Wolff Kishner Reduction || Pharmaceutical Organic Chemistry || Organic Chemistry Reaction Mechanism

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  • Опубліковано 19 січ 2025

КОМЕНТАРІ • 43

  • @laibaarain1886
    @laibaarain1886 Рік тому +2

    1- wolf kishner reduction reaction is a reaction in which carbonyl compounds ( aldehydes and ketones) are converted in to alkanes
    2-
    Step 1- formation of hydrazone
    Step 2- deprotonation of nitrogen
    Step 3- protonation of carbon
    Step 4- deprotonation of nitrogen
    Step 4- protonation of carbon
    3- - The rate determining step of this reaction is the bond formation pf the terminal carbon with hydrogen in the hydrazone anion induced by mildly electron withdrawing substituents.

  • @Lavisha_Gurwani
    @Lavisha_Gurwani Рік тому +1

    1. In this reduction of carbonyl compounds like aldehyde and ketone to alkanes takes place.
    2. 5 steps are involved
    a.Formation of hydrazone.
    b.Deprotonation of nitrogen of hydrazone.
    c.protonation of carbon of carbanion.
    d. Deprotonation of nitrogen.
    e.protonation of carbon of carbanion.
    3. Rate determining step is one of the slowest step of the reaction. In this WKR, bond formation of terminal carbon with hydrogen(hydrazone anion or protonation of carbon) is RD step.

  • @mohitjoshi6385
    @mohitjoshi6385 Рік тому +1

    Purwashi Mukesh 34
    1 the wolff kishner reduction is an organic reaction used to convert a aldehyde or ketone to alkane using hydrazine ,base and thermal conditions.
    2
    Step 1: Formation of hydrazone. ...
    Step 2: Deprotonation of Nitrogen. ...
    Step 3: Protonation of the Carbon. ...
    Step 4: Deprotonation of Nitrogen.
    Step 5: protonation of carbon
    3.The rate-determining step of this reaction is the bond formation of the terminal carbon with hydrogen (in the hydrazone anion).

  • @aqsamemon2073
    @aqsamemon2073 Рік тому +1

    1) The reduction of Aldehydes and ketones to alkanes
    2) first step formation of hydrazone, deprotonation of nitrogen, protonation of carbon, deprotonation of nitrogen, protonation of carbon
    3)The rate determine step of this reaction is the bond formation of the terminal carbon with hydrogen;
    Aqsa memon

  • @minhajaved3950
    @minhajaved3950 Рік тому +1

    1_ The reduction of aldehyde and ketones to alkanes.Condensation of carbonyl compound with hydrazine forms hydrazone and treatment with base induce the reduction of Carbon coupled with oxidation of hydrazine to gaseous nitrogen to yield corresponding alkanes
    2_ Step 1: formation of hydrazone
    Step 2: Deprotonation of nitrogen
    Step 3:Protonation of carbon
    Step 4: Deprotonation of nitrogen
    Step 5: Protonation of carbon
    3_ Rate determining step of this reaction is the bond formation of terminal carbon with hydrogen (in hydrazone anion)

  • @rehananoorr401
    @rehananoorr401 Рік тому +1

    1: wolf kishner reduction reaction is defined the reduction of aldehyde and ketone to form alkane.
    2: steps involved in the Wolf kishner reduction reaction:
    1 formation of hydrazone
    2 deprotonation of nitrogen
    3 protonation of carbon
    4 deprotonation of nitrogen
    5 protonation of carbon.
    3: the rate determining step of this reaction is the Bond formation of the terminal carbon with hydrogen.

  • @duausman671
    @duausman671 Рік тому +1

    Q:1
    It is the reduction reaction in which aldehyde and ketone reduce into alkane.
    Q:2
    Steps involved in reaction
    1: formation of hydrazone.
    2: deprotonation of nitrogen.
    3:protonation of carbon.
    4: deprotonation of nitrogen.
    5: protonation of carbon.
    Q:3
    Rate determining step is the bond formation of terminal carbon with hydrogen.

