Multiple myeloma is the most common primary neoplasm of the skeletal system. The disease is a malignancy of plasma cells. Plasma cells are a subset of B-cells, which are the producers of humoral immunity factors termed antibodies. However, if malignant transformation occurs in a single plasma cell, its clones produce only a single type of immunoglobulin, and electrophoresis demonstrates a monoclonal peak corresponding to this particular immunoglobulin. Reference: Shafer's 7th Edition Page 188
The most common bone cancer.....isn't it...Metastatic bone cancer...?
Multiple myeloma is the most common primary neoplasm of
the skeletal system. The disease is a malignancy of plasma cells.
Plasma cells are a subset of B-cells, which are the producers
of humoral immunity factors termed antibodies. However,
if malignant transformation occurs in a single plasma cell, its
clones produce only a single type of immunoglobulin, and
electrophoresis demonstrates a monoclonal peak corresponding
to this particular immunoglobulin.
Reference: Shafer's 7th Edition Page 188
Metastatic bone cancer are not cancers of bone, they are simply cancer of other organs metastasizing to bone.
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