Відео

Yikes… 11 days is not a lot for people who suffer from brain fog, PEM and exhaustion.

I have some questions: It is likely that the appointment of RFK Jr and his expressed plans for America public health will have an affect on ME/CFS research going forward? Also is there concern that the new department of government efficiency may deem research into ME/CFS as a waste and cut funding? If it does happen what will that mean for the future of this research? I'm worried

I’ve been on LDN for 5 months now. My brain fog has improved, but not my energy (yet). I’m at 4.5mg and my doctor recommended I increase the dosage. The first two months were really hard: I took it before bed, it messed with my sleep and made me drowsy all day. The brain fog was awful! But then I switched to taking it in the morning, my body got used to the medication and the drowsiness and brain fog slowly went away. I’d recommend taking it for more than two months - maybe even 6 - especially when you’re titrating up very slowly (I increased by 0.5mg every 2 weeks) because it takes time to work.

@youngerlab could Ldn help with Arachnoidits/spinal neuroinflammation and the pain and discomforting sensations/symptoms that arise from it, could it perhaps help bring the chronic ongoing inflamitory cascade closer to homeostasis once more? P.s also can you look into Spm's (specialised pro resolving mediators) and talk about them, they have helped me somewhat but also they look not only to have a good safety profile but they tackle inflammation in a novel way of which has some focus on resolution of which could be an important factor in the battle against inflammatory conditions

You mention causes of neuro inflammation but you don't mention food as a possible cause. It's well known that the refined carbs and seed oils in processed foods can cause inflammation, couldn't this be the cause of flares?

Any update on this research ?

Can we please try rTMS for CFS?

I use a cpap and still feel like I’m dying. I’m in Alabama, is there any way you guys could check me out?

One hopes the incoming government will see the obvious value of continuing research to help these people, given that the presumed head of that government views such people as somehow less than worthy of the investment. This research is extremely important for the veterans and for everyone with related illnesses and injuries. Thanks to all involved.

❤👍👍

It was is Remembrance Sunday here in the UK yesterday the 10th, the first Sunday in November, where we remember everyone who fought in wars all around the world. Thanks for helping Gulf War veterans and the rest of us who have ME or FMS. Congratulations on getting the grant application submitted.

First, I want to thank all the Veterans for your Service, Dedication and Sacrifice for America!! Dr. Younger, Thank You for all your hard work and dedication to find help and possibly cures for us with FM, ME/CFS and Gulf War Illness. I have great Appreciation and Gratitude for you all, Thank You So Much!!! 0:06

Thank you Dr. Younger turns out the biggest problem for me was/is parasites. Thank you for all the work you are doing to help the world at this time. Peace

Thank you, Dr. Younger. I am a Gulf War Veteran. I am a sick/ill Veteran. I am having an MRI of my brain and cervical spine in four days. Since most of my neurological symptoms are also MS symptoms the tests are to determine whether I have MS or GWI mimics MS. I already have swollen optic nerves. I have had MRIs of my brain in the past with normal results. However, I have never had a MRI of my spine.

Agent orange? And the rest of the rainbow vets and their offspring are suffering and dying

Thank you!

Dr Younger would it be possible to do the same test with people standing vertically? I am sure it will show reduced oxygen because the blood is pooling towards gravity as often also seen in other forms of autonomic small fiber neuropathy.

The difference between a good life and a bad life is how well you walk through the fire. - Carl Jung The fire of inflammation is quenched by high dose linalool. Thank me later LOL

My hypothesis as to why the "normal" group is so high, is because they aren't normal. People become adapted to low level chronic pain, to the point where they don't even notice it. Women are also known to have a higher pain tolerance than men, so it might be interesting to compare the CRP of men who identify as not having pain and the women who identify as not having pain. If the pain tolerance is a factor, then (for a sufficiently large and random populations) the men should have lower CRP (because they have a lower pain tolerance, if higher CRP is causing pain, then the men will select out of the control at lower CRP levels)

"I can't just show these data in a paper, it merely serves as an input to develop a hypothesis". Wish 80% of other medical researchers would think this way :-)

LDN did nothing for my CFS.

Thank you for your dedication and determination . I am a typical Fibro/ CFS patient. ( led speaker based support group 13 years at local hospital. My final diagnoses from neurosurgeon experts : Chiari 0 and tethered spinal cord. Specialized urodynamic studies are the only way to make a final diagnosis of TC. Long story. In the large volume Spinal Cord Medicine : Principles and Practice, ( editor in Chief Vernon W. Lin, MD, PhD) is an entire chapter “ Immune System and Inflammatory Response in Persons with SCI. “ SCI patients show multiple abnormalities in the laboratory testing of the immune and inflammatory response...” Tethered cord does not present as what doctors think of as the classic spinal cord injury. Neurosurgeon Mehmet Selcuki presented a paper stating that idiopathic scoliosis may be the only sign of TC. But also, hammer toes, high arches raise suspicious. A lot to this, but degree of spinal cord tension may present in a spectrum and degree of various symptoms. Checking to see if any research includes C reactive protein elevations. But mine was ekevated several years ago. Now - positive ANA and circulation immune complexes.

Dr. Younger, are you aware of any studies that support that magnesium theronate calms the microglila back into the resting state? I would speculate that people with neuroinflammation from mitochondrial dysfunction might benefit from this supplementation.

Yeah but... where is the money that is going to fund all of this coming from? Thin air?