  • @swebahhira5649
    @swebahhira5649 Рік тому +1

    Q:1 it is the reduction reaction in which aldehyde and ketone reduce to form alkane
    Q:2 steps involved in the reaction
    1.fromation of hydrazone
    2.deprotonation of nitrogen
    3.protonation of carbon
    4.deprotonation of nitrogen
    5.Protonation of carbon
    Q:3.rate determining steps in the bond fromation of terminal carbon with hydrogen

  • @sabafareedmalik
    @sabafareedmalik Рік тому +1

    1.it is the reduction reaction in which aldehyde and ketone reduced into alkane.
    2 .some step involved in this reaction mechanism.
    1.formation of hydrazone.
    2.deprotonation of nitrogen.
    3.protonation of carbon.
    4. Deprotonation of nitrogen.
    5.protonation of carbon.
    Ans3. Rate determining step is the bond formation of terminal carbon with hydrogen.

  • @aqsarao1957
    @aqsarao1957 Рік тому +1

    1.The reduction of aldehyde and ketone to Alkane.
    2.
    Step:1 Formation of hydrazone.
    Step:2 Deprotonation of Nitrogen.
    Step:3 Protonation of carbon.
    Step:4 Deprotonation of nitrogen.
    Step:5 Protonation of carbon.
    3.
    Rate determining step of this reaction is the bond formation of terminal carbon with hydrogen.

  • @aimanimrankhanzada5876
    @aimanimrankhanzada5876 Рік тому +1

    Question no:01
    The reduction of aldehydes & ketones to alkanes. Condensation of the carbonyl compound with hydrazine forms the hydrazone, and treatment with base induces the reduction of the carbon coupled with oxidation of the hydrazine to gaseous nitrogen, to yield the corresponding alkane.
    Question no:02
    •Step 1: Formation of hydrazone.
    •Step 2: Deprotonation of Nitrogen.
    •Step 3: Protonation of the Carbon.
    •Step 4: Deprotonation of
    Nitrogen.
    •Step 5: Protonation of Carbon.
    Question no: 03
    Step no: 01 in Wolff-Kishner reduction’s mechanism , the first step in this reaction is the formation of a hydrazone anion 1 by deprotonation of the terminal nitrogen by MOH. Semicarbazones are converted into the corresponding hydrazone before being deprotonated because they are used as substrates. According to a variety of mechanistic results, the formation of a new carbon-hydrogen bond at the carbon terminal in the delocalized hydrazone anion appears to be the rate-determining.

  • @mariyamshokat5195
    @mariyamshokat5195 Рік тому +1

    Q:1 the reduction of Aldehyde and ketone to alkane
    Q:2 ...step:1 formation of hydrazone
    Step:2 deprotonation of nitrogen
    Step:3 protonation of the carbon
    Step:4 deprotonation of nitrogen
    Step:5 protonation of cabon
    Q:3 the rate determining step of this reaction in the bond formation of the terminal carbon with hydrogen

  • @muznaarain2944
    @muznaarain2944 Рік тому +1

    Q1 The reaction in which Carbonyl compound(aldehyde and ketone) converted to alkane.
    Q2
    1) Formation of Hydrazone
    2) Deprotonation of Nitrogen
    3) Protonation of Carbon
    4) Deprotonation of Nitrogen
    5) Protonation of Carbon
    Q3 Rate limiting step for this reaction is when bond formed at terminal carbon with hydrogen(hydrozine anion).

  • @aishashakeel4327
    @aishashakeel4327 Рік тому +1

    Ans: 01
    Definition:
    The Wolff-Kishner reduction is an organic reaction used to convert an aldehyde or ketone to an alkane using hydrazine, base, and thermal conditions.
    Ans: 02
    Steps
    1. Formation of Hydrazone
    2. Deprotonation of Nitrogen
    3. Protonation of carbon
    4. Deprotonation of Nitrogen
    5. Protonation of Carbon
    Ans: 03
    RATE LIMITING STEPS:
    The rate-determining step of this reaction is the bond formation of the terminal carbon with hydrogen (in the hydrazone anion).

