Significance of Urea Cycle - 1) Toxic ammonia is converted into non-toxic urea 2) The cycle disposes off 2 waste products - CO2 & Ammonia 3) It forms semi-essential amino acid - Arginine 4) It participates in the regulation of blood pH, which depends upon ratio of dissolved CO2 (i.e. H2CO3 to HCO3-)
I just want to say here that, your videos are utterly brilliant and so simplified for a complex topic like urea cycle. The animation is very cool and enjoyable that it makes it easy to grasp even while learning this kind of boring topic. I must say that I was grappling with urea cycle for quite a while and found confusing to understand it, but your video made it so easy and even more simplified than that of the textbook. Thank you.
I am someone who has all was been interested in how the body works, I have been sick with Lyme disease, and my naturopath suggested I take ornithischians, and wow it has helped reduce my head pain, guess it was a missing link for me. It’s so interesting to learn how the urea cycle works and what part the ornithine plays.
Glutamate is a dominant intracellular aminoacid, not in the blood! It gets another NH4+ to form GLUTAMINE, and glutamine transports the nitrogen from the periferal tissues to the liver, muscle uses alanine because that is essentially free (only transamination). In the liver glutamine is again converted to glutamate :)
There is a mistake in this video at 0:57 . Ammonia is highly soluble in water. Thats why fishes excrete ammonia due to high volume of water around them. If human excrete ammonia it will require a large volume of water. So huge amount of Bodyfliuds will be lost.
And without seeing ur prophile name and picture , I knew I already knew !! U r an army cus these raspy and husky words are dominantly use in bts culture !! Oohhh lovely armies are everywhere 💜💜💜
Please make a video on reactions of amino acids, deamination, transamination, and on de novo fatty acid synthesis! Your explanation is very good and easy to understand. Kindly help us students out in such biochem topics!
I think you have the strcture of ornithine wrong. The amino group should be at the alpha carbon, the way you have it has carbon atom with 5 bonds. Same goes for citrulline, argininosuccinate and arginine.
Great video, but when you describe the argininosuccinate being broken down into arginine and fumarate, you must have made a mistake. Fumarate and succinate are very similar except that succinate has no carbon double bonds whereas fumarate has a C=C double bond with the central 2 carbons. You called the two molecules that resulted from that reaction arginine and fumarate. You must have meant succinate as there is no double bond between the middle carbons.
Significance of Urea Cycle - 1) Toxic ammonia is converted into non-toxic urea 2) The cycle disposes off 2 waste products - CO2 & Ammonia 3) It forms semi-essential amino acid - Arginine 4) It participates in the regulation of blood pH, which depends upon ratio of dissolved CO2 (i.e. H2CO3 to HCO3-)
Perfect
👍🏻
Thanks
I just want to say here that, your videos are utterly brilliant and so simplified for a complex topic like urea cycle. The animation is very cool and enjoyable that it makes it easy to grasp even while learning this kind of boring topic. I must say that I was grappling with urea cycle for quite a while and found confusing to understand it, but your video made it so easy and even more simplified than that of the textbook. Thank you.
💯💞
Tomorrow's my exam and I just remembered that I should study this ... Thanks a lot for making things easier
Me: looks up for a biochemistry topic
*finds a video by medsimplified
- realizes my work is simplified😁
Truly amazing!
It was amazing. I was struggling a lot with this pathway but you made it super clear. Thanks a lot!
You explained it in simplified manner, make it easier to understand. Thank you very much.
You are very welcome
This is a fantastic video. Simple, informative, and well-designed. 10/10. Thank you very much for simplifying a confusing topic.
It's a valuable video tq
I am someone who has all was been interested in how the body works, I have been sick with Lyme disease, and my naturopath suggested I take ornithischians, and wow it has helped reduce my head pain, guess it was a missing link for me. It’s so interesting to learn how the urea cycle works and what part the ornithine plays.
Glutamate is a dominant intracellular aminoacid, not in the blood! It gets another NH4+ to form GLUTAMINE, and glutamine transports the nitrogen from the periferal tissues to the liver, muscle uses alanine because that is essentially free (only transamination). In the liver glutamine is again converted to glutamate :)
There is a mistake in this video at 0:57 .
Ammonia is highly soluble in water. Thats why fishes excrete ammonia due to high volume of water around them.
If human excrete ammonia it will require a large volume of water. So huge amount of Bodyfliuds will be lost.
This is great
I have seen many videos regarding this topic, but no one has explained it as simplified as u❤️❤️
It is an amaziiiiiiing video, with fantastic explaination , Thank you.
Why us NH3 insoluble?
It is actually a highly soluble compound in water and dissolves as quickly as HCL in water
Sir love you sir ❤
You are the god for all students 😌
Your raspy voice makes me study more😂
And without seeing ur prophile name and picture , I knew I already knew !! U r an army cus these raspy and husky words are dominantly use in bts culture !!
Oohhh lovely armies are everywhere 💜💜💜
ammonia is a water-soluble compound
This is a fantastic video. Simple, informative, and well-designed. Would be interesting add a subtitles at the video.
Congratulations for you job.
