This guy changed my life. I had been suffering from bleeding ulcer from fourteen. My doc said exactly the same: stress! Fast forward over 25 years and finally my doc says it was found to be a bug! I actually took the pepto and two other drugs. Six weeks later, no burning pain. I love this guy...
Holy S**t Dave! This is one of your best EEVblogs ever! As a physician (pathologist) and electronics hobbyist I was thrilled and amazed to see you bring in one of the major heroes of medicine. Well done!
I didn't bring him in, he contacted me on Patreon said he's in town and wanted to drop by, he was here an hour later. Decided to switch on the camera just before we both had to go. This certainly wasn't planned.
Dr. Marshall is fascinating and what a great sense of humor! You guys got along so well. Great chemistry! I wish I could have been there. I'm going to replay this one over several time. Thank you!
do australians just have more character or something? the american equivalent of that guy would be some boring, humorless dude who is careful of everything he says. i've noticed the same with australian vs american news segments - australians just seem a lot less uptight and don't get offended at everything like americans do
It's a very egalitarian country. If you put yourself on a pedestal we will knock you right off it. Politicians fall over themselves to be a "man of the people" if they are male.
Our culture has WAY to many SJWs. ( but it's infecting the world now). Most of silicone valley and the mass media are infected by them so they spread the crap wide and far. Mob mentality is rampant, so anytime they can, they will try to destroy whatever/whoever they can for ratings and/or power.
Bismuth is actually considered extremely weakly radioactive. It was discovered in 2003. It's half-life is more than a billion times the estimated age of the universe though.
@@denny9931 Except that the Wismut AG despite its name (for non-german speakers, "Wismut" is the german name of bismuth) never produced any bismuth, only uranium (and they had some experimental tin and silver extraction plants for a while). Even though uranium mining stopped right after the reunification in 1991, Germany is still in fourth place worldwide in total accumulated uranium mined, after Canada, USA and Kazakhstan (until 2014 it was in third place, then Kazakhstan overtook, and Australia is about to surpass Germany within the next few years).
@@leocurious9919 Let's better say "is one of the german names". Both are still correct, and if you look over the centuries, it was a constant back and forth between "B" and "W" from different authors. Apparently there's a whole book about the possible origins of its name and why those two major variants exist in german.
Fantastic! This guy caused a paradigm shift in medicine! Think outside the box and eschew conformity and dogma. A personal hero of mine. Thanks. Barry and Dave
I suffered with reflux and ulcers for several decades until last year. I kept hearing the same BS from the doctors, it was stress related. Last year, I was having intestinal issues for a while and was regularly taking peptobismol a couple times a day. During the same time I was also going to the dentist for a dental implant. I thought the reflux pains were related to my dietary changes and the stress from the pending operation of the dental implant. The dentist prescribed me antibiotics after my dental implant operation. I was taking both pepto and the antibiotics for a little over a week. It wasn't until a couple months later, when I was finished with the implant procedure and was able to eat regularly again, that I noticed I did not have reflux pains any more. I never understood how or why, until now. I looked up Barry's research today and it correlated with my experience. To this day I still have no problem eating spicy foods such as hot sauce, spaghetti, sausage pizza, tomato paste was the worst, or even drink wine. It has been a whole new culinary experience for me since. Now I know why! Thank you Barry!
Well, there's the Nobel for Physics, which was every now and then awarded for stuff pertaining to electronics, or at the very least that found application mainly in electronics. For instance, in 2014 or 2015, the Nobel for Physics went to the team of Japanese guys who invented the blue LED in the early 1990s, one of whom was an actual electronic engineer. A few years earlier it was awarded, for inventing the CCD image sensor, to a team of Americans whose "piece" of applied physics they professed in isn't all that much removed from electronic engineering, and can properly be said to fall within "electronics done professionally" (though not necessarily in the sense of designing and testing circuits, but rather more basic research). And I could go on cherry picking Nobels all the way back to the early 20th century, e.g. to Guglielmo "father of the radio" Marconi in 1909, himself an electrical engineer by trade (I think the word "electronics" hadn't even been coined at the time, or at least wasn't in widespread use).
@@Krrypton I must admit I haven't know much about Nobel prizes I just made a fun comment. As you wrote there is the basic researchers the winners although Marconi rightfully fits here. His radio with spark gap and coherer we can call electronics. He used the available parts of the time and made an usable device. I think he wasn't the first or even the second in the research of radio transmission but he made it available for mass usage in the quote marks.