  • @mahiinoor4110
    @mahiinoor4110 Рік тому +1

    1) The reduction of Aldehydes and ketones to alkanes..
    2) first step;
    Formation of hydrazone
    Deprotonation of nitrogen
    Protonation of carbon
    Deprotonation of nitrogen
    Protonation of carbon
    3) The rate determine step of this reaction is the bond formation of the terminal carbon with hydrogen;

  • @rimshamughal1830
    @rimshamughal1830 Рік тому +1

    Q1
    Ans The wolf kishner raection is defined as the those type reduction reaction in which aldehyde and ketone reduce into the alkane
    Q2
    Ans The steps involve in the wolf kishner reaction
    1 ) Formation of hydrazone
    2) Deprotonation of nitrogen
    3. Protonation of carbon
    4. Deprotonation of nitrogen
    5. Protonation of carbon
    Q3
    Ans. The rate determing step is the bond formation with hydrazone.

  • @vershalohana1913
    @vershalohana1913 Рік тому +1

    Question no:1
    Wolff -kishner is the reduction of carbonyl compounds like aldehyde and ketone to from alkane
    Question no:2
    5 Step are involved:
    1.Formation of hydrazone
    2. Deprotonation of Nitrogen
    3. Protonation of Carbon
    4. Deprotonation of Nitrogen
    5. Protonation of Carbon
    Question no:3
    Rate determining step is the slowest step of reaction this reaction is the bond formation of the terminal carbon with hydrogen (hydrazone anion)

  • @nasharkhan344
    @nasharkhan344 Рік тому +1

    Question no:01
    The reduction of aldehydes and ketones to alkanes. Condensation of the carbonyl compound with hydrazine forms the hydrazone, and treatment with base induces the reduction of the carbon coupled with oxidation of the hydrazine to gaseous nitrogen, to yield the corresponding alkane.
    Question no:02
    Step 1: Formation of hydrazone. ...
    Step 2: Deprotonation of Nitrogen. ...
    Step 3: Protonation of the Carbon. ...
    Step 4: Deprotonation of
    Nitrogen.
    Step 5: Protonation of Carbon.
    Question no: 03
    Step no: 01 in Wolff-Kishner reduction’s mechanism According to Szmant’s research, the first step in this reaction is the formation of a hydrazone anion 1 by deprotonation of the terminal nitrogen by MOH. Semicarbazones are converted into the corresponding hydrazone before being deprotonated because they are used as substrates. According to a variety of mechanistic results, the formation of a new carbon-hydrogen bond at the carbon terminal in the delocalized hydrazone anion appears to be the rate-determining.

  • @emanfarooq9385
    @emanfarooq9385 Рік тому +1

    Q1 wolf kishner is the reduction of aldehydes and ketones to form alkanes
    Q2 (1) formation of hydrazone
    (2) deprotonation of nitrogen
    (3)protonation of carbon
    (4) deprotonation of nitrogen
    (5) protonation of carbon
    Q3 rate determining step of this reaction is the bond formation of terminal carbon with hydrogen

  • @uroojurooj392
    @uroojurooj392 Рік тому +1

    Question :1
    Wolf kishner reduction reaction is defined the reduction of aldehyde and ketone to form Alkane.
    Q2:
    Mechanism of wolf kishner reduction reaction:
    1: formation of hydrozone
    2: deprotonation of nitrogen
    3: protonation of carbon
    4: deprotonation of nitrogen
    5: protonation of carbon
    Q3:
    In rate limiting step:
    The carbon and hydrogen bond formation by mild electron withdrawing substitution,the highly electon withdrawing substitution decrease the negativity of nitrogen,make the difficult to break the bond N-H.

