Відео

Why in 2:55 second reaction is called 5-exo-trig, instead of 5-exo-tet? It is attacking sp3 carbon or am i mistaken

best video of all time?

Aw yee here we go

Peak cinema just dropped

Can we do argument on rhodium catalysis mechanism?

Could you do a video on Danieshksy Taxol please? Your videos are amazing! God bless you

Your highlighted work is appreciated 👍, and I have a humble suggestion which is that if you summarize the key steps from the synthetic background or key steps from the previously published papers will be more interesting.

Another excellent minilecture! I tried to dissect a total synthesis paper on my own recently, and kept thinking that I would have had a much better time if you had explained it every step of the way. Super happy you're making these lectures, keep it up!

Man I already seen all of them sob

Wake up guys new total synthesis just dropped!

What a fabulous channel

Hi! Nice video! I have a question. Why after the claisen condensation you made the noyori asymetric transfer hydrogenation?? I ask because after some steps the swern oxidation takes places so, why just reduce and protect one of the ketons normal, without quiral reactions? Congratulations again for the video :)

Excellent video! The redox fragmentation of the phthalimide to generate the alkoxy radical is also non-trivial.

Majestic

Thank you for taking the time to make such instructional videos!

2:48 the chromate ester elimination produces a Cr(IV) species, which should have the nominal formula H2CrO3. note that Cr(IV) is unstable and tends to decay to Cr(III) and eventually solid Cr2O3 (ask the solid state chemists or nanochemists about that mechanism, i’m out).

2:07 shouldn’t methylephedrine contain a benzene ring

at 8:08 I think is should be PPh3 and not Ph3

What a fascinating structure! Perfect explanation.👍🧪

It has been a few months now and I am still not over this synthesis! The fulvene chemistry is absolutely crazy and using a Heck reaction to essentially close the tetracyclic core is amazing. Love the channel!

It’s a good day when simplifying synthesis uploads Also I think the thionyl chloride elimination should proceed via the hemiacetal oxygen attacking thionyl chloride instead of the open chain form alcohol

Oh the one synthesis workshop did a podcast on, this is a really typical and cute molecule

Please don't stop doing what you're doing. Your effort is highly appreciated!

💯💯💯🔥🔥🔥

hey hows things .. i heard that special K hydrochloride is one of the hardest chemicals to make. is it??.. do you no how to synthesis it ??.. for educational purposes of course .. but do you.. im here in glasgow i used to get it for micro dosing for anxiety and it worked a treat.. now cant get any and all thats going about is this esketamine witch only effects the mind not the body.. cause i heard a few years back the patent ran out for k-hydrochloride so every one of the pharma co-op's make a K substitute or pre log.. cause who ever owns the patent now is not letting any other chemist or pharma company use it.. but id love to see the proper stuff again.. same with PCP .. i was born in 86 so i missed all that scene and never tried it.. would love too lol.. anyway good work and good vids.. im so interested in chemistry but self taught.. so just about got the just of it.. but id love to see a real chemist at work.. im a chef to trade and i gees its kinda the same just diff ingredients.. if you want to chat more in depth let me no and ill give you my email ... blessings ..

dope

At around 7:20 about the Beckmann Rearrangement, the HOMO is not actually the C-C sigma bond. It's just the transcoplanar arrangement of this bond and the N-O bond that makes the reaction happen.

It’s always a good day when simplifying synthesis uploads We aza, cope, mannich!

Im working on a fairly complex polyketide myself but wouldn't have come up with that strategy in weeks of daily brainstorming. Highly condensed alkaloids are a treasure trove of genius ideas put to the test.

I spent my masters degree working on a total synthesis. It didn't work, but it really has given me an appreciation for the work it needs. That cascade at the end was very elegant and I could only wish to see those disconnections. Just a side question, with aryl diazoniums to aryl azides - doesn't this usually proceed via the pentazole?

Yay new Simplifying Synthesis vid

Very clever analysis. I doff me hat to ye, lad.

It is Queen englis thanks I can understand was afraid of indian english but every queen english chemistry explaination channel is worth to be recomended. Just like with Prof dave explains.

Micromolar is not a low concentration for drug candidates.

Naw electrochem jumpscare 😭

Very nice synthesis, as per usual from the Baran group

It would be interesting to see if anti microbial activity is increased with the legthening of the macrocyclic framework ; althought maybe because of the probable non-linearity of a pure aliphatic legthening, the molecule would adopt an inefficient conformer

That DIBAL-H mechanism at 4:48 needs to be reworked. An electrophilic aluminum species (with an unoccupied p orbital) does not deliver a hydride to a carbonyl directly. It is a 2 step process (Lewis acid-base coordination of the C=O L.P. to the p* of the Al, then intramolecular hydride transfer of the corresponding adduct) It may sound like I am being pedantic, but I have numerous friends from numerous schools who have gotten this exact mechanism wrong (and in some cases chastised) by drawing it the way you have it in the video.

damn that Au catalyzed alkyne rearrangement though that was really cool allenes really do need to be used more often in synthesis, I rarely find them being used as intermediates these days

Thank you max miller

Do you have a simpler molecule beginner video 😂

i'm not sure if they cover this in the paper, but is there a reason they want to administer a prodrug at all? why not just give the API and you wouldn't have metabolism issue etc.

There is still the question if a shorter psilocin exposure can have the same therapeutic effect, which I doubt

Very informative about the lab methods used in this type of research, many thanks

Saw this article a while ago. It's great that you've made an easy to understand video on it!

Fantastic demonstration !🎉 A small typo: in any of first few slide where Negishi coupling mechanism has been shown, there after transmetallation it should take tosylate upon exchange not triflate. In short, it should be ZnBr(OTs) rather than ZnBr(OTf).

In the polycyclic system Hydrogen is behind the plane?? Benzyl gr also followed the same position.

So beneficial video. Please keep posting more and more. It will help students like me to build up ideas of how to design organic synthesis.

Hi so nice explanation. Is there any explanation for stereoselectivty of the Tsuji-Trost reaction?? Last HAT step why H added to right hand side??

When you look at the complexity of the receptor proteins, it's absolutely astounding how everything in biochemistry works so well!