PRIMARY BILIARY CHOLANGITIS Pathogenesis Symptoms Diagnostic criteria PBC Treatment (CIRRHOSIS)

0:00 Overview of Primary biliary cholangitis
1:07 Pathogenesis of Primary biliary cirrhosis
3:40 HLA association
10:26 Mechanism of clinical symptoms
13:40 Overview of diagnostic methods
15:00 Diagnostic criteria for PBD according to guidelines
16:26 Histology
17:40 Treatment of PBC
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[@alanphilips8413]

Good quality content...

[@Foxterrier]

Thank you, appreciate it very much )

[@user-zt2hz8ve9z]

Best explanation! thanks a lot for make this

[@Foxterrier]

Than you for feedback )

[@perorenchino2036]

I really love your videos,keep up the good work🥰

[@Foxterrier]

Thank you very much )))

[@learnwithveer]

Thank you so much 🙏🏽

[@Foxterrier]

Thanks, appreciate it very much )))

[@user-zt2hz8ve9z]

But one question if the antibody is against mitochondria protein and mitochondria inside cell why antibody destroy biliary cell ?

[@Foxterrier]

Hi. thanks for question. Antibodies that are produced against mitochondria, do not always target just mitochondria. Antibodies are highly reactive and there are some phenomena as molecular mimicry etc, when antibodies against 1 substance can target several others. In this case antibodies are produced against a particular subtance contained in the Mt (not against entire Mt) but can also target outer lining of biliary cells. You can watch Rheumatic fever - molecular mimicry is a signature feature of RF pathogenesis.