Thank you for making this so simple, helpful, and easy to understand!
Such a great video.
Fully got the concept.
Pls so more videos on biochem cycles like this.
this pathway but you made it super clear. Thanks a lot!
Thanku so much sir for this beautiful explanation 🙏✨
Thank you 💓 its very informative n interesting cz of u 🔥❤️
You are great sir. You literally cleared all my doubts .Thank you sir
Simply amazing video, high quality production, thx.
😍😍😍😍😍very nice for our studies
Thank u heartly
Glad you liked the video.😄
Thank you so much. Your explanations are always clear all my doubts. ❤❤
Thank you so much sir for making a complicated topic 'easy to understand'
I really appreciate your efforts
Keep it up !✨
this is a fantastic video! very clear and easy to understand. Thank you so much!!
Best explanation on this topic! Thank you so much
Brilliant video. So clear and easy to understand. Thanks
Glad it was helpful!
Your channel truly simplifies your way of teaching ❤️🙌
You made such a complicated cycle very easy for us...thanks sir..keep uploading more and more...
Very detailed and interactive explanation hats off pls upload more biochemistry videos
Please make a video on reactions of amino acids, deamination, transamination, and on de novo fatty acid synthesis! Your explanation is very good and easy to understand. Kindly help us students out in such biochem topics!
Bro u are wrong when u say ammonia is insoluble in water. But despite that good explanation
Best urea cycle explanation
You are a blessing for students 🌸
Thanks soooo much..much love from Nigeria 😍
simple, to the point and easy to understand thank you so much
Thank you so much sir for this video.
Thanks for clearing the major doubt on wondering y protein s broken down
Thank you for the kind words! I'm always here to answer your questions.
Theseasonorg explains the whole bible God bless
Sir but ammonia most soluble hota h....may u please check again
Superbbbbbbb explanation. it would be easy to grasp the concepts in this way
Amazing! Thanks mate!
Plz make vedio on whole protein metabolism plzz
Great work 👍 so simplified & perfectly explained video. Thnk u 😊😊
Your videos are very informative, concise and really helpful 100%
Thanks a lot sir.i have been searching for this lecture exactly.....😀😀
Very brilliant video 👏👏
Very nicely done this was informative and quite helpful! Keep up the great work!
It is very useful to us and make a video for metanephridia and protonephridia
Beautifully explained 😘
Amazing video! thank you so much!
Clear explanation 💚 Thanks
Hi bro
Ammonia is a water soluble compound then howcome it will be insoluble in water.
Which is crt? Please Explain bro
Not ammonia it's ammonium ion... Which is insoluble substance
Ammonia is highly soluable in water
Wow! Excellent video. Thanks!
please upload video on glycogenesis and glycogenolysis.
Thank u so much for such a great lecture
Is citrulline structure okay ?
Thank you so much for this!!
Very good video, but double check your structures. Carbon usually doesn't like to make more than 4 bonds...
Much love from Kerala 🤍
I think you have the strcture of ornithine wrong. The amino group should be at the alpha carbon, the way you have it has carbon atom with 5 bonds. Same goes for citrulline, argininosuccinate and arginine.
Little correction in the first step of urea cycle: the substrates are ammonium and bicarbonate (you mentioned carbon dioxide) if I'm not wrong Sir
you are right! thank youu!!
Much needed video sooo far
❤❤❤❤❤
Thank you so much ,🌹🌹🌹🌹🌹🌹🌹🌹🌹
Vwry welcome.
It was amazing but can you share net reaction of these reactions
U R Da Best Buddy🙌🤘❤️
Thank you for your videos
really amazing .......clear explanation thank u so much.
I LOVE YOU THANK YOU FOR THIS VIDEO!!!!!!
P
Very nice and easy presentation of such a vast topic 🤩🤩
Thank you for a fantastic explanation
well explained ....really appreciate your effort for the video
How are such animations made????
This is like wow wow wow..!!!!!! Sooooo goood so good.. ❤❤❤❤❤❤💖❤❤
Excellent Explanation 💛🙏
Thank you very much!!
Thank you so much ❤️❤️❤️ your video is very very helpful for me ..... ❤️❤️❤️❤️
Please video on C4 pathway
Fantastic video.....respect 😊
Thank you soooooo much you are fabulous
At 8:39 think you have written cytoplasm as cytoplam.
Great way of teaching
It's So simple, your videos are amazing
Great video, but when you describe the argininosuccinate being broken down into arginine and fumarate, you must have made a mistake. Fumarate and succinate are very similar except that succinate has no carbon double bonds whereas fumarate has a C=C double bond with the central 2 carbons. You called the two molecules that resulted from that reaction arginine and fumarate. You must have meant succinate as there is no double bond between the middle carbons.
Best explanation
Very easy thank you
Excellent video presentation
Very good explanation you made it vvv clear thanks🫶🏻
Please make the vdo on HMP shunt pathway!
Excellent👍🏼👌🏻👏🏻
Thank you so much
Can anyone confirm that arginine at 11:33 is missing a carbon in the amino acid backbone?
Thank you
Awesome video
Real Great work bro.....
Thanku so much ♥