Well, it's not always basic research, and certainly not always "pure" or theoretical physics. The first two examples above are on the cusp between applied physics and engineering (like much if not most R&D in electronics nowadays, for that matter). The Nobel for Physics has been established for _discoveries or inventions_ in physics, and that covers quite a lot ground, from theoretical physics to actually inventing devices like a new type of LED, image sensors, holography (Denis Gabor 1971, another electrical engineer), development of the electron microscope (1986), developing the integrated circuit (yet another electrical engineer) using the transistor whose invention was also awarded with a Nobel a few decades earlier... Now, of course, these are fruit of work that's much closer to basic research than a century ago, and usually involves a rather good grasp of theoretical physics, especially quantum mechanics - but then again, so does the design of, say, a new CPU by AMD or a new image sensor by Sony, which falls right under comparatively much more mundane "engineering". And inventions... well, it's been a long time since any noteworthy invention came out of "putting together available parts", the endless stream of prizes at hundreds or thousands of invention conferences and expositions around the world notwithstanding (and never even mind that 99% of these prizes are awarded for all sorts of useless and pointless contraptions).
Thanks Dave (my dad had an ulcer and was cured by Doctor Marshall's research). Drug companies loved selling what was in effect flavoured chalk to suppress symptoms instead of developing an actual cure, because there is so much more profit in servicing a chronic condition, than curing it.
Dr Marshall is right about how some individuals get the Nobel Prize based upon one of the committee members suffering from a particular malady. In 1998 the medicine prize was given to the 3 researchers that figured out how nitric oxide affected the cardiovascular system in such a way that it ultimately led to the creation of Viagra. No doubt a few of the older committee members were thankful for this accomplishment and thusly showed their appreciation with the award.
Please re-read my remarks and note what I said. I did not say they invented Viagra. I said their research led to it. Also I would take issue with accidental serendipity. The people working in this field are very good at applying abstractions to basic research and working out new pathways to discovery. It is a dynamic process. Heuristics at work.
Yes, the committee remarks were meant to be tongue in cheek. Dave and Dr. Marshall were incredible together. I felt my original remark was a play on the lightness of their banter. This conversation, for me, was probably the best one of all I have watched on Dave's channel. Too bad, as Dave remarked, they did not record the off camera comments. I would love to be in a pub with these two and be a fly on the wall.
This was a very interesting show from start to finish. It also contains the best description of physiology I have ever heard. My father was Donald Mathews. He wrote a little book called Measurements in Physiology which was used as the textbook in most of the colleges in the US and maybe the world and he never explained it to me that simply. From watching everyone of your videos I have come to two conclusions. Firstly you are a combination of three disparate and hard to find qualities, social talent, humor and knowledge and secondly Australians just have a different outlook on life than we in the US do. Thanks and keep up the good work Dave.
Gosh, I can only reiterate what has been said many times already in the comments... what an amazing bloke! Considering his academic credentials and life history how down to earth! Thoroughly interesting subject! Cheers Dave for turnin' the camera on and posting!
I spoke with my doctor about Dr Marshall only last year. He's a hero of mine for having infected himself with H. Pylori and then curing himself. It was quite controversial at the time. I'm happy he got the recognition he did, and managed to cure not one but two diseases. Meanwhile... Thomas Crapper was merely a plumber that invented some improvements to the water closet, including the floating ballcock. He had 9 patents when he died. Of course, his name is a coincidence and nothing at all to do with the word crap and its offshoots.
When I took over the family sheet metal workshop, we lent out some space for an installation consultant that worked for Flextronics. He went out and worked at Astra-Hässle's plant that makes Losec. They, A-H, ran the plant at full tilt so Orvar, the consultant, had a hard time getting access to the production lines, it ran 7-24, even on Christmas and New Year. A-H blamed it on expiring patents or something stupid like that. They knew that their new wonder drug wouldn't make money much longer. Treatment pays better than cures. Ten years later I helped some inventors, can't talk about that (NDA still in effect), both worked at CTH, one former professor and the other taught material science. They told me not to stress so much, because I would get stomach ulcers. I mentioned Astra's woes, Helicobacter Pylori, the cure, the Nobel Prize and they still didn't want to believe me. The professor had worked on studies on lung cancer in asbestos workers. (smoking + asbestos = 100% cancer in 20 years)
What an interesting bloke. I quite enjoyed the off-topic-interview format, would be good to see more! 👍 NSAIDs are actually more dangerous than people than people realise. I had stomach ulcers at 30 (otherwise healthy, aside from a longterm leg injury), I'm now a coeliac when there's no family history or prior symptoms.
I will watch it surely after I finish making corrections to my PhD thesis. DO NOT DO IT AT HOME!: Already had 5 energy drinks today. Feels like my heart might pop out, but science and engineering rules :)
@@macieknapora4591 Seriously, do not do that ever. I did similar things when I did my PhD thesis, and after a long PhD thesis battle, many body parts started to complain. I went to see different doctors for various pains over the coming 6 months, and only till not long from now they subsided.
