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Always interesting content, thanks for visuals too.

Important content, thanks for posting! And especially timely in the light of recent events.

Yes! I would love to hear your lectures on brain bioenergetics & neuroplasticity! I am a retired 71 year old without much education in biochemistry, although I earned a PhD in a somewhat related social science field, psychology. And I really enjoy the material you present. Understandable yet often challenge me to learn more. I am often exercising while listening so have to go back later to see the slides. Never boring. Thanks again.

Thanks Mark. Extremely important. Our economic system is predatory. Warped regulatory system allows for poisoning people for profit then inserting them into a malignant medical system which also maximizes profits (with the aid of insurance companies). Don't see our system changing - we need a massive change at the federal level, but it is moving backwards.

Thank you very interesting. Some education is surely coming to psychiatry.

Felicitaciones, maravillosa informaciòn, Mark deserve to have millions de seguidores... muy muy interesante. Saludos.

Thank you!

On the graphs shown at 7 min, it would have been very informative to examine the lifestyle of those 70 yo and older who perfumed at or above the fit line for 20 to 30 yos. I assume there was a subset who performed well across multiple parameters.

Much appreciate your work and effort to give real science lectures to the public ❤ - happy Thanksgiving 🦃🍁

Happy Thanksgiving Mark! Thank you for the series. It’s been wonderful

Covers the bases, thank you! (will be back to take in my next “third” soon! )

Thank you so much for this! My daughter had her first seizure at age 18 and we discovered a massive brain tumor. Surgery wasn’t successful and she had radiation and immunotherapy. Sad to say it’s been 3 years and she’s on 3 different seizure meds but continues to have refractory epilepsy. We are desperately looking for help for both the seizures and the tumor

haven't watched this one yet but i'm really enjoying the series. thanks for putting these out!

Thank you. If one already does TRE (daily 16/8 fasting and moderate daily exercise), but is older like me (70), do you think that an occasional day, maybe once a week or every 2 weeks, of lower calorie intake (< 1000) combined with a bit more exercise might aid in the turnover of older more compromised mitochondria? BTW, my ketone level tends to be in the 0.3 to 0.6 mmol/L range by the end of my 18 h daily fast which is a little higher than normal suggesting lower insulin.

Amazing stuff 🔥

Valter Longo say that is bad to skip breakfast because it is bad for the heart to go without it.

My question is if we would just increase blood flow with FAR infrared Mats instead of sports .. would there be a positive effect also on the brain.. Older people have mobility issues .. so if we would just increase bllod flow with FAR infrared .. would that be positive . So its it the exercise or the blood flow.

Mark thank you for putting together this amazing podcast. Just picked up your book - looking forward to getting through it

Thank you! This is excellent!

Thank you Mark!

Thank you, learned a lot. Please consider having Chris Palmer from Harvard on a future episode. A lot of great research about ketogenic diet and mental health

Have listened to the first 2 many times, will listen to this one many times and then over time revisit and watch all 3. What's cool is there's just more and more new discoveries, esp w Michael Levine's stuff but we are entering a fun era of health and understanding.

Excellent - thank you!

i been studying the Mitochondria for about 4 years with its motility seems very strange because they can move through Fission or fussion and with the micro tubles and Kinsen with Dynien as one transports them to the positive and the other Negative side of the cell. they do so much more than making ATP. I been studying Cancer for 6 year and after reading Otto Warburge theory of Cancer I got fascinated with them. could I ask some of my Mitochondria questions ?

What is your personal regimen for fasting and exercise? Trying to figure out what is minimum effective dose of fasting? Does benefits increase if you go for longer fasting time duration?

Thankyou .. i will have to listen to this a few more times , theres alot to comprehend,

Excellent presentation and thank you for this It takes effort to do these videos What’s your take on infrared activation of mitochondria in the outdoor human ?

awesome talk! iv heard a lot of this stuff discussed at surface level in a lot of other channels, but this feels like we're finally down to the nuts and bolts. thanks for taking the time

18:30 addiction hipocaMpus 25:00. / 36:20 mitochondria 💀

Host needs to get out in the Sun ☀️. Broad spectrum sunlight is the single biggest way to improve mitochondrial function and ATP generation.

You are great 😊😊

Great work 👏 very interesting electro ,fluidlike, thermodynamical feedback loops of energy & mass at work, that's for sure. The amount of variety in the tranfer of exchanges is extremely interesting. Messengers, kenesis, miyo, matrix, tubler its just about exhausted every similar type of cellular networking or mode of conversation humans have ever dreamed up and running out of words and operation to even name them with lol That's not even accounting all that is communicated within. Regulators and receptors, fission,fusion, etc etc

Thank you for sharing such valuable insights and making complex neuroscience topics accessible. Your videos are a great resource for anyone interested in understanding the brain, and your explanations are both clear and engaging. Looking forward to more of your content!

Thank you so much for doing this series of videos, fascinating subject ! 🙏

I really really like the graphics you use during this video. You also present the information very well. Keep making these!

