Thank you for your insights! I know you've talked about level 2 and 3 longevity interventions (Taurine, etc...) and you are not taking any other longevity supplements besides Vitamin D and rapamycin... But can you please talk about the supplements of Novos Labs since they point to you as one of their consultants. Second question. I did a dexa scan after watching one of your video's and it seems I have ostopenia. My doctor said that I could eat some more calcium rich foods but since I'm male that I shouldn't worry. So I've decided to try out calcium-akg... What do you think of that?
Maybe a focus on nutrition might be helpful to reduce il-11. My diet (whole food, no grains but wheat germ) reduces my cytokines in general. I've never checked for il-11. Maybe I should.
Hi Matt! One question regarding the difficulties in differentiating the "cancer supression" vs "biological age" effects of treatments in mouse. Wouldn't shifting to rat models in aging research be better since their end of life pathology exams show more "diverse" causes such as heart and kidney problems as well? For instance, would it be prohibitively expensive for the ITP to do tests in genetically heterogeneous rats instead? Interestingly, it seems that rapamycin does work on rats as well, further strengthening the idea that it is acting on the biology of aging itself.
I am curious to know how long the controls lived in the rapamycin experiment. You made it sounds as if the untreated mice lived longer (had to be 900 days plus). If that's the case, this plus the benefits of rapamycin, might have made them live longer compared to to their mice plus rapamycin and trametinib? Or am I seeing this wrong?
Unfortunate that you did not mention the impressive effect of reduced interleukin 11 around a variety of fibrotic diseases. Unfortunately the focus is entirely on lifespan where healthspan considerations may be just as important. For folks with a variety of chronic inflammatory conditions that result in fibrotic lesions, blocking interleukin 11 looks very promising
@@mannmstormMelatonin has been shown to reduce the production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α. Since IL-11 is often involved in inflammatory processes, it’s possible that melatonin may exert some regulatory influence on the pathways that modulate IL-11.
Dear Sir, I am 47 years old man, for 12 years I took prednisone and azathioprine because of autoimmune hepatitis. Now for fifteen years I have not taken them because I have achieved remission. My ALT and AST fluctuate between 20 and 30. I would like to take rapamycin for so-called "longevity". Have you had such a clinical case of autoimmune hepatitis and taking rapamycin for longevity?. I do not take any medication, except for vitamin D3. Can I aggravate the disease, or is it possible or regulate my immune system to decrease my ALT and AST below 20 ? Thank you very much in advance. Best regards, Robert.
Thanks Matt. Question; if it is really possible to measure a meaningful "biological age" just via DNA Methylation, would that not mean in return that most of the causes of aging truly are also in the epigenetics, like David Sinclair proposes?
But in the same genetic background the combination seems to work better. Mice are heterogenous and you cant think o f them like humans who are very similar to each other. So I would like to think there is something there. Also, I don't think you can superimpose data from two different genetic backgrounds and say that the life extinction obtained is similar. As Matt said the data does show that the combination works better.
Matt is always talking about “wrap a mice in…” and poor grammar aside, I wish he would tell us what the mice are wrapped in.
LOL
😂
😂
And he goes on and on about aisle 11 but fails to tell us which store! It's probably where he's getting the mouse wraps from.
This video is so important I watched it twice. And then shared it widely.
Trametinib 0.5mg is $3786.00 for 30 tabs
Thanks Matt, incredibly useful for the layperson. We need more of this type of information out there.
Found this episode to be very informative, thanks for providing the insight.
Thank you for your insights! I know you've talked about level 2 and 3 longevity interventions (Taurine, etc...) and you are not taking any other longevity supplements besides Vitamin D and rapamycin... But can you please talk about the supplements of Novos Labs since they point to you as one of their consultants.
Second question. I did a dexa scan after watching one of your video's and it seems I have ostopenia. My doctor said that I could eat some more calcium rich foods but since I'm male that I shouldn't worry. So I've decided to try out calcium-akg... What do you think of that?
Maybe a focus on nutrition might be helpful to reduce il-11.
My diet (whole food, no grains but wheat germ) reduces my cytokines in general. I've never checked for il-11. Maybe I should.
Hi Matt! One question regarding the difficulties in differentiating the "cancer supression" vs "biological age" effects of treatments in mouse. Wouldn't shifting to rat models in aging research be better since their end of life pathology exams show more "diverse" causes such as heart and kidney problems as well? For instance, would it be prohibitively expensive for the ITP to do tests in genetically heterogeneous rats instead? Interestingly, it seems that rapamycin does work on rats as well, further strengthening the idea that it is acting on the biology of aging itself.
I am curious to know how long the controls lived in the rapamycin experiment. You made it sounds as if the untreated mice lived longer (had to be 900 days plus).
If that's the case, this plus the benefits of rapamycin, might have made them live longer compared to to their mice plus rapamycin and trametinib?
Or am I seeing this wrong?
Talking about Rapamicin is just a tease since most of us cant get any...
If you look, it is very easy to find eg MD maybe Philly area will prescribe it, online places you can get it.
Unfortunate that you did not mention the impressive effect of reduced interleukin 11 around a variety of fibrotic diseases. Unfortunately the focus is entirely on lifespan where healthspan considerations may be just as important. For folks with a variety of chronic inflammatory conditions that result in fibrotic lesions, blocking interleukin 11 looks very promising
Do you have any suggestions on what foods or supplements?
@@mannmstorm not potently, but omega 3s and plant polyphenols reduce il cytokines.
@@mannmstormMelatonin has been shown to reduce the production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α. Since IL-11 is often involved in inflammatory processes, it’s possible that melatonin may exert some regulatory influence on the pathways that modulate IL-11.
@@mannmstormjust eat lots of cheddar cheese, which is one of the foods contains higher fatty15 (c15). C15 is IL-11 and mTOR inhibitor!
Hello Dr Matt. You have mentioned your rapa protocol is 12 weeks. Is that 12 weeks a year or do you resume after a break?
Dear Sir, I am 47 years old man, for 12 years I took prednisone and azathioprine because of autoimmune hepatitis. Now for fifteen years I have not taken them because I have achieved remission. My ALT and AST fluctuate between 20 and 30. I would like to take rapamycin for so-called "longevity". Have you had such a clinical case of autoimmune hepatitis and taking rapamycin for longevity?. I do not take any medication, except for vitamin D3. Can I aggravate the disease, or is it possible or regulate my immune system to decrease my ALT and AST below 20 ? Thank you very much in advance.
Best regards, Robert.
Thanks Matt. Question; if it is really possible to measure a meaningful "biological age" just via DNA Methylation, would that not mean in return that most of the causes of aging truly are also in the epigenetics, like David Sinclair proposes?
We'll do an episode about biological age/DNA methylation clocks in the future! - Tara
Do we know the average lifespan of those humans that have the mutation in IL-11 signalling? Is there an effect?
But in the same genetic background the combination seems to work better. Mice are heterogenous and you cant think o f them like humans who are very similar to each other. So I would like to think there is something there. Also, I don't think you can superimpose data from two different genetic backgrounds and say that the life extinction obtained is similar. As Matt said the data does show that the combination works better.
Siim Land in his most recent video is claiming glycine can extend lifespan in humans. Make out of that what you will.
Matt is the inverse of David Sinclair. And he sticks to an intellectual approach (unlike Rhonda P and Layme N).
Agree totally, trust gain inte long run…
except that Matt is now a rapamycin pitchman, not a salesperson on the level of Sinclair though headed in that direction unfortunately