'people have died from that many'....usually caused by some other underlying condition...ive routinely drunk 4-6 cans of energy drink a day for the last 10 years without any issues..most of the energy drinks have less caffeine than an expresso...
Wow. Barry is a great interview. So many fun stories. I forgot all about "ulcers", but your chat triggered memories of the days of "stress ulcers, no spicey food, etc...". Facinating! Thanks Dave.
One of your best interviews. I hope there is a second and third and more part for it; and if Dr Barry can hack some electronics stuff it will be even better. WOW!!!!
It may have been mentioned before (didn't scroll through the previous 374 comments), but the VintageTek museum is located on the Tektronix campus in Beaverton, OR. They've got limited open/operating hours, so be sure to check their website (or contact them) before popping in for a visit. Great place, with some awesome volunteers (and Tek technical royalty!).
Thumbs up for identifying posture as a big cause of aches and pains 👍. I'm a physical therapist and see pain patterns are often linked to a person's postural habits.
great info here and note to all the hospital he was working in (royal perth) ia 99.9% totaly goverment funded and treatment there is almost all medicare funded....gov funded health care works.
i have stomach ulcers... and it gets worse when i am in stress... it gets worse when i was out of my comfort zone(home)... like when i was with my relations.. bad frnds... etc....
Stress causes various hormones increases. Adrenaline, insulin, cortisol, and several others. Some of these also cause acid increases, so this will cause some of the additional irritation. These same changes contribute to various diseases directly and indirectly. Weight gains from chronically high insulin and cortisol compound the issues. Anyhow I am not a doctor, just have some experience with these issues. Stress probably doesn't directly cause various diseases, but almost certainly will contribute.
Apparently my doc was QUITE informed. He learned of your discovery back in either late 80's or early 90's and treated me for my ulcer problem with antibiotic treatment way back then.
S-100. Yes! Built my first computer in 1979, and it was a IMSI S-100 clone. Still a computer/electronics hobbyist, but I did work at a medical school...
I *OWN* an IMSI with a secondary terminal. Pretty rare these days. I have so far only found one other, and it is in a museum. gallery.anotherpower.com/main.php/v/My-projects/irc_posts/3801.jpg.html . Does this look familiar to you?
Never seen one like your''s . Must be a later model. Mine was made by Fulcrum, looked almost identical to the original IMSI, which was very similar to the Altair.
Thank you for your work and research Dr. Marshall. I have IBS...it’s awful but you and your colleagues give me hope that one day it can be treated effectively. It really means the world to me!
fun fact, in eastern Europe, bactericidal oils have been used against ulcers since 1940 pl.wikipedia.org/wiki/Balsam_Szostakowskiego my friend had stomach ulcers in the 1970s/80s and cured them that way by doctor's recommendation
I'm not aware of a vintagetech museum in Boulder. But there is a vintageTEK museum at the Tektronix campus here in Portland, Oregon. And I'm fairly certain that the picture you had at 46:48 was actually of the back wall there. On the off chance that this is the place you're talking about, then I'd be honored to have a Nobel laureate in the same city as me! vintagetek.org/ As a side note: California has Silicon Valley, sure. But did you know the Portland area has the Silicon Forest? Intel and Tektronix both got their start here. And a ton of other hardware companies maintain a presence in the area (Microchip, Maxim, Linear, ON, etc...). Take a gander sometime! en.wikipedia.org/wiki/Silicon_Forest
An idea for a video: How to tell a good used multi meter vs a bad one. I've seen some 'nice' multi meters in pawn shops for sale for cheap but have not bought them because I have no clue how to tell if they are still good.
Bring a battery, bring a resistor. Or multiple if you want to try all the ranges. You can also test current with the batter and resistor. Dave often judges a multimeter by its build quality and circuit quality. But yeah I reckon the shop wouldn't let you open it up. The most you can do is make sure it operates. If you could find pictures of it online or reviews then that would help.
+serpentza +ADVChina You should have this Nobel Prize winner Dr Barry Marshall on your channel to help educate Chinese people to this simple treatment to save lives from stomach ulcers and cancer.
Son of a bitch... I think I've been suffering from this bacterial infection for a greater than 7 years. I went and got some Pepto-Bismol on Sunday and I feel better than I have in nearly a decade. Thank you so much for for this video Dave you have absolutely no idea how grateful I am.
On the subject of electronic engineers getting migraines. Watch out for any old metal can transistors that have white crystals growing on the metal can or a white powered around them! I'm not 100% sure what it is, maybe arsenic or beryllium. But it will give you one HELL of a migraine if you get even a microscopic amount on your hands and then eat something. It might even kill in larger quantities
This was tremendously enjoyable, especially since I used to keep up with stuff like that and had read about the discovery when it was announced. When I told people about H. Pylori back then, of course they didn't believe me.