I have adhd you scientist are my only hope

Outstanding as always! thank you!!

I exercised almost daily since I was 60yo. As a lean 70yo man, I exercise EVERYDAY and eat daily omelet of 6x-large eggs (thanks Dr Harcombe & Dr Georgia Ede) and 1 small can of sardines (thanks to Dr Bozworth & Dr Dray) with garlic, ginger ETC cooked with EVOO. According to recent research - supplement of whey concentrate (not the isolate of which some good elements may have been removed). My daily protein is about 30-40 grams. For carbs I eat fruits, vegetables and honey - no rice, no bread, no sugar to maintain a lean healthy body. Excess proteins will be converted to carbs and fats. More heavy weights exercise will need much proteins foods that cannot be digested by older persons. Older persons [more than 40 yo] need only enough protein to maintain lean muscles for longer lifestyle. Spike protein is toxic (Refer to Dr. Campbell, Dr. Dan Zatarski, Dr. Longo, Dr. Rosdale, Dr. Tim Spector and others). Higher protein intake would require a person to lift heavier weights, which stresses the internal organs - heart, liver, kidneys, joints ETC - that’s why bodybuilders do not live long. I do not need much protein, because I maintain lean muscle mass for longer life. I do single leg or arm REDUCED EXERTION HIT [REHIT] daily for about 9-14 minutes for 2 sets [left side and right side] with 1-dumbbell [or 1-hand push-up] for 3-4 minutes until near exhaustion/failure to raise the heart-rate to about 90%, interspersed with 2-3 minutes rest; then repeat for the right side of the body. Add more dumbbell plates as we get stronger. The rest of the 9-14 minutes is for warm-up and cool down. Daily REDUCED EXERTION HIT [REHIT] with 2-exercises per day would sum-up to 14-exercises per week working different sets of muscles. Daily REHIT need less protein to metabolize for lean muscle-maintenance, until up to 140 maximum years. According to research, combined 1-dumbbell and cardio exercise increases health-span/life-span to 40+ years. Intermittent fasting must not be everyday - I sometimes eat 2x/week regularly when I feel hungry.

pregnant women not people... women get pregnant men don't

i believe dogs don't descend from wolves, these are two different species that evolved in isolation for quite a long period, as genetics suggests so proper comparison would be with these ancestral dogs not other branch that evolved by default with own typical specifics and is equally far from their common ancestor neanderthals also had a bigger brains, so yes the specific way of acquiring food matters here but also we differ from them big way because of speech related genes it may be that offensive hunting requires much more visual input, physical precision and higher muscle mass but also lower body mass directly impacts brain mass, as comparing our males and females animals were bigger in previous era when bigger fauna dominated and so they still hold genes and evolutionary library related to it as well there is a much simpler rule that big herd doesn't use brains that much... as it's self organisation takes over individual small group consideration if you can brute force with numbers you don't need any intricate strategy... and you don't need to watch your back as losses on edges of controlled territory simply can be ignored while keeping core devolved to save energy on unused systems while they compete much different way f.e. simping for humans for food.. or eating what easily multiplied because of invention of farming thank you for the great presentation!

I just came across your channel and am thoroughly impressed with the breadth of content you have. I intend to catch up on all these videos and look forward to more lectures like these in the future.

Have you considered adding a short qualification to say slap on the description somewhere that would tell the audience why you are qualified to discuss the topics at hand. I tend to avoid sources (vids) that I can't easily decipher credibility. Like listing the PHD and areas of work. Just something I personally like.

thank you soo much, for the knowledge

i appreciat the attemp... but the fist slide is utter nonsense. How can you think/write that the sun is the PROXIMAL source of energy? The proximal source = the surce that is closer/closest to the bain is the liver which prepares the glucose and ketone bodies. Also, the slide shows that you do not understand evolution. The whole theater of evolution is about getting rid of developmental constraints, in other words, from particular physics and particular chemistry, and particular biological environment, and if not possible, to render particularly strong influences back into the average. Hence generalists dominate this world: humans, rats, ants. so do yourself a favor and remove that first slide

Thank you, some of this is bringing back memories of good times in biology classes. I was astounded by some of these details. The human body is truly amazing.❤❤

Thank you! I definitely enjoyed this. Your summary of these processes was succinct yet cohesive & thorough. It helped me, a lay person, to better understand some of these processes & dynamics. I am wondering how caffeine might promote damaging excitotoxity. Looking forward to the test of this series!

Great topic Mark. Can't wait to dive into this series!

Echoing your Wow! I think it must’ve been a little tricky to title this conversation. I would have gone with Just Listen and Learn.

‘Too much enegy’… I immediately stood up and did my 4-minute nitrogen dump. Layperson speaking - if mice have more brown fat, can all of these diet experiments with mice really correlate to human metabolism.

Oh jesus "interviewer" says he doesnt even know what happened to Ms. Shaye and Lady Ruby, but asks about roodles??? ILY Dr. Lee; catch you on your other platforms, like Anthony Davis.'