Good to know James Parus. Even while recording these lectures for the healthcare professionals or students the intent was to make the content easy to digest for everyone.
Thank You very much for the lecture Doctor! Now I got it :) It was a really big help for Immunology final next week. I'm gonna watch Your other lectures too!
Hello Dr. Mobeen. Thanks for the great lecture. There is one more very very important way the cancer cells suppress the T-cells. The cancer cells over express the enzymes IDO (Indoleamine 2,3-dioxygenase) or TDO (Indoleamine 2,3-dioxygenas). These enzymes deplete the tryptophan concentration in the tumor micro-environment, thus reducing the tryptophan availability to T-cells and hence reduce their survival and growth.
Tumor suppressor genes are present every cell ...and actually it's growth suppressor genes ..these are genes which regulate growth. But when they are mutated tumor suppressor genes are only in cancer cells Thanks ...you explained nicely
Thank you for this presentation. Do you know any knowledge on anti-leukaemia immune surveillance? Several of the tumour markers presented on solid tumours are not expressed on leukaemic cells.
Why would the product of tumour suppressor genes be displayed on MHC 1 in cancerous cells, but not normal cells? Surely the TS gene would be expressed in normal cells anyway, so would still be detectable on MHC-1?
Pattern recognition. Recognition of abnormal proteins. Recognition of lack normal proteins, etc. Mostly the tumor cells get caught by NK cells due to the lack of MHC1 expression.
You are truly an inspiration, thank you so much for all your wonderful videos.
Great stuff - the best I've seen, really helpful! Love your detailed explanations. Many thanks!!
Thank you for uploading this! You're video's have been a big help in understanding immunology.
Thank you so much for sharing these videos. They are extremely helpful during my studies. You have a gift of teaching!
+Melody Agre thank you! We have more lectures drbeen.com.
your lecture is made super easly
great series, I'm not working in medical field, but I found this very informative and easy to follow.
Good to know James Parus. Even while recording these lectures for the healthcare professionals or students the intent was to make the content easy to digest for everyone.
I just .... love your teaching very very much!
Thank you so much doctor!! Ur video was really very helpful and it cleared all the concepts.
your effort is greatly appreciated. THANK YOU!
Thank you. Your studying well is greatly appreciated :-)
Thank You very much for the lecture Doctor! Now I got it :) It was a really big help for Immunology final next week. I'm gonna watch Your other lectures too!
+Mándy Dávid good to know. We have other systems uploaded on the drbeen.com.
Best video best explanation
Thank you and have a nice day sir! Xoxo
very well explained
thanks for the grate lecture.
there is one of the more very very important way of the cancer cells supress the t cells
thanks so much. this video really helped me. its now so simple and clear to me
MashaAllah this video so helpful for me and my friends
well explained , thank you doctor
Fantastic!
cool. Check drbeen.com for more lectures.
thank you ♥️♥️
Thank you a lot..
Thank you Dr , it was very helpful .
Marvellous... Sir...👌
Thanks a lot sir , very useful.
My pleasure. Enjoy!
thank you sir fo sir wonderful series on immunology.i loved to watch it and make my rheumatology easy
wonderful sir helpful lecture!
+muhammad tayyab thank you sir!
THANK YOU (From Dominican Republic.)
Welcome from US :-)
keep it up sir
+zarwa rana will do!
an excellent explanation of tumor immunity.. I will recommend it to my students!!
Thanks
my doctor , tomorrow is my final exam in immunology , and i am sure i will get very good result coz of your fantastic explanation :))
Good luck Yasser! Glad explanation is useful.
tremendous sir......
Thank you. Find more lectures here: www.drbeen.com/catalog
Mobeen Syed g
good video, this include mitosis?
Hello Dr. Mobeen. Thanks for the great lecture.
There is one more very very important way the cancer cells suppress the T-cells.
The cancer cells over express the enzymes IDO (Indoleamine 2,3-dioxygenase) or TDO (Indoleamine 2,3-dioxygenas). These enzymes deplete the tryptophan concentration in the tumor micro-environment, thus reducing the tryptophan availability to T-cells and hence reduce their survival and growth.
Thank you for sharing. Good point.
thanks a lot sir.......
Welcome. Check drbeen.com for more lectures.
Thank u sir!
Thank you so much, really helpful (y)
You are a champ
+Oyewusi Family thank you!
Really Helpful :)
what is maylance ? is that company ?? or what ?? interesting job you are doing sir .
+Venkteshwar Singh ranout yes it is a company. I am currently running drbeen corp.
thanks, doctor it was helpful!
Tumor suppressor genes are present every cell ...and actually it's growth suppressor genes ..these are genes which regulate growth.
But when they are mutated tumor suppressor genes are only in cancer cells
Thanks ...you explained nicely
Thank you for this presentation. Do you know any knowledge on anti-leukaemia immune surveillance? Several of the tumour markers presented on solid tumours are not expressed on leukaemic cells.
In which lecture do you talk about fas/fasL killing mechanisms? Like what you mentioned at 13:34
Joshua He - listen to the NK cell lecture. Also the initial big picture lectures have the Fas-FasL discussion too.
Sir, Start new session
Why would the product of tumour suppressor genes be displayed on MHC 1 in cancerous cells, but not normal cells? Surely the TS gene would be expressed in normal cells anyway, so would still be detectable on MHC-1?
thanks DR but what the roles of the tumor infiltrating lymphocytes
Thank you
Welcome!
thank you sir.. i have give a presentation on this topic, and it really gave me the knowledge i was looking for.:)
Good to hear. Study well and be the best doctor!
Thnx..:)
Hi, do you have any references for the types of antigens presented on a tumor cell?
sir could you please give a link for lecture related to FAS/FASL/CD98L, TNF between tumor cell and Cytotoxic T lymphocyte.
Hey sir? Wanna ask for a fovour!
Have you given some videos on neoplasia?? I actualy need those😢😢
Not yet. Planning for it soon.
gooooood good
hello sir can u explain in detail how MHC-1 express tumor supprssar gene on the surface.
Hi Dr Is there any immunotherapy available for EBV induced cancer? igg level for ebv > 600
Tumor suppersor gene most common RB produce gene on chromosome no.13 right sir???
+muhammad tayyab I think so!
How does the macrophages would kill the tumor cells? using what mechanism?
Pattern recognition. Recognition of abnormal proteins. Recognition of lack normal proteins, etc. Mostly the tumor cells get caught by NK cells due to the lack of MHC1 expression.
Tyrosinase not tyraminase
Tyraminase or tyrosinase
Hi
Dr. sab looking handsome ..!!
+Venkteshwar Singh ranout thank you!
Its true that he is handsome and nice to listen to he he
hahaha
i should just pay my uni fees to you instead of my own lect
sounds like a macrophage deficiency
Arey tata aur tsta toh bta
thanks
Welcome
thank you !!!
Welcome!