Biochemistry | Cytochrome P450 Catalytic Cycle

Welcome to Catalyst University! I am Kevin Tokoph, PT, DPT, and this is one of my earlier biochemistry videos where we discuss the catalytic cycle of the enzyme, cytochrome P450.
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[@addentist]

thank you very much your explications are so good

[@FizzlGrizzL]

you just blew my mind what a great video bro

[@CatalystUniversity]

Glad you enjoyed it!

[@vikiamidzic4650]

thank you!

[@pasqualegarruto3256]

grazie infinite!!!!! you best!

[@twoHRdrive]

For the homolytic bond cleavage of the oxygen molecule, I am a little confused. What exactly is setting off the homolytic cleavage in the first place? I get that one electron from the O-O double bond goes to one O atom, and the other electron to the other O atom. And I understand that Fe II donates an electron to one of the oxygens. But why does this cleavage of one of the molecular oxygen bonds happen? Any explanation would be immensely helpful! Thank you!

[@gautamkannan1909]

You just drew a piece of art!!!

[@vaishnaviramakrishna265]

You have a new subscriber 🙋.. thanks for the good teaching!

[@CatalystUniversity]

Thanks for the kind words!

[@joelpaz1929]

Thanks! Really helpful!

[@franct2805]

[@ashleyives6872]

At 5:30, why are you using singlet oxygen?
Thanks for the videos BTW, they're very helpful!

[@twoHRdrive]

Sorry for the silly question, but could you please explain how the heme iron reached an oxidation state of 3+ while chelated to the four nitrogens and the one sulfur? Hope to hear from you soon! :) Thanks!

[@NereticSC2]

If you want to get rid of the circle blinking up every time you touch down with your pen - just look at the windows configuration for mouse and pen - with your configuration it always trys to do a right click.

[@natalia9509]

Stupid question: my teacher said the sixth bond is initially with a H2O molecule. Is it because in that position it is exposed to an aqueous environment and therefore tends to bind the water molecule or is there another more specific (and correct) reason? Thank you for your videos, always extremely helpful! :)

[@kameshranjan3938]

Verry helpful...

[@anhhoanganh181]

DO you have any source?

[@SpaceAndStarsGalore]

You’re amazing !

[@CatalystUniversity]

Thank you!

[@Saruno1297]

❤️

[@CatalystUniversity]

Glad you like my video, Sara!

[@RunForFunFun]

Just curious. Isn't Ionic bond stronger than covalen bond? It seems you are saying covalent is stronger than the ionic

[@RunForFunFun]

Great explanation. Thank you

[@SharonCabanu]

Thank you very much! Such a nice explanation!