Metformin: Mechanism of Action
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- Опубліковано 18 лют 2021
- Metformin: Mechanism of action
Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class.
Still now it’s difficult to find a full explanation of the mechanism of action of metformin.
However, the primary effect of metformin is to activate the enzyme adenosine monophosphate activated protein kinase which is also called AMPK.
Metformin activates AMPK enzyme in liver which inhibits the gluconeogenesis. The inhibition of gluconeogenesis leads to decrease glucose production.
Patient with type 2 diabetes have considerably less fasting glycemia as well as lower post prandial hyperglycemia after administration of metformin. Also hypoglycemia is rare during metformin therapy. That’s why it is more appropriately termed as euglycemic agent.
There are other mechanisms also, like:
It increases the insulin sensitivity
Increases the fatty acid oxidation
Decreases the intestinal glucose absorption
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Excellent, thank you very much
Thank you for the video! I’m wondering if you have a video talking about GLP1a MOA ??? And/or compare metformin vs GLP1?
Thank u so muchhh seriously it was helpful
Just in two minutes.. you resolve my 2yrs problem 🤗
😀😀😀 exactly
Very well said.❤️❤️❤️👌👌👌👌
went from 90 to 120 kgs in 5 years. result? insulin tolerance that creates constant hunger even after 1-2 hours of eating properly. my doctor started 1000mg/day on metmorfin and after a few weeks of getting used to it I'm finally seeing results. now it takes at least 6-7 hours for me to feel hunger after a meal. lost 2 kgs already. gotta lose 20 more and I'm golden.
Wow, man. Good for you. Congratulations and Godspeed. 💪
Super helpful video!
Glad it was helpful!
Thank you ,sir
Very useful
Ive been taking this for roughly two months now. I have not noticed much decrease in hunger. Ive noticed a slight uptake in appetite. I eat and feel hungry a few hour later as if i had not eaten anything.
What are you eating? It might have caused a sugar spike then crash which makes you hungry. Also it is advised often to eat smaller more frequent meals. Exercise is always helpful, too. Not just for weightloss but for your body in general and your mind. Of course double check my advise with your doctor because I'm not a doctor at all, I just have learned some stuff along the way.
change your diat to fat mostly, eat IF only, stay healthy !
Maybe you ate placebo food, and the bluff wore off?
@@blue5659 😄🤷
So nice video
Thanks
what VIDEO EDITOR YOU R USING
i accidently took metformin tablet, now i am feeling week,now what should i do?
I accidently took metformin and now alltime i feel weak,now what should i do?
Good information
Thanks
Sir !
your effort is appreciated.
Keep making medicine topics in mnemonics.
Thank you
Your are most welcome. Keep watching
YUP SO USEFUL. CUT SHORT MY RESEARCH TIMES. I COMPLETED MBBS IN 2012 BUT IM NOT PRACTICING SINCE 2018. NOW 2022 IM HAVING GDM WITH MY FIRST PREGNANCY, I NEED TO REVISE THE TOPIC SO I CAN TAKE CARE MY BODY BETTER. BTW I LOVE FOODS TOO MUCH AND ALWAYS HUNGRY THATS WHY GDM 😭😭😭
please help/when i must eat metrofrim xr ? morning or after dinner? i have insomnia when i use in night ! can i use it at morning single dos?
Morning while you are having breakfast
Like boss....
Thank you 👏
You're welcome 😊
Can’t understand a word ...
My mother's parameter :
PP Sugar: 180
Fasting Sugar : 140
Age : 59
Weight : 54
Please advice whether I should start metformin 500 or teneligliptine 20 for the above case ? I don't want to start with both salts first up
Consult her doctor, not UA-cam. 😉 Always ask your doctor. They know you best.
What is the mechanism for the reduction of weight?
He explains this under “other mechanisms”.
- Increased insulin sensitivity
-Increased Fatty Acid Oxidation
- Decreases intestinal glucose absorption
- Delays gastric emptying.
You will more readily burn fat.
You will have more stable blood sugar levels.
You will absorb less of the potential glucose consumed.
You will feel fuller for longer, likely increasing time between meals.
Phenformin also belongs to this class
It does indeed reduce appetite. I've stopped eating in between meals.
@Thru the eyes of God right after breakfast and and after dinner. Do not eat empty stomach. You'll see effects after couple of doses.
Wow 😳😳
You didn’t explain anything man what is molecular mechanism ?
You are describing effects (or phenotypes), not mechanics. This mixup in terminology makes your video deceptive.
🙏🥹🙏🏻
It makes me fart like crazy
First sentence was 🫡🫡
We don't get MOA of metfomin anywhere but question papers have that question 😂😂😂
But your video was short and sweet thank you, hitting the like button for this video
People will do anything to continue eating sugar
Get someone to do this who can speak english
@silva1320 WHERE DID YOU LEARN ENGLISH AT?
I put closed captioning on.
Ungrateful fool.
🙏🏻🙏🥹