Understanding Gilbert's Syndrome with Maria Allerton (née Shaflender)
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- Опубліковано 20 лип 2021
- Subscribe to the podcast here: www.fxmedicine.com.au/podcast
Gilbert’s syndrome is a genetic condition that affects the liver’s ability to process bilirubin. Although generally considered harmless, in fact patients with this condition can suffer from fatigue, gastrointestinal issues and fat soluble vitamin deficiencies.
In this episode, Nutritionist Maria Allerton (née Shaflender) talks to us in depth about Gilbert’s syndrome, speaking both from vast clinical experience and personal perspective. She discusses some of the subtle symptoms of the condition, the connections between Gilbert’s and pyroluria, why patients need to be careful when taking medications, as well as her preferred dietary and supplement interventions.
Find today's transcript and show notes here: www.fxmedicine.com.au/podcast...
COVERED IN THIS EPISODE
[00:58] Welcoming back Maria Allerton (née Shaflender)
[01:40] What is Gilbert’s syndrome?
[03:15] Subtle symptoms of Gilbert’s syndrome
[04:17] What else can cause elevated bilirubin?
[05:03] Orthodox treatment of Gilbert’s is lacking
[06:09] Triggers of Gilbert’s syndrome
[09:07] Connections between Gilbert’s and pyroluria
[11:05] Gilbert’s impairs glucuronidation
[14:36] Oestrogen detoxification
[17:04] Farmers and increased risk
[19:23] Does treatment help?
[20:51] Jaundice in infants - is there a correlation?
[22:20] Pathology
[25:19] Treatment approaches
[27:54] Gilbert’s syndrome and the microbiome
[30:13] Exercise
[33:35] Dietary recommendations
[37:32] SNPs to be aware of
[39:40] Medication metabolism and alternative options
[44:11] Fat soluble vitamins
[45:34] Safety considerations
[47:31] Getting patients onboard with changes
[49:09] Thanking Maria and closing remarks
****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.**** - Наука та технологія
I have tears in my eyes as I feel I have finally found somewhere/one that understands what I don't understand. I thought that some of the things I live with are independent issues, and maybe they are, but I was diagnosed with Gilbert's 20 odd years ago and never really understood what it is and as we know Doctor's really are somewhat dismissive of it. As im going through a spell now, triggered by stress and worry, and had to tell my employer that I think its Gilbert's, I got the natural ???? Reaction. So for the first time, and i've no idea why I never thought of this before, I wondered if there is anything on UA-cam that would describe it. Then I came across your video and my goodness, it feels like a helping hand has just been reached out to me. Im going to look further into what you do and learn more. Thank you so much. Stewart
Same here, only I was very recently diagnosed in my 40's! My mind is blown because I've had every ailment she mentioned. This explains my life so much even down to the epigenitics of my alcoholic father. Mind blown!
Thank you 🙏🏽 we need more awareness.. we need to educate people around the syndrome and have some hope for a one street supplement for us. So much spendings into pills and loss of hope amongst us
Thank you. I have been trying your tips and I'm feeling much better ❤
A great interview, thank you both so much for sharing the knowledge and wisdom, a lot to learn here.
Seeing years after years printing of Gilbert's syndrom on my lab tests, asking GPs about it and getting no where. Ive got a long way to clean up the mess.....
Thx to both of you
Thank you for putting all the puzzle pieces together!!
I have Gilberts and my oldest daughter was just diagnosed as well.
So much of what you’ve said is helping me connect the dots. Drugs and alcohol heavy in my family. I don’t drink or take pain meds because of how it tanks my system. So many women in my family have had their gallbladders removed after childbirth. I cut out fatty foods and increased coffee intake after my first born and was able my gallbladder. Now though I tolerate coffee poorly.
Dandelion is my best friend. I notice zinc helped my psoriasis, another dot you’ve helped me connect.