Now that we have rapid h. pylori tests and everbody with ulcers are routinely tested, we know not all ulcers are caused by h. pylori. But if yours are, well, good on you. I'm not slighting the work of Marshall et al. at all here. But in this interview he's a bit too categorical. I'm not saying that stress is an explanation for the remaining cases, by the way.
Stress causes the fight or flight response in our bodies though, and being in that mode for too long damages vital organs in the body, due the adrenaline etc being in the system for longer than intended, e.g. nature only intends it to do that for mins or hours at a time, NOT a permanent daily state. So I would say that stress is pretty dangerous in that scenario, but apart from that the doctor here is correct about it wrongly being used to brush patients off with a duff diagnosis.
Am I deaf or where did the part go where he talks about taking out is medal to get into a expo via the back entrance. Did you edit the video via youtube's fancy online video post-censoring tools?
This is brilliant.
And the first time I've shared an EEVblog link with my sister (who is a nurse).
...and now she is fixing boards for a living.
It's like a science/electronics version of Joe Rogan lol this should become a regular thing.
It was the first time my wife who's also nurse shown some interest in this blog. Hope it wasn't the last.
This guy changed my life. I had been suffering from bleeding ulcer from fourteen. My doc said exactly the same: stress! Fast forward over 25 years and finally my doc says it was found to be a bug!
I actually took the pepto and two other drugs. Six weeks later, no burning pain.
I love this guy...
How long ago was this? I had the diagnosis and treatment for bacterial infection in late 80's or early 90's.
wolvenar late 90's
My wife had ulcers too, and the bacteria was the diagnose. Some pills later, she is cured from ulcers. Now I know whom to thank it for.
You won't believe it but I know doctors who still believe that H. Pylori is a controversy. Or should I say "doctors".
@@dmitryivanov2960 I think "doctors" is the correct denomination.
Holy S**t Dave! This is one of your best EEVblogs ever! As a physician (pathologist) and electronics hobbyist I was thrilled and amazed to see you bring in one of the major heroes of medicine. Well done!
I didn't bring him in, he contacted me on Patreon said he's in town and wanted to drop by, he was here an hour later. Decided to switch on the camera just before we both had to go. This certainly wasn't planned.
I love that it happened that way Dave. But you were there and you helped it to happen.
Dr. Marshall is fascinating and what a great sense of humor! You guys got along so well. Great chemistry! I wish I could have been there. I'm going to replay this one over several time. Thank you!
@@EEVblog Even better!
If I hadn't have happened to check my email for that Patreon message we would have missed it, as he only had a few hours to kill that afternoon.
"Do it properly over a few beers" :)
The disappointment when he finds out Dave doesn't drink...
Wait, isn't Dr Marshall the one who purposely ingested Helicobacter pylori bacteria in order to prove his hypothesis?
Yup, that's him!
What a legend
I've always held Dr Marshall in high regard - until his discovery, my life was goddamn unbearable
do australians just have more character or something? the american equivalent of that guy would be some boring, humorless dude who is careful of everything he says. i've noticed the same with australian vs american news segments - australians just seem a lot less uptight and don't get offended at everything like americans do
It's a very egalitarian country. If you put yourself on a pedestal we will knock you right off it. Politicians fall over themselves to be a "man of the people" if they are male.
Our culture has WAY to many SJWs. ( but it's infecting the world now). Most of silicone valley and the mass media are infected by them so they spread the crap wide and far. Mob mentality is rampant, so anytime they can, they will try to destroy whatever/whoever they can for ratings and/or power.
wolvenar Also the lawsuit culture, slightest mistake and get dragged to court.
@@wolvenar im quite sure australia or canada is way more multicultural compared to us americans in general ( incl conservative
@@mistakenotou7681 Truely depends on where in America you are.
Bismuth is actually considered extremely weakly radioactive. It was discovered in 2003.
It's half-life is more than a billion times the estimated age of the universe though.
If it came from Wismut AG it certainly is! :D
@@denny9931 Except that the Wismut AG despite its name (for non-german speakers, "Wismut" is the german name of bismuth) never produced any bismuth, only uranium (and they had some experimental tin and silver extraction plants for a while). Even though uranium mining stopped right after the reunification in 1991, Germany is still in fourth place worldwide in total accumulated uranium mined, after Canada, USA and Kazakhstan (until 2014 it was in third place, then Kazakhstan overtook, and Australia is about to surpass Germany within the next few years).
@@blahfasel2000 ""Wismut" is the german name of bismuth"
Was, not is :)
@@leocurious9919 Let's better say "is one of the german names". Both are still correct, and if you look over the centuries, it was a constant back and forth between "B" and "W" from different authors. Apparently there's a whole book about the possible origins of its name and why those two major variants exist in german.
