Відео

Por favor estudien la intolerancia al ejercicio y PEM

Gracias por la información y su interés en ayudarnos a los pacientes con ME/CFS

Would taking naltrexone at low doses be compatible with desvenlafaxin?

Do you think that starting with a naltrexone dose of 0.1 can avoid anxiety and insomnia side effects?

Is the paper big pharma?

I'm responding to nattokinaise enzyme.

Oh, and overlapping confidence intervals do not automatically indicate non-statistical significance.

Biostatistician, here. What is the CI for the effect size, i.e., difference between arms, which appears to be about 17%, arithmetically (not the individual point estimates for each arm)? Also, p values are declared statistically significant based on the alpha level selected as part of the design of the study, and the p is a probability, specifically the probability, under the assumption that the null hypothesis is true (and the null here is that there is no difference between arms, which the study would like obviously to be able to reject with the evidence from the study), that we would see the difference between arms of this size, or larger, under hypothetically conducted repeated randomized trials run (over and over) exactly like this one. Of course this RCT is only conducted once but statistical science (probability distribution functions) knows how likely our result is from all hypothetically possible results of this same trial, and that is what our probability is. So for me, as a biostatistician, I look at the effect size to see if it is compelling clinically (does it make a difference to the patient, and compared to other treatments, etc.), and the actual p value. The p value in this study indicates that the is result is quite unlikely (a bit more than 1 in 20 chance) assuming that there is no difference between arms. Hence, since this result is so unlikely assuming no effect, we reject our initial assumption of no difference between arms in favor of the alternative (hypothesis) that the difference is real--even, for me--if it does not technically achieve statistical significance by being p less than or equal to 0.05. This is an evocative study and should be followed by a larger one soon (my son has ME/CFS). I am a bit concerned about loss to follow up and would like to see the reasons for drop out from each arm to begin to understand whether the attrition is systematic (caused by something important) or not. My sincere apologies for the long post! Am open to questions if anyone has interest.

I think low cortisol is much more common now in the Long Covid sufferers, a paper even got published last fall in Nature about this.

I'm 62 now. I wonder if I should get my hopes up.

👍

Could it be poor glymphatic system drainage ? (it is a puzzle)

One company is selling for $8k/year 😅 taxpayers already funded all this research. Those people should be in prison for life

I have wondered if I might have this, but my symptoms have too many correlations to people in my environment and their subversive behaviors connected to depletions of my resources outside of my physical body as well as depletions of my physical bodys strength, health, energy. So i just figured im surrounded by body snatching vampires.

Fungi make and also consume OAA. Are we going to keep ignoring that all this is caused by fungi?

It's clear these people are looking for medicines not root cause. Everyone is so tired of the medical medicine nonsense.

Thanks again! The price and the conflicts of interest worry me. I hope they publish some bloodtest data. And if it helps 40% then an attempt at finding what cluster benefits would also be very useful.

I had really bad heart burn when I took OAA, even if I took it with food. Had to stop after 2 days.

I was interested in OAA for ME/CFS and found a comment about a previous paper by 2 of these authors that gave me pause. This is the previous paper: translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03488-3 and this is the comment/complaint an ME/CFS patient wrote up about it drive.google.com/file/d/1wBJrMdBl7JME5ZL5Qb-x_0ppMu-U5idq/view. I'd be curious of your thoughts @youngerlab. The complaints about the previous paper are roughly that (1) Cash did not disclose his financial interests in OAA (2) suboptimal trial design (they used a "historical placebo" arm, i.e. placebo data from other studies) (3) overlapping case and recovery definitions and (4) "impossible" biological claims about how OAA might be working via NAD+. I think the new paper addresses a lot of these concerns but I haven't read it in detail yet and I'm wondering if you think it's fair to be a bit cautious about it given the issues with the previous paper.

If these companies that produce this Oxalocetate really knew what CFS is, had it, they would open a non-profit to get this to as many CFS sufferers as possible.

I felt really unwell after taking a low dose of OAA (500mg) for just a few days. Any idea why? Was any follow up done on the participants who dropped out of the study?