I’ve done everything my western doctors have said to do, stay hydrated, eat regularly, avoid alcohol and manage stress but just last night I had to leave a dinner party because of abdominal pain. I train martial arts and often feel like my liver is not keeping up after strenuous classes. Thank you for offering an online course! I’m excited to take it and share it with my doctor. ❤
Thank you for this information!!! 🙏🏼🙏🏼🙏🏼🙏🏼
So grateful that I came across this podcast! You have completely connected so many dots for me. You have unpacked my experience and complications with Gilbert’s syndrome to a tee. I was diagnosed in my late teens while the doctors discovered I had endometriosis. No connection had ever been made. I also had my gallbladder removed in my 40s, struggled with h-pylori, anxiety, ibs, osteoporosis at 27, brain fog, low vitamin D levels, family history of alcoholism on father’s side, multiple generations of medium-scale gardening and pesticide exposure, etc. The list goes on and on. I realized very early on that I have a sensitivity to medications. I haven’t had acetaminophen or ibuprofen in over 20 years. This podcast just validated so many of my health experiences. Thank you for trying to educate people. I really wish more doctors understood that this syndrome has so many layers to it and that they wouldn’t dismiss it as a benign issue. My daughter has just been diagnosed with it as well. Thanks to what you have just connected for me, I will do everything in my power to make sure she doesn’t have as many complications as me. Thank you, again. 🙏🏻
Thank you for honest discussion about effects of elevated bilirubin
Just came across this. Interesting that my 21 year old son has just been diagnosed with GS. My mum passed away about 8 years ago from breast cancer, my biological father was an alcoholic, and I have ongoing gluten and dairy issues, nausea, fatigue, depression , and already had my gallbladder out etc….all the same things as my son, although he hasn’t had his gallbladder out now. Will definitely look into the natural medication side of things. Thanks
Fantastic information!
Jaundice (hyperbilirubinemia) is also a listed side effect of the Vitamin K injection given at birth. I wondering how this relates to the genetic component of Gilbert’s syndrome and glucaronadation 🤔
Awesome listen. 28 yr old male living with this. My doctor has no treatment for it . I’ve gone down one hell of a road learning but I’ve never used calcium d glucorate. Thanks Maria and great host
Did it help?
how was it?
Thanks
This was so informative thank you. I’ve had a Gilbert’s diagnosis for 7 years, the GP dismissed it, but interestingly it’s been printed on all my medical referrals since but it’s never been looked at for my complaints of debilitating fatigue and brain fog. I’ve finally found a naturopath and holistic GP team and after listening to me complain of my symptoms and why I’m there the naturopath said that it sounded like we need to investigate my liver and gallbladder, and that’s when I remembered I had Gilbert’s and it was like a lightbulb moment for the naturopath that treats a number of Gilbert’s patients. I felt so seen at that moment. Like this pod cast says I was born with jaundice, I had determined that I think I had leaky gut, I cannot tolerate the pill and turn into a psycho on it, I cannot have pain killers on an empty stomach as I get really nauseous, I cannot have aspirin, it’s a disaster if I do. I’m on medication for anxiety. I actually was born in Russia too. So many ticks. I got diagnosed during my first pregnancy so that’s the probable hormonal trigger. Until this podcast all I heard about really is the jaundice symptoms that I don’t really get, but the fatigue is actually disabling me. Ironically I have to take caffeine and other stimulants to get through the day so it’s perpetuating the cycle. My naturopath thinks that my iron retention issues have something to do with it, she’s found most of the Gilbert’s patients have iron issues. Currently started on detox supplements and going through complete bloods. But gee wiz if all my fatigue is caused by Gilbert’s I’ll be pretty pissed with the doctors for ignoring it because I’ve been asking for help for so long
Hey I struggle with it too, what are you doing/using to improve the condition?
Привет, подскажи пожалуйста что тебе выписали?
Ask your naturopath about Chris Palmer. He is a Harvard train psychiatrist who treats treatment resistant patients metabolically. He has tons of interviews on UA-cam and a book called Mind Energy. I hope it's helpful.