Fantastic! This guy caused a paradigm shift in medicine! Think outside the box and eschew conformity and dogma. A personal hero of mine. Thanks. Barry and Dave
+EEVblog more of this, loved this chat!
What a lovely man, different than all doctors i have seen in my life.
_"I can't remember why we got off on a tangent"..._ LOL the whole thing has been _off on a tangent!_ - 19:47
Yeah! That is what I did. I became a doctor to fund my electronics hobby/obsession. :-D
Yeah, but where do you find the time for it now being a doctor? Or is it just me and my inability to manage time?
@@wolvenar Yup. Radiologist. :-D
I suffered with reflux and ulcers for several decades until last year. I kept hearing the same BS from the doctors, it was stress related.
Last year, I was having intestinal issues for a while and was regularly taking peptobismol a couple times a day. During the same time I was also going to the dentist for a dental implant. I thought the reflux pains were related to my dietary changes and the stress from the pending operation of the dental implant. The dentist prescribed me antibiotics after my dental implant operation. I was taking both pepto and the antibiotics for a little over a week. It wasn't until a couple months later, when I was finished with the implant procedure and was able to eat regularly again, that I noticed I did not have reflux pains any more. I never understood how or why, until now. I looked up Barry's research today and it correlated with my experience.
To this day I still have no problem eating spicy foods such as hot sauce, spaghetti, sausage pizza, tomato paste was the worst, or even drink wine.
It has been a whole new culinary experience for me since. Now I know why!
Thank you Barry!
I could listen to this guy talk all day. Great video.
In the nutshell don't do electronic professionally and you can have the Nobel prize :)
Well, there's the Nobel for Physics, which was every now and then awarded for stuff pertaining to electronics, or at the very least that found application mainly in electronics. For instance, in 2014 or 2015, the Nobel for Physics went to the team of Japanese guys who invented the blue LED in the early 1990s, one of whom was an actual electronic engineer. A few years earlier it was awarded, for inventing the CCD image sensor, to a team of Americans whose "piece" of applied physics they professed in isn't all that much removed from electronic engineering, and can properly be said to fall within "electronics done professionally" (though not necessarily in the sense of designing and testing circuits, but rather more basic research). And I could go on cherry picking Nobels all the way back to the early 20th century, e.g. to Guglielmo "father of the radio" Marconi in 1909, himself an electrical engineer by trade (I think the word "electronics" hadn't even been coined at the time, or at least wasn't in widespread use).
@@Krrypton I must admit I haven't know much about Nobel prizes I just made a fun comment. As you wrote there is the basic researchers the winners although Marconi rightfully fits here. His radio with spark gap and coherer we can call electronics. He used the available parts of the time and made an usable device. I think he wasn't the first or even the second in the research of radio transmission but he made it available for mass usage in the quote marks.
Well, it's not always basic research, and certainly not always "pure" or theoretical physics. The first two examples above are on the cusp between applied physics and engineering (like much if not most R&D in electronics nowadays, for that matter). The Nobel for Physics has been established for _discoveries or inventions_ in physics, and that covers quite a lot ground, from theoretical physics to actually inventing devices like a new type of LED, image sensors, holography (Denis Gabor 1971, another electrical engineer), development of the electron microscope (1986), developing the integrated circuit (yet another electrical engineer) using the transistor whose invention was also awarded with a Nobel a few decades earlier...
Now, of course, these are fruit of work that's much closer to basic research than a century ago, and usually involves a rather good grasp of theoretical physics, especially quantum mechanics - but then again, so does the design of, say, a new CPU by AMD or a new image sensor by Sony, which falls right under comparatively much more mundane "engineering". And inventions... well, it's been a long time since any noteworthy invention came out of "putting together available parts", the endless stream of prizes at hundreds or thousands of invention conferences and expositions around the world notwithstanding (and never even mind that 99% of these prizes are awarded for all sorts of useless and pointless contraptions).
whoever is the first to dislike this video has never had ulcera.
That person probably just has stress.
Thanks Dave (my dad had an ulcer and was cured by Doctor Marshall's research). Drug companies loved selling what was in effect flavoured chalk to suppress symptoms instead of developing an actual cure, because there is so much more profit in servicing a chronic condition, than curing it.
What a beautiful video, loved it!
So happy to share share with such remarkable people a passion for electronics.
Dr Marshall is right about how some individuals get the Nobel Prize based upon one of the committee members suffering from a particular malady.
In 1998 the medicine prize was given to the 3 researchers that figured out how nitric oxide affected the cardiovascular system in such a way that it ultimately led to the creation of Viagra. No doubt a few of the older committee members were thankful for this accomplishment and thusly showed their appreciation with the award.
