Neuroscience - Long-Term Potentiation
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- Опубліковано 5 лис 2013
- Long-term potentiation is thought to be the molecular event that contributes to learning. Through synaptic plasticity LTP is established between various neurons, allowing for the learning process to occur. This video explains the molecular underpinnings leading up to LTP including both early and late phase changes. The video begins with the action potential and outlines the various stages required to establish synaptic changes. These synaptic changes lead to the formation of a stronger synapse and ultimately a stored memory within the brain.
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Visit Carleton's Neuroscience Department at carleton.ca/neuroscience/ and check out the podcast at mindingthebrainpodcast.com
It's funny to think that by watching this video I learn how memory works, and by doing so, the exact mechanisms that are displayed in this video IS HAPPENING IN MY HIPPOCAMPUS RIGHT NOW AS WE SPEAK, I CAN FEEL THE GROWTH OF NEW SYNAPSES BY THE INFLUX OF CA2+ IN THE POSTSYNAPTIC CA1 CELL. THE ACTION POTENTIALS ARE AT A ALL TIME HIGH RIGHT NOW.
I thought the same thing and actually laughed out loud at this lmao
Hi Paolo, you might love Havening Techniques :)
you're high
haha love it
It’s not a mechanism tho
How is it that when one person (or three!) explain this it makes absolutely no sense and this makes it seem so super simple! I don't understand how people passed exams without google and youtube!! thank you so much!! xo
Thanks for the feedback, Annie. Glad it was useful!
Lol, they read good textbooks.
3:26 Well thanks for reminding me while I'm studying for my exam today.
I'm studying this the night before of my exam. I understand I'm screwed.
I'm studying this a few hours before my exams lol
me too 😅
I've watched a lot of videos about neuroscience. A lot are good, some are great, this was magnificent!
A great deal of long-term depression happened while I was watching this
😂😂😂
Wow! I can't express how glad I am that I found this video. My book was not able to explain it as clear as this presentation, my understanding of this subject just expanded because of this video. Thanks!
I'd like to thank all the people involved in making this very informative video. LTP is a rather complex process and you have managed to make a video that explains the phenomenon in a precise way which makes the concept easier to comprehend. Thank you!
Being able to visualize this helps so much more than just reading and looking at pictures in the textbook. I don't think I'll ever forget this now, thanks !
The person or persons who created this video know exactly what they talk about - if anyone is doing psycho-biology this is a really helpful source since it explains simply - but in depth - what LTP is. For sure I am coming back for more, keep on doing these videos.
Seriously this video was so awesome!!!! It was so helpful to see the representation of the long-term potentiation and hear the very clear explanation of what was happening. Definitely recommending this video to people in my class. Thank you!
Thank you for your explanation! Made an hour long lecture much more understandable and bearable!!
Brilliant! Dale Purves' "Neuroscience" offers some really in-depth stuff, but generally fails at mashing in small nails with big mallets, which we sometimes need when cramming. Succinct and precise, and gorgeously presented. Kudos!
Fantastic video, thank you very much. This hopefully was part of the LTP in my studying and the forming of new AMPA receptors which hopefully will last a long time!
I feel so much better about taking this biopsych final now! Thank you!
By far the best video I've seen! thanks
AWESOME VIDEO!! excellent explanation and one of the best voice over's I've ever heard! Great voice! And great explanation. Helped me understand it so much better!! Cannot thank you enough for this.
Best explanation I've come across so far. Gr8 animation!
Just had my neurosciece lecture about long term potentiation and depression this week. I wasn't able to focus in class. Glad I found your video it is super helpful!
Love from Sheffield
excellent! very clear explanation for a very confusing topic! thanks a lot
It's 7 years later, but still. It's a great explanation of the LTP. Thank you!
Thank you for the video! Is very clear and understandable, it has been a great help for me!
THANKS SOOOOOO SOOOO MUCH, this helps a heck of a alot!!!! i can not thank you enough for making this clip!!!
Concise yet well explained!
Wow, this is an amazing video. I when to lecture, read the notes carefully and read the chapter in Neuroscience book and was still not fully understanding this. After the video I understand it fully. Thank you.
Really good video. Excellent animations and commentary. Beautifull!
Really enjoyed and benefited from this. Please keep them coming!
absolutely brilliant video - thank you so much! My lecturer couldn't explain this properly and through one video i've got it!
This si what i already needed, You' re the best
This is what my teacher took an hour to explained, but explained very good in 8min, thanks!!
Amazing informative video of LTP
My primary interest and major is in Computer Science but I have very strong interest in Neuroscience, as well.
