Lymphoma Explained Clearly - Hodgkins & Non-Hodgkin's Pathophysiology
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- Опубліковано 7 чер 2024
- Understand Non-Hodgkin's Lymphoma with this clear explanation from Dr. Seheult of www.medcram.com/?Y...
This is video 1 of 2 on lymphoma.
Speaker: Roger Seheult, MD
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
Co-founder of www.medcram.com/?Y...
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I was diagnosed with Hodgin Lymphoma since last month, now im getting chemotherapy. Pray for me, i hope luck is in my side so I can be Cured
dwi dyyra 🙏
Praying for God to lay his hand upon you and restore u to perfect health. God loves you
You’ll get through this most high has your back🙏🏾
I'm not studying to be a doctor/nurse or anything. but my daughter was just diagnosed with lymphoma and this is the most informative video I have seen. Thank you!
Diagnosed in May of 2021 with diffuse lg B Cell non Hodgkin's lymphoma. Started aggressive chemo immediately, May -dec of 2021. Shrunk the tumor, but my body has not been the same. I lost 110 pounds, constant fatigue, have had COVID 4 times, spent Jan of 2022 in the hospital fighting COVID and pneumonia, while just coming off chemo, my face has aged at least 10 year's. If I get a recurrent diagnosis, I'll think twice about chemo.
See the whole series at www.medcram.com along with other top quality videos including reviews in pulmonary, cardiology, infectious disease, and hematology!
Good day thanks for coming back to me to hear you. Such a wonderful voice and way to make me understand everything even english is not my mother language. Bless you.
i have seen many lectures meant for medical students but they are not as full of information as this one...this is really great :) this lecture was worth spending time...moving on to next lecture with high hopes
Dude i love your channel.Every time im stuck in first aid I always wind up at your videos.
Hello, that was great, please more lectures about chemotherapy and cancer
first time to understand lymphoma , Thanks Dr
Just add that, bcl2 is antiapoptotic gene that gets overexpressed when translocated next to IgH gene (on Chr 14), so cells skip apoptosis, hence lymphoma.
thanks for the video :). one thing i wanted to mention... i assumed that the translocation(14:18) of the bcl2 gene to the Ig heavy chain locus caused overexpression of bcl2 which stabalized the mitochondria and prevented apoptosis...rendering the cell immortal...
In January I was diagnosed with T cell anaplastic large cell lymphoma, ALK positive. Truly fascinating stuff I’ve learned throughout this.
I was diagnose with t cell non Hodgkin's as well back in 2016, still fighting this .
I m learning a lot about this type of cancer.
Its a hard war in your body. Somehow I keep getting another chance, ja
Thx
I was taught that Bcl-2 allowed the cell to avoid apoptosis, and the translocation junctions the Bcl-2 gene to the gene encoding the heavy chain of immunoglobulins. B cells transcribe the immunoglobulin genes a lot, so every time the heavy chain gene was being transcribed, the Bcl-2 gene would be transcribed too, giving the cell more Bcl-2 and therefore more evasion of apoptosis...and I just realised someone else has already explained this further down but oh well :p nice video though! thanks!
i thought the same bcl-2 and bcl-x antiapoptosis ???
It inhibits and induces cell death.
Last night I noticed my right side under my arm to the front is swollen,were the lymph nodes are. Just one side very visibly. I don't feel a lump underneath but I didn't palpate to much because it makes me feel uncomfortable. I made a doctor appointment and it's in 8 days.. my biological sister has had breast cancer twice and 3 of my paternal aunts have had breast cancer. My mother who is in her 70s never had cancer but her along with my sister and paternal aunts test positive for braket. I never got tested because my insurance would not cover. The spit sample they took on me was sent for testing but I recieved a letter saying they couldn't test. But anyways.. I have a doc appointment soon and I'm hoping I don't have cancer .I would hope whoever is reading this can say a prayer for me. I'm 46 years old and my name is Tina.
This is very helpful. Thank you so much!
Excellent as usual.
thank you so much
it really helps me a lot
Thank you . It was of Great help
great!! can you please do one on Diabetes??? thank you
This was very useful.thank you sir
All I know is I had diffused large B cell non Hoskins lymphoma. I finished my chemo Jan18, 2018. Feel great. It was found when I got my mammogram. Lady's get your mammogram every year.
Great! Thanks!
You made a mistake while explaining follicular lymphoma t(14;18). bcl-2 is an ANTI-apoptotic gene that codes for stabilization of the mitochondrial membrane preventing cytochrome c loss from the inner mitochondrial space (and downstream caspase cascade). The translocation to the heavy chain locus on chromosome 14 results in overexpression of bcl-2 making the cells unresponsive to apoptosis.
Thank you!
Great!
Thanks alot .
I’ve been treating for non-Hodgkins lymphoma and before my last treatment I was diagnosed with classic Hodgkin lymphoma I my lung. How could this happen.?
Thanks alot :)!
I just got a NHL diagnosis 2 days ago. I see the Oncologist/Hematologist Aug 10.
Excellent presentation.
Thanks.
Thank you so much.
Amazing doctor .. Thank you very much!!
لا شكر علي واجب
+crazy doc clearly😎
very good but i ask the difference between leukemia &lymphoma blastic
Very nice, useful video! Just noted one mistake at ~16:32. c-MYC is not a tyrosine kinase. Its a DNA binding transcription factor.
Yes, thank you for this clarification. c-MYC is part of a cascade that is part of a tyrosine kinase pathway, but is not a tyrosine kinase gene as I suggested.
