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Richard, you are looking AMAZING! Notably less grey and younger skin. Absolutely obvious. Wow, just wow. I recently started taking NMN again, along with resveratrol, after almost a year off it; big mistake on my part. I'm not liking my grey spreading out like a wild fire at 49. Doing cardio and kickboxing for exercise too. Thank you for motivating me to stay consistent! 🙏
Good one but hard to get a prescription if you don't have one of these - Doxycycline is an antibiotic that's used to treat infections including: chest and dental infections. skin infections and conditions like rosacea. sexually transmitted infections
Nice video! Great to see they are focusing on older mice, so the trial lengths can be shorter. And good they are using technology that would be translated to humans. A question - how come Sinclair hasn't done anything beyond the optic rejuvenation?
Its clearly early days and still in need of improvement (and I have no doubt we'll see quick strides in that), but this study showed two significant firsts: its the first time partial reprogramming is shown to enhance longevity in non-progeric mice, and its also the first time its done as a systemic exogenous gene therapy (rather than breeding mice with an osk cassette built in).
Partial reprogramming is good but the cells revert to an earlier differentiated stage. This means the cells in the eye can only become a younger eye cell - capable of dividing for replacing damaged cells and for rejuvenation. Going full way back to stem cells is more valuable because the pluripotent stem cells can circulate and become anything - which is useful for full body repair. This could lengthen the lifetime of the mice in question. Maybe the balanced approach is to have a mixture of partial reprogramming to fix the immediate needs of some critical systems risking failure, and a full programming to fix the entire organism.
I’m confused by your “extended by 109%”. If you increase something by 100% then you double the initial amount. Also, I repeat my question for before, how does cellular reprogramming affect age related diseases? I wish you would include this question when interviewing your guests promoting rejuvenation. Thanks Richard.
Hi Scott, thanks for the question. Paul's answer is correct, the remaining lifespan was more than double in the treatment group. I did put my thoughts in response to your previous question. You could also look at ua-cam.com/video/NHzp0lbhsaU/v-deo.html at around 2:50 when I ask Dr Dadvidsohn about this in the specific case of heart disease in dogs.
"how does cellular reprogramming affect age related diseases?" It doesn't, that's why the mice died, usually from failure of critical systems. I think mice are simple creatures of special purposes and they don't have a sophisticate immune system similar to what we possess. But I think it also does cure age related diseases if the reprogramming is widespread and effective because the environmental factors are capable of supporting rejuvenation. I'm saying that gene is only part of the whole picture because those activated genes need to be expressed . Say we activate the gene for hair color but if the person is bald, then those genes are not expressed. To get the hair growing one needs to dilate the tiny capillaries which bring oxygen and nutrients to the hair stems. One way of doing this is by blocking DHT. Some view diseases as consequence of aging.
7% overall lifespan extension. I really appraciate their hard work but to put it into context such extension is so very modest... Do they have any plan to improve the effect?
I'd imagine every company working on this field is constantly working towards improving their current results. I don't know if I agree with 7% being modest given it was very late into their life span that they started being treated. When taking into account remaining life expectancy only, the increase was of over 100%. If we also take into account the lengths we'll go to just to keep an elder relative with us just for one or two more years (usually in very fragile states) this sounds actually very good in context. Especially while considering the stark healthspan contrast.
This was applied to the equivalent of an 80 year old. A lot of the other interventions that cause longer lifespans need to be taken younger. So 7% for an 80 year old isn’t bad.
Hi Thanks for the question. I have two thoughts on this. One is that given how old the mice were I think it is quite impressive. I don't think any other intervention can achieve the same. On the other hand, you would hope to see full body reprogramming make them younger and so produce a longer extension. I think the answer is that it is very early days and this is just one of the first steps.
Hi Charles, thanks for your comment. Telomeres are bit of a mystery to me. It seems possible for them to get longer but I thought hTerT was not expressed in human somatic cells. Dr Sebastiano from Turn Bio, who are also working on a partial reprogramming solution, specifically said he did not want to see them active as it would imply that the cell had passed the point of no return.