Please re-read my remarks and note what I said. I did not say they invented Viagra. I said their research led to it. Also I would take issue with accidental serendipity. The people working in this field are very good at applying abstractions to basic research and working out new pathways to discovery. It is a dynamic process. Heuristics at work.
Yes, the committee remarks were meant to be tongue in cheek. Dave and Dr. Marshall were incredible together. I felt my original remark was a play on the lightness of their banter. This conversation, for me, was probably the best one of all I have watched on Dave's channel. Too bad, as Dave remarked, they did not record the off camera comments. I would love to be in a pub with these two and be a fly on the wall.
I didn't think it possible, but this guy talks more than you Dave :-)
This by far is the most, coolest guest ever!
Yes, probably.
But then there's the YOLO moments with the siglent CEO...
Ibrahim Ulf Karlsson Ob! Smack!.....I’ll have to find that!
Lifesaver, Not much more to say. Big Thumbs Up..
My old work supervisor was always popping antacids for "Stress Ulcers", little did he know.
This was a very interesting show from start to finish. It also contains the best description of physiology I have ever heard. My father was Donald Mathews. He wrote a little book called Measurements in Physiology which was used as the textbook in most of the colleges in the US and maybe the world and he never explained it to me that simply. From watching everyone of your videos I have come to two conclusions. Firstly you are a combination of three disparate and hard to find qualities, social talent, humor and knowledge and secondly Australians just have a different outlook on life than we in the US do. Thanks and keep up the good work Dave.
Dave is among the bright people of the world. I love this because I believe he's a real winner
I actually corrected my posture automatically when I clicked this :D
"Tim Cook phone" lol.. Trump called Tim Cook as Tim Apple so ;)
Gosh, I can only reiterate what has been said many times already in the comments... what an amazing bloke! Considering his academic credentials and life history how down to earth! Thoroughly interesting subject! Cheers Dave for turnin' the camera on and posting!
I hope this is the first in a series of personal interviews with Nobel winners by Dave. Just give them a call, Dave.
Dave - get Dr Marshall in again bloody marvellous!
Man, I’d put this discovery up with a lot of other notable discoveries like penicillin, insulin and vaccines.
For sure!
That was a good video. I've been tested for Helicobacter pylori in the past, now I know who discovered it.
Great one Dave! You should go to that vintage Tek museum with him and do a special!!
World Community Grid (BOINC citizen science) has the Microbiome Immunity Project to study microbiome of the human gut.
I spoke with my doctor about Dr Marshall only last year. He's a hero of mine for having infected himself with H. Pylori and then curing himself. It was quite controversial at the time. I'm happy he got the recognition he did, and managed to cure not one but two diseases.
Meanwhile... Thomas Crapper was merely a plumber that invented some improvements to the water closet, including the floating ballcock. He had 9 patents when he died. Of course, his name is a coincidence and nothing at all to do with the word crap and its offshoots.
Damn, I thought from the thumbnail that EEVblog had been given a Nobel prize. Still good to see fantastic interview with a top notch scientist.
When I took over the family sheet metal workshop, we lent out some space for an installation consultant that worked for Flextronics. He went out and worked at Astra-Hässle's plant that makes Losec. They, A-H, ran the plant at full tilt so Orvar, the consultant, had a hard time getting access to the production lines, it ran 7-24, even on Christmas and New Year. A-H blamed it on expiring patents or something stupid like that. They knew that their new wonder drug wouldn't make money much longer. Treatment pays better than cures.
Ten years later I helped some inventors, can't talk about that (NDA still in effect), both worked at CTH, one former professor and the other taught material science. They told me not to stress so much, because I would get stomach ulcers. I mentioned Astra's woes, Helicobacter Pylori, the cure, the Nobel Prize and they still didn't want to believe me. The professor had worked on studies on lung cancer in asbestos workers. (smoking + asbestos = 100% cancer in 20 years)
Great episode. And a big thanks to dr. Marshall, your research has changed my dads life.
Could of listened to Barry talking for hours his story's and knowledge is fascinating as well as being down to earth
What an interesting bloke. I quite enjoyed the off-topic-interview format, would be good to see more! 👍
NSAIDs are actually more dangerous than people than people realise. I had stomach ulcers at 30 (otherwise healthy, aside from a longterm leg injury), I'm now a coeliac when there's no family history or prior symptoms.
Wow - what an awesome guy - a guy an ordinary bloke could have a beer with and he won a Nobel prize!
1st time I watched Dave's long video without a break. Dr. Marshall is hilarious.
I will watch it surely after I finish making corrections to my PhD thesis. DO NOT DO IT AT HOME!: Already had 5 energy drinks today. Feels like my heart might pop out, but science and engineering rules :)
5 is seriously dangerous, people have died from that many.