Cesium is found in natural nonradioactive form. . Thiosufate. . In fresh unpolluted water helps. .the lymph glands clear. . Redhills bakin powder without alluminum is a great buffer. .
very nice!!!:):)
I'm so lost and confused :( I had melanoma and surgery removed it, but a year later it's back in my neck in lymph nodes, is this lymphoma? Because I have all lymphoma symptoms but my oncologist has not said anything about lymphoma. I have serious bone pain I lower body and night sweats quite often as well as my body gets so itchy mostly at night and has often kept me awake all night. My doctor has not diagnosed anything except he says it could be anxiety, I had a PET scan and it apparently shows just one spot on my neck which I'm getting surgically removed a second time, parotidoctomy and neck dissection to remove all nodes in the area. Does anyone have any input on this? I need to talk to someone
Chris, bone pain and night sweats are signs of leukemia. You should talk to The Leukemia and Lymphoma Society to see what information and help they can give you. Take care of yourself, mythical beast.
hi! may you please do a video about BMT and PBSCT...thanks!
Thanks alot .... go ahead
So what. Which ones are more serious and when should you think about treatment?
When you give plasma, do they take your white blood cells and give you back your red blood cells? I ask this because I have read that NHL increases when people give their plasma overtime.
Not a comment, I'm just putting this here for reference as I read this video. I got tired of pausing and going into my iBooks to see lab work. Remove if you want. Thank you.
Large B cell lymphoma. Large atypical cells positive for cd20, pax5, significant patchy staining for bcl-6. The large cells are negative for ae1/ae3 cd3,c5,cd10, and cyclin d1. Small background lymphocytes show populations that are both cd20 and pax5 positive as well as a population that is cd3 cd5positive. Positive staining for bcl6 may indicate lymphoma of center cell origin.
+Michelle Denise awesome! Your comments also help others. It's the beauty of this platform. Thank you!
I have a solid, swollen lymph node on my neck that cant be moved, it's been there for 3 weeks now and no other symptons, I have an appointment today, I'm so concerned.
Any update?
Can people with lymphoma maybe non hodgkins or hodgkins... When they have swollen lymph node for more than 1 -2 years and then the lymph node decrease in size in a few months and then maybe spread to other lymph nodes causing them to be slightly swollen? If that makes sense I'm sorry if it doesn't
No mention of diffuse large B cell lymphoma?
RIGHT?! That's what my daughter was just diagnosed with. I was hoping to see something about it, but didn't. I still learned a lot though.
What he referred to as the first intermediate lymphoma under ‘follicular’ is most likely diffuse large B cell lymphoma. He mentioned that it was a progression of follicular lymphoma to a “large cell lymphoma”. He just didn’t use all of its title
Good approach... But you should update this according to current WHO terms otherwise it will cause confusion
cMyc is NOT a tyrosine kinase gene. It is a transcription factor
Dose all lymphoma show in blood tests?
SuperNinger no, I’ve heard of tons of patients that had a blood test that came back normal but they later got diagnosed by a biopsy. The only way to diagnose lymphoma is a biopsy.
Can Hodgkin's Lymphoma - C81 be cured?
Health Anxiety 😔😥
I have been having health issues for last three years including recurrent cervical lymph node swelling but on the right cervical node should I ask my pc to look for lymphoma as it’s been three years almost of same lymph node swelling and a normal body temp of 99 degrees since pre covid era also I am a legionaires survivor idk if I can ask for guidance or not but opinions r welcome
Can lymphoma be diagnosed through a blood test ? I hate biopsies....
no
So how are you supposed to work out the actual cell deformities (cleaved, chronic or acute, follicles or diffuse) from the actual names of the cancer?
E.g- Small Lymphositic Lymphoma.
*(As far as I can tell, its small=so acute cells, (but apparently it looks like CLL, a large matured cell-why?). And they are B-cells, but the name only mentions that its in the Lymphoid lineage so how can you tell they are B???)
E.g- Lymphoblastic Lymphoma (I get they are blast cells (immature, acute)..where does the name indicate a Tcell??)
Am I to understand that the names hardly give you an incite to the cell deformities ?
I have it in my lungs not fun in pain but cant have chemo had radation ..theres gotta be a cure my nephew died from it alot do ..whys that?
I get it :)
Lymphoma vs herndisk?
Follicular lymphoma- TX: low dose chemo or rituximab-anti-cd20 ab
I have RA i take chemotherapy. So I guess I’m like one of those Tcell Bcell that don’t want to die. 😂 sometimes best medicine 💊 is a good lol. Good luck 🤞🏼
Clear as mud
I hope Gavi is okay
but where is the multiple myeloma and plasmacytoma?
+Berhiv DURSUN
Technically they are Lymphomas, you're right. However they are usually discussed separately as "Plasma Cell Disorders", along with Waldenstroms Macroglobulinemia.
dumb nut
when you cut 80% in to two, it should be 50% still. I was waiting for the other 20%, expecting there was another variant of B Non-Hodgkins, yet still, very informative and helpful.
🤔nothing about CD20, MCL, 11 &.14 translocation..?..🤷🏻♂
I need a smart doctor like yourself... I am so sick.. I know this crap is in my bones, my nurse practitioner thinks i'm crazy.. my family misses the real me.. I actually hate how you warn on what's on tests, cuz my weird sickness (I have had dr.s Talk about lymphoma for 9mons now) I guess I will die, and my pretend doctors will lose their jobs... that is a horrible and sad statement..
Trust your instincts, never the "professionals"! I almost died bc of quacks.
How are you now?
A *pop* toe sis
This explains nothing
CD19... covid-19?
Eat more alkaline foods and never need to worry about being sick ever.
Dieter Soegemeier what are those?
Now take the tras out of the water. . .your least common denominator