Are these tests hsCRP tests?

thank you for your work! people like you give me hope. :)

If I do have inflammation issues it must be coming from my brain because my levels are always normal. I thought the pain and fatigue is coming from inflammation in the brain 🤷

Thank you for keeping us all updated with your research. 🙏

There's an add about Covid vaccination attached to this video. My ME/CFS doctor don't recommend any vaccination for ME/CFS patients. I feel this is a good and right advise for me (everyone need to make a decision for themselves) Could you please highlight ME/CFS and different vaccinations?

I'm wondering what is the relationship between CRP and ESR? I have always had normal CRP but ESR is elevated. I understand both are markers for inflammation - do you have info on this please?

ERROR: The hs-CRP values I show in this video are in mg/L units (not mg/dL as I claimed). I will look over the videos and see if I need to remove them or reupload with notes added. For now, just note that all values I mention are actually mg/L, which is what you are most likely to see from your clinic or hospital anyway. Sorry for the mixup! - Jarred Younger

ERROR: The hs-CRP values I show in this video are in mg/L units (not mg/dL as I claimed). I will look over the videos and see if I need to remove them or reupload with notes added. For now, just note that all values I mention are actually mg/L, which is what you are most likely to see from your clinic or hospital anyway. Sorry for the mixup! - Jarred Younger

From Australia, my CRP which should have been between 2- 3. I was seriously ill with diverticultus with a CRP if 248 I nearly died. 1 year later admitted to hospital with a CRP 75 antibiotics drip 3 days. 3 years later CRP 9. Still very ill with my bowel disease.

Hi I have just come across your videos on pain and inflammation, I have question, if do not mind as a scientist and running trials on people with inflammation. Do you use people from the EDS community because we have13 different genre faults with connective tissue all over the body and different types of inflammation that if you don't EDS it maybe of interest to you on some level investigation, thanks for blood test info, stay safe 🙏🏴󠁧󠁢󠁥󠁮󠁧󠁿

Does the same pattern show up in men with ME/CFS?

I wonder if CRP would fluctuate through the day?

CRP is too broad - we need commercial tests for individual interleukins. Psoriatic Arthritis has the same problem - often low CRP, low TNF, but raised IL-23/IL17. Another problem is raised CRP is used as a metric to select patients for clinical trials (since they want a number to treat). Subsequently, doctors are biased by those results into thinking CRP has to be high to indicate PsA (while this is only true <50%). So it becomes a self-fulfilling prophecy. We have to be very careful in choosing a metric which might actually condemn half the people with the disease. ME/CFS might fall into the same CRP trap. Also we need immune repertoire sequencing to easily identify/exclude autoimmune diseases. Celiac for example get's diagnosed on a few well-characterized antibodies and the rest gets put into a basket of 'Non-Celiac Gluten Sensitivity' simply because those additional antibodies were never characterized.

Hi I’m sick for 65 years and never had a raised CRP so wondering why? I have pain , fatigue and hypothalamic pituitary dysfunction. Any ideas 13:40

Hi I’m sick for 65 years and never had a raised CRP so wondering why? I have pain , fatigue and hypothalamic pituitary dysfunction. Any ideas

What about nasal spray glutathione?

Just started taking neonatal adrenal glands. Seems to be helping post-mold.

I got a me/cfs , fibromyalgia,ibs diagnosis 3 years now ,i looked up the many blood test i have done and i found crp values 2 times witch is always below 0,3 . Watching your analysis and even though iam male and your data is from female i should start questioning my diagnosis.

Would you say Gulf War Illness is also Long COVID (long Lyme, mycotoxin toxicity, etc)? Are they just different names for an as yet unnamed post infectious disease or post traumatic event disease?

I went from 11 - 5.7 with LDN in a few months. Working on the last bit!

Most fibromyalgia is really just horribly treated myofascial pain syndrome. Myofascial pain syndrome is more common than fibromyalgia. Evidence for an association of serum microanalytes and myofascial pain syndrome Aishwarya Pradeep 1, Aybike Birerdinc 2, Travis Branigan 3, Vy Phan 1, Hailey Morris 1, Jay Shah 1, Secili DeStefano 4, Siddhartha Sikdar 5, John Srbely 3, Dinesh Kumbhare 6, Antonio Stecco 7, James Paik 8, Lynn H Gerber

I know it's a triggering drug in political terms but I understand ivermectin is being used in long COVID in Australia to good effect. It's a massive anti inflammatory

I really love your videos. Most researchers are terrified of talking about conjectures just in case they might turn out to be wrong. It's very refreshing to hear you speculate on some theories. Keep it up please! As to CRP, I wonder if it could be an early predictor to later chronic diseases. There are a lot of slow developing chronic diseases that we miss because we look at the wrong parameters, and we classify people as "healthy" although some blood values are already far in the red. (IMO "healthy" is much, much more than "symptom free".) Take for example fasting insulin and/or the HOMA score which are excellent predictors of later T2D, but they're missed in practice because hardly anyone measures fasting insulin. (Everyone looks only at blood glucose which is often lags decades behind insulin.) So, if we had time, then I'd take 1000 "healthy controls", partition them by CRP, observe them for 10 years and see which kind of chronic diseases they develop. My conjecture would be that those with high CRP have a much higher risk of developing ME/CFS or Fibromyalgia.

Test everyone for ochratoxin A. from aspergillus.

were the participants in this study asked to discontinue use of anti-inflammatories before having the blood tests? if not, why not? thank you very much for your work.

Excellent! 😎❤🤨