖
When you learn more from this guy's free UA-cam videos than the classes you pay $102k for... You are amazing!!! Thank you for everything!!!!
you really are so good... how does you make things so easy to digest and understand. thank you so much!!!
The way you explain the concepts is truely wonderful ! just love watching your videos..
Concepts simplified..hats off ninja nerd👍
Hey first I want to be thankful for your hard work I appreciate it
But I have to notice when checked your notes on the Ninja Need website I understand you wrote PSNS has No effect on Contractility BUT you know PSNS has a little bit of supply of cardiomyocytes which are located in the atrium (ref: Guyton) so The effect of the parasympathetic nervous system on the heart rate is based on ACh binding to muscarinic receptors.
Muscarinic receptors (M2) is a Gi bound protein which means that alpha-GDP subunit of Gi protein inhibits the activity of adenylyl cyclase. Due to a decrease/halt in this activity, the intracellular concentration of the cAMP is decreased as well as the activity of protein kinase A.
Therefore, the influx of sodium and calcium ions into the cell is reduced which prolongs the duration of slow depolarization so depolarization before reaching the threshold. The beta and gamma subunits of the G protein travel along the cell membrane binding to GIRK potassium channels. GIRK potassium channels open allowing for the outflux of potassium ions from the cell to occur. Because of GIRK potassium channel activity, the membrane potential is more negative and therefore it is more difficult to induce an action potential after ACh binds to muscarinic receptors.
YOU MAKE IT SO EASY TO UNDERSTAND. HATS OFF
Sir thank you so much for clearing all the concepts in such a decent amount of time🙏
Absolute LEGEND!!! Thank you so much for all your work. I don't know what I would do without you