@@ModernHealthspan No; I listened to the interview & that’s not what he said. You didn’t asked him about activating telomerase through hTerT which he would support if the need arises. - You asked him if OSKM could elongate telomeres- which it could but this would mean the cell has lost its identity. That’s why he is happy that OSKM when used in partial reprogramming do NOT cause telomelere elongation. - If hTerT would activate telomerase to elongate telomeres, he would be delighted and even proposed it himself.
Telomeres lengthen automatically with meditation and sleep. This implies a systemic change to the body environment, which in turns signals the telomeres to lengthen. Activating hTeRT is risking cancer. Cancer cells mostly have long telomeres but I'd say some don't. But with the help of activation, they would welcome the opportunity to divide. I don't think telomeres is an active anti-aging area of research and I agree it's not a promising path.
Sorry to be negative but various forms of genetic engineering have been talked about for at least 20 years for curing various diseases and it has not been widely practiced today. If age reversal genetic engineering is thought as a way to cure old age diseases then it will be met with the same fate. This is because the body environment (my terminology) needs to support gene expression. If one takes all sort of genetic modifications and munches on McDonald's all day long then it's not going to help.
10% discounts off all products at Renue By Science : tinyurl.com/3bj65wev For Subscriptions, use code SUBMHS
Liposomal CaAKG, Use code 615325 for 20% discount. : tinyurl.com/29j5pfcd until Jan 31, 2023
DoNotAge 10% off all products Code MODERNHEALTHSPAN donotage.org/products/
NOVOS Core & NOVOS Boost novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
ProHealth 10% of all products Code MODERN : prohealth.pxf.io/c/3176409/1541296/17976
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Excellent presentation! As an old retired scientist, I appreciate your efforts.
Hi Thanks for your kind comments!
Rejuvenate Bio is doing potentially revolutionary stuff. Amazing.
Hi thanks for sharing! I think so too.
Richard, you are looking AMAZING! Notably less grey and younger skin. Absolutely obvious. Wow, just wow. I recently started taking NMN again, along with resveratrol, after almost a year off it; big mistake on my part. I'm not liking my grey spreading out like a wild fire at 49. Doing cardio and kickboxing for exercise too. Thank you for motivating me to stay consistent! 🙏
Thank you for this excellent review!
Hi Richard. Thanks for sharing.
Hey Ron, thank you!
This is a smart experiment setup that tests the techniques that will lead to a practical human therapy.
Good one but hard to get a prescription if you don't have one of these - Doxycycline is an antibiotic that's used to treat infections including: chest and dental infections. skin infections and conditions like rosacea. sexually transmitted infections
Hi, Thanks for your comment. Not 100% clear on your meaning but to be clear the doxycycline will not do anything without the AAV's also included.
Doxicycline grows naturally on trees. Lichen moss. People make tea out of it.
If it’s an antibiotic then grated raw garlic and raw coconut oil may nice overlap most of this
Once they come up with elixir of life, I'm going to buy that stock.
Yuvan E5 ;)
relaxe agora Sam ua-cam.com/video/ipuqLy87-3A/v-deo.html
Nice video! Great to see they are focusing on older mice, so the trial lengths can be shorter. And good they are using technology that would be translated to humans. A question - how come Sinclair hasn't done anything beyond the optic rejuvenation?
Its clearly early days and still in need of improvement (and I have no doubt we'll see quick strides in that), but this study showed two significant firsts: its the first time partial reprogramming is shown to enhance longevity in non-progeric mice, and its also the first time its done as a systemic exogenous gene therapy (rather than breeding mice with an osk cassette built in).
can't believe it's just a 7% increase in median lifespan and 8% increase in max lifespan
so this experiment did not reverse the age of mice to the age which is equivalent to like 20 for human ,it just prolong a little bit lifespan
Partial reprogramming is good but the cells revert to an earlier differentiated stage. This means the cells in the eye can only become a younger eye cell - capable of dividing for replacing damaged cells and for rejuvenation. Going full way back to stem cells is more valuable because the pluripotent stem cells can circulate and become anything - which is useful for full body repair. This could lengthen the lifetime of the mice in question. Maybe the balanced approach is to have a mixture of partial reprogramming to fix the immediate needs of some critical systems risking failure, and a full programming to fix the entire organism.