@@EEVblog Yes, I should have wrote: DO NOT DO IT AT HOME!
@@macieknapora4591 Seriously, do not do that ever. I did similar things when I did my PhD thesis, and after a long PhD thesis battle, many body parts started to complain. I went to see different doctors for various pains over the coming 6 months, and only till not long from now they subsided.
'people have died from that many'....usually caused by some other underlying condition...ive routinely drunk 4-6 cans of energy drink a day for the last 10 years without any issues..most of the energy drinks have less caffeine than an expresso...
@@bskull3232 Past that phase . But thanks for your concern. But I confirm, this puts enormous strain on a body and mind.
Wow. Barry is a great interview. So many fun stories. I forgot all about "ulcers", but your chat triggered memories of the days of "stress ulcers, no spicey food, etc...". Facinating! Thanks Dave.
I am pretty sure I am watching TWO Nobel Laureates (comment from the future).
Fascinating!!! Wonderful video Dave!
Fascinating, and he seems like a top bloke.
One of your best interviews. I hope there is a second and third and more part for it; and if Dr Barry can hack some electronics stuff it will be even better. WOW!!!!
It may have been mentioned before (didn't scroll through the previous 374 comments), but the VintageTek museum is located on the Tektronix campus in Beaverton, OR. They've got limited open/operating hours, so be sure to check their website (or contact them) before popping in for a visit. Great place, with some awesome volunteers (and Tek technical royalty!).
Thumbs up for identifying posture as a big cause of aches and pains 👍. I'm a physical therapist and see pain patterns are often linked to a person's postural habits.
How to get better posture anyway? And how do I know what is a good posture and what isnt?
Very impressive Interview, Barry is such a interesting person and of course Dave too hope to see more videos like that.
Christmas came early. Legend on the show
great info here and note to all the hospital he was working in (royal perth) ia 99.9% totaly goverment funded and treatment there is almost all medicare funded....gov funded health care works.
i have stomach ulcers... and it gets worse when i am in stress...
it gets worse when i was out of my comfort zone(home)... like when i was with my relations.. bad frnds... etc....
Stress causes various hormones increases. Adrenaline, insulin, cortisol, and several others. Some of these also cause acid increases, so this will cause some of the additional irritation. These same changes contribute to various diseases directly and indirectly. Weight gains from chronically high insulin and cortisol compound the issues. Anyhow I am not a doctor, just have some experience with these issues. Stress probably doesn't directly cause various diseases, but almost certainly will contribute.
hell-ayah that is how great things are discovered BY CHANCE
The really great discoveries are almost never initiated by EUREKA but rather by "That's strange..."
Is it too early to start chanting: Long live the wise, we are not worthy.. ;)
Now that was an excellent interview and chat, nice one Dave and Dr. Marshall
6:10 😆 Nobel laureate... cant do an American accent!
Damn this was super interesting! 👍
Recently a link has been found between cortisol and Alzheimers. Cortisol is known as the stress hormone.
So he is the guy I can thank. So with that. Thank you for your work that long ago fixed my ulcer.
Apparently my doc was QUITE informed. He learned of your discovery back in either late 80's or early 90's and treated me for my ulcer problem with antibiotic treatment way back then.
S-100. Yes! Built my first computer in 1979, and it was a IMSI S-100 clone.
Still a computer/electronics hobbyist, but I did work at a medical school...
I *OWN* an IMSI with a secondary terminal. Pretty rare these days. I have so far only found one other, and it is in a museum. gallery.anotherpower.com/main.php/v/My-projects/irc_posts/3801.jpg.html .
Does this look familiar to you?
Never seen one like your''s . Must be a later model. Mine was made by Fulcrum, looked almost identical to the original IMSI, which was very similar to the Altair.
Well done Dave, absolutely brilliant guest and a brilliant host.
I remember this discovery of ulcers being caused by bacteria because at the time I did have an ulcer and his findings helped rid me of the bacteria :)
This is awesome Dave! Bring more people like this on. It shows what electronics enables!
Cracking interview Dave! Two Ozzie blocks just yakking away about electronics and stuff. One of them just happens to have a Nobel Prize...
Accurate summary!
What a fun and interesting conversation. You should have Nobel laureates on more often.
Absolutely brilliant. Thanks for that, Dave!
The vintageTEK Museum is in Portland, Oregon, not Colorado. We would welcome a visit by Dr. Marshall at any time.
What is the instrument with the tiny screen on the right?
Looks like a Thandar oscilloscope UK made
Thank you for your work and research Dr. Marshall. I have IBS...it’s awful but you and your colleagues give me hope that one day it can be treated effectively. It really means the world to me!
fun fact, in eastern Europe, bactericidal oils have been used against ulcers since 1940 pl.wikipedia.org/wiki/Balsam_Szostakowskiego
my friend had stomach ulcers in the 1970s/80s and cured them that way by doctor's recommendation
2K being loosy goosy with code.
