Multicellular Spheroid Dissociator

Stem cells are often grown in chemically defined media where they spontaneously aggregate into spheroids. Stem cell aggregation has been a technical hurdle for generating a large quantity of high quality stem cells. Dr. John Kim and his team from the Department of Chemical and Biological Engineering has invented a Multicellular Spheroid Dissociator, which is designed to provide an on-line dissociation to ensure disaggregation of stem cell spheroids into single cells that can be circulated back into a bioreactor to result in a more homogeneous population of stem cells. This technology is currently U.S. patent-pending and is poised to provide a great benefit to all scientists and developers who routinely perform cell and tissue culture. This also includes various pharmaceutical companies and R&D laboratories that rely on bioprocessing and where there is a need for high precision and low variability between batches of biological products. By implementing the Multicellular Spheroid Dissociator in their existing production line, cell quality can be maintained and variability can be minimized to help deliver a more reliable quality bioproduct.