Do a grey hair update, please!
use tinta ua-cam.com/video/ipuqLy87-3A/v-deo.html
They need to develop some way for reprogramming without using a virus
"Gross teratoma" would not develop in mice that old, or can it?
I’m confused by your “extended by 109%”. If you increase something by 100% then you double the initial amount. Also, I repeat my question for before, how does cellular reprogramming affect age related diseases? I wish you would include this question when interviewing your guests promoting rejuvenation. Thanks Richard.
Hi Scott, thanks for the question. Paul's answer is correct, the remaining lifespan was more than double in the treatment group. I did put my thoughts in response to your previous question. You could also look at ua-cam.com/video/NHzp0lbhsaU/v-deo.html at around 2:50 when I ask Dr Dadvidsohn about this in the specific case of heart disease in dogs.
I agree, the title was very misleading...
"how does cellular reprogramming affect age related diseases?"
It doesn't, that's why the mice died, usually from failure of critical systems. I think mice are simple creatures of special purposes and they don't have a sophisticate immune system similar to what we possess.
But I think it also does cure age related diseases if the reprogramming is widespread and effective because the environmental factors are capable of supporting rejuvenation. I'm saying that gene is only part of the whole picture because those activated genes need to be expressed . Say we activate the gene for hair color but if the person is bald, then those genes are not expressed.
To get the hair growing one needs to dilate the tiny capillaries which bring oxygen and nutrients to the hair stems. One way of doing this is by blocking DHT.
Some view diseases as consequence of aging.
7% overall lifespan extension. I really appraciate their hard work but to put it into context such extension is so very modest... Do they have any plan to improve the effect?
I'd imagine every company working on this field is constantly working towards improving their current results.
I don't know if I agree with 7% being modest given it was very late into their life span that they started being treated. When taking into account remaining life expectancy only, the increase was of over 100%. If we also take into account the lengths we'll go to just to keep an elder relative with us just for one or two more years (usually in very fragile states) this sounds actually very good in context. Especially while considering the stark healthspan contrast.
This was applied to the equivalent of an 80 year old. A lot of the other interventions that cause longer lifespans need to be taken younger. So 7% for an 80 year old isn’t bad.
Very Nice interview. How the results can be so modest? Were the cells actually not so rejuvanated? Or not all cells were rejuvanated? Or?
Hi Thanks for the question. I have two thoughts on this. One is that given how old the mice were I think it is quite impressive. I don't think any other intervention can achieve the same. On the other hand, you would hope to see full body reprogramming make them younger and so produce a longer extension. I think the answer is that it is very early days and this is just one of the first steps.
Seems a more competitive field. newatlas.com/biology/epigenetic-reboot-reverse-aging-extend-lifespan/
I find OSK to be an encouraging approach, but I also hope they try adding hTeRT to the transgene.
Hi Charles, thanks for your comment. Telomeres are bit of a mystery to me. It seems possible for them to get longer but I thought hTerT was not expressed in human somatic cells. Dr Sebastiano from Turn Bio, who are also working on a partial reprogramming solution, specifically said he did not want to see them active as it would imply that the cell had passed the point of no return.
@@ModernHealthspan No; I listened to the interview & that’s not what he said. You didn’t asked him about activating telomerase through hTerT which he would support if the need arises. - You asked him if OSKM could elongate telomeres- which it could but this would mean the cell has lost its identity. That’s why he is happy that OSKM when used in partial reprogramming do NOT cause telomelere elongation. - If hTerT would activate telomerase to elongate telomeres, he would be delighted and even proposed it himself.
Telomeres lengthen automatically with meditation and sleep. This implies a systemic change to the body environment, which in turns signals the telomeres to lengthen. Activating hTeRT is risking cancer. Cancer cells mostly have long telomeres but I'd say some don't. But with the help of activation, they would welcome the opportunity to divide.
I don't think telomeres is an active anti-aging area of research and I agree it's not a promising path.
Sorry to be negative but various forms of genetic engineering have been talked about for at least 20 years for curing various diseases and it has not been widely practiced today. If age reversal genetic engineering is thought as a way to cure old age diseases then it will be met with the same fate. This is because the body environment (my terminology) needs to support gene expression. If one takes all sort of genetic modifications and munches on McDonald's all day long then it's not going to help.