41:26, absolutely 100% correct Maria Allerton, when l was 17, in 1992, l had smoked soap-bar hash, with adverse effects, which consequently left me with derealization mental disorder, and because l had Gilberts syndrome it would have such a detrimental effect on my liver.
Thanks! Since couple of years I haven’t had my bilirubin in range. I run a lot (More than 50 miles a week) and I know that this increases it as well. Is there anything I can do to prevent the increase? Or do I just have to accept it?
Hi
I have Gilbert’s and I’m now 57 and this has opened up a whole new world to me as I’ve been struggling for years and years and couldn’t work out why ! I now have something to actually work on to change my life symptoms. Sorry but I couldn’t understand about vitamin D . Is it something I should be talking along with K2 or were you implying NOT to take it to help my symptoms? ? Thanks
I think she's saying don't, the whole section on vitamins a d and K at the end confused me too.
Can i go for hair transplant
Hi, I have a question…I use oestrogen patches after menopause, I was wondering whether calcium d glucarate would still be ok to take as I also have Gilbert’s syndrome? I had oestrogen dominance and had a large fibroid which has been removed 13 years ago, I don’t have my ovaries either so I’m needing oestrogen in the form of patches. Will,the calcium d glucarate interfere with my oestrogen levels….I need it because of my Gilbert’s to reduce my bilirubin level which is now 33. I’m in the UK. Thanks 🙏
Such a good question!! I believe our GS led to estrogen dominance and fibroids (I’m almost 42 and going to have a hysterectomy because I have so many fibroids and some are quite large). Calcium d glucarate use has decreased ALL my pms, and I’ve only used it for 1.5 months. Question is, do you really need the estrogen? How do you feel when you are not on it?
@@lowlylisalisa hi it’s nice to get a reply. I had a full hysterectomy when I was 43, 13 years ago. I have oestrogen patches as they help my mood plus I’ve also learnt that it protects our bones too…helping with osteoporosis. I was wondering when and how often you take the calcium d glucarate? I wish I knew someone that I could discuss issues with…doctors here don’t have a clue. I’m totally trying to heal myself with supplements etc. I have thyroid issues too and I have so much anxiety. I keep going down rabbit holes.
@@angelataylor2049 I’ve been taking 500mg twice a day of the calcium d glucarate as my estrogen dominant symptoms have been intense. In this short span of time, one and a half months of use I no longer have breast tenderness, night sweats, hormonal acne on the chin line and cyclical headaches a week prior to menstruation only presented itself as one headache the day before my last period started. I believe calcium D glucarate will benefit you in more ways than you realize since people with Gilbert syndrome, struggle with detoxification. I might also have a full hysterectomy so I’m curious about the estrogen patch as well. Hypothyroidism also plays into GS, and the lady in the video mentioned pyroluria, and now I’m seeing the connection of vit b6 issues and fibroids and GS!! It’s all in the same rabbit hole! You have to be your doctor and keep searching! So many docs have no idea how to help because they consider this benign and look at us, we ended up with large fibroids!!
@@angelataylor2049 I’m also taking a bunch of supplements, especially the ones the lady mentioned in this video as well as bile acids and Tudca for fat digestion. I also make my own tea decoction with a bunch of herbs to help support my liver and well being so I believe that also has helped my pms this last month.
Ok has anyone had luch with a food or supplement that lowers your bilirubin and decreases jaundice???
The sound makes it so hard to listen and understand((
Can someone comment if there is a connection between enlarged liver and GS
Probably as liver function impaired in the detox 2 pathway
This^! Mine always hurts. Even in the morning now to just lean forward it is so tender.
@@Nushka23 have you tried calcium d glucarate? Also milk thistle is awesome for the liver, I buy the bulk powder and add a heaping tsp in my water and drink it down
@@lowlylisalisa Do you notice a difference? I haven't but I will definitely look into it.