  • @mazharali1260
    @mazharali1260 Рік тому +1

    Ans 1. Reduction of aldehyde and ketone with hydrazine produce hydrazone reaction with base convert hydrazone to alkane both reaction together produce Wolff kishner reduction. Ans 2.step in reaction.1 formation of hydrazone.2 deprotonation of nitrogen.3 protonation of carbon.4 deprotonation of nitrogen.5 protonation of carbon. Ans 3. The rate determining step is the bond formation of the terminal carbon with hydrogen

  • @muskanharoon3466
    @muskanharoon3466 Рік тому +1

    Q#1 wolf kishner is the reduction of aldehyde and ketones to form alkanes
    Q#2
    The steps involved in reaction mechanism.
    1 formation of hydrazone
    2 deprotonation of nitrogen
    3 protonation of carbon
    4 deprotonation of nitrogen
    5 protonation of carbon.
    Q#3 The rate determining step is the bond formation of terminal carbon with hydrogen

  • @ayeshagul1843
    @ayeshagul1843 Рік тому +1

    Q1= The reduction of aldehydes and ketones to alkene
    2= The step involved in wolf reduction reaction are
    1 Formation of Hydrogen
    2Deprotation of nitrogen
    3 protonation of the carbon
    4Deprotation of nitrogen
    5Protonation of carbon
    Q3= Rate determining step is the bond formation of terminal carbon with hydrogen

  • @zohamemon115
    @zohamemon115 Рік тому +1

    Q:1 DEFINITION OF WOLF-KISHNER REDUCTION
    ANS:-
    Wolf kishner reduction is a reaction in which carbonyl containing compounds (aldehyde and ketone) are converted into alkane
    Q:2 STEPS
    ANS:
    Steps involved in wolf kishner reduction reaction are:
    1) formation of hydrazone
    2) Deprotonation of nitrogen
    3) Protonation of carbon
    4) deprotonation of nitrogen
    5) protonation of carbon.
    Q:3RATE LIMITING STEPS
    ANS:
    THE rate Determining step of this reaction is the bond formation of the terminal carbon with hydrogen {in the hydrazone anion}.

  • @rumiikhan-kc8hv
    @rumiikhan-kc8hv Рік тому

    1) The reduction of Aldehydes and ketones to alkanes
    2) first step formation of hydrazone, deprotonation of nitrogen, protonation of carbon, deprotonation of nitrogen, protonation of carbon
    3)The rate determine step of this reaction is the bond formation of the terminal carbon with hydrogen;
    Bakhtawar aijaz

  • @muskan6350
    @muskan6350 Рік тому +1

    Ans .wolf kishner is used to convert carbonyl into methylene groups.
    Ans.1 FoRMation of hydrazone.
    2 Deprotonation of nitrogen.
    3 Protonation of carbon.
    4 Deprotonation of nitrogen.
    5 Protonation og carbon.
    Ans. Rate determining step of this reaction is the bond formation of terminal carbon with hydrogen....

  • @syedazehra4269
    @syedazehra4269 Рік тому +1

    Qno:1
    Ans: wolf kishner is the reduction of Aldehyde and ketones to form Alkanes.
    Qno:2
    Ans:Steps involved in reaction mechanism are :
    i) Formation of hydrazone
    ii) deprotonation of nitrogen
    iii) protonation of carbon
    iv) deprotonation of nitrogen
    v) protonation of carbon
    Qno:3
    Ans: Rate determining steps is the bond formation of terminal carbon with hydrogen

  • @dr.shaguftaagro5739
    @dr.shaguftaagro5739 Рік тому +1

    Ana1. Reduction of aldehyde and ketone into alkan
    Answer.2 Formation of hydrogen
    2 Deprotonation of nitrogen
    3 Protonation of carbon
    4 Deprotonation of carbon
    5 Protonation of nitrogen
    Ans3. Rate determining steps in the bond formation of terminal carbon with hydrogen

