Your videos are precise yet comprehensive. Well explained and not painstakingly long. It's rare to find these qualities in online chemistry videos. Very well done. :))
You're so welcome! It's not dumbing it down, though. It's just finding a way that makes it easier to understand. The subject and the students are still just as smart ;)
@@gartyqam Yeah, if all those smart asses had a life, a lot of others with a life would be dead; without this shit no drug and pill would be on this earth...
no question is a dumb question, you ask so you can learn. The pi bond is nucleophilic and while it appears happy, it can easily be enticed to break and attack an electrophile. In the case of oxgyen, because the O-O is very weak and unstable, it's very reactive. (the oxidation number of a peroxide is only -1 making it more susceptible to be attacked compared to the happy -2 oxygen)
Very good video !! Well understood. However, I only wished I saw this video months ago before learning this mechanism by means of a much more difficult way !
I have not made a UA-cam video on epoxide ring-opening reactions, but you can find this and more in my Organic Chemistry Study Hall. I recommend joining to dive deep into this reaction and others. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/
I have a doubt. Alkenes on oxidation with Baeyer's reagent give us diols as our products. Does this follow the same, or some similar mechanism of alkene epoxidation? This is because in my textbook, alkene epoxidation is omitted and many other reactions are present such as polymerisation, Addition of Sulphuric Acid, Oxidation (as given above) and etc.
I'm sorry, but I don't offer tutoring over social media. For help with questions like this and more, I recommend joining the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/
So I understand that peroxy acid and it's instability is the driving force of the mechanism, but I don't understand (as the original question asks) why her first step is the pi bond attacking an oxygen. Can anyone elaborate?
the oxygen isn't the electrophile, in this case, the oxygen is slightly negative because it draws the electrons from the hydrogen atom closer to itself making it slightly more reactive than the adjacent oxygen which is attached to a carbon (an electron donating group). The pi bond, on the other hand, is electrophilic in this case (since carbon prefers to have all single bonds instead of sharing electrons). as a result, the (electrophilic) pi bond attacks the unstable electron rich to try to saturate itself. when it does this the electrons from the pi-bond between the carbons move to attack the oxygen and as a result, leaves the adjacent carbon electron deficient with a positive charge. The oxygen, still being electron rich then attacks this positive charge and gives up its proton to help stabilize the charge (if it held onto the hydrogen it would have a + formal charge and would still need to get rid of the hydrogen somehow ).
When you look at the cyclic nature of this reaction, it only makes sense for the further oxygen to get attacked. The closer one on the carbon is needed to form the carbonyl and attacking IT would stop the cyclic flow of electrons as I've shown here
This was so much better than the Organic Chemsitry Tutor epoxide video
Glad you found this helpful!
Your videos are precise yet comprehensive. Well explained and not painstakingly long. It's rare to find these qualities in online chemistry videos. Very well done. :))
Thanks so much for your kind words, happy to help
you are so simple in your explanations your dumb it down for us that are not so good in O Chem thanks a lot Mrs Leah.
You're so welcome! It's not dumbing it down, though. It's just finding a way that makes it easier to understand. The subject and the students are still just as smart ;)
Leah You are saving my academic life!!!! I wish I could afford ur tutoring sessions!!! Thank you for these videos! from one nerd to another
You're welcome Nati. Glad the channel helped.
Maam I am from India. These videos are very useful to me . Thanks to u for uploading these videos.
same here, life saver !!
You're so welcome!
awesome explanation...
learning orgo was never such easier...
thanks a lot..
great work😃😃
Glad it helped!
WOW. Ive never thought of using butter as a reagent before. Ill have to try that!
:)
Thanks for explaining this mechanism. It's fascinating!
Glad you liked it!
The way you teach is amazing..
So happy to help!
You made it 10x better to study!
YAY!
YOU'RE MAGIC ! thank you for your videos queenn
You're so welcome!
so wonderfully explained Leah 💖💖💖💖💖💖💖
Glad you liked it!!
you totally saved my life.thank you sooo much.
I'm so glad to help!
u ever wonder how ppl found all o f this out????
they hav no life
literally all the time, like wtf
It's very similar to music theory believe it or not
@@gartyqam Yeah, if all those smart asses had a life, a lot of others with a life would be dead; without this shit no drug and pill would be on this earth...
@@gartyqam Nah they prolly got a better life than you lil kid
This is a dumb question but at 5:18 why would alkene break its pi bond and use its electrons to attack oxygen?
no question is a dumb question, you ask so you can learn.
The pi bond is nucleophilic and while it appears happy, it can easily be enticed to break and attack an electrophile. In the case of oxgyen, because the O-O is very weak and unstable, it's very reactive.