@@Nushka23 i definitely dont notice a difference when i take the calcium d glucarate, but many have reported that the evidence is in the blood work, that bilirubin levels will be lower (i think Maria even mentioned that in this video). I havent had blook work yet since taking the cdg, its been about 2-3 months. The milk thistle definitely helps with digestion so i take that after my meals. I was diagnosed with uterine fibroids a few months ago and began a deep dive into all my health issues and discovered my gilbert's could be a root cause for the fibroids as estrogen is not properly metabolized for those who have gilberts. I have been making a tea decoction with herbs that the liver loves, some are burdock root, dandelion root and yellow dock root and turmeric and ginger and a few others, i find that this has gently helped my liver detox--something like that might help you as well.
NOT CORRECT. There is genetic testing for GS - UGT1A1 genotyping for Gilbert Syndrome. Also, SIBO, IBS, GLUTEN SENSITIVITY is connected with high billirubin. I was having SIBO, enzyme defect, correct my diet and lowered bilirubin.
Very interesting, what diet did you follow to achieve this? My husband was diagnosed with Gilbert's due to high bilirubin count, and lately feeling very unwell (bit not jaundiced). I've been trying to figure out what sort of diet would help him. I'm very interested in finding out other Gilbert's people experience with Keto and carnivore (even though it seems counterintuitive to what should be followed). He seems to do overall better on a low-carb diet (not necessarily high fat) with mostly red meat
@@mariliseinch2561 you can not diagnose gilberts without genetic testing!!! Google it. GS is effect not cause. Boiled stemed vegetables, very low beef meat. No sugar, just now a then fruits. No sugar EVER! No cookies no sweets EVER. No gluten no bread EVER! AND SO ON... Majority of people cant do even this...will power is very small.. so they accept its a gillberts and continue living poor life...When I corrected my diet my memory, sleep energy skyrocket. I m a different men.
@touch_master my bilirubin was 1.6 and doctor said it was gilbert's I've had blood test done and never had a high bilirubin in the past....do I have this or do I just need to eat right....and what should I eat specifically
@@thekingt1153 my bilirubin was 40. Its a very broad and wide subject, cant write about it on youtube comments. You have to research it. But with food i fix my high bilirubin, and i feel much better now.
I'm wondering where to obtain the genetic testing? My identical twin sister has just been diagnosed so I'm seeking where to get a gene test done on myself. She went in for another complaint but the Dr tested for GS also and found it.
Music way too loud
Has anyone else with GS have a Turmeric intolerance?
We think that my husband had Gilbert’s. He’s been on keto for 6 years 😳 maybe that’s the problem! Ughhh
I disagree with the comment regarding avoiding the keto diet. As a person with Gilbert's Syndrome, I have thrived and healed my gut, my mental health and metabolic system with a keto/carnivore diet. Meat is rich with taurine needed for bile production plus, the more healing animal fat you eat, the more bile you generate. Also, be mindful of taking omega-3 fish oils if diagnosed with a concomitant pyrrole disorder. Omega-3s can interfere with the conversion of omega-6 to arachidonic acid, which is impaired in pyroluria, and increase systemic inflammation, especially neuroinflammation. This may increase the risk of people with bipolar or schizophrenia worsening their symptoms. It is recommended to consider using gamma-linolenic acid omega-6 oils such as evening primrose or borage oils.
Helle are you here?
I've felt better on keto too but wonder if it's because of eating meat or because now I'm not eating the things that were causing my issues like gluten and dairy. I am reevaluating just keto now and I know if I eat wheat, dairy, even sugar, it makes me feel very weird. Which keto is a good diet because it keeps me off all the stuff that makes me feel like crapand mentally insane
@@RunIntoTheSkyNonprofit 👍
Thanks for sharing your experience. I had the symptoms of Gilbert’s since my youth. I often wondered why I feel slightly sick and sometimes nauseated when I try Keto. About 20 years ago I tried Suzanne Sommers diet. I felt okay on carb meals but felt so unwell on high fat meals. With Keto it was weird, I had a sense of feeling healthy yet sick on my stomach. I never did longer than 2 weeks as I started feeling unwell overall.
Keto almost killed me, wish I knew before trying that i have gilberts