  • @afrahirfan8032
    @afrahirfan8032 Рік тому +1

    Q#1
    The Reduction of aldehyde and ketones to alkanes
    Q#2
    Steps involved in Wolf krishner mechanism are
    1. Formation of hydrazone
    2. Deprotonation of Nitrogen
    3. Protonation of carbon
    4. Deprotonation of Nitrogen
    5. Protonation of carbon
    Q#3
    The rate determining step of this is the bond formation of terminal carbon with hydrogen (hydrazone ion)

  • @sadiapanhwar
    @sadiapanhwar Рік тому +1

    Ans reduction of aldhyde and ketone into Alkane.
    Ans
    Formation of hydrozone
    Deprotonation of nitrogen
    Protonation of carbon
    Protonation of nitrogen
    Deprotonation of carbon.
    Ans.rate determining steps in the bond formation of terminal carbon with hydrogen

  • @To_explorelife34
    @To_explorelife34 Рік тому +1

    Q1.It is the reduction reaction in which aldehyde and ketones reduces into alkanes.
    Q2.some steps are involved in this reaction mechanism.
    1.formation of hydrazone
    2.deprotonation of nitrogen
    3.protonation of the carbon
    4.deprotonation of nitrogen
    5.protonation of carbon
    Q3:The rate limiting step is the step 1 in which the formation of new bond between terminal carbon and hydrogen (hydrazone anion).

  • @astheticyaneesa2315
    @astheticyaneesa2315 Рік тому +1

    Q1
    Ans: The Wolff-Kishner reduction is a reaction used to convert carbonyl functionalities into methylene groups
    De-protonation of the hydrazone by an alkoxide base to form a diimide anion by a concerted, solvent-mediated protonation/de-protonation step is the rate deciding step of the reaction.
    Q2
    Ans: Step 1: Formation of hydrazone. ...
    Step 2: Deprotonation of Nitrogen. ...
    Step 3: Protonation of the Carbon. ...
    Step 4: Deprotonation of Nitrogen
    Q3
    Ans : The rate-determining step of this reaction is the bond formation of the terminal carbon with hydrogen (in the hydrazone anion). The carbon-hydrogen bond formation is helped by mildly electron-withdrawing substituents.
    Aneesa 08

  • @aimanansari2837
    @aimanansari2837 Рік тому +1

    Q1 it is the reduction reaction in which aldehyde and ketones reduce into alkanes.
    Q2 step 1(formation of hydrazone)
    Step 2(deprotonation of nitrogen)
    Step 3(protonation of carbon)
    Step 4(deprotonation of nitrogen)
    Step 5( protonation of carbon)
    Q3 the rate limiting step is the step no 1 in which the formation new bond between terminal carbon and hydrogen (hydrazone anion)

  • @asiabaloch5834
    @asiabaloch5834 Рік тому +1

    Wolf kishner is the reduction of aldehyde and ketones to form alkanes
    Q2: steps involved in reaction mechanism are
    1 formation of hydrazone
    2 deprotonation of nitrogen
    3 protonation of carbon
    4 deprotonation of nitrogen
    5 protonation of carbon
    Q3: rate determining step is the bond formation of terminal carbon with hydrogen

  • @zainabfarooq4572
    @zainabfarooq4572 Рік тому +1

    Ans no 1: The Wolff-kishner reduction is an organic reaction which used to convert an aldehyde or ketone to an alkane using hydrazone , hydrazine .
    Ans no 2 : first step formation of hydrazone . 2nd step deprotonation of nitrogen . 3rd step protonation of the carbon . 4th step is again deprotonation of nitrogen . 5th step is protonation of carbon.
    Ans no 3 : the rate limiting step is the lowest step of reaction . this reaction is the bond formation of the terminal carbon with hydrogen taking place basically the carbon-hydrogen bond formation is helped by mildly electron withdrawing substituents . highly electron withdrawing substituents decrease the negative charge of the terminal nitrogen , making it difficult to break the N-H bond .