(the oxidation number of a peroxide is only -1 making it more susceptible to be attacked compared to the happy -2 oxygen)
Thankyou!♡
Thanks Leah Fisch! Now I have a hope in passing my 1st year of Chem BSc! hahaha
You're very welcome!
Very good video !! Well understood. However, I only wished I saw this video months ago before learning this mechanism by means of a much more difficult way !
Glad the video helped you understand the topic better! You are very much welcome!
thank you so much for this amazing video💕💕 did you explain the topic that follows alkene epoxidation (anti and syn dihydroxylation)?
You can find my entire alkene series here: leah4sci.com/alkene-reactions/
Excellent explanation
Glad you enjoyed it!
Well summarized
Glad you liked it, thanks for watching!
Thanks! This has been very helpful.
you're very welcome!
You saved the day for me # Thank you Leah
Awesome! You're very welcome!
Your vids help a loooot
Glad to hear that!
Quality teaching mam amazing
Aww thanks!
Did you ever make a video on how to open an epoxide? (like what you do in anti-dihydroxylation)
I have not made a UA-cam video on epoxide ring-opening reactions, but you can find this and more in my Organic Chemistry Study Hall. I recommend joining to dive deep into this reaction and others. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/
I have a doubt. Alkenes on oxidation with Baeyer's reagent give us diols as our products. Does this follow the same, or some similar mechanism of alkene epoxidation? This is because in my textbook, alkene epoxidation is omitted and many other reactions are present such as polymerisation, Addition of Sulphuric Acid, Oxidation (as given above) and etc.
I'm sorry, but I don't offer tutoring over social media. For help with questions like this and more, I recommend joining the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/
thank you Leah!
You're very welcome!
That is great video ♥️
Thank you!!
Very helpful. Thank you
You're welcome! Glad to help! :)
thanks
You're welcome
Mam can you please upload or tell me if you have uploaded video for diels alder reaction??
I have a short series on the Diels Alder Reaction that you can find at leah4sci.com/diels-alder-reaction-mechanism-organic-chemistry/
you are great thanks
You're very welcome!
Thank you
You are very welcome!
very good
Thanks
i want the free book how can i get the book ?
You can sign up here: leah4sci.com/orgosecrets
Thank youu💕💕💕
You're welcome!
how would one go from trans alkene to cis epoxide? or cis alkene to trans epoxide?
flip the alkene first (dihalide -> alkyne -> partial reduction)
Will this apply to sharpless asymmetric epoxidation
I'm not familiar enough with that reaction to answer your question.
thank you!
You're very welcome!
Why does this reaction start? Why does the pi bond attack the oxygen with two lone pairs already? What makes that oxygen electrophilic?
it also looks strange to me.
unstability of peroxy acid is driving force of mechanism .
So I understand that peroxy acid and it's instability is the driving force of the mechanism, but I don't understand (as the original question asks) why her first step is the pi bond attacking an oxygen. Can anyone elaborate?
the oxygen isn't the electrophile, in this case, the oxygen is slightly negative because it draws the electrons from the hydrogen atom closer to itself making it slightly more reactive than the adjacent oxygen which is attached to a carbon (an electron donating group). The pi bond, on the other hand, is electrophilic in this case (since carbon prefers to have all single bonds instead of sharing electrons). as a result, the (electrophilic) pi bond attacks the unstable electron rich to try to saturate itself. when it does this the electrons from the pi-bond between the carbons move to attack the oxygen and as a result, leaves the adjacent carbon electron deficient with a positive charge. The oxygen, still being electron rich then attacks this positive charge and gives up its proton to help stabilize the charge (if it held onto the hydrogen it would have a + formal charge and would still need to get rid of the hydrogen somehow ).
actually this can be understood by HOMO LUMO concept.
why red color oxygen reacted with alkene and not green oxygen?
When you look at the cyclic nature of this reaction, it only makes sense for the further oxygen to get attacked. The closer one on the carbon is needed to form the carbonyl and attacking IT would stop the cyclic flow of electrons as I've shown here
i can't thank u enough
You're so welcome!
are you the person who made Fischer projections??
lol, nope!
Wow👌👌👌👍👍
😊
Anti or syna addition
Epoxides are very tight rings and cannot exist anti
thanksssss!!!!!
You're so welcome!
thnksssss
welcome
goddess!!
Thanks?
thanks a lot .do you have email please
This is probably too late, but you can contact me here: leah4sci.com/contact/
will u marry me plz
Umm...how about we keep our relationship professional?
Thank you
You're welcome!