Thank you Dr Younger. Your time and efforts are greatly appreciated. Wishing you a wonderful Christmas. I hope you get a chance to rest up, and to have some fun. All the best ☺🌲🎁🎄

The rice flour might be playing a role in causing people to drop out. Rice flour causes me significant gut problems, to the point that I can't take any supplements that contain it. Maybe I'm not the only one?

Thank you as always, Dr Younger :)

It's the best time of the week once again!

Thanks for this video, it sounds like OAA could be useful. Merry Christmas and Happy Holidays to you and yours, Dr Younger. I hope you get some time off. Thanks for posting all your videos in 2024, it’s been so interesting and uplifting to know a little of what’s going on. Love from the UK 🇬🇧

Try ozempic. It works. Cures many inflammatory conditions.

How much would the results of this study be affected by the possibility of subtypes of MECFS? So the responders would be a subtype, and for them this treatment is a really good option. It seems like this is a good example of of a treatment working really well for a subgroup, but overall it wouldn’t meet the standard for approval as a treatment?

Thank you for the good news Dr. Younger

Looking at the graphs, it seems the responders (40%) got significant to large benefits, while the rest (60%) got almost no, or no benefit. So, to Dr Younger’s point - it would be interesting to try to understand why the responders responded, and the others didn’t. They note in the paper that there will be further analysis on this. At this stage, it seems like it is a coin toss as to whether benefits might be attained from taking this. Need more evidence!

Anyone know what foods possibly contain OAA? As a supplement it is probably derived from a food?

Thank you 🙏🏼

Thank you for that info as im not up to date with anything ,nor have a Dr now looking after me,passed away 😢😢I'll look into it,although Ive reacted to EVERYTHING ive ever been trialled on so be interested in any/all side effects if ever you do video on that.Im not well enough to read the Paper.Thanks Dr Younger you're Amazing & Always give hope.😊

🎄Merry Christmas & Happy New Year to ALL on Dr Youngers Channel🎄🥳😊

If you are going to purchase OAA to try - please please check the back of the bottle as some contain VITAMIN C as part of the total mgs of OAA which is misleading (benegene do this on the 250mg tablets). You are not getting 250mg OAA, only 100mg plus 150mg of vitamin C. 250mg is stated on the front of the bottle which is misleading. The 500mg cfs tablets are actually just 500mg OAA from benegene I believe.

How long do you have to take it? What happens after the 3 months, does the fatigue come back? Thank you Dr Younger for all your work

If you take out the high responders (40%), the average improvement is about 10-15%? So would you conclude that for 60% of the people on the trial, the improvements are not especially significant? Or is that a flawed conclusion?

I know of a repeated failures of the use of RCT, including a triple-blinded study, during a single research topic done by world-class research universities. Open label studies are as legitimate as RCT.

Thank you Dr Younger for your commitment to this work. I enjoy your videos. It's meaningful to us. May God bless you ❤

Wow I was going to ask you about this study, without knowing you were going to do a video on it!

Important note: I mentioned in the video that there are several sources of OAA with different prices. Looking more closely, I see that the commercially available products use the same source for OAA, and appear to have similar costs. They generally would cost $650USD per month. Cost will obviously be a significant barrier for many or most people considering this potential treatment. - Jarred Younger

Is this something I can take along with LDN? (LDN doesn't help as much as it did the first few years. I"m on 6mg and that's as high as my doctor will prescribe.)

Why is it so expensive?

Terra Biological claims to have cracked the nut on making a stabilized OAA. That seems to be one of the pitfalls of just grabbing a bottle labeled OAA.

Looks promising as a boost to quality of life.

What other OAA are there? I didnt find any except for the terra biological one that has 3 brands in different doses(jubilance, benagene, OAA CFS) the highest dose there is 500mg and it's 500$ for a bottle of 90 capsules, it's about 670$ a month for 2000mg! in the first trial they went up to 3000mg, this supplement price is unreal.

Thanks for a great review

Sounds promising! I hope you take some time off and recharge. 😎

thank you dr younger. my daughter and i, like so many others, really need help.

Love your Videos !