Looks at a sprinkler board with 32 bit ARM micro with 64k of just flash... Yeah.
Thanks, Dave. That was a treat! :)
Where is part 2 :D So great.
IT WAS THOMAS CRAPPER!!!!
I may not know a lot of things but I know my Beavis & Butthead bathroom history.
I'm not aware of a vintagetech museum in Boulder.
But there is a vintageTEK museum at the Tektronix campus here in Portland, Oregon.
And I'm fairly certain that the picture you had at 46:48 was actually of the back wall there.
On the off chance that this is the place you're talking about, then I'd be honored to have a Nobel laureate in the same city as me!
vintagetek.org/
As a side note: California has Silicon Valley, sure. But did you know the Portland area has the Silicon Forest?
Intel and Tektronix both got their start here. And a ton of other hardware companies maintain a presence in the area (Microchip, Maxim, Linear, ON, etc...).
Take a gander sometime!
en.wikipedia.org/wiki/Silicon_Forest
Saved the best story for the end! LOL.
An idea for a video: How to tell a good used multi meter vs a bad one.
I've seen some 'nice' multi meters in pawn shops for sale for cheap but have not bought them because I have no clue how to tell if they are still good.
You can't know without trying it. See if it's in calibration. Do all the ranges work?
@@userPrehistoricman so how would you go about testing this in a pawn shop?
Bring a battery, bring a resistor. Or multiple if you want to try all the ranges. You can also test current with the batter and resistor.
Dave often judges a multimeter by its build quality and circuit quality. But yeah I reckon the shop wouldn't let you open it up. The most you can do is make sure it operates.
If you could find pictures of it online or reviews then that would help.
Finally someone who can outtalk Dave ;)
Looks like dave took a photo of Dr Marshall, and uploaded it to wikipedia. Interesting, Binarysequence... heh :)
More Barry! MOAR! :)
+serpentza +ADVChina You should have this Nobel Prize winner Dr Barry Marshall on your channel to help educate Chinese people to this simple treatment to save lives from stomach ulcers and cancer.
Son of a bitch... I think I've been suffering from this bacterial infection for a greater than 7 years. I went and got some Pepto-Bismol on Sunday and I feel better than I have in nearly a decade. Thank you so much for for this video Dave you have absolutely no idea how grateful I am.
Little advice:please change your website link in UA-cam to HTTPS.
On the subject of electronic engineers getting migraines.
Watch out for any old metal can transistors that have white crystals growing on the metal can or a white powered around them!
I'm not 100% sure what it is, maybe arsenic or beryllium. But it will give you one HELL of a migraine if you get even a microscopic amount on your hands and then eat something. It might even kill in larger quantities
This was tremendously enjoyable, especially since I used to keep up with stuff like that and had read about the discovery when it was announced. When I told people about H. Pylori back then, of course they didn't believe me.
Looks like his wiki page picture was taken in this lab:
en.wikipedia.org/wiki/Barry_Marshall
Now that we have rapid h. pylori tests and everbody with ulcers are routinely tested, we know not all ulcers are caused by h. pylori. But if yours are, well, good on you.
I'm not slighting the work of Marshall et al. at all here. But in this interview he's a bit too categorical.
I'm not saying that stress is an explanation for the remaining cases, by the way.
Stress causes the fight or flight response in our bodies though, and being in that mode for too long damages vital organs in the body, due the adrenaline etc being in the system for longer than intended, e.g. nature only intends it to do that for mins or hours at a time, NOT a permanent daily state. So I would say that stress is pretty dangerous in that scenario, but apart from that the doctor here is correct about it wrongly being used to brush patients off with a duff diagnosis.
A very enjoyable 49 minutes and 12 seconds.
Am I deaf or where did the part go where he talks about taking out is medal to get into a expo via the back entrance. Did you edit the video via youtube's fancy online video post-censoring tools?
I know a biographer who has written books on interesting Nobel laureates.
I think he'd be interested in writing a biography on Barry Marshall.
Nice guest you had there Dave :)
Medical electronics and medical applications of electronics are two fields I am very interested in.
The Nobel Foundation had arround 400 million USD in funds 2015 so they wont runt out of money any time soon!
38:55 So Aussie indeed!!!
Dave, you should have asked him about the HIV virus. How does it remain undefeated after many decades?
This was awesome!
More, please!
Barry is so awesome, there are only a few interviews with him on YT but they are definitely worth seeking out!
I think I got an ulcer today, hurts like hell, google told me it was stress so this video might’ve saved my ass, thank you!