I had difficulties understanding the working of synapse and neurotransmitters for memory.
This video is very informative! My question has been successfully answered :)
It's perfect. Thanks from Brazil.
our teacher recommended this video. It is impossible to make it clearer than here. thank you
Great video! thanks for making and posting.
Very informative and efficient. Thank you!
This video changed my life
Gr8 video! Besides the misspelling of the AMPA- receptor (thumbs up!)
awesome, clear and concise
concise yet detailed description. thanks. now to study LTD
This was even better than reading Purves. LTP memorized in 8 minuts. Great!
Thanks!! Really good video, perfect for understanding the mechanism.
Cheers from Chile
There is one more part of the early phase of the LTP that also strengthens the synapse. Part of the protein kinase cascade includes the movement of AMPA receptors from the base of the dendritic spines to the tips of the spines, allowing for a greater chance of contact with glutamate in the synapse. The video mentioned new AMPA receptors being installed from storage, but this facet of the LTP is just movement of previously installed receptors away from the cell body and toward the synapse.
Wow. Thank you for this video! My textbook really was not explain this in a digestible way (could be that there were no helpful diagrams and I’m very visual), but you guys made this very comprehendible! Seems as though many other people’s textbooks are also not very clear as well, which is interesting because after watching this it seems like a fairly straightforward concept. Could be that reading NMDA (especially when your brain registers it as MDMA because you watch to much Joe Rogan), AMPA and glutamate over and over gets a bit overwhelming and distracting from all of the actual concept of the function.
Thank you! This video was so helpful, like the person under me, I felt the need to create an account just to say thank you!
Great Video! Thank you very much
Brilliant video. Thank you!
Brilliantly explained, thank you! :)
the best lecture with extraordinary explanation of the physiology of memory tq so much for your help and support..............
Very clear explanation, thank you.
Una maravilla este video! Increíble!
Great video, thanks!!
Very good video. Made the topic very easy to understand
Thank you! This is fantastic!
this was brilliant, and saved me from having to wrack my brain over written notes. thank you!
This was great!!
I wasnt logged into my account, but i did after watching this video just so that i could "LIKE" and Comment on your video :)
TheSick83 Thank you! We appreciate it! :)
Very nicely explained
Thank you so much. It's much clearer now
Great video! really helping me understand the concept.
This video is great and very didactic! It helped me a lot, thank you!
Well done, Thank you!
This VDO is very helpful. Thank you so muchh
Great video on the topic! Better if links to videos of related topics are provided to form a playlist of the subject. Keep it up!
Thank you so much for making this great video! It finally makes sense (although I may need to watch it one more time to strengthen the connections, haha).
Very beautiful and helpful Animation
My professor should just show us this video instead of the 20 page incomprehensible power point slides. I was able to piece everything together so easily with this video. Great video!
Great video, thanks
I appreciate this. Awesome!
Slowest action potential I ever saw XD
I don;t know why this made me laugh.
Very useful information provided by this video !
THANK YOU! This was awesome! I've breen struggling to understand LTP for such a long time! I'm giving a presentation about memory and plasticity in a few days and now I think I finally understood this!
doing the same in 2024 haha
This was so much more clear than my professor was!
Nicely explained
Kudos to the speaker, who speaks VERY clearly and at a good pace! It can be frustrating to watch a video on complex material and not be able to understand the speaker, or hear a speaker to talks too fast to follow well.
great... helped me in understanding the concept... Thank u.....
Well explained. Thank you :)
Amazing video! Thanks a lot!
Good explanation!
Made it very clear!
great video! explained it better than my book thank you!
Excellent! Great video, it helps me a lot!
Great video thanks a lot 👍
Awesome material!
Thanks for the video! It is a helpful supplement for studying for a test I have to take.
This was super helpful, thank you!
Really nice explanation! Thx
lovely video
Loved this video.
Very helpful. Thank you!
Nice! Very interesting
That was really helpful, thank you soooo much
i have exam tomorrow and this is more clear than some of my lectures. THANK YOU
+luciferin22 same!
+luciferin22 Same!!
Same here
Thanks to the writers and animators and whoever made this video possible.
Best explanation
Perfect. thank you very much. It helped me a lot
Thank you for this awesome explanation of LTP. Now I can finish my paper (as soon as I figure out how to give credit in a citation of a youtube video). (:
V helpful for my exam tomorrow, thanks!
this helped so much, thanks!
Excellent video and graphics! Should it also be mentioned that the CREB has to be phosphorylated in order to activate and enhance gene transcription?
Really really informative and helpful video! thank you so much!!!! :)