Diffuse Large B-Cell Lymphoma Diagnosis& Treatment | Aggressive B-Cell Non-Hodgkin’s Lymphoma
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- Опубліковано 15 чер 2024
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Hematological malignancies can be divided into leukemias, lymphomas, and multiple myeloma.
Lymphomas can be divided into Hodgkin's lymphoma and non-Hodgkin's lymphoma.
Non-Hodgkin's lymphoma can be subdivided into aggressive lymphoma and indolent lymphoma.
Aggressive non-Hodgkin's lymphomas include:
*Diffuse large B-cell lymphoma (DLBCL)
*Burkitt's lymphoma.
*Mantle cell lymphoma.
*Precursor T-cell lymphoblastic lymphoma.
*B-lymphoblastic lymphoma.
Indolent non-Hodgkin's lymphomas include:
*Follicular lymphoma
*Marginal zone B-cell lymphoma (MALToma)
*Hairy cell leukemia/ lymphoma.
*Waldenstrom macroglobulinemia.
*Mycosis fungoides/ Sezary syndrome.
Diffuse Large B-cell lymphoma (DLBCL) is an aggressive Non-Hodgkin's lymphoma (NHL)...It's the most common NHL.
To diagnose, you need a core needle biopsy or an excisional biopsy of the lymph node
Uric acid levels can be high---Give allopurinol (Xanthine oxidase inhibitor).
Staging of cancer is important (Ann-Arbor classification based on history, physical exam and CT scan)
Treatment: Combination Chemotherapy (R-CHOP) regimen.
Tumor lysis syndrome can ensue.
PET scan is helpful.
The lymph node is a bean-shaped body (not a gland) that interrupts the flow of lymph through the lymphatic vessels.
Afferent lymphatics go towards the lymph node, while efferent exits the node. The lymph node has cortex (which contains the follicle, germinal center, mantle, and margin).
Lymphocyte activation and differentiation occur in the lymph node.
Lymph is a colorless fluid that floats in the lymphatic vessels (lymphatics) of your lymphatic systems.
Formed from the interstitial fluid (extracellular fluid) and returns back to the big veins (Superior vena cava) through the thoracic duct and Right lymphatic duct.
Lymph slows down when it passes in lymph nodes.
Lacteals are a special type of lymph, they are milky because they contain chylomicrons.
Lymph node enlargement can happen in cases of lymphoma (painless lymphadenopathy) or infection (painful).
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I had an exam last week .. I watched many sections of your explanation and I benefited and learned a lot! .. My meeting was excellent
My pleasure 😇...So happy you did well on your exam 👍👍...Please share my videos if you can!
@@MedicosisPerfectionalis sure we shared it already on facebook for other med students in my college..we love you
❤️❤️❤️
Love how u explain it wish U posted this in 2018
Could you please make a video series on ECG/EKG. That would be so nice of you.
R-CHOP (Rituximab + cyclophosphamide, doxorubicin, vincristine, and prednisone) was introduced in this vedio, and is the treatment of DLBCL.
Great job!! Thank you!
My pleasure 😇
Good luck guys 💕💖
Excellent explanation
Thank you 🙏
Can you use only radiation on Reoccurrence if it’s in the mediastinum?? That’s what I did
Can we use Bilnatumomab for treating relapsed DLBCL NHL ?
On 6th R CHOP cycle after complete response after 4 cycles with Deauville score 2.. Will I need radiation after 6 ?
In the last video you said NHL leads to Hypercalcemia but here you're saying just the opposite. Which one is right?🤔Thx in advance
I have had a chest X Ray and have been referred for a CT scan because I have a widened mediastinal. Nothing has been diagnosed as yet. But your video is much appreciated. Like you I cannot find others to speak to.
I - Answer c, II - Answer d
I thought the medium survival rate for high grade diffuse large B cell is more than 1-2 years? Whats the basis for 1-2 years?
1- Stage 4
2- R-CHOP
Brilliant
Thank you 🙏
LDH,M2M decreases and beta-2 microglobulin increases after 6 cycles of bendamustine+retuximab
if we get very small lymph nodes in pet scan what exactly it indicates??
Beta-2 microglobulin increases what is the meaning
answers: C, D
Hi sir can u put a presentation regarding autism if possible
Hey! Thanks for asking...I will add it to my list.
what the answer be?
My Father is diagnosed with Stage 3 Non Hodgkin's Lymphoma and Treatment is going on USA .. he had his 1st session of Chemo and doing well.. what is the survival rate of Stage 3 Non Hodgkin's Lymphoma DLBCL ?
@@inmyth1944 My Father have Triple Hit Non Hodgkins Lymphoma which is not common...and he had 3 session of Chemo and doing alright...
Thanks for asking
The life and death is the only thing which is in the hand of Allah ,u dont give ur own survival rate to himself just for one minute only
We give the survival rate even tomato or other things but we dont give the survival rate to himself
3B and RCHOP only as the pt is old...so palliative chemo
Preety Makhija
Why 3B? He doesn’t show any B symptoms, the cough is due to compression on the airways (and B symptoms do not include cough nor pain). And palliative chemo is when the patient is old AND refractory to first-line treatment, so R-CHOP is given with a curative intent. Age over 60 and stage 3 do give him an unfavorable prognosis, but it doesn’t mean he’s in the palliative stage just yet.
Can severe spine pain be caused by follicular lymphoma transformed into aggressive diffuse large b cell lymphoma?
Could be ankylosing spondylitis
Hi, what is the name of the video where you explain why HSCT is only for young patients? Great video again!
Thanks a ton.
I don’t remember the exact video.
But the answer is:
1) There is a supply and demand issue here...These operations are very expensive so we preserve it for young patients.
2) Old patients usually die from something else other than cancer (e.g. heart disease, stroke,...etc)
3) The outcome (success rate) is much better in the young than the old.
Are you a new viewer? Welcome 🙏
Thanks for answering so fast! Yes, I am a new viewer 👍🏼
Glad to have you here 😊
D, D?
Hey guys! Can someone tell me why it’s stage III and not stage II on the Ann-Arbor system?
What’s the difference between stage II and III?
it crosses the diaphragm (inguinal below, mediastinum above)
@@sophiakerzner543 Thank you!!!!
🌱U are the plant of everyone('medicos out there,) hopes to get the correct knowledge.. Thnk u a lot
😊😊 Thanks a million 😊😊
Can you please help me by sharing?
@@MedicosisPerfectionalis sure... 100%promise 🌱
stage III because it is in the mediastinum and the inguinal nodes
Give R-CHOP and avoid radiation because it is not localized in one area... Right?😏😏
Yes Ryan. Radiation can ONLY BE USED when there's no metastatic positive nodes/tumors as in Stage 3.
Answers?
D and D
C
👏👍
❤
Thank you!
D
R-CHOP
CAR T CELL is a CURE
R CHOP
I have large b lymphoma
I never knew HIV was involved with some cancers
Yes, it is
i cant speed up most f ur videos
Why?