Hi! Great video by the way :) Not sure if you will respond but im still going to ask my question I tried the code myself, but instead of plotting it on a graph, i printed the values as an array of numbers My problem is that, the simulation i use displays sodium and potassium currents as picoamperes And im not sure on how to convert the results from the code to picoamperes Is it possible? Could you help out if possible?
Hi, I think the values of current are implied to be in nanoamperes. Nano is 10^-9 and pico is 10^-12 so you can multiply the currents by 1000 to get picoamperes. Let me know if that helps and if I understand your issue correctly!
Where did you take the equations for use in the Github? for Hodgkin Huxley article appear other expressions, little different. I'm interesting for the article for use the model. Thanks u!!
hey in the equation of Im how come the deactivation constant h is with m and n is raised to its fourth power? isnt na ions supposed to have inactivation gates only?
Good question! Basically, - n is the gating variable of the voltage-gated potassium channel - m is the gating variable of the voltage-gated sodium channel - h is the inactivation gate of the voltage-gated sodium channel Voltage-gated potassium and sodium channels are tetramers and, if we assume that each subunit works independently, the gating variable must be put to the fourth power. Since voltage-gated potassium channels only have n, then it becomes n^4. In voltage-gated sodium channels, one subunit contributes to the inactivation whereas the other 3 contribute to the gating (opening), thus, the probability is m^3 • h. Let me know if this makes sense. If not, I explained this concept in this video: ua-cam.com/video/no_1cElnSIQ/v-deo.html
Thank you for the video. In the 1952 paper, the expression for alpha_n, beta_n, alpha_m, beta_m, alpha_h, beta_h are different. Could you kindly give the reference to the expressions used in the code?
In this video (ua-cam.com/video/no_1cElnSIQ/v-deo.html at 10:30) where I cover the Hodgkin-Huxley model in more detail I mention why the equations of alpha n, ... differ. In brief, the equations are set up a bit differently from the 1952 paper because we use different conventions for voltage. Let me know if that helps!
Hi! Great video by the way :)
Not sure if you will respond but im still going to ask my question
I tried the code myself, but instead of plotting it on a graph, i printed the values as an array of numbers
My problem is that, the simulation i use displays sodium and potassium currents as picoamperes
And im not sure on how to convert the results from the code to picoamperes
Is it possible? Could you help out if possible?
Hi, I think the values of current are implied to be in nanoamperes. Nano is 10^-9 and pico is 10^-12 so you can multiply the currents by 1000 to get picoamperes. Let me know if that helps and if I understand your issue correctly!
Where did you take the equations for use in the Github? for Hodgkin Huxley article appear other expressions, little different. I'm interesting for the article for use the model. Thanks u!!
It is possible that they might have changed the code over time. What I show in the video is the version they had in 2022.
hey in the equation of Im how come the deactivation constant h is with m and n is raised to its fourth power?
isnt na ions supposed to have inactivation gates only?
Good question! Basically,
- n is the gating variable of the voltage-gated potassium channel
- m is the gating variable of the voltage-gated sodium channel
- h is the inactivation gate of the voltage-gated sodium channel
Voltage-gated potassium and sodium channels are tetramers and, if we assume that each subunit works independently, the gating variable must be put to the fourth power. Since voltage-gated potassium channels only have n, then it becomes n^4. In voltage-gated sodium channels, one subunit contributes to the inactivation whereas the other 3 contribute to the gating (opening), thus, the probability is m^3 • h.
Let me know if this makes sense.
If not, I explained this concept in this video: ua-cam.com/video/no_1cElnSIQ/v-deo.html
Thank you for the video. In the 1952 paper, the expression for alpha_n, beta_n, alpha_m, beta_m, alpha_h, beta_h are different. Could you kindly give the reference to the expressions used in the code?
In this video (ua-cam.com/video/no_1cElnSIQ/v-deo.html at 10:30) where I cover the Hodgkin-Huxley model in more detail I mention why the equations of alpha n, ... differ. In brief, the equations are set up a bit differently from the 1952 paper because we use different conventions for voltage. Let me know if that helps!
Thank you very much. This helps.