  • @aleebaimran5135
    @aleebaimran5135 Рік тому +1

    Ans 1 : wolf kishner is the reduction of aldehydes and ketones to form alkanes Ans 2: first step : formation of hydrazone ,2 : deprotonation of nitrogen,3: protonation of carbon ,4: deprotonation of nitrogen ,5: protonation of carbon Ans 3: rate determining step of this reaction is the bond formation of terminal carbon with hydrogen .

  • @mahrukhkamboh7145
    @mahrukhkamboh7145 Рік тому +1

    Question 01.
    Ans: The Wolf Kishner reduction is defined as the reaction In which aldehyde and ketone that are the carbonyl containing compounds converted into the alkane.
    Question no 02
    Ans: 5 steps which are involved in Wolf Kishner reduction.
    Their names are:
    Step 01. Formation of Hydrazone
    Step 02. Deprotonation of Nitrogen
    Step 03. Protonation of the carbon
    Step 04. Deprotonation of Nitrogen
    Step 05. Protonation of Carbon
    Question 03.
    Ans: The rate-determining step of this reaction is the bond formation of the terminal carbon with hydrogen (in the hydrazone anion).

  • @palwishaamber3159
    @palwishaamber3159 Рік тому +1

    Ans 1 It is the reduction reaction in which aldehyde and ketone reduce into alkanes. Ans2 step 1 formation of hydrazone. Step 2 deprotonation of nitrogen. Step 3 protonation of carbon. Step 4 deprotonation of nitrogen. Step 5 protonation of carbon. Ans 3 Rate determining step of this reaction is the bond formation of terminal carbon with hydrogen .

  • @makhdoombilawal132
    @makhdoombilawal132 Рік тому +1

    Ans1
    Reduction of aldehydes and ketones to alkane.
    Ans2
    Step1: formation of hydrazone
    2: deprotonation of nitrogen
    3: protonation of carbon
    4: deprotonation of nitrogen
    5: protonation of carbon.
    Ans3
    The rate determining step of this reaction is the bond formation of the terminal carbon with hydrogen.

  • @mahnoorarain7435
    @mahnoorarain7435 Рік тому +1

    1) The reduction of Aldehydes and ketones to alkanes
    2) first step formation of hydrazone, deprotonation of nitrogen, protonation of carbon, deprotonation of nitrogen, protonation of carbon
    3)The rate determine step of this reaction is the bond formation of the terminal carbon with hydrogen;

  • @uswahkhan7687
    @uswahkhan7687 Рік тому +1

    Q1. It is the reduction reaction in which aldehyde or ketone reduced to the alkane.
    Q2. Some steps involved in this reaction mecahnism,
    1. Formation of hydrazone
    2. Deprotonation of nitrogen
    3. Protonqtion of carbon
    4. Deprotonation of nitrogen
    5. Deprotonation of carbon
    Q3. Rate determining is the bond formation of terminal carbon with hydrogen

  • @hassanzardari570
    @hassanzardari570 Рік тому +1

    Q.1 The reaction in which Carbonyl compound (aldehyde and ketone ) converted converted to alkane
    Q.2
    1, Formation of Hydrazone
    2, Deprotonation of Nitrogen
    3, Protonation of Carbon
    4, Deprotonation of Nitrogen
    5, Protonation of Carbon
    Q.3
    Rate limiting step for this reaction is when bond formed at terminal carbon with hydrogen ( hydrozine anion) .

  • @saman.farooq149
    @saman.farooq149 Рік тому +1

    Q1. It is the reduction reaction in which aldehyde or ketone reduced to the alkane.
    Q2. Some steps involved in this reaction mecahnism,
    1. Formation of hydrazone
    2. Deprotonation of nitrogen
    3. Protonqtion of carbon
    4. Deprotonation of nitrogen
    5. Deprotonation of carbon
    Q3. Rate determining is the bond formation of terminal carbon with hydrogen